Early palliative care for adults with advanced cancer

Haun, Markus W; Estel, Stephanie; Rücker, Gerta; Friederich, Hans-Christoph; Villalobos, Matthias; Thomas, Michael; Hartmann, Mechthild

doi:10.1002/14651858.cd011129.pub2

Cited by 757Palliative Care and End-of-Life IssuesPalliative and Oncologic CareCancer survivorship and care

Early palliative care for adults with advanced cancer

Open access

Haun, Markus W, Estel, Stephanie, Rücker, Gerta, Friederich, Hans-Christoph, Villalobos, Matthias, Thomas, Michael, Hartmann, Mechthild·2017·Cochrane Database of Systematic Reviews

DOI 10.1002/14651858.cd011129.pub2PMC PMC6481832

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Incurable cancer, which often constitutes an enormous challenge for patients, their families, and medical professionals, profoundly affects the patient's physical and psychosocial well-being. In standard cancer care, palliative measures generally are initiated when it is evident that disease-modifying treatments have been unsuccessful, no treatments can be offered, or death is anticipated. In contrast, early palliative care is initiated much earlier in the disease trajectory and closer to the diagnosis of incurable cancer. OBJECTIVES: To compare effects of early palliative care interventions versus treatment as usual/standard cancer care on health-related quality of life, depression, symptom intensity, and survival among adults with a diagnosis of advanced cancer. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycINFO, OpenGrey (a database for grey literature), and three clinical trial registers to October 2016. We checked reference lists, searched citations, and contacted study authors to identify additional studies. SELECTION CRITERIA: Randomised controlled trials (RCTs) and cluster-randomised controlled trials (cRCTs) on professional palliative care services that provided or co-ordinated comprehensive care for adults at early advanced stages of cancer. DATA COLLECTION AND ANALYSIS: We used standard methodological procedures as expected by Cochrane. We assessed risk of bias, extracted data, and collected information on adverse events. For quantitative synthesis, we combined respective results on our primary outcomes of health-related quality of life, survival (death hazard ratio), depression, and symptom intensity across studies in meta-analyses using an inverse variance random-effects model. We expressed pooled effects as standardised mean differences (SMDs, or Hedges' adjusted g). We assessed certainty of evidence at the outcome level using GRADE (Grading of Recommendations Assessment, Development, and Evaluation) and created a 'Summary of findings' table. MAIN RESULTS: We included seven randomised and cluster-randomised controlled trials that together recruited 1614 participants. Four studies evaluated interventions delivered by specialised palliative care teams, and the remaining studies assessed models of co-ordinated care. Overall, risk of bias at the study level was mostly low, apart from possible selection bias in three studies and attrition bias in one study, along with insufficient information on blinding of participants and outcome assessment in six studies.Compared with usual/standard cancer care alone, early palliative care significantly improved health-related quality of life at a small effect size (SMD 0.27, 95% confidence interval (CI) 0.15 to 0.38; participants analysed at post treatment = 1028; evidence of low certainty). As re-expressed in natural units (absolute change in Functional Assessment of Cancer Therapy-General (FACT-G) score), health-related quality of life scores increased on average by 4.59 (95% CI 2.55 to 6.46) points more among participants given early palliative care than among control participants. Data on survival, available from four studies enrolling a total of 800 participants, did not indicate differences in efficacy (death hazard ratio 0.85, 95% CI 0.56 to 1.28; evidence of very low certainty). Levels of depressive symptoms among those receiving early palliative care did not differ significantly from levels among those receiving usual/standard cancer care (five studies; SMD -0.11, 95% CI -0.26 to 0.03; participants analysed at post treatment = 762; evidence of very low certainty). Results from seven studies that analysed 1054 participants post treatment suggest a small effect for significantly lower symptom intensity in early palliative care compared with the control condition (SMD -0.23, 95% CI -0.35 to -0.10; evidence of low certainty). The type of model used to provide early palliative care did not affect study results. One RCT reported potential adverse events of early palliative care, such as a higher percentage of participants with severe scores for pain and poor appetite; the remaining six studies did not report adverse events in study publications. For these six studies, principal investigators stated upon request that they had not observed any adverse events. AUTHORS' CONCLUSIONS: This systematic review of a small number of trials indicates that early palliative care interventions may have more beneficial effects on quality of life and symptom intensity among patients with advanced cancer than among those given usual/standard cancer care alone. Although we found only small effect sizes, these may be clinically relevant at an advanced disease stage with limited prognosis, at which time further decline in quality of life is very common. At this point, effects on mortality and depression are uncertain. We have to inte

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/14651858.cd011129.pub2

Cites

166 of 166 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

People with advanced cancer have a higher risk of mental health problems, including mood disorders, depressive symptoms, cognitive disorders, anxiety, insomnia, and death ideas.
“Las personas con cáncer avanzado presentan aún mayor riesgo de presentar problemas de salud mental (8-10) , con prevalencias elevadas de trastornos del estado de ánimo y síntomas depresivos, trastornos cognitivos, ansiedad, insomnio e ideas de muerte (11-13) .”
From AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso. (2025) · cites this paper as [12]
The Description of the condition section (page not provided) says advanced cancer puts patients’ psychological health at high risk and mentions mental confusion and psychological distress. The review also measures depressive symptoms. It does not establish the claimed elevated prevalence of the full list—mood and cognitive disorders, anxiety, insomnia, and ideas of death—or specify a comparison for the higher-risk claim. (LLM, conf=0.83)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582 · see citing works
Introduction to Meta‐Analysis
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009) · doi:10.1002/9780470743386 · Cited by 14,225 · see citing works
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00136 · Cited by 10,349 · see citing works
GRADE guidelines: 3. Rating the quality of evidence
Balshem, H., Helfand, M., Schünemann, H. J., Oxman, A. D., Kunz, R., Brozek, J., Vist, G. E., Falck-Ytter, Y., Meerpohl, J., & Norris, S. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.015 · Cited by 8,285 · see citing works
Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer
Temel, J. S., Greer, J. A., Muzikansky, A., Gallagher, E. R., Admane, S., Jackson, V. A., Dahlin, C. M., Blinderman, C. D., Jacobsen, J., Pirl, W. F., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000678 · Cited by 7,482 · see citing works
Practical methods for incorporating summary time-to-event data into meta-analysis.
Tierney, J. F., Stewart, L. A., Ghersi, D., Burdett, S., & Sydes, M. R. (2007) · Trials · doi:10.1186/1745-6215-8-16 · Cited by 6,208 · see citing works
Untitled work
(2008) · Cited by 3,790 · see citing works
GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)
Guyatt, G. H., Oxman, A. D., Vist, G., Kunz, R., Brozek, J., Alonso-Coello, P., Montori, V., Akl, E. A., Djulbegovic, B., & Falck-Ytter, Y. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.017 · Cited by 2,798 · see citing works
Chapter 9: Analysing Data and Undertaking Meta-Analyses
Deeks, J. J., Higgins, J. P. T., & Altman, D. G. (2008) · Cited by 2,782 · see citing works
The Global Burden of Cancer 2013
Fitzmaurice, C., Dicker, D., Pain, A. W., Hamavid, H., Moradi‐Lakeh, M., MacIntyre, M. F., Allen, C., Hansen, G. M., Woodbrook, R., Wolfe, C. D. A., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.0735 · Cited by 2,709 · see citing works
Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update
FERRELL, B. R., Temel, J. S., Temin, S., Alesi, E. R., Balboni, T. A., Basch, E., Firn, J. I., Paice, J. A., Peppercorn, J. M., Phillips, T., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.1474 · Cited by 2,148 · see citing works
The PRECIS-2 tool: designing trials that are fit for purpose
Loudon, K., Treweek, S., Sullivan, F., Donnan, P., Thorpe, K. E., & Zwarenstein, M. (2015) · BMJ · doi:10.1136/bmj.h2147 · Cited by 1,846 · see citing works
GRADE guidelines: 8. Rating the quality of evidence—indirectness
Guyatt, G. H., Oxman, A. D., Kunz, R., Woodcock, J., Brozek, J., Helfand, M., Alonso-Coello, P., Falck-Ytter, Y., Jaeschke, R., Vist, G., et al. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.04.014 · Cited by 1,843 · see citing works
Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial
Zimmermann, C., Swami, N., Krzyzanowska, M., Hannon, B., Leighl, N., Oza, A., Moore, M., Rydall, A., Rodin, G., Tannock, I., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62416-2 · Cited by 1,781 · see citing works
Effects of a Palliative Care Intervention on Clinical Outcomes in Patients With Advanced Cancer: The Project ENABLE II Randomized Controlled Trial
Bakitas, M., Lyons, K. D., Hegel, M. T., Balan, S., Brokaw, F. C., Seville, J., Hull, J. G., Li, Z., Tosteson, T. D., Byock, I. R., et al. (2009) · JAMA · doi:10.1001/jama.2009.1198 · Cited by 1,726 · see citing works
A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers
Thorpe, K. E., Zwarenstein, M., Oxman, A. D., Treweek, S., Furberg, C. D., Altman, D. G., Tunis, S., Bergel, E., Harvey, I., Magid, D. J., et al. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2008.12.011 · Cited by 1,389 · see citing works
Systematic Review: The Relationship between Clinical Experience and Quality of Health Care
Choudhry, N., Fletcher, R., & Soumerai, S. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-4-200502150-00008 · Cited by 1,348 · see citing works
American Society of Clinical Oncology Provisional Clinical Opinion: The Integration of Palliative Care Into Standard Oncology Care
Smith, T. J., Temin, S., Alesi, E. R., Abernethy, A. P., Balboni, T. A., Basch, E., FERRELL, B. R., Loscalzo, M., Meier, D. E., Paice, J. A., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.5161 · Cited by 1,313 · see citing works
Quality End-of-Life Care: Patients' Perspectives
Singer, P. A., Martin, D. K., & Kelner, M. (1999) · JAMA · doi:10.1001/jama.281.2.163 · Cited by 1,287 · see citing works
Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial
Bakitas, M. A., Tosteson, T. D., Li, Z., Lyons, K. D., Hull, J. G., Li, Z., Dionne-Odom, J. N., Frost, J., Dragnev, K. H., Hegel, M. T., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.6362 · Cited by 1,219 · see citing works
Depression and cancer mortality: a meta-analysis
Pinquart, M., & Duberstein, P. R. (2010) · Psychological Medicine · doi:10.1017/s0033291709992285 · Cited by 1,083 · see citing works
Chapter 10: Addressing reporting biases
Egger, M., & Moher, D. (2011) · Cited by 977 · see citing works
Aggressiveness of Cancer Care Near the End of Life: Is It a Quality-of-Care Issue?
Earle, C. C., Landrum, M. B., Souza, J. M., Neville, B. A., Weeks, J. C., & Ayanian, J. Z. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.15.8253 · Cited by 950 · see citing works
Health Care Costs in the Last Week of Life: Associations With End-of-Life Conversations
Zhang, B., Wright, A. A., Huskamp, H. A., Nilsson, M. E., Maciejewski, M. L., Earle, C. C., Block, S. D., Maciejewski, P. K., & Prigerson, H. G. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.587 · Cited by 898 · see citing works
Chapter 12: Interpreting results and drawing conclusions
Schünemann, H. J., Oxman, A. D., Jonathan, J., & Glasziou, P. (2011) · Cited by 873 · see citing works
Increased Satisfaction with Care and Lower Costs: Results of a Randomized Trial of In‐Home Palliative Care
Brumley, R., Enguidanos, S., Jamison, P., Seitz, R., Morgenstern, N., Saito, S., McIlwane, J., Hillary, K., & Gonzalez, J. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01234.x · Cited by 845 · see citing works
Effects of Early Integrated Palliative Care in Patients With Lung and GI Cancer: A Randomized Clinical Trial
Temel, J. S., Greer, J. A., El-Jawahri, A. R., Pirl, W. F., Park, E. R., Jackson, V. A., Back, A. L., Kamdar, M. M., Jacobsen, J. C., Chittenden, E., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.5046 · Cited by 839 · see citing works
Palliative Care for the Seriously Ill
Kelley, A. S., & Morrison, R. S. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1404684 · Cited by 817 · see citing works
GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines
Alonso-Coello, P., Oxman, A. D., Moberg, J., Brignardello-Petersen, R., Akl, E. A., Davoli, M., Treweek, S., Mustafa, R. A., Vandvik, P. O., Meerpohl, J., et al. (2016) · BMJ · doi:10.1136/bmj.i2089 · Cited by 814 · see citing works
Effect of spiritual well-being on end-of-life despair in terminally-ill cancer patients
McClain, C. S., Rosenfeld, B., & Breitbart, W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13310-7 · Cited by 812 · see citing works
Effectiveness and cost-effectiveness of home palliative care services for adults with advanced illness and their caregivers
Gomes, B., Calanzani, N., Curiale, V., McCrone, P., Higginson, I. J., & de Brito, M. F. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007760.pub2 · Cited by 797 · see citing works
GRADE guidelines: 11. Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes
Guyatt, G., Oxman, A. D., Sultan, S., Brozek, J., Glasziou, P., Alonso-Coello, P., Atkins, D., Kunz, R., Montori, V., Jaeschke, R., et al. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2012.01.006 · Cited by 762 · see citing works
Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2002) · Journal of Health Services Research & Policy · doi:10.1258/1355819021927674 · Cited by 755 · see citing works
Chapter 16: Special Topics in Statistics
Higgins, J. P. T., Deeks, J. J., & Altman, D. (2008) · Cited by 702 · see citing works
Longitudinal Perceptions of Prognosis and Goals of Therapy in Patients With Metastatic Non–Small-Cell Lung Cancer: Results of a Randomized Study of Early Palliative Care
Temel, J. S., Greer, J. A., Admane, S., Gallagher, E. R., Jackson, V. A., Lynch, T. J., Lennes, I. T., Dahlin, C., & Pirl, W. F. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.4459 · Cited by 700 · see citing works
Four-Week Prevalence of Mental Disorders in Patients With Cancer Across Major Tumor Entities
Mehnert, A., Brähler, E., Faller, H., Härter, M., Keller, M., Schulz, H., Wegscheider, K., Weis, J., Boehncke, A., Hund, B., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.0086 · Cited by 649 · see citing works
Chemotherapy Use, Performance Status, and Quality of Life at the End of Life
Prigerson, H. G., Bao, Y., Shah, M. A., Paulk, M. E., LeBlanc, T. W., Schneider, B. J., Garrido, M. M., Reid, M. C., Berlin, D., Adelson, K. B., et al. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.2378 · Cited by 648 · see citing works
The Prognostic Significance of Patient-Reported Outcomes in Cancer Clinical Trials
Gotay, C. C., Kawamoto, C. T., Bottomley, A., & Efficace, F. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.3439 · Cited by 645 · see citing works
Effect of Early Palliative Care on Chemotherapy Use and End-of-Life Care in Patients With Metastatic Non–Small-Cell Lung Cancer
Greer, J. A., Pirl, W. F., Jackson, V. A., Muzikansky, A., Lennes, I. T., Heist, R. S., Gallagher, E. R., & Temel, J. S. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.35.7996 · Cited by 575 · see citing works
Impact of an Inpatient Palliative Care Team: A Randomized Controlled Trial
Gade, G., Venohr, I., Conner, D., McGrady, K., Beane, J., Richardson, R. H., Williams, M. P., Liberson, M., Blum, M., & Penna, R. D. (2008) · Journal of Palliative Medicine · doi:10.1089/jpm.2007.0055 · Cited by 564 · see citing works
Palliative Care
Morrison, R. S., & Meier, D. E. (2004) · New England Journal of Medicine · doi:10.1056/nejmcp035232 · Cited by 542 · see citing works
General population and cancer patient norms for the functional assessment of cancer therapy-general (FACT-G)
Brucker, P. S., Yost, K., Cashy, J., Webster, K., & Cella, D. (2005) · Evaluation & the Health Professions · doi:10.1177/0163278705275341 · Cited by 528 · see citing works
American Society of Clinical Oncology Statement: Toward Individualized Care for Patients With Advanced Cancer
Peppercorn, J. M., Smith, T. J., Helft, P. R., Debono, D. J., Berry, S. R., Wollins, D. S., Hayes, D. M., Roenn, J. H. V., & Schnipper, L. E. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.1744 · Cited by 524 · see citing works
Benefits of Early Versus Delayed Palliative Care to Informal Family Caregivers of Patients With Advanced Cancer: Outcomes From the ENABLE III Randomized Controlled Trial
Dionne-Odom, J. N., Azuero, A., Lyons, K. D., Hull, J. G., Tosteson, T. D., Li, Z., Li, Z., Frost, J., Dragnev, K. H., Akyar, İ., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.7824 · Cited by 500 · see citing works
Making trials matter: pragmatic and explanatory trials and the problem of applicability
Treweek, S. P., & Zwarenstein, M. (2009) · Trials · doi:10.1186/1745-6215-10-37 · Cited by 482 · see citing works
The Comprehensive Care Team
Rabow, M. W., Dibble, S. L., Pantilat, S. Z., & McPhee, S. J. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.1.83 · Cited by 469 · see citing works
Effectiveness of Specialized Palliative Care
Zimmermann, C., Riechelmann, R. P., Krzyzanowska, M. K., Rodin, G., & Tannock, I. F. (2008) · JAMA · doi:10.1001/jama.299.14.1698 · Cited by 468 · see citing works
40-year trends in an index of survival for all cancers combined and survival adjusted for age and sex for each cancer in England and Wales, 1971–2011: a population-based study
Quaresma, M., Coleman, M. P., & Rachet, B. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61396-9 · Cited by 458 · see citing works
When do we need to care about the caregiver? Supportive care needs, anxiety, and depression among informal caregivers of patients with cancer and cancer survivors
Sklenarova, H., Krümpelmann, A., Haun, M. W., Friederich, H., Huber, J., Thomas, M., Winkler, E. C., Herzog, W., & Hartmann, M. (2015) · Cancer · doi:10.1002/cncr.29223 · Cited by 438 · see citing works
Self-citation
What Is the Evidence That Palliative Care Teams Improve Outcomes for Cancer Patients and Their Families?
Higginson, I. J., & Evans, C. (2010) · The Cancer Journal · doi:10.1097/ppo.0b013e3181f684e5 · Cited by 405 · see citing works
Perceptions of palliative care among patients with advanced cancer and their caregivers
Zimmermann, C., Swami, N., Krzyzanowska, M. K., Leighl, N. B., Rydall, A. C., Rodin, G., Tannock, I. F., & Hannon, B. L. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.151171 · Cited by 381 · see citing works
Impacting quality of life for patients with advanced cancer with a structured multidisciplinary intervention: a randomized controlled trial
Rummans, T. A., Clark, M. M., Sloan, J. A., Frost, M. H., Bostwick, J. M., Atherton, P. J., Johnson, M. E., Gamble, G., Richardson, J., Brown, P., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.06.209 · Cited by 353 · see citing works
Early integration of palliative care services with standard oncology care for patients with advanced cancer
Greer, J. A., Jackson, V. A., Meier, D. E., & Temel, J. S. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21192 · Cited by 346 · see citing works
Concepts and definitions for “supportive care,” “best supportive care,” “palliative care,” and “hospice care” in the published literature, dictionaries, and textbooks
Hui, D., de la Cruz, M., Mori, M., Parsons, H. A., Kwon, J. H., Vigil, I. T., Kim, S., Dev, R., Hutchins, R. D., Liem, C., et al. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1564-y · Cited by 343 · see citing works
Dying from cancer: results of a national population-based investigation
Addington-Hall, J. M., & McCarthy, M. I. (1995) · Palliative Medicine · doi:10.1177/026921639500900404 · Cited by 308 · see citing works
Early Palliative Care in Advanced Lung Cancer
Yoong, J., Park, E. R., Greer, J. A., Jackson, V. A., Gallagher, E. R., Pirl, W. F., Back, A. L., & Temel, J. S. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1874 · Cited by 283 · see citing works
Early Specialty Palliative Care — Translating Data in Oncology into Practice
Parikh, R. B., Kirch, R. A., Smith, T. J., & Temel, J. S. (2013) · New England Journal of Medicine · doi:10.1056/nejmsb1305469 · Cited by 279 · see citing works
Prospective Cohort Study of Hospital Palliative Care Teams for Inpatients With Advanced Cancer: Earlier Consultation Is Associated With Larger Cost-Saving Effect
May, P., Garrido, M. M., Cassel, J. B., Kelley, A. S., Meier, D. E., Normand, C. E. M., Smith, T. J., Stefanis, L., & Morrison, R. S. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.60.2334 · Cited by 279 · see citing works
A High-Volume Specialist Palliative Care Unit and Team May Reduce In-Hospital End-of-Life Care Costs
Smith, T. J., Coyne, P. J., Cassel, B. J., Penberthy, L., Hopson, A., & Hager, M. A. (2003) · Journal of Palliative Medicine · doi:10.1089/109662103322515202 · Cited by 257 · see citing works
Emergency Department–Initiated Palliative Care in Advanced Cancer
Grudzen, C. R., Richardson, L. D., Johnson, P. N., Hu, M., Wang, B., Ortiz, J. M., Kistler, E. A., Chen, A., & Morrison, R. S. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2015.5252 · Cited by 256 · see citing works
A review of the trials which examine early integration of outpatient and home palliative care for patients with serious illnesses.
Davis, M. P., Temel, J. S., Balboni, T. A., & Glare, P. A. (2015) · PubMed · doi:10.3978/j.issn.2224-5820.2015.04.04 · Cited by 255 · see citing works
Minimal clinically important differences in the Edmonton Symptom Assessment Scale in cancer patients: A prospective, multicenter study
Hui, D., Shamieh, O. M., Paiva, C. E., Perez‐Cruz, P. E., Kwon, J. H., Muckaden, M. A., Park, M., Yennurajalingam, S., Kang, J. H., & Bruera, E. D. (2015) · Cancer · doi:10.1002/cncr.29437 · Cited by 251 · see citing works
Attrition rates, reasons, and predictive factors in supportive care and palliative oncology clinical trials
Hui, D., Glitza, I., Chisholm, G., Yennu, S., & Bruera, E. (2013) · Cancer · doi:10.1002/cncr.27854 · Cited by 250 · see citing works
A problem solving intervention for caregivers of cancer patients
Toseland, R. W., Blanchard, C. G., & McCallion, P. (1995) · Social Science & Medicine · doi:10.1016/0277-9536(94)e0093-8 · Cited by 247 · see citing works
Quality of Life in Palliative Cancer Care: Results From a Cluster Randomized Trial
Slaaen, M., Fayers, P. M., Loge, J. H., Ahlner‐Elmqvist, M., & Kaasa, S. (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.18.3884 · Cited by 245 · see citing works
Phase II Study of an Outpatient Palliative Care Intervention in Patients With Metastatic Cancer
Follwell, M. J., Burman, D., Le, L. W., Wakimoto, K., Seccareccia, D., Bryson, J., Rodin, G., & Zimmermann, C. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.17.7568 · Cited by 238 · see citing works
Depression and Survival in Metastatic Non–Small-Cell Lung Cancer: Effects of Early Palliative Care
Pirl, W. F., Greer, J. A., Traeger, L., Jackson, V., Lennes, I. T., Gallagher, E. R., Perez-Cruz, P., Heist, R. S., & Temel, J. S. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.3166 · Cited by 228 · see citing works
Does Palliative Care Improve Outcomes for Patients with Incurable Illness? A Review of the Evidence
El-Jawahri, A. R., Greer, J. A., & Temel, J. S. (2011) · The Journal of Supportive Oncology · doi:10.1016/j.suponc.2011.03.003 · Cited by 221 · see citing works
Impact of care at comprehensive cancer centers on outcome: Results from a population‐based study
Wolfson, J. A., Sun, C., Wyatt, L., et al. (2015) · Cancer · doi:10.1002/cncr.29576 · Cited by 217 · see citing works
Dyadic psychosocial intervention for advanced lung cancer patients and their family caregivers: Results of a randomized pilot trial
Badr, H., Smith, C. B., Goldstein, N. E., Gomez, J. E., & Redd, W. H. (2014) · Cancer · doi:10.1002/cncr.29009 · Cited by 214 · see citing works
Elements of effective palliative care models: a rapid review
Luckett, T., Phillips, J. L., Agar, M. R., Virdun, C., Green, A., & Davidson, P. M. (2014) · BMC Health Services Research · doi:10.1186/1472-6963-14-136 · Cited by 213 · see citing works
Interdisciplinary Palliative Care for Patients With Lung Cancer
FERRELL, B. R., Sun, V. C.-Y., Hurria, A., Cristea, M. C., Raz, D. J., Kim, J. Y., Reckamp, K. L., Williams, A. C., Borneman, T. R., Uman, G. C., et al. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.07.005 · Cited by 207 · see citing works
Defining the palliative care patient: A systematic review
Mechelen, W. V., Aertgeerts, B., Ceulaer, K. D., Thoonsen, B., Vermandere, M., Warmenhoven, F. C., van Rijswijk, E., & Lepeleire, J. D. (2012) · Palliative Medicine · doi:10.1177/0269216311435268 · Cited by 201 · see citing works
Integration of Oncology and Palliative Care: A Systematic Review
Hui, D., Kim, Y. J., Park, J. C., Zhang, Y., Strasser, F., Cherny, N. I., Kaasa, S., Davis, M. P., & Bruera, E. D. (2014) · The Oncologist · doi:10.1634/theoncologist.2014-0312 · Cited by 190 · see citing works
The project ENABLE II randomized controlled trial to improve palliative care for rural patients with advanced cancer: Baseline findings, methodological challenges, and solutions
Bakitas, M. A., Lyons, K. D., Hegel, M. T., Balan, S., Barnett, K. N., Brokaw, F. C., Byock, I. R., Hull, J. G., Li, Z., McKinstry, E., et al. (2009) · Palliative & Supportive Care · doi:10.1017/s1478951509000108 · Cited by 189 · see citing works
Components of Early Outpatient Palliative Care Consultation in Patients with Metastatic Nonsmall Cell Lung Cancer
Jacobsen, J. C., Jackson, V. A., Dahlin, C. M., Greer, J. A., Perez‐Cruz, P. E., Billings, J. A., Pirl, W. F., & Temel, J. S. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.0382 · Cited by 181 · see citing works
Systematic versus on-demand early palliative care: A randomised clinical trial assessing quality of care and treatment aggressiveness near the end of life
Maltoni, M. C., Scarpi, E., Dall’Agata, M., Schiavon, S., Biasini, C., Codecà, C., Broglia, C. M., Sansoni, E., Bortolussi, R., Garetto, F., et al. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.10.004 · Cited by 180 · see citing works
Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial
Maltoni, M. C., Scarpi, E., Dall’Agata, M., Zagonel, V., Bertè, R., Ferrari, D., Broglia, C. M., Bortolussi, R., Trentin, L., Valgiusti, M., et al. (2016) · European Journal of Cancer · doi:10.1016/j.ejca.2016.06.007 · Cited by 177 · see citing works
Models of integration of oncology and palliative care.
Hui, D., & Bruera, E. D. (2015) · PubMed · doi:10.3978/j.issn.2224-5820.2015.04.01 · Cited by 172 · see citing works
Impact of early palliative care on caregivers of patients with advanced cancer: cluster randomised trial
McDonald, J. C., Swami, N., Hannon, B. L., Lo, C., Pope, A. J., Oza, A., Leighl, N. B., Krzyzanowska, M. K., Rodin, G., Le, L. W., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw438 · Cited by 172 · see citing works
Benefit of Early Palliative Care Intervention in End-Stage Liver Disease Patients Awaiting Liver Transplantation
Baumann, A. J., Wheeler, D., James, M., Turner, R., Siegel, A., & Navarro, V. J. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2015.07.014 · Cited by 162 · see citing works
Palliative Care — A Shifting Paradigm
Kelley, A. S., & Meier, D. E. (2010) · New England Journal of Medicine · doi:10.1056/nejme1004139 · Cited by 160 · see citing works
Cancer's Next Frontier
Elkin, E. B., & Bach, P. B. (2010) · JAMA · doi:10.1001/jama.2010.283 · Cited by 155 · see citing works
Early palliative care and metastatic non-small cell lung cancer
Irwin, K. E., Greer, J. A., Khatib, J., Temel, J. S., & Pirl, W. F. (2013) · Chronic Respiratory Disease · doi:10.1177/1479972312471549 · Cited by 145 · see citing works
Phase II Study: Integrated Palliative Care in Newly Diagnosed Advanced Non–Small-Cell Lung Cancer Patients
Temel, J. S., Jackson, V. A., Billings, J. A., Dahlin, C. M., Block, S. D., Buss, M. K., Ostler, P. A., Fidias, P. M., Muzikansky, A., Greer, J. A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.2627 · Cited by 143 · see citing works
Impact on caregiver burden of a patient-focused palliative care intervention for patients with advanced cancer
O'Hara, R. E., Hull, J. G., Lyons, K. D., Bakitas, M. A., Hegel, M. T., Li, Z., & Ahles, T. A. (2010) · Palliative & Supportive Care · doi:10.1017/s1478951510000258 · Cited by 133 · see citing works
The Integration of Early Palliative Care With Oncology Care: The Time Has Come for a New Tradition
Bauman, J. R., & Temel, J. S. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0177 · Cited by 127 · see citing works
Symptoms tell it all: A systematic review of the value of symptom assessment to predict survival in advanced cancer patients
Trajkovic, M., de Graeff, A., Voest, E. E., & Teunissen, S. C. C. M. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.02.011 · Cited by 126 · see citing works
Multicenter Randomized Trial of Centralized Nurse-Led Telephone-Based Care Coordination to Improve Outcomes After Surgical Resection for Colorectal Cancer: The CONNECT Intervention
Young, J. M., Butow, P. N., Walsh, J., Durcinoska, I., Dobbins, T., Rodwell, L., Harrison, J. D., White, K., Gilmore, A., Hodge, B. E., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.1036 · Cited by 118 · see citing works
Effects of a Problem-Solving Intervention (COPE) on Quality of Life for Patients with Advanced Cancer on Clinical Trials and their Caregivers: Simultaneous Care Educational Intervention (SCEI): Linking Palliation and Clinical Trials
Meyers, F. J., Carducci, M. A., Loscalzo, M. J., Linder, J. F., Greasby, T. A., & Beckett, L. A. (2011) · Journal of Palliative Medicine · doi:10.1089/jpm.2010.0416 · Cited by 112 · see citing works
A Nurse Practitioner Directed Intervention Improves the Quality of Life of Patients with Metastatic Cancer: Results of a Randomized Pilot Study
Dyar, S., Lesperance, M., Shannon, R. P., Sloan, J. A., & Colón‐Otero, G. (2012) · Journal of Palliative Medicine · doi:10.1089/jpm.2012.0014 · Cited by 111 · see citing works
Communication in palliative care: a review of recent literature
de Haes, J. C. J. M., & Teunissen, S. C. C. M. (2005) · Current Opinion in Oncology · doi:10.1097/01.cco.0000167735.26454.79 · Cited by 106 · see citing works
Project ENABLE: A Palliative Care Demonstration Project for Advanced Cancer Patients in Three Settings
Bakitas, M. A., Stevens, M. M., Ahles, T. A., Kirn, M., Skalla, K. A., Kane, N., Greenberg, E. R., & The Project Enable Co-Investigators (2004) · Journal of Palliative Medicine · doi:10.1089/109662104773709530 · Cited by 104 · see citing works
An Advanced Practice Nurse Coordinated Multidisciplinary Intervention for Patients with Late-Stage Cancer: A Cluster Randomized Trial
McCorkle, R. C., Jeon, S., Ercolano, E. A., Lazenby, M., Reid, A., Davies, M. J., Viveiros, D., & Gettinger, S. N. (2015) · Journal of Palliative Medicine · doi:10.1089/jpm.2015.0113 · Cited by 98 · see citing works
Randomized Controlled Trial of a Structured Intervention to Facilitate End-of-Life Decision Making in Patients With Advanced Cancer
Stein, R. A., Sharpe, L., Bell, M. L., Boyle, F. M., Dunn, S. M., & Clarke, S. J. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.8872 · Cited by 97 · see citing works
Randomised clinical trial of early specialist palliative care plus standard care versus standard care alone in patients with advanced cancer: The Danish Palliative Care Trial
Grøenvold, M., Petersen, M. A., Damkier, A., Neergaard, M. A., Nielsen, J. B., Pedersen, L., Sjøgren, P., Strömgren, A. S., Vejlgaard, T. B., Gluud, C. N., et al. (2017) · Palliative Medicine · doi:10.1177/0269216317705100 · Cited by 97 · see citing works
Clinician Roles in Early Integrated Palliative Care for Patients with Advanced Cancer: A Qualitative Study
Back, A. L., Park, E. R., Greer, J. A., Jackson, V. A., Jacobsen, J. C., Gallagher, E. R., & Temel, J. S. (2014) · Journal of Palliative Medicine · doi:10.1089/jpm.2014.0146 · Cited by 93 · see citing works
Oncologists' perspectives on concurrent palliative care in a National Cancer Institute-designated comprehensive cancer center
Bakitas, M. A., Lyons, K. D., Hegel, M. T., & Ahles, T. A. (2012) · Palliative & Supportive Care · doi:10.1017/s1478951512000673 · Cited by 92 · see citing works
Simultaneous Care: Disease Treatment and Palliative Care Throughout Illness
Meyers, F. J., & Linder, J. F. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.01.104 · Cited by 90 · see citing works
Palliative Care Version 1.2016
Levy, M., Smith, T. J., Alvarez-Perez, A., Back, A. L., Baker, J. N., Beck, A. C., Block, S. D., Dalal, S., Dans, M. C., Fitch, T. R., et al. (2016) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2016.0009 · Cited by 85 · see citing works
Training general practitioners in early identification and anticipatory palliative care planning: a randomized controlled trial
Thoonsen, B., Vissers, K. C. P., Verhagen, S. C. A. H. H. V. M., Prins, J. B., Bor, H. H. J., van Weel, C., Groot, M. M., & Engels, Y. (2015) · BMC Family Practice · doi:10.1186/s12875-015-0342-6 · Cited by 85 · see citing works
Patient perspectives on participation in the ENABLE II randomized controlled trial of a concurrent oncology palliative care intervention: Benefits and burdens
Maloney, C., Lyons, K. D., Li, Z., Hegel, M. T., Ahles, T. A., & Bakitas, M. A. (2012) · Palliative Medicine · doi:10.1177/0269216312445188 · Cited by 83 · see citing works
How systematic reviews cause research waste
Roberts, I., & Ker, K. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00489-4 · Cited by 83 · see citing works
Associations between advanced cancer patients' survival and family caregiver presence and burden
Dionne-Odom, J. N., Hull, J. G., Martin, M. Y., Lyons, K. D., Prescott, A. T., Tosteson, T. D., Li, Z., Akyar, İ., Raju, D. A., & Bakitas, M. A. (2016) · Cancer Medicine · doi:10.1002/cam4.653 · Cited by 80 · see citing works
Hospital-Based Palliative Medicine Consultation: A Randomized Controlled Trial
Pantilat, S. Z. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.460 · Cited by 79 · see citing works
Exercise training in patients with advanced gastrointestinal cancer undergoing palliative chemotherapy: a pilot study
Jensen, W., Baumann, F. T., Stein, A., Bloch, W., Bokemeyer, C., de Wit, M., & Oechsle, K. (2014) · Supportive Care in Cancer · doi:10.1007/s00520-014-2139-x · Cited by 78 · see citing works
The Next Era of Palliative Care
Schenker, Y., & Arnold, R. M. (2015) · JAMA · doi:10.1001/jama.2015.11217 · Cited by 73 · see citing works
Early integration of palliative care into oncology: evidence, challenges and barriers.
Zhi, W. I., & Smith, T. J. (2015) · PubMed · doi:10.3978/j.issn.2224-5820.2015.07.03 · Cited by 72 · see citing works
Cost-effectiveness of early palliative care intervention in recurrent platinum-resistant ovarian cancer
Lowery, W. J., Lowery, A. W., Barnett, J. C., Lopez-Acevedo, M., Lee, P. S., Secord, A. A., & Havrilesky, L. J. (2013) · Gynecologic Oncology · doi:10.1016/j.ygyno.2013.06.011 · Cited by 68 · see citing works
Integration of early specialist palliative care in cancer care and patient related outcomes: A critical review of evidence
Salins, N. S., Ramanjulu, R., Patra, L. P., Deodhar, J. K., & Muckaden, M. A. (2016) · Indian Journal of Palliative Care · doi:10.4103/0973-1075.185028 · Cited by 65 · see citing works
TREATMENT OF INOPERABLE CARCINOMA OF BRONCHUS
Laing, A. H., Berry, R. J., Newman, C. R., et al. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92654-9 · Cited by 63 · see citing works
Early Palliative Care in Advanced Oncologic and Non-Oncologic Chronic Diseases: A Systematic Review of Literature
Tassinari, D., Drudi, F., Monterubbianesi, M. C., et al. (2015) · Reviews on Recent Clinical Trials · doi:10.2174/1574887110666151014141650 · Cited by 63 · see citing works
How useful are systematic reviews for informing palliative care practice? Survey of 25 Cochrane systematic reviews
Wee, B. L., Hadley, G., & Derry, S. (2008) · BMC Palliative Care · doi:10.1186/1472-684x-7-13 · Cited by 61 · see citing works
Age and Gender Moderate the Impact of Early Palliative Care in Metastatic Non-Small Cell Lung Cancer
Nipp, R. D., Greer, J. A., El-Jawahri, A. R., Traeger, L. N., Gallagher, E. R., Park, E. R., Jackson, V. A., Pirl, W. F., & Temel, J. S. (2015) · The Oncologist · doi:10.1634/theoncologist.2015-0232 · Cited by 61 · see citing works
The Meaning of Life Intervention for Patients With Advanced-Stage Cancer: Development and Pilot Study
Mok, E., Lau, K., Lai, T. T.-K., & Ching, S. S. Y. (2012) · Oncology nursing forum · doi:10.1188/12.onf.e480-e488 · Cited by 60 · see citing works
Depression, anxiety and disease-related distress in couples affected by advanced lung cancer
Haun, M. W., Sklenarova, H., Villalobos, M., Thomas, M., Brechtel, A., Löwe, B., Herzog, W., & Hartmann, M. (2014) · Lung Cancer · doi:10.1016/j.lungcan.2014.09.009 · Cited by 59 · see citing works
Self-citation
Early identification of and proactive palliative care for patients in general practice, incentive and methods of a randomized controlled trial
Thoonsen, B., Groot, M. M., Engels, Y., Prins, J. B., Verhagen, S. C. A. H. H. V. M., Galesloot, C., van Weel, C., & Vissers, K. C. P. (2011) · BMC Family Practice · doi:10.1186/1471-2296-12-123 · Cited by 58 · see citing works
Discussing prognosis and end-of-life care in the final year of life: a randomised controlled trial of a nurse-led communication support programme for patients and caregivers
Walczak, A., Butow, P. N., Clayton, J. M., Tattersall, M. H. N., Davidson, P. M., Young, J. M., & Epstein, R. M. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005745 · Cited by 54 · see citing works
Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses
Hussain, J. A., White, I. R., Langan, D., Johnson, M. J., Currow, D. C., Torgerson, D. J., & Bland, M. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.12.003 · Cited by 52 · see citing works
Has CONSORT improved the reporting of randomized controlled trials in the palliative care literature? A systematic review
Piggott, M., McGee, H. M., & Feuer, D. J. (2004) · Palliative Medicine · doi:10.1191/0269216304pm857oa · Cited by 51 · see citing works
Emergency Department–triggered Palliative Care in Advanced Cancer: Proof of Concept
Kistler, E. A., Morrison, R. S., Richardson, L. D., et al. (2015) · Academic Emergency Medicine · doi:10.1111/acem.12573 · Cited by 51 · see citing works
Outcomes in systematic reviews of complex interventions never reached “high” GRADE ratings when compared with those of simple interventions
Movsisyan, A., Melendez-Torres, G. J., & Montgomery, P. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.03.014 · Cited by 50 · see citing works
The impact of lung cancer surgery on quality of life trajectories in patients and family caregivers
Kim, J. Y., Sun, V., Raz, D. J., Williams, A. C., Fujinami, R., Reckamp, K., Koczywas, M., Cristea, M., Hurria, A., & Ferrell, B. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.08.011 · Cited by 48 · see citing works
Users identified challenges in applying GRADE to complex interventions and suggested an extension to GRADE
Movsisyan, A., Meléndez‐Torres, G. J., & Montgomery, P. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.09.010 · Cited by 46 · see citing works
A pilot randomised controlled trial to reduce suffering and emotional distress in patients with advanced cancer
Lloyd‐Williams, M., Cobb, M., O'Connor, C., Dunn, L., & Shiels, C. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.013 · Cited by 46 · see citing works
A tailored, supportive care intervention using systematic assessment designed for people with inoperable lung cancer: a randomised controlled trial
Schofield, P. E., Ugalde, A., Gough, K., Reece, J., Krishnasamy, M., Carey, M. L., Ball, D., & Aranda, S. K. (2013) · Psycho-Oncology · doi:10.1002/pon.3306 · Cited by 36 · see citing works
The integration of palliative care and oncology: the evidence.
Roenn, J. H. V., & Temel, J. S. (2011) · PubMed · Cited by 36 · see citing works
Psychological factors at early stage of treatment as predictors of receiving chemotherapy at the end of life
Fujisawa, D., Temel, J. S., Traeger, L. N., Greer, J. A., Lennes, I. T., Mimura, M., & Pirl, W. F. (2015) · Psycho-Oncology · doi:10.1002/pon.3840 · Cited by 34 · see citing works
Can early introduction of specialized palliative care limit intensive care, emergency and hospital admissions in patients with severe and very severe COPD? a randomized study
Weber, C., Stirnemann, J., Herrmann, F. R., Pautex, S., & Janssens, J.-P. (2014) · BMC Palliative Care · doi:10.1186/1472-684x-13-47 · Cited by 32 · see citing works
Implementation of supportive care and best supportive care interventions in clinical trials enrolling patients with cancer
Lee, R. T., Ramchandran, K. J., Sanft, T. B., & Roenn, J. V. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv207 · Cited by 30 · see citing works
Resource allocation issues concerning early palliative care.
Gaertner, J., Maier, B.-O., & Radbruch, L. (2015) · PubMed · doi:10.3978/j.issn.2224-5820.2015.07.02 · Cited by 29 · see citing works
Early Contact with Palliative Care Services: A Randomized Trial in Patients with Newly Detected Incurable Metastatic Cancer
Tattersall, M. H. N. (2014) · Journal of Palliative Care & Medicine · doi:10.4172/2165-7386.1000170 · Cited by 26 · see citing works
The systematic early integration of palliative care into multidisciplinary oncology care in the hospital setting (IPAC), a randomized controlled trial: the study protocol
Vanbutsele, G., Belle, S. V., Laat, M. D., Surmont, V. F. M., Geboes, K. P., Eecloo, K., Pardon, K., & Deliëns, L. (2015) · BMC Health Services Research · doi:10.1186/s12913-015-1207-3 · Cited by 25 · see citing works
Better Palliative Care for All
Kamal, A. H., LeBlanc, T. W., & Meier, D. E. (2016) · JAMA · doi:10.1001/jama.2016.6491 · Cited by 21 · see citing works
Detailed statistical analysis plan for the Danish Palliative Care Trial (DanPaCT)
Johnsen, A. T., Petersen, M. A., Gluud, C. N., Lindschou, J., Fayers, P. M., Sjøgren, P., Pedersen, L., Neergaard, M. A., Vejlgaard, T. B., Damkier, A., et al. (2014) · Trials · doi:10.1186/1745-6215-15-376 · Cited by 20 · see citing works
Communicating a prognosis in advanced cancer.
Sinclair, C. T. (2006) · PubMed · Cited by 20 · see citing works
The impact of early palliative care on the quality of care during the last days of life: what does the evidence say?
Zambrano, S. C., Fliedner, M., & Eychmüller, S. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000240 · Cited by 20 · see citing works
A randomised, multicentre clinical trial of specialised palliative care plus standard treatment versus standard treatment alone for cancer patients with palliative care needs: the Danish palliative care trial (DanPaCT) protocol
Johnsen, A. T., Damkier, A., Vejlgaard, T. B., Lindschou, J., Sjøgren, P., Gluud, C. N., Neergaard, M. A., Petersen, M. A., Lundorff, L. E., Pedersen, L., et al. (2013) · BMC Palliative Care · doi:10.1186/1472-684x-12-37 · Cited by 18 · see citing works
Emergency department-initiated palliative care for advanced cancer patients: protocol for a pilot randomized controlled trial
Kandarian, B. S., Morrison, R. S., Richardson, L. D., Ortiz, J. M., & Grudzen, C. R. (2014) · Trials · doi:10.1186/1745-6215-15-251 · Cited by 17 · see citing works
A multicentre non-blinded randomised controlled trial to assess the impact of regular early specialist symptom control treatment on quality of life in malignant mesothelioma (RESPECT-MESO): study protocol for a randomised controlled trial
Gunatilake, S. C., Brims, F., Fogg, C., Lawrie, I., Maskell, N. A., Forbes, K., Rahman, N. M., Stephen Morris, A., Ogollah, R. O., Gerry, S., et al. (2014) · Trials · doi:10.1186/1745-6215-15-367 · Cited by 15 · see citing works
Abstracts of the 8th World Research Congress of the European Association for Palliative Care (EAPC)
Jones, L., Harrington, J., Lord, K., et al. (2014) · Palliative Medicine · doi:10.1177/0269216314532748 · Cited by 14 · see citing works
Integrating Early Palliative Care for Patients With HIV
Lofgren, S. M., Friedman, R., Ghermay, R., George, M., Pittman, J. R., Shahane, A., Zeimer, D., del Rı́o, C., & Marconi, V. C. (2014) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909114550391 · Cited by 13 · see citing works
A phase II study in advanced cancer patients to evaluate the early transition to palliative care (the PREPArE trial): protocol study for a randomized controlled trial.
do Carmo, T. M., Paiva, B. S. R., de Siqueira, M. R., da Rosa, L. D. T. B., de Oliveira, C. Z., Nascimento, M. S. D. A., & Paiva, C. E. (2015) · Trials · doi:10.1186/s13063-015-0655-8 · Cited by 12 · see citing works
Early Palliative Care—Health services research and implementation of sustainable changes: the study protocol of the EVI project
Meffert, C., Gaertner, J., Seibel, K., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1453-0 · Cited by 12 · see citing works
Randomized trial of early integrated palliative and oncology care.
Temel, J. S., El-Jawahri, A. R., Greer, J. A., Pirl, W. F., Jackson, V. A., Park, E. R., Back, A. L., Muzikansky, A., Kamdar, M. M., Rinaldi, S. P., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.10003 · Cited by 12 · see citing works
Depression, survival, and epidermal growth factor receptor genotypes in patients with metastatic non-small cell lung cancer
Pirl, W., Traeger, L., Greer, J., Jackson, V., Lennes, I., Gallagher, E., Sequist, L., & Temel, J. (2013) · Palliative & Supportive Care · doi:10.1017/s1478951512001071 · Cited by 11 · see citing works
MASCC 2013 Abstracts
Fernandez-Ortega, P. M., Montserrat, M., Martinez, A. S., et al. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1798-3 · Cited by 11 · see citing works
Abstracts
Smith, A., Heiniger, L., Butow, P., Grimison, P., Klein, B., Wootten, A., Abbott, J., Price, M., McJannett, M., Tran, B., et al. (2015) · Psycho-Oncology · doi:10.1002/pon.3873 · Cited by 10 · see citing works
Practical tools for implementing early palliative care in advanced lung cancer
Janssens, A., Teugels, L., Kohl, S., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.00382-2015 · Cited by 8 · see citing works
Integrating early palliative care (EPC) in the management of lung cancer: The role of the thoracic oncologist
Janssens, A., Teugels, L., Kohl, S., et al. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.08.016 · Cited by 7 · see citing works
Early palliative care and integration of palliative care models in modern oncology practices.
Simone, C. B. (2015) · PubMed · doi:10.3978/j.issn.2224-5820.2015.07.07 · Cited by 6 · see citing works
Randomized trial of inpatient palliative care in patients hospitalized for hematopoietic stem cell transplantation (HCT).
El-Jawahri, A. R., LeBlanc, T. W., Vandusen, H. B., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.26_suppl.103 · Cited by 3 · see citing works
Randomized trial of an inpatient palliative care intervention in patients hospitalized for hematopoietic stem cell transplantation (HCT).
El-Jawahri, A. R., LeBlanc, T. W., Traeger, L. N., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.10004 · Cited by 3 · see citing works
Symposia
Gomes, B. I. 0.-0.-8.-1., Calanzani, N., Pinheiro, M. J., et al. (2014) · Psycho-Oncology · doi:10.1111/j.1099-1611.2014.3693 · Cited by 2 · see citing works
Randomized Trial of Inpatient Palliative Care Intervention for Patients Hospitalized for Hematopoietic Stem Cell Transplantation (HCT)
El-Jawahri, A. R., LeBlanc, T. W., Vandusen, H. B., et al. (2017) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2016.12.102 · Cited by 2 · see citing works
Characteristics and Outcomes of Persons with Advanced Cancer Associated with Having a Family Caregiver: A Classification Tree Analysis (S724)
Dionne-Odom, J. N., Raju, D. A., Hull, J. G., et al. (2015) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2014.11.205 · Cited by 1 · see citing works
185: The SPECIAL trial: exploring the place of early specialist palliative care in UK lung cancer management
Ahmedzai, S. H., Milroy, R., Billingham, L. J., et al. (2015) · Lung Cancer · doi:10.1016/s0169-5002(15)50179-7 · Cited by 1 · see citing works
A phase II randomized study to evaluate a new psychosocial intervention (PI) plus early palliative care (PC) in the reduction of depression of advanced cancer patients (ACP): The PREPArE trial.
Paiva, C. E., do Carmo, T. M., de Oliveira, C. Z., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.e21626 · Cited by 1 · see citing works
Early palliative care intervention for women with gynecologic malignancies.
Arsdale, A. R. V., Klobocista, M. M., Zanartu, C., et al. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2016.34.15_suppl.e21508 · Cited by 1 · see citing works
Untitled work
Morita (2000) · doi:10.1002/(sici)1099-1611(200003/04)9:2

Flagged first, then by citations

Research works printed but not linked: 6

Dowsett SM, Saul JL, Butow PN, Dunn SM, Boyer MJ, Findlow R, et al. Communication styles in the cancer consultation: preferences for a patient-centred approach. Psycho-Oncology 2000;9:147-56. [DOI: 10.1002/ (SICI)1099-1611(200003/04)9:2<147::AID-PON443>3.0.CO;2-X]
Higgins 2011a Higgins JPT, Green S. Chapter 4: Guide to the contents of a Cochrane protocol and review. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
Higgins 2011b Higgins JPT, Deeks JJ. Chapter 7: Selecting studies and collecting data. In: Higgins JPT, Green S editor(s). Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
McDonald J, Swami N, Hannon B, Lo C, Pope A, Oza A, et al. Impact of early palliative care on caregivers of patients with advanced cancer: cluster randomised trial. Annals of Oncology 2016;[Epub ahead of print]:Sep 29. [DOI: 10.1093/annonc/ mdw438] · DOI
placebo.ab. Early palliative care for adults with advanced cancer (Review) Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Appendix 3. Seach strategy for Embase (OvidSP) 1. exp Palliative Care/ 2. palliat*.tw.
hospice*.tw. Early palliative care for adults with advanced cancer (Review) Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Cochrane Library Trusted evidence. Informed decisions. Better health. Cochrane Database of Systematic Reviews 9. ("end-stage disease*" or "end stage disease* or end-stage illness" or "end stage").tw.

Sorted by citations

Advance Care Planning Improves Psychological Symptoms But Not Quality of Life and Preferred End-of-Life Care of Patients With Cancer
Tang, S. T., Chen, J.-S., Wen, F.-H., Chou, W.-C., Chang, J. W.-C., Hsieh, C.-H., & Chen, C. H. (2019) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.7106 · Cited by 58 · see citing works
Mindfulness-Based stress reduction in early palliative care for people with metastatic cancer: A mixed-method study
Poletti, S., Razzini, G., Ferrari, R., Ricchieri, M. P., Spedicato, G. A., Pasqualini, A., Buzzega, C., Artioli, F., Petropulacos, K., Luppi, M., et al. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102218 · Cited by 48 · see citing works
Using the ‘Social Marketing Mix Framework’ to explore recruitment barriers and facilitators in palliative care randomised controlled trials? A narrative synthesis review
Dunleavy, L., Walshe, C., Oriani, A., & Preston, N. (2018) · Palliative Medicine · doi:10.1177/0269216318757623 · Cited by 33 · see citing works
Applying the Multiphase Optimization Strategy for the Development of Optimized Interventions in Palliative Care
Wells, R. D., Guastaferro, K., Azuero, A., Rini, C., Hendricks, B. A., Dosse, C., Taylor, R., Williams, G. R., Engler, S., Smith, C., et al. (2021) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2020.11.017 · Cited by 28 · see citing works
Extent and determinants of terminally ill cancer patients’ concordance between preferred and received life-sustaining treatment states: an advance care planning randomized trial in Taiwan
Wen, F.-H., Chen, J.-S., Chou, W.-C., Chang, W.-C., Hsieh, C.-H., & Tang, S. T. (2019) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2019.04.010 · Cited by 17 · see citing works
AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso.
Placer García, L. D., Torrijos Zarcero, M., Rocamora González, C., Muñoz San José, A., & Palao Tarrero, Á. I. (2025) · Psicooncologia · doi:10.5209/psic.102233 · Cited by 1 · see citing works

Barriers to regular exercise among adults at high risk or diagnosed with type 2 diabetes: a systematic review
Korkiakangas, E. E., Alahuhta, M. A., & Laitinen, J. H. (2009) · Health Promotion International · doi:10.1093/heapro/dap031 · Cited by 276 · see citing works
Locating qualitative studies in dementia on MEDLINE, EMBASE, CINAHL, and PsycINFO: A comparison of search strategies
Rogers, M., Bethel, A. C., & Abbott, R. A. (2017) · Research Synthesis Methods · doi:10.1002/jrsm.1280 · Cited by 25 · see citing works
An integrative review of supportive relationships between child‐bearing women and midwives
Morbaty, H. Y. A., Ebert, L. M., Dowse, E., & Chan, S. W. (2022) · Nursing Open · doi:10.1002/nop2.1447 · Cited by 39 · see citing works
Age and quality of life of family caregivers of individuals with dementia living at home: Systematic literature review
Vass, D. C. D. O. C. D., & Aubeeluck, A. (2014) · Journal of Alzheimers Disease & Parkinsonism
Institutionally based health care workers' exposure to traumatogenic events: Systematic review of PTSD presentation
Robertson, N., & Perry, A. H. (2010) · Journal of Traumatic Stress · doi:10.1002/jts.20537 · Cited by 41 · see citing works

Authors: Haun, M. W., Estel, S., Rücker, G., Friederich, H.-C., Villalobos, M., Thomas, M., & Hartmann, M.
Affiliations: University Hospital Heidelberg (DE)
University of Freiburg (DE)
Düsseldorf University Hospital (DE)
ORCID: Haun, Markus W
Rücker, Gerta
Friederich, Hans-Christoph
Villalobos, Matthias
Thomas, Michael
Hartmann, Mechthild
Venue: Cochrane Database of Systematic Reviews
Publisher: Wiley
Published: 2017-06-12
Volume: 2017
Issue: 6
Pages: CD011129-CD011129
ISSN: 1361-6137 (ISSN-L)
1465-1858
DOI: 10.1002/14651858.cd011129.pub2
PMC: PMC6481832
OpenAlex: W2626539441
Cited by: 757
References: 166
Citations by year: 2026: 41 · 2025: 91 · 2024: 116 · 2023: 85 · 2022: 108 · 2021: 109 · 2020: 84 · 2019: 69 · 2018: 43 · 2017: 8 · 2015: 1 · 2014: 1
FWCI: 9.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cochrane Database of Systematic Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Society of Clinical Oncology
National Institute for Health and Care Research
Ministero della Salute
National Institutes of Health
Medical Research Council
National Health and Medical Research Council
National Cancer Institute
National Institute of Nursing Research
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Keywords: early palliative care, advanced cancer, health-related quality of life, depression, symptom intensity, survival, palliative care team, psychosocial well-being, symptom management, end-of-life care, risk of bias, quality of evidence, adverse events, family caregivers
MeSH terms: Communication, Humans, Neoplasms, Palliative Care, Physician-Patient Relations, Quality of Life

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Early palliative care for adults with advanced cancer

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks