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Cited by 294

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Associations of Insulin Resistance and Adiponectin With Mortality in Women With Breast Cancer

Open access
Duggan, Catherine, Irwin, Melinda L., Xiao, Liren, Henderson, Katherine D., Smith, Ashley Wilder, Baumgartner, Richard N., Baumgartner, Kathy B., Bernstein, Leslie, Ballard-Barbash, Rachel, McTiernan, Anne·2011·Journal of Clinical Oncology
DOI 10.1200/jco.2009.26.4473
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Abstract

Purpose: Overweight or obese breast cancer patients have a worse prognosis compared with normal-weight patients. This may be attributed to hyperinsulinemia and dysregulation of adipokine levels associated with overweight and obesity. Here, we evaluate whether low levels of adiponectin and a greater level of insulin resistance are associated with breast cancer mortality and all-cause mortality. Patients and Methods: We measured glucose, insulin, and adiponectin levels in fasting serum samples from 527 women enrolled in the Health, Eating, Activity, and Lifestyle (HEAL) Study, a multiethnic, prospective cohort study of women diagnosed with stage I-IIIA breast cancer. We evaluated the association between adiponectin and insulin and glucose levels (expressed as the Homeostatic Model Assessment [HOMA] score) represented as continuous measures and median split categories, along with breast cancer mortality and all-cause mortality, using Cox proportional hazards models. Results: Increasing HOMA scores were associated with reduced breast cancer survival (hazard ratio [HR], 1.12; 95% CI, 1.05 to 1.20) and reduced all-cause survival (HR, 1.09; 95% CI, 1.02 to 1.15) after adjustment for possible confounders. Higher levels of adiponectin (above the median: 15.5 μg/mL) were associated with longer breast cancer survival (HR, 0.39; 95% CI, 0.15 to 0.95) after adjustment for covariates. A continuous measure of adiponectin was not associated with either breast cancer–specific or all-cause mortality. Conclusion: Elevated HOMA scores and low levels of adiponectin, both associated with obesity, were associated with increased breast cancer mortality. To the best of our knowledge, this is the first demonstration of the association between low levels of adiponectin and increased breast cancer mortality in breast cancer survivors.

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Metadata

Authors
Duggan, C., Irwin, M. L., Xiao, L., Henderson, K. D., Smith, A. W., Baumgartner, R. N., Baumgartner, K. B., Bernstein, L., Ballard-Barbash, R., & McTiernan, A.
Venue
Journal of Clinical Oncology
Publisher
American Society of Clinical Oncology (ASCO)
Published
2011-01-01
Volume
29
Issue
1
Pages
32-39
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
DOI
10.1200/jco.2009.26.4473
OpenAlex
W2151396655
Cited by
294
References
58
FWCI
13.25
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Associations of Insulin Resistance and Adiponectin With Mortality in Women With Breast Cancer. https://app.cochat.ai/papers/10.1200/jco.2009.26.4473
The paper
Duggan, C., Irwin, M. L., Xiao, L., Henderson, K. D., Smith, A. W., Baumgartner, R. N., Baumgartner, K. B., Bernstein, L., Ballard-Barbash, R., & McTiernan, A. (2011). Associations of Insulin Resistance and Adiponectin With Mortality in Women With Breast Cancer. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2009.26.4473

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.