Association of TET1 expression with colorectal cancer progression

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

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The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

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Active DNA demethylation: many roads lead to Rome

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

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Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

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Reduced genomic 5-methylcytosine content in human colonic neoplasia.

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TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)

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DNA Methylation, Its Mediators and Genome Integrity

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Cancer-associated IDH mutations: biomarker and therapeutic opportunities

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TET1 Suppresses Cancer Invasion by Activating the Tissue Inhibitors of Metalloproteinases

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Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage

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Connections between TET proteins and aberrant DNA modification in cancer

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Epigenetics and Colorectal Cancer Pathogenesis

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Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands

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Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis

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TET1 plays an essential oncogenic role in MLL -rearranged leukemia

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Colorectal Cancer Epigenetics: Complex Simplicity

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TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway

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TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma

Mariani, C. J., Vasanthakumar, A., Madžo, J., Yesilkanal, A. E., Bhagat, T. D., Yu, Y., Bhattacharyya, S., Wenger, R. H., Cohn, S. L., Nanduri, J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.040 · Cited by 165 · see citing works

TET1 regulates hypoxia-induced epithelial-mesenchymal transition by acting as a co-activator

Tsai, Y.-P., Chen, H.-F., Chen, S.-Y., Cheng, W.-C., Wang, H.-W., Shen, Z.-J., Song, C., Teng, S.-C., He, C., & Wu, K.-J. (2014) · Genome biology · doi:10.1186/s13059-014-0513-0 · Cited by 152 · see citing works

Hypoxia Drives Breast Tumor Malignancy through a TET–TNFα–p38–MAPK Signaling Axis

Wu, M.-Z., Chen, S.-F., Nieh, S., Benner, C. W., Ger, L., Jan, C., Ma, L., Chen, C., Hishida, T., Chang, H., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3208 · Cited by 136 · see citing works

Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis

Nagaraju, G. P., Bramhachari, P. V., Raghu, G., & El‐Rayes, B. F. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.005 · Cited by 114 · see citing works

5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy

Vasanthakumar, A., & Godley, L. A. (2015) · Cancer Genetics · doi:10.1016/j.cancergen.2015.02.009 · Cited by 114 · see citing works

DNA hypomethylation in cancer: Epigenetic scars of a neoplastic journey

Smet, C. D., & Loriot, A. E. (2010) · Epigenetics · doi:10.4161/epi.5.3.11447 · Cited by 88 · see citing works

Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer

Liu, Y., Yu, S.-J., Qi, H., Yang, Y., & Shao, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133896 · Cited by 82 · see citing works

Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions

Zou, X., Zhang, B., Zhang, X., Chen, M., Cao, J., & Liu, W. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.01.029 · Cited by 77 · see citing works

Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation

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Global DNA hypomethylation and hypoxia‐induced expression of the ten eleven translocation ( TET ) family, TET 1, in scleroderma fibroblasts

Hattori, M., Yokoyama, Y., Hattori, T., Motegi, S., Amano, H., Hatada, I., & Ishikawa, O. (2015) · Experimental Dermatology · doi:10.1111/exd.12767 · Cited by 53 · see citing works

Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis

Chen, H., & Wu, K. (2016) · Biomedicine · doi:10.7603/s40681-016-0001-9 · Cited by 52 · see citing works

Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer

Rawłuszko-Wieczorek, A. A., Siera, A., Horbacka, K., Horst, N., Krokowicz, P., & Jagodziński, P. P. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1901-2 · Cited by 48 · see citing works

IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer

Zhu, S., Zhang, J., Xu, F., Xu, E., Ruan, W., Ma, Y., Huang, Q., & Lai, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.59 · Cited by 30 · see citing works

Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients

Yu, D., Li, Z., Gan, M., Zhang, H., Yin, X., Tang, S., Wan, L., Tian, Y., Zhang, S., Zhu, Y., et al. (2015) · Tumor Biology · doi:10.1007/s13277-015-3588-7 · Cited by 23 · see citing works

Targeting cancer vulnerabilities with high-dose vitamin C

Ngo, B., Van Riper, J. M., Cantley, L. C., & Yun, J. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0135-7 · Cited by 423 · see citing works

Methylation Dynamics of RASSF1A and Its Impact on Cancer

Malpeli, G., Innamorati, G., Decimo, I., Bencivenga, M., Kamdje, A. H. N., Perris, R., & Bassi, C. (2019) · Cancers · doi:10.3390/cancers11070959 · Cited by 79 · see citing works

TET1 promotes 5hmC-dependent stemness, and inhibits a 5hmC-independent epithelial-mesenchymal transition, in cervical precancerous lesions

Su, P., Hsu, Y., Huang, R., Chen, L.-Y., Chao, T., Liao, C.-C., Chen, C.-W., Wu, T.-I., Mao, S.-P., Balch, C., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.01.033 · Cited by 47 · see citing works

Ten–eleven translocase: key regulator of the methylation landscape in cancer

Shekhawat, J. K., Gauba, K., Gupta, S., Choudhury, B., Purohit, P., Sharma, P., & Banerjee, M. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03641-3 · Cited by 40 · see citing works

Reduction of circular RNA expression associated with human retinoblastoma

Lyu, J., Wang, Y., Zheng, Q., Hua, P., Zhu, X., Li, J.-K., Li, J., Ji, X., & Zhao, P. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.03.017 · Cited by 38 · see citing works

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

Amirkhah, R., Naderi‐Meshkin, H., Shah, J. S., Dunne, P. D., & Schmitz, U. (2019) · Cells · doi:10.3390/cells8080929 · Cited by 39 · see citing works

Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells

Wang, K., Chen, Z., Shi, J., Feng, Y., Yu, M., Sun, Y., Zhuang, Q., Liang, B., Luo, G., Xu, X., et al. (2020) · The Prostate · doi:10.1002/pros.24029 · Cited by 31 · see citing works

Alterations of regulatory factors and DNA methylation pattern in thyroid cancer

Iancu, I. V., Botezatu, A., Plesa, A., Huică, I., Fudulu, A., Albulescu, A., Bostan, M., Mihaila, M. A., Grancea, C., Manda, D. A., et al. (2020) · Cancer Biomarkers · doi:10.3233/cbm-190871 · Cited by 29 · see citing works

TET1 suppresses colon cancer proliferation by impairing β‐catenin signal pathway

Guo, H., Zhu, H., Zhang, J., Wan, B., & Shen, Z. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28522 · Cited by 28 · see citing works

MicroRNA-191 regulates endometrial cancer cell growth via TET1-mediated epigenetic modulation of APC

Yang, C., Ota-Kurogi, N., Ikeda, K., Okumura, T., Horie‐Inoue, K., Takeda, S., & Inoue, S. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa014 · Cited by 26 · see citing works

TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation

Yatagai, N., Saito, T., Akazawa, Y., Hayashi, T., Yanai, Y., Tsuyama, S., Ueyama, H., Murakami, T., Watanabe, S., Nagahara, A., et al. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2508-9 · Cited by 26 · see citing works

TET1 inhibits cell proliferation by inducing RASSF5 expression

Li, B.-T., Yu, C. Y., Xu, Y., Liu, S., Fan, H., & Pan, W. (2017) · Oncotarget · doi:10.18632/oncotarget.21189 · Cited by 19 · see citing works

The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem cell differentiation

Sun, D., Qin, Z., Xu, Y., Xiao, Q., Xu, Y., Bai, M., Li, W., Liu, Y., Zheng, W., & Zhang, Z. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.11.003 · Cited by 18 · see citing works

Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells

Rea, M., Gripshover, T. C., & Fondufe‐Mittendorf, Y. N. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.11.015 · Cited by 17 · see citing works

TET1: The epigenetic architect of clinical disease progression

Jabbari, K., Khalafizadeh, A., Sheikhbahaei, M., Soltaninejad, H., & Babashah, S. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101513 · Cited by 15 · see citing works

Validation of molecular biomarkers for preoperative diagnostics of human papillary thyroid carcinoma in fine needle aspirates

Sadowski, S. M., Petrenko, V., Meyer, P., Pusztaszeri, M. P., Brulhart‐Meynet, M., Masson, M. H., Triponez, F., Philippé, J., & Dibner, C. (2019) · Gland Surgery · doi:10.21037/gs.2018.11.04 · Cited by 14 · see citing works

Role of circular RNAs in retinoblastoma

Li, F., Yin, Y.-K., Zhang, J., Gong, H.-P., & Hao, X. (2022) · Functional & Integrative Genomics · doi:10.1007/s10142-022-00942-9 · Cited by 13 · see citing works

DNA, RNA, and histone methylation regulation enzymes and their crosstalk in colorectal carcinogenesis and progression: a review of molecular mechanisms, clinical implications, and future perspectives

Qian, S., Song, H., Huang, L., Hua, H. M., Zhang, X., Li, Z., Pu, M., Huang, H., & Zhang, J. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00823-6 · Cited by 9 · see citing works

Gene-body hypermethylation controlled cryptic promoter and miR26A1-dependent EZH2 regulation of TET1 gene activity in chronic lymphocytic leukemia

Kopparapu, P. K., Morsy, M. H. A., Kanduri, C., & Kanduri, M. (2017) · Oncotarget · doi:10.18632/oncotarget.20668 · Cited by 9 · see citing works

DNA Methylation Mechanism

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Circ_0007919 exerts an anti-tumor role in colorectal cancer through targeting miR-942–5p/TET1 axis

Zhao, X., Cui, D., Fang, Y., Yang, L.-C., & Huang, B. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153704 · Cited by 7 · see citing works

TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma

Qiu, T., Wang, X., Du, F., Hu, X., Sun, F., Song, C., & Zhao, J. (2022) · World Journal of Surgical Oncology · doi:10.1186/s12957-022-02581-7 · Cited by 7 · see citing works

Prognostic role of high TET1 expression in patients with solid tumors

Ke, Q., Wang, K., Fan, M., Li, M., Luo, G., & Wang, D. (2020) · Medicine · doi:10.1097/md.0000000000022863 · Cited by 5 · see citing works

Long non-coding RNAs promote colorectal cancer development through other epigenetic modifications

Wang, G., Ma, Q., Zhu, N., Yan, Y., Chen, Z., Hong, X., Lai, Y., Chen, X., Li, N., & Yu, W. (2025) · Gastroenterology report · doi:10.1093/gastro/goaf081 · Cited by 5 · see citing works

Aberrations of DNA methylation in cancer

Павловна, М. В., Usalka, O., Makus, J., Popova, V. G., Trapeznikova, E., Khayrieva, G., Sagitova, G. R., Михайловна, Ж. Е., Bukina, A. Y., Геннадиевна, Я. М., et al. (2022) · Advances in molecular oncology · doi:10.17650/2313-805x-2022-9-4-24-40 · Cited by 4 · see citing works

Putative promoters within gene bodies control exon expression via TET1‐mediated H3K36 methylation

Ma, L., Muhammad, T., Wang, H., Du, G., Sakhawat, A., Wei, Y., Khan, A. A., Cong, X., & Huang, Y. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29566 · Cited by 3 · see citing works

2-Oxoglutarate-dependent dioxygenases as oxygen sensors: their importance in health and disease

Lee, P. W. T., Kobayashi, M., Dohkai, T., Takahashi, I., Yoshida, T., & Harada, H. (2024) · The Journal of Biochemistry · doi:10.1093/jb/mvae087 · Cited by 4 · see citing works

DNA Hydroxymethylation in the Regulation of Gene Expression in Human Solid Cancer

Alcaráz‐Estrada, S. L., Leija-Montoya, G., Serafín‐Higuera, N., García, S. I., Millán-Testa, C. E., Sierra-Martínez, M., Blanco-Morales, M., & Sandoval-Basilio, J. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92016 · Cited by 3 · see citing works

The functional role of circular RNAs in the pathogenesis of retinoblastoma: a new potential biomarker and therapeutic target?

Fath, M. K., Benam, S. P., Esfahani, N. K., Shahkarami, N., Shafa, S., Bagheri, H., Shafagh, S.-G., Payandeh, Z., & Barati, G. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03144-2 · Cited by 2 · see citing works

Hydroxymethylation Influences on Intestinal Epithelial Cells in Health and Disease

Huff-Hardy, K., & Kwon, J. H. (2018) · InTech eBooks · doi:10.5772/intechopen.72989

Epigenetic modifications and regulations in gastrointestinal diseases

Bhattacharya, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-823931-5.00005-0

Immunotherapy and immunomodulation in colorectal cancer treatment resistance

Damane, B. P., Mulaudzi, T. V., Montwedi, O. D., Mabeta, P., Kader, S., Leenders, W. P. J., & Dlamini, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-33475-7.00013-5

Additional file 1 of TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma

Qiu, T., Wang, X., Du, F., Hu, X., Sun, F., Song, C., & Zhao, J. (2022) · Figshare · doi:10.6084/m9.figshare.19568629

Identification of TET1-positive nuclear bodies in colorectal cancer cells : how Vitamin C and herbicides could both impact DNA demethylation in solid tumors

Osmani, N. E. (2022) · doi:10.70675/44703178z2ad1z4ebcza891z61cf9febffe8

Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer

Rawłuszko-Wieczorek, A. A., Siera, A., Horbacka, K., Horst, N., Krokowicz, P., & Jagodziński, P. P. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1901-2 · Cited by 48 · see citing works

The demethylation of genes antagonized by TET1 in the regulation of the Wnt/β-catenin signaling pathway impacts the biological characteristics of colorectal cancer.Preprint

Wang, K., Ding, H., Guo, K., Chen, Q., Qiu, W., & Chen, S. (2023) · Research Square · doi:10.21203/rs.3.rs-3675529/v1 · Cited by 1 · see citing works

Abstract 1054: Aberrant TET1 methylation closely associated with CpG island methylator phenotype in colorectal cancer

Ichimura, N., Shinjo, K., Ohka, F., Katsushima, K., Hatanaka, A., Tojo, M., Shimizu, Y., Yamamoto, E., Suzuki, H., & Kondo, Y. (2015) · Cancer Research · doi:10.1158/1538-7445.am2015-1054 · Cited by 3 · see citing works

Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer

Ichimura, N., Shinjo, K., An, B., Shimizu, Y., Yamao, K., Ohka, F., Katsushima, K., Hatanaka, A., Tojo, M., Yamamoto, E., et al. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0306 · Cited by 52 · see citing works

miR-506 inhibits cell proliferation and invasion by targeting TET family in colorectal cancer.

Wu, M., Zhang, Y., Tang, A., & Tian, L. (2016) · PubMed Central · Cited by 11 · see citing works