The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Colorectal Cancer Epigenetics: Complex Simplicity
Abstract
Colorectal cancer (CRC) has predominantly been considered a genetic disease, characterized by sequential accumulation of genetic alterations. Growing evidence indicates that epigenetic alterations add an additional layer of complexity to the pathogenesis of CRC, and characterize a subgroup of colorectal cancers with a distinct etiology and prognosis. Epigenetic dysregulation in colorectal cancer is organized at multiple levels, involving DNA methylation, histone modifications, nucleosomal occupancy and remodeling, chromatin looping, and noncoding RNAs. Interactions between these processes and complex associations with genetic alterations have recently been unraveled. It appears that CRC epigenetics will be the paradigm for multistep carcinogenesis, as CRC genetics has been for the past three decades. This review integrates recent data on epigenetic regulation of gene expression in CRC and describes how the understanding of these processes will alter the management of CRC.
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Cites
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An Integrated Three-Long Non-coding RNA Signature Predicts Prognosis in Colorectal Cancer Patients
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Histone modifications as a pathogenic mechanism of colorectal tumorigenesis
Gargalionis, A. N., Piperi, C., Adamopoulos, C., & Papavassiliou, A. G. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.05.002 · Cited by 53
Association of TET1 expression with colorectal cancer progression
Tian, Y., Pan, F., Sun, X., Gan, M., Lin, A., Zhang, D., Zhu, Y., & Lai, M. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2016.1253767 · Cited by 34
Hsu, H.-C., Liu, Y.-S., Tseng, K.-C., Yang, T.-S., Yeh, C.-Y., You, J.-F., Hung, H.-Y., Chen, S.-J., & Chen, H.-C. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1782-4 · Cited by 29
Metadata
- Authors
- van Engeland, M., Derks, S., Smits, K. M., Meijer, G. A., & Herman, J. G.
- Venue
- Journal of Clinical Oncology
- Published
- 2011-04-01
- Volume
- 29
- Issue
- 10
- Pages
- 1382-1391
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2121239890
- Cited by
- 199
- References
- 14
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- van Engeland, M., Derks, S., Smits, K. M., Meijer, G. A., & Herman, J. G. (2011). Colorectal Cancer Epigenetics: Complex Simplicity. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2010.28.2319
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