The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Depression and Survival in Metastatic Non–Small-Cell Lung Cancer: Effects of Early Palliative Care
Open accessAbstract
Purpose: In a randomized trial, early palliative care (EPC) in patients with metastatic non–small-cell lung cancer (NSCLC) was observed to improve survival. In a secondary analysis, we explored the hypothesis that the survival benefit resulted from improving depression. Patients and Methods: In total, 151 patients with newly diagnosed metastatic NSCLC participated in a randomized trial of EPC integrated with standard oncology care versus standard oncology care alone. Depression was assessed at baseline and at 12 weeks with the Patient Health Questionnaire-9 (PHQ-9) and was scored diagnostically by using Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, criteria for major depression syndrome (MDS). Depression response was considered ≥ 50% reduction in PHQ-9 scores at 12 weeks. Survival differences were tested with log-rank and Cox proportional hazards models. Results: At baseline, 21 patients (14%) met MDS criteria. MDS significantly predicted worse survival (hazard ratio, 1.82; P = .02). Patients assigned to EPC had greater improvements in PHQ-9 scores at 12 weeks (P < .001); among patients with MDS, those receiving EPC had greater rates of depression response at 12 weeks (P = .04). However, improvement in PHQ-9 scores was not associated with improved survival, except in a sensitivity analysis in which patients who died before 12 weeks were modeled to have worse depression. The group randomly assigned to EPC remained independently associated with survival after adding improvement in PHQ-9 scores to the survival model. Conclusion: Depression predicted worse survival in patients with newly diagnosed metastatic NSCLC. Although EPC was associated with greater improvement in depression at 12 weeks, the data do not support the hypothesis that treatment of depression mediated the observed survival benefit from EPC.
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“Hospice use of any type and duration is strongly associated with better OS in patients with advanced cancer,119 including those specifically with lung cancer.120”
From Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (2015) · cites this paper as [120]
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2 retracted
Psychotherapy for depression among incurable cancer patients
Akechi, T., Okuyama, T., Onishi, J., Morita, T., & Furukawa, T. A. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005537.pub2 · Cited by 198
RetractedAntidepressants for depression in medical illness
Gill, D. B. E. C., & Hatcher, S. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001312 · Cited by 123
RetractedBaron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Spitzer, R. L. (1999) · JAMA · doi:10.1001/jama.282.18.1737 · Cited by 9,802
Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer
Temel, J. S., Greer, J. A., Muzikansky, A., Gallagher, E. R., Admane, S., Jackson, V. A., Dahlin, C. M., Blinderman, C. D., Jacobsen, J., Pirl, W. F., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000678 · Cited by 7,482
Self-citationDepression and cancer mortality: a meta-analysis
Pinquart, M., & Duberstein, P. R. (2010) · Psychological Medicine · doi:10.1017/s0033291709992285 · Cited by 1,083
Depression as a predictor of disease progression and mortality in cancer patients: A Meta‐Analysis
Satin, J. R., Linden, W., & Phillips, M. J. (2009) · Cancer · doi:10.1002/cncr.24561 · Cited by 972
Spitzer, R. L., Williams, J. B. W., & Kroenke, K. (1999) · PsycTESTS Dataset · doi:10.1037/t02598-000 · Cited by 590
Giese-Davis, J., Collie, K., Rancourt, K. M. S., Neri, E., Kraemer, H. C., & Spiegel, D. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.4455 · Cited by 458
Spitzer, R. L. (1999) · Medical Entomology and Zoology · Cited by 429
Research works printed but not linked: 2
- Akechi T, 2008, Cochrane Database Syst Rev, 2, CD005537
- Gill D, 2000, Cochrane Database Syst Rev, 2, CD001312
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FERRELL, B. R., Temel, J. S., Temin, S., Alesi, E. R., Balboni, T. A., Basch, E., Firn, J. I., Paice, J. A., Peppercorn, J. M., Phillips, T., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.1474 · Cited by 2,148
Self-citationBakitas, M. A., Tosteson, T. D., Li, Z., Lyons, K. D., Hull, J. G., Li, Z., Dionne-Odom, J. N., Frost, J., Dragnev, K. H., Hegel, M. T., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.6362 · Cited by 1,219
Distress Management, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology
Riba, M. B., Donovan, K. A., Andersen, B., Braun, I., Breitbart, W. S., Brewer, B. W., Buchmann, L. O., Clark, M. M., Collins, M., Corbett, C., et al. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2019.0048 · Cited by 871
Masters, G. A., Temin, S., Azzoli, C. G., Giaccone, G., Baker, S., Brahmer, J. R., Ellis, P. M., Gajra, A., Rackear, N., Schiller, J. H., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.62.1342 · Cited by 850
Early palliative care for adults with advanced cancer
Haun, M. W., Estel, S., Rücker, G., Friederich, H.-C., Villalobos, M., Thomas, M., & Hartmann, M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011129.pub2 · Cited by 757
Metadata
- Authors
- Pirl, W. F., Greer, J. A., Traeger, L., Jackson, V., Lennes, I. T., Gallagher, E. R., Perez-Cruz, P., Heist, R. S., & Temel, J. S.
- Affiliations
- Massachusetts General Hospital (US)
- All authors: Massachusetts General Hospital Cancer Center, Boston, MA.
- ORCID
- Venue
- Journal of Clinical Oncology
- Published
- 2012-04-20
- Volume
- 30
- Issue
- 12
- Pages
- 1310-1315
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- PMC
- PMC3341144
- OpenAlex
- W2136456300
- Cited by
- 228
- References
- 28
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 6 · 2022: 18 · 2021: 8 · 2020: 21 · 2019: 14 · 2018: 28 · 2017: 28 · 2016: 23 · 2015: 19 · 2014: 19 · 2013: 18 · 2012: 5
- FWCI
- 18.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Oncology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (K23CA115908)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Keywords
- early palliative care, metastatic non-small cell lung cancer, depression, survival, major depressive disorder, PHQ-9, mediation analysis, psychological distress in cancer patients
- MeSH terms
- Age Factors, Aged, Carcinoma, Non-Small-Cell Lung, Depressive Disorder, Female, Humans, Lung Neoplasms, Male, Middle Aged, Palliative Care, Prognosis, Quality of Life, Reference Values, Sex Factors, Time Factors, Comorbidity, Proportional Hazards Models, Survival Analysis, Risk Assessment, Terminally Ill, Secondary Prevention
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