A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
Open accessAbstract
Purpose: Panitumumab, a fully human antibody targeting the epidermal growth factor receptor, is active in patients with metastatic colorectal cancer (mCRC). This trial evaluated panitumumab added to bevacizumab and chemotherapy (oxaliplatin- and irinotecan-based) as first-line treatment for mCRC. Patients and Methods: Patients were randomly assigned within each chemotherapy cohort to bevacizumab and chemotherapy with or without panitumumab 6 mg/kg every 2 weeks. The primary end point was progression-free survival (PFS) within the oxaliplatin cohort. Tumor assessments were performed every 12 weeks and reviewed centrally. Results: A total of 823 and 230 patients were randomly assigned to the oxaliplatin and irinotecan cohorts, respectively. Panitumumab was discontinued after a planned interim analysis of 812 oxaliplatin patients showed worse efficacy in the panitumumab arm. In the final analysis, median PFS was 10.0 and 11.4 months for the panitumumab and control arms, respectively (HR, 1.27; 95% CI, 1.06 to 1.52); median survival was 19.4 months and 24.5 months for the panitumumab and control arms, respectively. Grade 3/4 adverse events in the oxaliplatin cohort (panitumumab v control) included skin toxicity (36% v 1%), diarrhea (24% v 13%), infections (19% v 10%), and pulmonary embolism (6% v 4%). Increased toxicity without evidence of improved efficacy was observed in the panitumumab arm of the irinotecan cohort. KRAS analyses showed adverse outcomes for the panitumumab arm in both wild-type and mutant groups. Conclusion: The addition of panitumumab to bevacizumab and oxaliplatin- or irinotecan-based chemotherapy results in increased toxicity and decreased PFS. These combinations are not recommended for the treatment of mCRC in clinical practice.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the PACCE study, combined use of panitumumab with chemotherapy and bevacizumab may result in adverse outcomes irrespective of RAS mutation status.
“The PACCE study evaluated the addition of panitumumab to chemotherapy and bevacizumab, showing that the combined use of two biological agents may result in adverse outcomes irrespective of RAS mutation status [19].”
From RAS Mutations in Advanced Colorectal Cancer: Mechanisms, Clinical Implications, and Novel Therapeutic Approaches (2025) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
New Guidelines to Evaluate the Response to Treatment in Solid Tumors
Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660 · see citing works
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., Holmgren, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032691 · Cited by 10,968 · see citing works
Cunningham, D., Humblet, Y., Siena, S., Khayat, D., Bleiberg, H., Santoro, A., Bets, D., Mueser, M., Harstrick, A., Verslype, C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033025 · Cited by 5,035 · see citing works
<i>K-ras</i> Mutations and Benefit from Cetuximab in Advanced Colorectal Cancer
Karapetis, C. S., Khambata-Ford, S., Jonker, D. J., O'Callaghan, C. J., Tu, D., Tebbutt, N. C., Simes, R. J., Chalchal, H., Shapiro, J. D., Robitaille, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0804385 · Cited by 3,622 · see citing works
Douillard, J., Cunningham, D., Roth, A., Navarro, M., James, R., Karasek, P., Jandik, P., Iveson, T., Carmichael, J., Alakl, M., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02034-1 · Cited by 3,256 · see citing works
Amado, R. G., Wolf, M., Peeters, M., Van Cutsem, E., Siena, S., Freeman, D. J., Juan, T., Sikorski, R., Suggs, S., Radinsky, R., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.7116 · Cited by 3,207 · see citing works
Self-citationGiantonio, B. J., Catalano, P. J., Meropol, N. J., O'Dwyer, P. J., Mitchell, E. P., Alberts, S. R., Schwartz, M. A., & Benson, A. B. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.6305 · Cited by 2,279 · see citing works
Self-citationVan Cutsem, E., Peeters, M., Siena, S., Humblet, Y., Hendlisz, A., Neyns, B., Canon, J.-L., Van Laethem, J.-L., Maurel, J., Richardson, G., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.08.1620 · Cited by 1,979 · see citing works
Self-citationCetuximab for the Treatment of Colorectal Cancer
Jonker, D. J., O'Callaghan, C. J., Karapetis, C. S., Zalcberg, J. R., Tu, D., Au, H.-J., Berry, S. R., Krahn, M., Price, T., Simes, R. J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071834 · Cited by 1,904 · see citing works
Cetuximab in the treatment of colorectal cancer.
Goldberg, R. M., Venook, A. P., & Schilsky, R. L. (2004) · PubMed · Cited by 1,518 · see citing works
Sobrero, A. F., Maurel, J., Fehrenbacher, L., Scheithauer, W., Abubakr, Y. A., Lutz, M. P., Vega-Villegas, M. E., Eng, C., Steinhauer, E. U., Prausová, J., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.1193 · Cited by 940 · see citing works
Kabbinavar, F. F., Schulz, J. J., McCleod, M., Patel, T. N., Hamm, J. T., Hecht, J. R., MASS, R. D., Perrou, B., Nelson, B. J., & Novotny, W. F. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.112 · Cited by 926 · see citing works
Self-citationHerbst, R. S., Johnson, D. H., Mininberg, E. D., Carbone, D. P., Henderson, T., Kim, E. S., Blumenschein, G., Lee, J. J., Liu, D. D., Truong, M. T., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.477 · Cited by 526 · see citing works
Saltz, L. B., Lenz, H., Kindler, H. L., Höchster, H. S., Wadler, S., Hoff, P. M., Kemeny, N. E., Hollywood, E. M., Gönen, M., Quinones, M., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.12.0949 · Cited by 424 · see citing works
Ciardiello, F., Bianco, R., Damiano, V., Fontanini, G., Caputo, R., Pomatico, G., Placido, S. D., Bianco, A. R., Mendelsohn, J. M., & Tortora, G. (2000) · PubMed · Cited by 379 · see citing works
Cutsem, E. V., Láng, I., D’Haens, G., Moiseyenko, V. M., Załuski, J., Folprecht, G., Tejpar, S., Kisker, O., Stroh, C., & Rougier, P. R. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.2 · Cited by 372 · see citing works
Cutsem, E. V., Nowacki, M. P., Láng, I., Cascinu, S., Shchepotin, I. B., Maurel, J., Rougier, P. R., Cunningham, D., Nippgen, J., & Köhne, C.-H. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.25.18_suppl.4000 · Cited by 313 · see citing works
Jung, Y. D., Mansfield, P. F., Akagi, M., Takeda, A., Liu, W., Bucana, C. D., Hicklin, D. J., & Ellis, L. M. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00013-8 · Cited by 248 · see citing works
Bokemeyer, C., Bondarenko, I., Hartmann, J. T., de Braud, F., Volovat, C. D., Nippgen, J., Stroh, C., Celik, I., & Koralewski, P. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.4000 · Cited by 240 · see citing works
Shaheen, R. M., Ahmad, S. A., Liu, W., Reinmuth, N., Jung, Y. D., Tseng, W. W., Drazan, K. E., Bucana, C. D., Hicklin, D. J., & Ellis, L. M. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1936 · Cited by 235 · see citing works
Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
Hecht, J. R., Patnaik, A., Berlin, J. D., Venook, A. P., Malik, I. A., Tchekmedyian, S., Navale, L., Amado, R. G., & Meropol, N. J. (2007) · Cancer · doi:10.1002/cncr.22915 · Cited by 202 · see citing works
Self-citationCutsem, E. V., Siena, S., Humblet, Y., Canon, J.-L., Maurel, J., Bajetta, E., Neyns, B., Kotasek, D., Santoro, A., Scheithauer, W., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm399 · Cited by 155 · see citing works
Self-citationPunt, C. J. A., Tol, J. A. M. G., Rodenburg, C. J., Cats, A., Creemers, G. J. M., Schrama, J. G., Erdkamp, F., Vos, A. H., Mol, L., & Antonini, N. F. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.lba4011 · Cited by 128 · see citing works
Berlin, J. D., Posey, J. A., Tchekmedyian, S., Hu, E. H.-L., Chan, D., Malik, I. A., Yang, L., Amado, R. G., & Hecht, J. R. (2007) · Clinical Colorectal Cancer · doi:10.3816/ccc.2007.n.011 · Cited by 95 · see citing works
Self-citationTejpar, S., Peeters, M., Humblet, Y., Vermorken, J. B., Hertogh, G. D., Roock, W. D., Nippgen, J., von Heydebreck, A., Stroh, C., & Cutsem, E. V. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.4001 · Cited by 92 · see citing works
Meyerhardt, J. A., Stuart, K. E., Fuchs, C. S., Zhu, A. X., Earle, C. C., Bhargava, P., Blaszkowsky, L. S., Enzinger, P. C., Mayer, R. J., Battu, S., et al. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm124 · Cited by 78 · see citing works
Bleomycin in Testicular Cancer: Will Pharmacogenomics Improve Treatment Regimens?
Bokemeyer, C. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.2991 · Cited by 46 · see citing works
Siena, S., Tabernero, J. M., Burkes, R. L., Cassidy, J., Cunningham, D., Barugel, M. E., Humblet, Y., McPhie, C., Shing, M., & Douillard, J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.4034 · Cited by 28 · see citing works
Peeters, M., Wilson, G., Ducreux, M. P., Cervantes, A. M. R., André, T., Hotko, Y., Lordick, F., Collins, S., Shing, M., & Price, T. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.4064 · Cited by 23 · see citing works
Cohn, A. L., Smith, D. A., Neubauer, M., Houston, G. A., Khandelwal, P., Wiggans, R. G., Suzuki, S., Yassine, M., Deeter, R. G., & Sikorski, R. S. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.26.15_suppl.4127 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology
Benson, A. B., Venook, A. P., Al-Hawary, M. M., Arain, M. A., Chen, Y., Ciombor, K. K., Cohen, S. A., Cooper, H. S., Deming, D. A., Farkas, L. M., et al. (2021) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2021.0012 · Cited by 1,709 · see citing works
Self-citationBreast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology
Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A. E., ELIAS, A. D., Farrar, W. B., Forero, A., Giordano, S. H., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0012 · Cited by 1,607 · see citing works
Schmoll, H., Cutsem, E. V., Stein, A., Valentini, V., Glimelius, B. L. G., Haustermans, K. M., Nordlinger, B., van de Velde, C. J., Balmañà, J., Reguła, J., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds236 · Cited by 1,509 · see citing works
Cunningham, D., Atkin, W. S., Lenz, H., Lynch, H. T., Minsky, B. D., Nordlinger, B., & Starling, N. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60353-4 · Cited by 1,407 · see citing works
Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology
Benson, A. B., Venook, A. P., Cederquist, L., Chan, E., Chen, Y., Cooper, H. S., Deming, D. A., Engstrom, P. F., Enzinger, P. C., Fichera, A., et al. (2017) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2017.0036 · Cited by 1,329 · see citing works
Salem, R., Lewandowski, R. J., Mulcahy, M. F., Riaz, A., Ryu, R. K., Ibrahim, S., Atassi, B., Baker, T., Gates, V. L., Miller, F. H., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.006 · Cited by 1,070 · see citing works
Maughan, T. S., Adams, R. A., Smith, C. G., Meade, A. M., Seymour, M. T., Wilson, R. H., Idziaszczyk, S., Harris, R., Fisher, D., Kenny, S. L., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60613-2 · Cited by 960 · see citing works
Venook, A. P., Niedzwiecki, D., Lenz, H.-J., Innocenti, F., Fruth, B., Meyerhardt, J. A., Schrag, D., Greene, C., O'Neil, B. H., Atkins, J. N., et al. (2017) · JAMA · doi:10.1001/jama.2017.7105 · Cited by 898 · see citing works
Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer
Bardelli, A., & Siena, S. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.6116 · Cited by 746 · see citing works
Delivering affordable cancer care in high-income countries
Sullivan, R., Peppercorn, J., Sikora, K., Zalcberg, J., Meropol, N. J., Amir, E., Khayat, D., Boyle, P., Autier, P., Tannock, I. F., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70141-3 · Cited by 718 · see citing works
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
Wheeler, D. L., Dunn, E. F., & Harari, P. M. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.97 · Cited by 683 · see citing works
Antiangiogenic therapy: impact on invasion, disease progression, and metastasis
Ebos, J. M. L., & Kerbel, R. S. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.21 · Cited by 685 · see citing works
Engstrom, P. F., Arnoletti, J. P., Benson, A. B., Chen, Y., Choti, M. A., Cooper, H. S., Covey, A. M., Dilawari, R. A., Early, D. S., Enzinger, P. C., et al. (2009) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2009.0056 · Cited by 682 · see citing works
DeepSynergy: predicting anti-cancer drug synergy with Deep Learning
Preuer, K., Lewis, R. P. I., Hochreiter, S., Bender, A., Bulusu, K. C., & Klambauer, G. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx806 · Cited by 651 · see citing works
Loupakis, F., Ruzzo, A., Cremolini, C., Vincenzi, B., Salvatore, L., Santini, D., Masi, G., Stasi, I., Canestrari, E., Rulli, E., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605177 · Cited by 562 · see citing works
Richman, S. D., Seymour, M. T., Chambers, P., Elliott, F., Daly, C. L., Meade, A. M., Taylor, G., Barrett, J. H., & Quirke, P. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.4295 · Cited by 560 · see citing works
Siena, S., Bianchi, A. S., Nicolantonio, F. D., Balfour, J., & Bardelli, A. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp280 · Cited by 526 · see citing works
Lacouture, M. E., Mitchell, E. P., Piperdi, B., Pillai, M. V., Shearer, H., Iannotti, N. O., Xu, F., & Yassine, M. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.7828 · Cited by 478 · see citing works
Self-citationFOxTROT Collaborative Group (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70348-0 · Cited by 472 · see citing works
Machine learning approaches to drug response prediction: challenges and recent progress
Adam, G. A., Rampášek, L., Safikhani, Z., Smirnov, P., Haibe‐Kains, B., & Goldenberg, A. (2020) · npj Precision Oncology · doi:10.1038/s41698-020-0122-1 · Cited by 427 · see citing works
Chibaudel, B., Maindrault‐Gœbel, F., Lledo, G., Mineur, L., André, T., Bennamoun, M., Mabro, M., Artru, P., Carola, É., Flesch, M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.4344 · Cited by 394 · see citing works
Seymour, M., Brown, S., Middleton, G., Maughan, T., Richman, S. D., Gwyther, S. J., Lowe, C., Seligmann, J., Wadsley, J., Maisey, N. R., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70163-3 · Cited by 387 · see citing works
Colorectal cancer: From prevention to personalized medicine
Binefa, G. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i22.6786 · Cited by 381 · see citing works
Colon Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology
Benson, A. B., Venook, A. P., Adam, M. A., Chang, G. J., Chen, Y., Ciombor, K. K., Cohen, S. A., Cooper, H. S., Deming, D. A., Garrido‐Laguna, I., et al. (2024) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2024.0029 · Cited by 406 · see citing works
Self-citationSolbiati, L., Ahmed, M., Cova, L., Ierace, T., Brioschi, M., & Goldberg, S. N. (2012) · Radiology · doi:10.1148/radiol.12111851 · Cited by 365 · see citing works
Targeting angiogenesis: progress with anti-VEGF treatment with large molecules
Grothey, A., & Galanis, E. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.110 · Cited by 356 · see citing works
Exploring immunotherapy in colorectal cancer
Weng, J., Li, S., Zhu, Z., Liu, Q., Zhang, R., Yang, Y., & Li, X. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01294-4 · Cited by 355 · see citing works
How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question
Fojo, T., & Grady, C. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp177 · Cited by 349 · see citing works
Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy
Martinelli, E., Palma, R. D., Orditura, M., Vita, F. D., & Ciardiello, F. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03992.x · Cited by 334 · see citing works
Mechanisms of resistance to anti-EGFR therapy in colorectal cancer
Zhao, B., Wang, L., Qiu, H., Zhang, M., Sun, L., Peng, P., Yu, Q., & Yuan, X. (2017) · Oncotarget · doi:10.18632/oncotarget.14012 · Cited by 319 · see citing works
Stereotactic body radiotherapy for colorectal liver metastases
Chang, D. T., Swaminath, A., Kozak, M. M., Weintraub, J., Koong, A. C., Kim, J., Dinniwell, R. E., Brierley, J. D., Kavanagh, B. D., Dawson, L. A., et al. (2011) · Cancer · doi:10.1002/cncr.25997 · Cited by 301 · see citing works
Abou‐Elkacem, L., Arns, S., Brix, G., Gremse, F., Zopf, D., Kiessling, F. M., & Lederle, W. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1162 · Cited by 283 · see citing works
Colorectal liver metastases: Current management and future perspectives
Martin, J. L., Petrillo, A., Smyth, E. C., Shaida, N., Khwaja, S. A., Cheow, H. K., Duckworth, A., Heister, P. M., Praseedom, R., Jah, A., et al. (2020) · World Journal of Clinical Oncology · doi:10.5306/wjco.v11.i10.761 · Cited by 279 · see citing works
Yamazaki, K., Nagase, M., Tamagawa, H., Ueda, S., Tamura, T., Murata, K., Nakajima, T. E., Baba, E., Tsuda, M., Moriwaki, T., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw206 · Cited by 270 · see citing works
Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis
Larsen, A. K., Ouaret, D., Ouadrani, K. E., & Petitprez, A. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.03.012 · Cited by 267 · see citing works
Loges, S., Schmidt, T., & Carmeliet, P. (2010) · Genes & Cancer · doi:10.1177/1947601909356574 · Cited by 257 · see citing works
Kummar, S., Chen, H. X., Wright, J., Holbeck, S. L., Millin, M. D., Tomaszewski, J. E., Zweibel, J., Collins, J. M., & Doroshow, J. H. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3216 · Cited by 249 · see citing works
Resistance to Targeted Therapies: Refining Anticancer Therapy in the Era of Molecular Oncology
Ellis, L. M., & Hicklin, D. J. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1070 · Cited by 248 · see citing works
Cooper, K. L., Madan, J. J., Whyte, S., Stevenson, M., & Akehurst, R. L. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-404 · Cited by 246 · see citing works
S3-Leitlinie – Kolorektales Karzinom
Schmiegel, W., Buchberger, B., Follmann, M., Graeven, U., Heinemann, V., Langer, T. G., Nothacker, M., Porschen, R., Rödel, C. M., Rösch, T., et al. (2017) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0043-121106 · Cited by 242 · see citing works
Anti-VEGF therapies in the clinic
Meadows, K. L., & Hurwitz, H. I. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006577 · Cited by 237 · see citing works
Metastatic Colorectal Cancer: From Improved Survival to Potential Cure
Gallagher, D. J., & Kemeny, N. E. (2010) · Oncology · doi:10.1159/000315730 · Cited by 237 · see citing works
Evading tumor evasion: Current concepts and perspectives of anti-angiogenic cancer therapy
Abdollahi, A., & Folkman, J. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2009.12.001 · Cited by 232 · see citing works
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma
Sathornsumetee, S., Desjardins, A., Vredenburgh, J. J., McLendon, R. E., Marcello, J. E., Herndon, J. E., Mathe, A., Hamilton, M., Rich, J. N., Norfleet, J. A., et al. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq099 · Cited by 230 · see citing works
The Great Escape; the Hallmarks of Resistance to Antiangiogenic Therapy
B, J. R. V. B., Nowak-Sliwinska, P. M., Huijbers, E. J. M., Thijssen, V. L., & Griffioen, A. W. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.010215 · Cited by 211 · see citing works
Karagkounis, G., Torbenson, M. S., Daniel, H. D. J., Azad, N. S., Diaz, L. A., Donehower, R. C., Hirose, K., Ahuja, N., Pawlik, T. M., & Choti, M. A. (2013) · Cancer · doi:10.1002/cncr.28347 · Cited by 194 · see citing works
Berlin, J. D., Bendell, J. C., Hart, L. L., Firdaus, I., Gore, I., Hermann, R. C., Mulcahy, M. F., Zalupski, M. M., Mackey, H. M., Yauch, R. L., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1800 · Cited by 182 · see citing works
BRAF-mutated, Microsatellite-stable Adenocarcinoma of the Proximal Colon
Pai, R. K., Jayachandran, P., Koong, A. C., Chang, D. T., Kwok, S., Ma, L., Arber, D. A., Balise, R. R., Tubbs, R. R., Shadrach, B. L., et al. (2012) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31824430d7 · Cited by 182 · see citing works
Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia
Rapisarda, A., & Melillo, G. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.64 · Cited by 175 · see citing works
Monoclonal antibodies in the treatment of metastatic colorectal cancer: A review
Tol, J., & Punt, C. J. A. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.03.012 · Cited by 175 · see citing works
Monoclonal antibodies for the treatment of cancer
Shuptrine, C. W., Surana, R., & Weiner, L. M. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.009 · Cited by 172 · see citing works
Dahabreh, I. J., Terasawa, T., Castaldi, P. J., & Trikalinos, T. A. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-1-201101040-00006 · Cited by 169 · see citing works
Ways to Enhance Lymphocyte Trafficking into Tumors and Fitness of Tumor Infiltrating Lymphocytes
Bellone, M., & Calcinotto, A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00231 · Cited by 165 · see citing works
Castleman disease in the 21st century: an update on diagnosis, assessment, and therapy.
van Rhee, F., Stone, K., Szmania, S. M., Barlogie, B., & Singh, Z. N. (2010) · PubMed · Cited by 164 · see citing works
Cascone, T., Herynk, M. H., Xu, L., Du, Z., Kadara, H. N., Nilsson, M. B., Oborn, C. J., Park, Y., Erez, B., Jacoby, J. J., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42405 · Cited by 160 · see citing works
Acquired resistance to EGFR‐targeted therapies in colorectal cancer
Emburgh, B. O. V., Bianchi, A. S., Nicolantonio, F. D., Siena, S., & Bardelli, A. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.05.003 · Cited by 160 · see citing works
Dillman, R. O. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2010.0902 · Cited by 156 · see citing works
Passardi, A., Nanni, O., Tassinari, D., Turci, D., Cavanna, L., Fontana, A., Ruscelli, S., Mucciarini, C., Lorusso, V., Ragazzini, A., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv130 · Cited by 158 · see citing works
Monoclonal Antibodies Targeting Vascular Endothelial Growth Factor
Hsu, J. Y., & Wakelee, H. A. (2009) · BioDrugs · doi:10.2165/11317600-000000000-00000 · Cited by 146 · see citing works
Argiris, A. E., Kotsakis, A. P., HOANG, T. N., Worden, F. P., Savvides, P. S., Gibson, M. K., Gyanchandani, R., Blumenschein, G. R., Chen, H. X., Grandis, J. R., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mds245 · Cited by 148 · see citing works
KRAS Mutation in Colon Cancer: A Marker of Resistance to EGFR-I Therapy
Siddiqui, A. D., & Piperdi, B. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0811-z · Cited by 145 · see citing works
Evaluating Many Treatments and Biomarkers in Oncology: A New Design
Kaplan, R. S., Maughan, T., Crook, A. M., Fisher, D. J., Wilson, R. H., Brown, L. C., & Parmar, M. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.50.7905 · Cited by 143 · see citing works
Mechanisms of resistance to HER family targeting antibodies
Kruser, T. J., & Wheeler, D. L. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.01.009 · Cited by 141 · see citing works
Petrelli, F., Cabiddu, M., Borgonovo, K., & Barni, S. (2012) · Annals of Oncology · doi:10.1093/annonc/mdr592 · Cited by 140 · see citing works
Molecular‐targeted agents combination therapy for cancer: Developments and potentials
Li, F., Zhao, C., & Wang, L. (2013) · International Journal of Cancer · doi:10.1002/ijc.28261 · Cited by 137 · see citing works
Takemura, N., Saiura, A., Koga, R., Arita, J., Yoshioka, R., Ono, Y., Hiki, N., Sano, T., Yamamoto, J., Kokudo, N., et al. (2012) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-012-0959-z · Cited by 132 · see citing works
Effects of systemic chemotherapy on the liver
Ramadori, G., & Cameron, S. (2010) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31651-5 · Cited by 132 · see citing works
An Update on the Current and Emerging Targeted Agents in Metastatic Colorectal Cancer
Chu, E. (2011) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2011.05.005 · Cited by 130 · see citing works
A Systems Approach for Tumor Pharmacokinetics
Thurber, G. M., & Weissleder, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024696 · Cited by 130 · see citing works
Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment
Capdevila, J., Élez, E., Macarulla, T. M., Ramos, F. J., Ruiz-Echarri, M., & Tabernero, J. M. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.02.001 · Cited by 130 · see citing works
Meyerhardt, J. A., Li, L., Sanoff, H. K., Carpenter, W. R., & Schrag, D. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.9650 · Cited by 129 · see citing works
Siu, L. L., Shapiro, J. D., Jonker, D. J., Karapetis, C. S., Zalcberg, J. R., Simes, J. R., Couture, F., Moore, M. J., Price, T. J., Siddiqui, J., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.0543 · Cited by 126 · see citing works
Péron, J., Maillet, D., Gan, H. K., Chen, E. X., & You, B. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2013.49.3981 · Cited by 126 · see citing works
Okines, A. F. C., Ashley, S. E., Cunningham, D., Oates, J. R., Turner, A., Webb, J., Saffery, C., Chua, Y. J., & Chau, I. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.29.2847 · Cited by 125 · see citing works
EGFR and KRAS in Colorectal Cancer
Markman, B., Ramos, F. J., Capdevila, J., & Tabernero, J. M. (2010) · Advances in clinical chemistry · doi:10.1016/s0065-2423(10)51004-7 · Cited by 126 · see citing works
Bevacizumab-Induced Normalization of Blood Vessels in Tumors Hampers Antibody Uptake
Arjaans, M., Munnink, T. H. O., Oosting, S. F., van Scheltinga, A. G. T. T., Gietema, J. A., Garbacik, E. T., Timmer‐Bosscha, H., Hooge, M. N. L., Schroder, C. P., & de Vries, E. G. E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3518 · Cited by 123 · see citing works
Tournigand, C., Chibaudel, B., Samson, B., Scheithauer, W., Vernerey, D., Mésange, P., Lledo, G., Viret, F., Ramée, J., Tubiana-Mathieu, N., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00216-8 · Cited by 123 · see citing works
Sforza, V., Martinelli, E., Ciardiello, F., Gambardella, V., Napolitano, S., Martini, G., della Corte, C., Cardone, C., Ferrara, M. L., Reginelli, A., et al. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i28.6345 · Cited by 123 · see citing works
Chemotherapy Before Liver Resection of Colorectal Metastases
Lehmann, K., Rickenbacher, A., Weber, A., Pestalozzi, B. C., & Clavien, P. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e3182356236 · Cited by 120 · see citing works
Wasan, H. S., Meade, A. M., Adams, R., Wilson, R. H., Pugh, C., Fisher, D. J., Sydes, B., Madi, A., Sizer, B., Lowdell, C. P., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70106-8 · Cited by 121 · see citing works
Anti-angiogenic therapies for metastatic colorectal cancer
Wagner, D., Arnold, D., Grothey, A. A., Haerting, J., & Unverzagt, S. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005392.pub3 · Cited by 119 · see citing works
Pak, L. M., Kemeny, N. E., Capanu, M., Chou, J. F., Boucher, T. M., Cercek, A., Balachandran, V. P., Kingham, T. P., Allen, P. J., DeMatteo, R. P., et al. (2017) · Journal of Surgical Oncology · doi:10.1002/jso.24898 · Cited by 120 · see citing works
Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer
Chan, D. L. H., Segelov, E., Wong, R. S., Smith, A., Herbertson, R. A., Li, B. T., Tebbutt, N. C., Price, T. J., & Pavlakis, N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007047.pub2 · Cited by 116 · see citing works
Balancing the efficacy and toxicity of chemotherapy in colorectal cancer
Braun, M. S., & Seymour, M. (2010) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834010388342 · Cited by 115 · see citing works
VEGF pathway targeting agents, vessel normalization and tumor drug uptake: from bench to bedside
Arjaans, M., Schroder, C. P., Oosting, S. F., Dafni, U. G., Kleibeuker, J. E., & de Vries, E. G. E. (2016) · Oncotarget · doi:10.18632/oncotarget.6918 · Cited by 113 · see citing works
Treatment in advanced colorectal cancer: what, when and how?
Chau, I., & Cunningham, D. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605061 · Cited by 112 · see citing works
Rovers, K. P. B., Bakkers, C., Simkens, G. A. A. M., Burger, J. W. A., Nienhuijs, S. W., Creemers, G., Thijs, A. M. J., Brandt‐Kerkhof, A. R. M., Madsen, E. V. E., Ayez, N., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5545-0 · Cited by 111 · see citing works
Saridaki, Z., Papadatos-Pastos, D., Tzardi, M. N., Mavroudis, D., Bairaktari, E. T., Arvanity, H., Stathopoulos, E. N., Georgoulias, V., & Souglakos, J. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605694 · Cited by 112 · see citing works
Fojo, T., & Parkinson, D. R. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1277 · Cited by 110 · see citing works
Oikonomou, E., Koustas, E., Goulielmaki, M., & Pintzas, A. (2014) · Oncotarget · doi:10.18632/oncotarget.2555 · Cited by 108 · see citing works
Adverse Events Associated with Anti-EGFR Therapies for the Treatment of Metastatic Colorectal Cancer
Fakih, M., & Vincent, M. (2010) · Current Oncology · doi:10.3747/co.v17is1.615 · Cited by 147 · see citing works
Targeting Multiple Kinase Pathways: A Change In Paradigm
Gossage, L., & Eisen, T. G. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3182 · Cited by 109 · see citing works
Finding the tumor copycat: Therapy fails, patients don’t
Ellis, L. M., & Fidler, I. J. (2010) · Nature Medicine · doi:10.1038/nm0910-974 · Cited by 109 · see citing works
Vale, C. L., Tierney, J. F., Fisher, D. J., Adams, R., Kaplan, R. S., Maughan, T., Parmar, M., & Meade, A. M. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.11.002 · Cited by 107 · see citing works
Amit, O., Mannino, F., Stone, A., Bushnell, W., Denne, J. S., Helterbrand, J. D., & Burger, H.-U. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.02.013 · Cited by 107 · see citing works
Sorafenib: Where Do We Go from Here?
Siegel, A. B., Olsen, S. K., Magun, A. M., & Brown, R. S. (2010) · Hepatology · doi:10.1002/hep.23633 · Cited by 106 · see citing works
Making the best of PARP inhibitors in ovarian cancer
Banerjee, S. N., Kaye, S. B., & Ashworth, A. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.116 · Cited by 105 · see citing works
Šeruga, B., Sterling, L., Wang, L. E., & Tannock, I. F. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.9624 · Cited by 107 · see citing works
Rizzo, S., Bronte, G., Fanale, D., Corsini, L. R., Silvestris, N., Santini, D., Gulotta, G., Bazan, V., Gebbia, N., Fulfaro, F., et al. (2010) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(10)70021-9 · Cited by 163 · see citing works
Li, Z., Zhao, L., Yu, L., & Wei, M. (2020) · Gastroenterology report · doi:10.1093/gastro/goaa022 · Cited by 104 · see citing works
- Authors
- Hecht, J. R., Mitchell, E., Chidiac, T., Scroggin, C., Hagenstad, C., Spigel, D., Marshall, J., Cohn, A., McCollum, D., Stella, P., Deeter, R., Shahin, S., & Amado, R. G.
- Affiliations
- Amgen (United States) (US)
- Venue
- Journal of Clinical Oncology
- Published
- 2009-02-10
- Volume
- 27
- Issue
- 5
- Pages
- 672-680
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2002226820
- Cited by
- 850
- References
- 30
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 19 · 2023: 10 · 2022: 21 · 2021: 15 · 2020: 29 · 2019: 29 · 2018: 26 · 2017: 38 · 2016: 44 · 2015: 57 · 2014: 56 · 2013: 88 · 2012: 101
- FWCI
- 53.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- metastatic colorectal cancer, panitumumab, bevacizumab, oxaliplatin, irinotecan, EGFR inhibition, first-line chemotherapy, progression-free survival, treatment toxicity, KRAS mutation, anti-EGFR monoclonal antibody
- MeSH terms
- Bevacizumab, Irinotecan, Oxaliplatin, Panitumumab, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Organoplatinum Compounds, Colorectal Neoplasms, Antibodies, Monoclonal, Humanized
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
