Under-Representation of Older Adults in Cancer Registration Trials: Known Problem, Little Progress
Abstract
The oncology literature from the last decade is replete with articleslamentingthescarcityofdatatoguidetreatmentdecisionsforthe elderly population with cancer. With the aging of the United States and worldwide population and the known association between older ageandcancer, 1 cliniciansandresearchersunderstandtheimportance of studying the efficacy and toxicity of cancer therapies in this at-risk population. The importance of this knowledge is highlighted by the US Food and Drug Administration in its Guideline for the Study of Drugs Likely to Be Used in the Elderly, 2 which advocates enrollment of older adults in clinical trials as a means to understand treatment effects among differing populations. Almostadecadeago,JournalofClinicalOncologyhighlightedthe under-representation of older adults in registration trials for new cancertherapiesfrom1992to2002.Talaricoetal 3 showedtheproportions enrolled onto registration trials versus the proportions in the overall populations age 65, 70, and 75 years were 36%, 20%, and9%comparedwith60%,46%,and31%,respectively.Theauthors surmised that decline in functional reserve, increased comorbid con
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The inclusion of elderly patients in clinical cancer studies is usually insufficient.
“their inclusion in clinical studies is usually insufficient, as patients over 75 years of age represent less than 10% of patients with cancer [150, 151]”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [150]
Cites
Future of Cancer Incidence in the United States: Burdens Upon an Aging, Changing Nation
Smith, B. D., Smith, G. L., Hurria, A., Hortobágyi, G. N., & Buchholz, T. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.8983 · Cited by 1,723 · see citing works
Self-citationTalarico, L., Chen, G., & Pazdur, R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.175 · Cited by 727 · see citing works
Kornblith, A. B., Kemeny, M. M., Peterson, B. L., Wheeler, J., Crawford, J., Bartlett, N. L., Fleming, G. F., Graziano, S. L., Muss, H. B., Cohen, H. J., et al. (2002) · Cancer · doi:10.1002/cncr.10792 · Cited by 180 · see citing works
Geriatric oncology research in the cooperative groups: A report of a SIOG special meeting
Hurria, A., Cohen, H. J., & Extermann, M. (2010) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2010.03.005 · Cited by 69 · see citing works
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Immunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Battisti, N. M. L., Mislang, A. R., Cooper, L., O'Donovan, A., Audisio, R. A., Cheung, K.-L., Sarrió, R. G., Stauder, R., Soto-Perez-de-Celis, E., Jaklitsch, M., et al. (2020) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2020.07.008 · Cited by 79 · see citing works
How to Implement a Geriatric Assessment in Your Clinical Practice
Sattar, S., Alibhai, S. M. H., Wildiers, H., & Puts, M. T. E. (2014) · The Oncologist · doi:10.1634/theoncologist.2014-0180 · Cited by 75 · see citing works
Association of age with efficacy of immunotherapy in metastatic melanoma
Jain, V., Hwang, W.-T., Venigalla, S., Nead, K. T., Lukens, J. N., Mitchell, T. C., & Shabason, J. E. (2020) · The Oncologist · doi:10.1634/theoncologist.2019-0377 · Cited by 55 · see citing works
Experiences of healthcare providers of older adults with cancer during the COVID-19 pandemic
Krok-Schoen, J. L., Pisegna, J. L., BrintzenhofeSzoc, K., MacKenzie, A. R., Canin, B., Plotkin, E., Boehmer, L. M., & Shahrokni, A. (2021) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2020.09.021 · Cited by 27 · see citing works
- Authors
- Scher, K. S., & Hurria, A.
- Affiliations
- City Of Hope National Medical Center (US)
- Venue
- Journal of Clinical Oncology
- Published
- 2012-06-10
- Volume
- 30
- Issue
- 17
- Pages
- 2036-2038
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2045805729
- Cited by
- 432
- References
- 4
- Citations by year
- 2026: 13 · 2025: 28 · 2024: 25 · 2023: 29 · 2022: 41 · 2021: 39 · 2020: 53 · 2019: 30 · 2018: 41 · 2017: 31 · 2016: 25 · 2015: 24 · 2014: 25 · 2013: 15 · 2012: 13
- FWCI
- 12.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- older adults, underrepresentation in clinical trials, clinical trial recruitment, geriatric oncology, comorbidities, functional reserve
- MeSH terms
- Aged, Antineoplastic Agents, Clinical Trials as Topic, Geriatrics, Humans, Medical Oncology, Neoplasms, Patient Participation, United States, Drug Approval, SEER Program, Patient Selection
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