Overcoming CYP1A1/1A2 mediated induction of metabolism by escalating erlotinib dose in current smokers
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PURPOSE: Cigarette smoking induces CYP1A1/1A2 and is hypothesized to alter erlotinib pharmacokinetics. This study aimed to determine the maximum tolerated dose (MTD) of erlotinib in advanced non-small-cell lung cancer (NSCLC) patients who smoke and compare the pharmacokinetics of erlotinib at the MTD in current smokers with 150 mg. PATIENTS AND METHODS: Cohorts of NSCLC patients currently smoking > or = 10 cigarettes per day for > or = 1 year received escalating doses of erlotinib for 14 days until dose-limiting toxicity (DLT). A separate cohort of patients was then randomly assigned to erlotinib at either MTD or 150 mg daily with pharmacokinetics assessed at day 14. Erlotinib was continued until progression or intolerable toxicity. RESULTS: Four dose levels were evaluated in 22 patients: 200, 250, 300, and 350 mg. DLT was observed in one of six patients at 300 mg (rash) and two of five patients at 350 mg (acneiform dermatitis and fatigue/decreased Eastern Cooperative Oncology Group performance status). Thirty-five patients were randomly assigned to 150 mg or 300 mg. Common adverse events (all grades) were: skin toxicity (150 mg, 29%; 300 mg, 67%), diarrhea (150 mg, 18%; 300 mg, 50%), and fatigue (150 mg, 12%; 300 mg, 17%). Erlotinib exposure was dose-proportional within dose range tested. Median steady-state trough erlotinib plasma concentrations were 0.375 and 1.22 microg/mL for 150 mg and 300 mg, respectively. CONCLUSION: The MTD of erlotinib in NSCLC patients who smoke was 300 mg. Steady-state trough plasma concentrations and incidence of rash and diarrhea in smokers at 300 mg were similar to those in former or never smokers receiving 150 mg in previous studies. The potential benefit of higher erlotinib doses in current smokers warrants further evaluation.
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Smoking reduces erlotinib bioavailability.
“smoking reduces erlotinib bioavailability [40].”
From Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (2016) · cites this paper as [40]
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Cites
Erlotinib in Previously Treated Non–Small-Cell Lung Cancer
Shepherd, F. A., Rodrigues Pereira, J., Ciuleanu, T., Tan, E. H., Hirsh, V., Thongprasert, S., Campos, D., Maoleekoonpiroj, S., Smylie, M., Martins, R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050753 · Cited by 5,419 · see citing works
Erlotinib in Lung Cancer — Molecular and Clinical Predictors of Outcome
Tsao, M., Sakurada, A., Cutz, J.-C., Zhu, C., Kamel‐Reid, S., Squire, J. A., Lorimer, I. A. J., Zhang, T., Liu, G., Daneshmand, M., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050736 · Cited by 1,815 · see citing works
Hidalgo, M., Siu, L. L., Nemunaitis, J., Rizzo, J., Hammond, L. A., Takimoto, C., Eckhardt, S. G., Tolcher, A., Britten, C. D., Denis, L., et al. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.13.3267 · Cited by 1,001 · see citing works
Drug Interactions with Tobacco Smoking
Zevin, S., & Benowitz, N. L. (1999) · Clinical Pharmacokinetics · doi:10.2165/00003088-199936060-00004 · Cited by 702 · see citing works
Sequist, L. V. D., Bell, D. W., Lynch, T. J., & Haber, D. A. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.3585 · Cited by 617 · see citing works
Massarelli, E., Varella‐Garcia, M., Tang, X., Xavier, A. C., Ozburn, N. C., Liu, D. D., Bekele, B. N., Herbst, R. S., & Wistuba, I. I. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-3043 · Cited by 594 · see citing works
Effects of smoking on the pharmacokinetics of erlotinib
Hamilton, M., Wolf, J. L., Rusk, J., Beard, S. E., Clark, G. M., Witt, K., & Cagnoni, P. J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2235 · Cited by 312 · see citing works
Self-citationDifferential Metabolism of Gefitinib and Erlotinib by Human Cytochrome P450 Enzymes
Li, J., Zhao, M., He, P., Hidalgo, M. M., & Baker, S. D. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0088 · Cited by 310 · see citing works
Bezjak, A., Tu, D., Seymour, L., Clark, G. M., Trajković, A., Zukin, M., Ayoub, J., Lago, S., Ribeiro, R. D. A., Gerogianni, A., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.05.8073 · Cited by 295 · see citing works
Improved Survival in Never-Smokers vs Current Smokers With Primary Adenocarcinoma of the Lung
Nordquist, L. T., Simon, G. R., Cantor, A. B., Alberts, W. M., & Bepler, G. (2004) · CHEST Journal · doi:10.1378/chest.126.2.347 · Cited by 228 · see citing works
Johnson, J. R., Cohen, M. H., Sridhara, R., Chen, Y., Williams, G. M., Duan, J. Z., Gobburu, J. V. S., Booth, B. P., Benson, K. A., Leighton, J., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0790 · Cited by 224 · see citing works
Smoking affects treatment outcome in patients with advanced nonsmall cell lung cancer
Tsao, A. S., Liu, D., Lee, J. J., Spitz, M., & Hong, W. K. (2006) · Cancer · doi:10.1002/cncr.21884 · Cited by 173 · see citing works
Clark, G. M., Zborowski, D. M., Santabarbara, P., Ding, K., Whitehead, M., Seymour, L., & Shepherd, F. A. (2006) · Clinical Lung Cancer · doi:10.3816/clc.2006.n.022 · Cited by 158 · see citing works
Prognostic factors versus predictive factors: Examples from a clinical trial of erlotinib
Clark, G. M. (2007) · Molecular Oncology · doi:10.1016/j.molonc.2007.12.001 · Cited by 142 · see citing works
Cigarette smoking and irinotecan treatment: pharmacokinetic interaction and effects on neutropenia.
van der Bol, J. M., Mathijssen, R. H. J., Loos, W. J., Friberg, L. E., van Schaik, R. H. N., de Jonge, M. J. A., Planting, A. S. T., Verweij, J., Sparreboom, A., & de Jong, F. A. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.6115 · Cited by 128 · see citing works
Clark, G. M., Zborowski, D. M., Culbertson, J. L., Whitehead, M., Savoie, M., Seymour, L., & Shepherd, F. A. (2006) · Journal of Thoracic Oncology · doi:10.1016/s1556-0864(15)30414-7 · Cited by 98 · see citing works
Preclinical studies with Erlotinib (Tarceva)
Akita, R. W., & Sliwkowski, M. X. (2003) · Seminars in Oncology · doi:10.1016/s0093-7754(03)70011-6 · Cited by 95 · see citing works
Erlotinib: Optimizing Therapy with Predictors of Response?
Goodin, S. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0426 · Cited by 22 · see citing works
Shepherd, F. A., Ding, K., Sakurada, A., Santos, G. D. C., Zhu, C., Seymour, L., Whitehead, M., Kamel‐Reid, S., Squire, J. A., & Tsao, M. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.7571 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 20 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Novello, S., Barlesi, F., Califano, R., Cufer, T., Ekman, S., Levra, M. G., Kerr, K., Popat, S., Reck, M., Senan, S., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw326 · Cited by 2,631 · see citing works
Planchard, D., Popat, S., Kerr, K., Novello, S., Smit, E. F., Faivre-Finn, C., Mok, T. S., Reck, M., Van Schil, P. E., Hellmann, M. D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy275 · Cited by 2,274 · see citing works
Peters, S., Adjei, A. A., Gridelli, C., Reck, M., Kerr, K. M., & Felip, E. (2012) · Annals of Oncology · doi:10.1093/annonc/mds226 · Cited by 930 · see citing works
Reck, M., Popat, S., Reinmuth, N., Ruysscher, D. D., Kerr, K. M., & Peters, S. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu199 · Cited by 679 · see citing works
Zhu, A. X., Rosmorduc, O., Evans, T. R. J., Ross, P. J., Santoro, A., Carrilho, F. J., Bruix, J., Qin, S., Thuluvath, P. J., Llovet, J. M., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.53.7746 · Cited by 577 · see citing works
Clinical pharmacokinetics of tyrosine kinase inhibitors
van Erp, N. P., Gelderblom, H., & Guchelaar, H.-J. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.08.004 · Cited by 503 · see citing works
Lee, C. K., Wu, Y.-L., Ding, P. N., Lord, S. J., Inoue, A., Zhou, C., Mitsudomi, T., Rosell, R., Pavlakis, N., Links, M., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.1736 · Cited by 327 · see citing works
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
Janne, P. A., Gray, N. S., & Settleman, J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2871 · Cited by 303 · see citing works
Wu, Y.-L., Planchard, D., Lü, S., Sun, H., Yamamoto, N., Kim, D., Tan, D. S.-W., Yang, J. C., Azrif, M., Mitsudomi, T., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy554 · Cited by 292 · see citing works
Drug-microbiota interactions: an emerging priority for precision medicine
Zhao, Q. C., Chen, Y., Huang, W., Zhou, H., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01619-w · Cited by 296 · see citing works
Zhou, S.-F., Wang, B., Yang, L.-P., & Liu, J. (2009) · Drug Metabolism Reviews · doi:10.3109/03602530903286476 · Cited by 262 · see citing works
Roberts, P. J., Stinchcombe, T. E., Der, C. J., & Socinski, M. A. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.27.4365 · Cited by 240 · see citing works
Clinical Pharmacokinetics of Tyrosine Kinase Inhibitors
Gion, P. D., Kanefendt, F., Lindauer, A., Scheffler, M., Doroshyenko, O., Fuhr, U., Wolf, J., & Jaehde, U. (2011) · Clinical Pharmacokinetics · doi:10.2165/11593320-000000000-00000 · Cited by 224 · see citing works
Self-citationMartins, R. G., Parvathaneni, U., Bauman, J. E., Sharma, A. K., Raez, L. E., Papagikos, M. A., Yunus, F., Kurland, B. F., Eaton, K. D., Liao, J. J., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.3299 · Cited by 205 · see citing works
Jimenez-Ruiz, C. A., Andreas, S., Lewis, K. E., Tønnesen, P., van Schayck, O. C. P., Hájek, P., Tonstad, S., Dautzenberg, B., Fletcher, M. J., Masefield, S. C., et al. (2015) · European Respiratory Journal · doi:10.1183/09031936.00092614 · Cited by 195 · see citing works
Determining the optimal dose in the development of anticancer agents
Mathijssen, R. H. J., Sparreboom, A., & Verweij, J. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.40 · Cited by 183 · see citing works
Freudlsperger, C., Burnett, J. R., Friedman, J., Kannabiran, V. R., Chen, Z., & Waes, C. V. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.541440 · Cited by 183 · see citing works
Smoking Cessation: An Integral Part of Lung Cancer Treatment
Cataldo, J. K., Dubey, S., & Prochaska, J. J. (2010) · Oncology · doi:10.1159/000319937 · Cited by 181 · see citing works
Clinicopathologic Features of Advanced Squamous NSCLC
Socinski, M. A., Obasaju, C. K., Gandara, D. R., Hirsch, F. R., Bonomi, P., Bunn, P. A., Kim, E. S., Langer, C. J., Natale, R. B., Novello, S., et al. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.05.024 · Cited by 183 · see citing works
Lee, S. M., Khan, I., Upadhyay, S., Lewanski, C. R., Falk, S. J., Skailes, G., Marshall, E., Woll, P. J., Hatton, M. Q. F., Lal, R., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70412-6 · Cited by 178 · see citing works
Self-citationTobacco smoking after diagnosis of cancer: clinical aspects
Jassem, J. (2019) · Translational Lung Cancer Research · doi:10.21037/tlcr.2019.04.01 · Cited by 168 · see citing works
Duruisseaux, M., Besse, B., Cadranel, J. L., Pérol, M., Mennecier, B., Bigay-Game, L., Descourt, R., Dansin, É., Audigier-Valette, C., Moreau, L., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15746 · Cited by 157 · see citing works
Peters, S., Zimmermann, S., & Adjei, A. A. (2014) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2014.06.010 · Cited by 155 · see citing works
Effects of Cigarette Smoking on Metabolism and Effectiveness of Systemic Therapy for Lung Cancer
O'Malley, M. W., King, A. N., Conte, M. L., Ellingrod, V. L., & Ramnath, N. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000191 · Cited by 139 · see citing works
Reungwetwattana, T., Weroha, S. J., & Molina, J. R. (2011) · Clinical Lung Cancer · doi:10.1016/j.cllc.2011.09.004 · Cited by 125 · see citing works
Solassol, I., Pinguet, F., & Quantin, X. (2019) · Biomolecules · doi:10.3390/biom9110668 · Cited by 123 · see citing works
Clinical Pharmacokinetics of Tyrosine Kinase Inhibitors
Scheffler, M., Gion, P. D., Doroshyenko, O., Wolf, J., & Fuhr, U. (2011) · Clinical Pharmacokinetics · doi:10.2165/11587020-000000000-00000 · Cited by 110 · see citing works
Self-citationLankheet, N. A. G., Knapen, L. M., Schellens, J. H. M., Beijnen, J. H., Steeghs, N., & Huitema, A. D. R. (2013) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000004 · Cited by 109 · see citing works
Razak, A. R. A., Soulières, D., Laurie, S. A., Hotte, S. J., Singh, S., Winquist, E., Chia, S., Tourneau, C. L., Nguyen‐Tan, P. F., Chen, E. X., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds503 · Cited by 104 · see citing works
Synthetic Pot: Not Your Grandfather’s Marijuana
Ford, B. M., Tai, S., Fantegrossi, W. E., & Prather, P. L. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.12.003 · Cited by 102 · see citing works
Clinical Pharmacokinetics of Tyrosine Kinase Inhibitors
Josephs, D. H., Fisher, D. S., Spicer, J. F., & Flanagan, R. J. (2013) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e318292b931 · Cited by 86 · see citing works
Effects of Tobacco Smoking and Nicotine on Cancer Treatment
Petros, W. P., Younis, I. R., Ford, J. N., & Weed, S. A. (2012) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.2012.01117 · Cited by 86 · see citing works
Therapeutic strategy for advanced EGFR mutant non-small-cell lung carcinoma
Cadranel, J. L., Ruppert, A.-M., Beau‐Faller, M., & Wislez, M. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.06.009 · Cited by 80 · see citing works
Thomas, F., Rochaix, P., White‐Koning, M., Hennebelle, I., Sarini, J., Benlyazid, A., Malard, L., Lefebvre, J., Chatelut, É., & Delord, J. P. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.05.007 · Cited by 81 · see citing works
Clinical Significance of Smoking Cessation in Subjects With Cancer: A 30-Year Review
Florou, A., Gkiozos, I., Tsagouli, S. K., Souliotis, K. N., & Syrigos, K. N. (2014) · Respiratory Care · doi:10.4187/respcare.02559 · Cited by 78 · see citing works
Balagula, Y., Garbe, C., Myskowski, P. L., Hauschild, A., Rapoport, B. L., Boers-Doets, C. B., & Lacouture, M. E. (2011) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2010.04791.x · Cited by 70 · see citing works
Selective Inhibition of Human Solute Carrier Transporters by Multikinase Inhibitors
Johnston, R. A., Rawling, T., Chan, T., Zhou, F., & Murray, M. T. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.059097 · Cited by 67 · see citing works
Impact of Smoking on Lung Cancer Treatment Effectiveness: A Review
Condoluci, A., Mazzara, C., Zoccoli, A., Pezzuto, A., & Tonini, G. (2016) · Future Oncology · doi:10.2217/fon-2015-0055 · Cited by 64 · see citing works
Xu, Z., & Li, J. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s194870 · Cited by 58 · see citing works
Hasegawa, Y., Ando, M., Maemondo, M., Yamamoto, S., Isa, S., Saka, H., Kubo, A., Kawaguchi, T., Takada, M., Rosell, R., et al. (2015) · The Oncologist · doi:10.1634/theoncologist.2014-0285 · Cited by 56 · see citing works
Danson, S. J., Rowland, C., Rowe, R., Ellis, S. P., Crabtree, C., Horsman, J. M., Wadsley, J., Hatton, M. Q. F., Woll, P. J., & Eiser, C. (2015) · Supportive Care in Cancer · doi:10.1007/s00520-015-2928-x · Cited by 53 · see citing works
Self-citationBart, A. G., & Scott, E. E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005588 · Cited by 49 · see citing works
Tiseo, M., Andreoli, R., Gelsomino, F., Mozzoni, P., Azzoni, C., Bartolotti, M., Bortesi, B., Goldoni, M., Silini, E. M., Palma, G. D., et al. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.12.001 · Cited by 44 · see citing works
Clinical Development of Vascular Disrupting Agents: What Lessons Can We Learn From ASA404?
LoRusso, P. M., Boerner, S. A., & Hunsberger, S. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.1311 · Cited by 43 · see citing works
Petit-Jean, E., Buclin, T., Guidi, M., Quoix, É., Gourieux, B., Decosterd, L. A., Gairard-Dory, A., Ubeaud-Séquier, G., & Widmer, N. (2014) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000097 · Cited by 43 · see citing works
Roach, M. C., Rehman, S. S. U., DeWees, T. A., Abraham, C. D., Bradley, J. D., & Robinson, C. G. (2015) · Practical Radiation Oncology · doi:10.1016/j.prro.2015.09.005 · Cited by 41 · see citing works
Evolution of systemic therapy for advanced pancreatic cancer
Renouf, D. J., & Moore, M. J. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.21 · Cited by 41 · see citing works
Faehling, M., Eckert, R., Kuom, S., Kamp, T., Stoiber, K., & Schumann, C. (2010) · Oncology · doi:10.1159/000315731 · Cited by 40 · see citing works
Harada, T., López-Chávez, A., Xi, L., Raffeld, M. A., Wang, Y., & Giaccone, G. (2010) · Oncogene · doi:10.1038/onc.2010.545 · Cited by 38 · see citing works
Erlotinib in the treatment of non-small cell lung cancer: current status and future developments.
Gridelli, C., Maione, P., Bareschino, M. A., Schettino, C., Sacco, P. C., Ambrosio, R., Barbato, V., Falanga, M., & Rossi, A. (2010) · PubMed · Cited by 38 · see citing works
Optimizing the Management of Advanced Non-small-Cell Lung Cancer: A Personal View
Vincent, M. D. (2009) · Current Oncology · doi:10.3747/co.v16i4.465 · Cited by 36 · see citing works
Role of Erlotinib in the Treatment of Non-Small Cell Lung Cancer
Piperdi, B., & Perez-Soler, R. (2012) · Drugs · doi:10.2165/1163018-s0-000000000-00000 · Cited by 35 · see citing works
Ranson, M., Shaw, H. M., Wolf, J., Hamilton, M., McCarthy, S. P., Dean, E. J., Reid, A. H. M., & Judson, I. R. (2009) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-009-1133-3 · Cited by 35 · see citing works
Self-citationSmoking Cessation in Lung Cancer
Andreas, S., Rittmeyer, A., Hinterthaner, M., & Huber, R. M. (2013) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2013.0719 · Cited by 35 · see citing works
Boeck, S. H., Vehling‐Kaiser, U., Waldschmidt, D., Kettner, E., Märten, A., Winkelmann, C., Klein, S., Kojouharoff, G., Gauler, T. C., von Weikersthal, L. F., et al. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32833123ed · Cited by 34 · see citing works
A phase II study of erlotinib in gemcitabine refractory advanced pancreatic cancer
Renouf, D. J., Tang, P. A., Hedley, D. W., Chen, E., Kamel‐Reid, S., Tsao, M., Tran‐Thanh, D., Gill, S., Dhani, N. C., Au, H., et al. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.04.008 · Cited by 31 · see citing works
Mitchell, P. L. R., Mok, T. S. K., Barraclough, H., Strizek, A., Lew, R. A., & Kooten, M. V. (2011) · Clinical Lung Cancer · doi:10.1016/j.cllc.2011.08.003 · Cited by 31 · see citing works
Duong, S., & Leung, M. (2010) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155210381794 · Cited by 30 · see citing works
MacLeod, A. K., Lin, D., Huang, J. T.-J., McLaughlin, L. A., Henderson, C. J., & Wolf, C. R. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3555 · Cited by 28 · see citing works
Kolesar, J., Peh, K. H., Thomas, L., Baburaj, G., Mukherjee, N., Kantamneni, R., Lewis, S. C., Pai, A., Udupa, K., Kumar, N. A. N., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01534-8 · Cited by 29 · see citing works
Li, X., Huang, C., Xie, X., Wu, Z., Tian, X., Wu, Y., Du, X., & Shi, L. (2020) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13309 · Cited by 28 · see citing works
Hamada, A., Sasaki, J.-I., Saeki, S., Iwamoto, N., Inaba, M., Ushijima, S., Urata, M., Kishi, H., Fujii, S., Semba, H., et al. (2012) · Pharmacogenomics · doi:10.2217/pgs.11.176 · Cited by 27 · see citing works
Effects of continued tobacco use during treatment of lung cancer
Waller, L. L., Weaver, K. E., Petty, W. J., & Miller, A. A. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.140 · Cited by 27 · see citing works
Self-citationElsherbiny, M. E., & Brocks, D. R. (2011) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.596204 · Cited by 26 · see citing works
O’Bryant, C. L., Haluska, P., Rosen, L. S., Ramanathan, R. K., Venugopal, B., Leong, S., Boinpally, R., Franke, A., Witt, K., Evans, J., et al. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-011-1733-6 · Cited by 25 · see citing works
Self-citationCigarette Smoking and Gemcitabine-Induced Neutropenia in Advanced Solid Tumors
O'Malley, M. W., Healy, P. N., Daignault, S. D., & Ramnath, N. (2013) · Oncology · doi:10.1159/000355107 · Cited by 25 · see citing works
Management strategies in pancreatic cancer
Campen, C. J., Dragovich, T., & Baker, A. F. (2011) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp100254 · Cited by 24 · see citing works
Pillai, V. C., Venkataramanan, R., Parise, R. A., Christner, S. M., Gramignoli, R., Strom, S. C., Rudek, M. A., & Beumer, J. H. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.052100 · Cited by 24 · see citing works
Sibbald, M., Yan, A. T.-K., Huang, W., Fox, K. A. A., Gore, J. M., Steg, P. G., Eagle, K. A., Brieger, D. B., Montalescot, G., & Goodman, S. G. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.07.026 · Cited by 23 · see citing works
Das, M. S., Padda, S. K., Frymoyer, A. R., Zhou, L. Y., Riess, J. W., Neal, J. W., & Wakelee, H. A. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.06.011 · Cited by 23 · see citing works
Lankheet, N. A. G., Schaake, E. E., Burgers, S. A., van Pel, R., Beijnen, J. H., Huitema, A. D. R., & Klomp, H. M. (2014) · Clinical Lung Cancer · doi:10.1016/j.cllc.2014.12.012 · Cited by 23 · see citing works
McGranahan, T. M., & Nagpal, S. (2017) · Current Treatment Options in Oncology · doi:10.1007/s11864-017-0466-0 · Cited by 21 · see citing works
Safety profile of new anticancer drugs
Mansi, L., Thiery-Vuillemin, A., Nguyen, T., Bazán, F., Calcagno, F., Rocquain, J., Demarchi, M., Villanueva, C., Maurina, T., & Pivot, X. B. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740330903530663 · Cited by 20 · see citing works
Phelps, M. A., Stinchcombe, T. E., Blachly, J. S., Zhao, W., Schaaf, L. J., Starrett, S. L., Wei, L., Poi, M. J., Wang, D., Papp, A., et al. (2014) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2014.93 · Cited by 21 · see citing works
Management of tyrosine kinase inhibitor resistance in lung cancer with EGFR mutation
Becker, K. D. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i4.560 · Cited by 19 · see citing works
Gougis, P., Palmieri, L., Funck‐Brentano, C., Paci, A., Flippot, R., Mir, O., & Coriat, R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.06.006 · Cited by 20 · see citing works
Using erlotinib to treat patients with non-small cell lung cancer who continue to smoke
Waller, L. L., Miller, A. A., & Petty, W. J. (2009) · Lung Cancer · doi:10.1016/j.lungcan.2009.08.014 · Cited by 16 · see citing works
Self-citationSong, X., Varker, H., Eichelbaum, M. F., Stopfer, P., Shahidi, M., Wilson, K. L., Kaiser, R., & Finnern, H. W. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.01.016 · Cited by 15 · see citing works
Yamamoto, Y., Saita, T., Yamamoto, Y. L., & Shin, M. (2018) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2017.10.002 · Cited by 15 · see citing works
Choi, H.-G., Jeon, J., Im, Y., Kim, Y., Song, E., Seo, Y.-H., Cho, S.-J., & Kim, M. (2014) · Clinical Drug Investigation · doi:10.1007/s40261-014-0248-4 · Cited by 14 · see citing works
“Stop Smoking!” Do We Say It Enough?
Hildebrand, J. R., & Sastry, S. (2013) · Journal of Oncology Practice · doi:10.1200/jop.2013.000890 · Cited by 14 · see citing works
Faehling, M., Achenbach, J., Staib, P., Steffen, U., Tessen, H. W., Gaillard, V. E., & Brugger, W. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2649-x · Cited by 14 · see citing works
Smit, E. F., Wu, Y.-L. L. C., Gervais, R., Zhou, C., Felip, E., Feng, J., Güçlü, S. Z., Hoiczyk, M., Dorokhova, E., Freudensprung, U., et al. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.06.019 · Cited by 13 · see citing works
Visentin, M., Biason, P., & Toffoli, G. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.05.005 · Cited by 13 · see citing works
Thienopyridine efficacy and cigarette smoking status
Bliden, K. P., Baker, B., Nolin, T. D., Jeong, Y., Bailey, W. L., Tantry, U. S., & Gurbel, P. A. (2013) · American Heart Journal · doi:10.1016/j.ahj.2012.12.024 · Cited by 12 · see citing works
High cyclin D3 expression confers erlotinib resistance in aerodigestive tract cancer
Petty, W. J., Voelzke, W. R., Urbanic, J. J., Varela, V. A., Waller, L. L., Swift, C. B., Graham, R. M., Memoli, V. A., & Dragnev, K. H. (2011) · Lung Cancer · doi:10.1016/j.lungcan.2011.04.004 · Cited by 12 · see citing works
Self-citationEpidermal Growth Factor Receptor Pathway
Bonomi, P. (2010) · Journal of Thoracic Oncology · doi:10.1097/01.jto.0000391370.86753.90 · Cited by 12 · see citing works
Drug Exposure: Still an Excellent Biomarker
Meza–Junco, J., & Sawyer, M. B. (2009) · Biomarkers in Medicine · doi:10.2217/bmm.09.58 · Cited by 11 · see citing works
Kumar, R., Lu, S. K., Minchom, A. R., Sharp, A., Davidson, M., Gunapala, R., Yap, T. A., Bhosle, J., Popat, S., & O'Brien, M. E. R. (2015) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-015-2950-1 · Cited by 10 · see citing works
Self-citationSantarpía, M., Pas, T. M. D., Altavilla, G., Spaggiari, L., & Rosell, R. (2013) · Future Oncology · doi:10.2217/fon.13.6 · Cited by 10 · see citing works
Yamamoto, Y., Iida, S., Kawanishi, T., & Fukuoka, M. (2014) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12232 · Cited by 10 · see citing works
Epidermal Growth Factor Receptor Inhibitors: Current Status and Future Directions
Chen, H. X., Cleck, J. N., Coelho, R. P., & Dancey, J. E. (2009) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2009.10.002 · Cited by 10 · see citing works
Mavoglurant reduces cocaine use in patients with cocaine use disorder in a phase 2 clinical trial
Gomez‐Mancilla, B., Dürsteler, K. M., Vogel, M., Herdener, M., Torrens, M., Gálvez, B. P., Gual, A., Corral, R. M., Kuper, E., Mosca, D., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adi4505 · Cited by 8 · see citing works
Suzuki, H., Hirashima, T., Okamoto, N., Yamadori, T., Tamiya, M., Morishita, N., Shiroyama, T., Otsuka, T., Kitai, K., & Kawase, I. (2012) · 癌症:英文版 · doi:10.5732/cjc.012.10160 · Cited by 7 · see citing works
Zheng, S., Wang, R., Zhang, Y., Pan, Y., Cheng, C., Zheng, D., Sun, Y., & Chen, H. (2016) · Cancer Medicine · doi:10.1002/cam4.764 · Cited by 7 · see citing works
Late phase 1 studies: concepts and outcomes
Benítez, J. C., Géraud, A., Texier, M., Massard, C., Paci, A., Soria, J., & Besse, B. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00467-8 · Cited by 7 · see citing works
Smoking Cessation with Lung Cancer: Not Too Little, Never Too Late!
Gemine, R. E., & Lewis, K. E. (2016) · EMJ Respiratory · doi:10.33590/emjrespir/10311510 · Cited by 7 · see citing works
Liao, D., Liu, Z., Zhang, Y., Liu, G., Yao, D., Cao, L., Chen, Y., Fu, Y., Yang, N., & Xiang, D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00664 · Cited by 7 · see citing works
Le tabac et ses conséquences dans le cadre du traitement du cancer bronchique
Rivera, C., Rivera, S., Fabre, E., Pricopi, C., Pimpec‐Barthes, F. L., & Riquet, M. (2015) · Revue de Pneumologie Clinique · doi:10.1016/j.pneumo.2014.11.009 · Cited by 6 · see citing works
Rapid onset of conjunctivitis associated with overdosing of erlotinib
Sun, P., Long, J., Chen, P., He, Q., Gao, X., & Li, S. (2017) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12641 · Cited by 7 · see citing works
- Authors
- Hughes, A. N., O'Brien, M. E. R., Petty, W. J., Chick, J. B., Rankin, E., Woll, P. J., Dunlop, D., Nicolson, M., Boinpally, R., Wolf, J., & Price, A.
- Affiliations
- Aberdeen Royal Infirmary (GB)
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2009-03-10
- Volume
- 27
- Issue
- 8
- Pages
- 1220-1226
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC2667823
- OpenAlex
- W2140617449
- Cited by
- 144
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 11 · 2014: 15 · 2013: 19 · 2012: 9
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- erlotinib, cigarette smoking, non-small cell lung cancer, maximum tolerated dose, pharmacokinetics, dose-limiting toxicity, rash, diarrhea, dose escalation, drug metabolism
- MeSH terms
- Erlotinib Hydrochloride, Aged, Carcinoma, Non-Small-Cell Lung, Female, Humans, Lung Neoplasms, Male, Middle Aged, Quinazolines, Smoking, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Maximum Tolerated Dose, Protein Kinase Inhibitors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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