The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Depression and Survival in Metastatic Non–Small-Cell Lung Cancer: Effects of Early Palliative Care
Open accessAbstract
Purpose: In a randomized trial, early palliative care (EPC) in patients with metastatic non–small-cell lung cancer (NSCLC) was observed to improve survival. In a secondary analysis, we explored the hypothesis that the survival benefit resulted from improving depression. Patients and Methods: In total, 151 patients with newly diagnosed metastatic NSCLC participated in a randomized trial of EPC integrated with standard oncology care versus standard oncology care alone. Depression was assessed at baseline and at 12 weeks with the Patient Health Questionnaire-9 (PHQ-9) and was scored diagnostically by using Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, criteria for major depression syndrome (MDS). Depression response was considered ≥ 50% reduction in PHQ-9 scores at 12 weeks. Survival differences were tested with log-rank and Cox proportional hazards models. Results: At baseline, 21 patients (14%) met MDS criteria. MDS significantly predicted worse survival (hazard ratio, 1.82; P = .02). Patients assigned to EPC had greater improvements in PHQ-9 scores at 12 weeks (P < .001); among patients with MDS, those receiving EPC had greater rates of depression response at 12 weeks (P = .04). However, improvement in PHQ-9 scores was not associated with improved survival, except in a sensitivity analysis in which patients who died before 12 weeks were modeled to have worse depression. The group randomly assigned to EPC remained independently associated with survival after adding improvement in PHQ-9 scores to the survival model. Conclusion: Depression predicted worse survival in patients with newly diagnosed metastatic NSCLC. Although EPC was associated with greater improvement in depression at 12 weeks, the data do not support the hypothesis that treatment of depression mediated the observed survival benefit from EPC.
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“Hospice use of any type and duration is strongly associated with better OS in patients with advanced cancer,119 including those specifically with lung cancer.120”
From Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (2015) · cites this paper as [120]
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2 retracted
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- Akechi T, 2008, Cochrane Database Syst Rev, 2, CD005537
- Gill D, 2000, Cochrane Database Syst Rev, 2, CD001312
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A study of psychiatric comparability in subjects with malignancy
Narayanasamy, G. (2016) · IOSR Journal of Dental and Medical Sciences · doi:10.9790/0853-1509025077
Einbindung von Palliative Care in die onkologische Versorgung
Fliedner, M. (2017) · Pflegezeitschrift · doi:10.1007/s41906-017-0165-2
Lee, J. Y. (2015) · Seoul National University Open Repository (Seoul National University)
Clinicians’ Perspectives on Adopting a Lung Cancer Palliative Care Intervention
Siler, S. (2017) · The Scholars Repository - LLU (Loma Linda University)
Psychiatric Aspects of Non-cardiac Thoracic Surgery
Prince, E. J., Piddoubny, W., Caro, M. A., Gerstenblith, T. A., & Bienvenu, O. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-99774-2_9
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Zimmaro, L. A. (2018) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/3047
“predicts worse survival among lung cancer patients (Pirl et al., 2012).”
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Depression Accelerates Tumor Cell Proliferation Via Regulating Serotonin/miR-144 Axis in NSCLC Mice
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“Also, depression is related with worse survival in patients with newly diagnosed NSCLC [43].”
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“Depression is said to be associated with poorer survival in newly diagnosed non-small cell lung carcinoma patients [10,11].”
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When Prognosis Is Extremely Short: Approach to Depression Care in the Last Days to Weeks of Life
Lee, W., Draper, B., Agar, M. R., & Currow, D. C. (2025) · Journal of Palliative Medicine · doi:10.1089/jpm.2024.0420
“3,4 These symptoms often coexist with other psycho-existential distress symptoms, including anxiety, hopelessness, pointless-ness, and the wish to die.”
Xie, W., Zhang, G., Wan, T., & Xu, L. (2025) · Medicine · doi:10.1097/md.0000000000042248
“[30] Notably, the partner not only serves as the primary caregiver but also plays a crucial role as a source of spiritual support.”
Jin, D. O. N. G., Xufeng, L. V., Chi, J., & Wang, D. (2025) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.25.16844-8
Weng, J., Wild, E., Chesak, S. S., Rhee, L., Piderman, K. M., Santiago, A. L., Rinker, C., Felt, M., Fischer, K. M., Ingram, C. J., et al. (2025) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/10499091251361467
Hjermstad, M. J., Aass, N., Andersen, S., Brunelli, C., Dajani, O. F., Garresori, H., Hamre, H., Haukland, E. C., Holmberg, M., Jordal, F., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12072576
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“These factors are increasingly acknowledged as critical influences on cancer outcomes, with evidence linking psychiatric illness and substance abuse to increased mortality and reduced treatment adherence [7,8].”
Neural state as a determinant of tumor immunity in lung cancer
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“Depression, in turn, has been associated with a worse prognosis in these patients [28].”
Metadata
- Authors
- Pirl, W. F., Greer, J. A., Traeger, L., Jackson, V., Lennes, I. T., Gallagher, E. R., Perez-Cruz, P., Heist, R. S., & Temel, J. S.
- Affiliations
- Massachusetts General Hospital (US)
- All authors: Massachusetts General Hospital Cancer Center, Boston, MA.
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2012-04-20
- Volume
- 30
- Issue
- 12
- Pages
- 1310-1315
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC3341144
- OpenAlex
- W2136456300
- Cited by
- 228
- References
- 28
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 6 · 2022: 18 · 2021: 8 · 2020: 21 · 2019: 14 · 2018: 28 · 2017: 28 · 2016: 23 · 2015: 19 · 2014: 19 · 2013: 18 · 2012: 5
- FWCI
- 18.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (K23CA115908)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Keywords
- early palliative care, metastatic non-small cell lung cancer, depression, survival, major depressive disorder, PHQ-9, mediation analysis, psychological distress in cancer patients
- MeSH terms
- Age Factors, Aged, Carcinoma, Non-Small-Cell Lung, Depressive Disorder, Female, Humans, Lung Neoplasms, Male, Middle Aged, Palliative Care, Prognosis, Quality of Life, Reference Values, Sex Factors, Time Factors, Comorbidity, Proportional Hazards Models, Survival Analysis, Risk Assessment, Terminally Ill, Secondary Prevention
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