The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Expression Signature of E2F1 and Its Associated Genes Predict Superficial to Invasive Progression of Bladder Tumors
Open accessAbstract
Purpose: In approximately 20% of patients with superficial bladder tumors, the tumors progress to invasive tumors after treatment. Current methods of predicting the clinical behavior of these tumors prospectively are unreliable. We aim to identify a molecular signature that can reliably identify patients with high-risk superficial tumors that are likely to progress to invasive tumors. Patients and Methods: Gene expression data were collected from tumor specimens from 165 patients with bladder cancer. Various statistical methods, including leave-one-out cross-validation methods, were applied to identify a gene expression signature that could predict the likelihood of progression to invasive tumors and to test the robustness of the expression signature in an independent cohort. The robustness of the gene expression signature was validated in an independent (n = 353) cohort. Results: Supervised analysis of gene expression data revealed a gene expression signature that is strongly associated with invasive bladder tumors. A molecular classifier based on this gene expression signature correctly predicted the likelihood of progression of superficial tumor to invasive tumor. Conclusion: We present a molecular signature that can predict, at diagnosis, the likelihood of bladder cancer progression and, possibly, lead to improvements in patient therapy.
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Cited by
Chen, Z., Zhou, L., Liu, L., Hou, Y., Xiong, M., Yang, Y., Hu, J., & Chen, K. (2020) · Nature Communications · doi:10.1038/s41467-020-18916-5 · Cited by 694
Casein kinase 1α: biological mechanisms and theranostic potential
Jiang, S., Zhang, M., Sun, J., & Yang, X. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0236-z · Cited by 130
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers
Gu, Y., Tang, S., Wang, Z., Cai, L., Lian, H., Shen, Y., & Zhou, Y. (2021) · Bioengineered · doi:10.1080/21655979.2021.1973220 · Cited by 99
Overexpression of SHMT2 predicts a poor prognosis and promotes tumor cell growth in bladder cancer
Zhang, P., & Yang, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.682856 · Cited by 41
Histone deacetylase 8 is deregulated in urothelial cancer but not a target for efficient treatment
Lehmann, M., Hoffmann, M. J., Koch, A., Ulrich, S. M., Schulz, W. A., & Niegisch, G. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-014-0059-8 · Cited by 34
Metadata
- Authors
- Lee, J.-S., Leem, S.-H., Lee, S.-Y., Kim, S.-C., Park, E.-S., Kim, S.-B., Kim, S.-K., Kim, Y.-J., Kim, W.-J., & Chu, I.-S.
- Venue
- Journal of Clinical Oncology
- Published
- 2010-06-01
- Volume
- 28
- Issue
- 16
- Pages
- 2660-2667
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2114299743
- Cited by
- 342
- References
- 32
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, J.-S., Leem, S.-H., Lee, S.-Y., Kim, S.-C., Park, E.-S., Kim, S.-B., Kim, S.-K., Kim, Y.-J., Kim, W.-J., & Chu, I.-S. (2010). Expression Signature of E2F1 and Its Associated Genes Predict Superficial to Invasive Progression of Bladder Tumors. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2009.25.0977
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