The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Long-Term and Late Effects of Germ Cell Testicular Cancer Treatment and Implications for Follow-Up
Abstract
Germ cell testicular cancer (TC) represents a malignancy with high cure rates. Since the introduction of cisplatin-based chemotherapy in the late 1970s, the 5-year survival rate has increased considerably, and it is currently above 95%. Because TC is usually diagnosed before the age of 40 years, these men can expect to live for another 40 to 50 years after being successfully treated. This success, however, is hampered by an increased risk of long-term and late effects of treatment. Secondary malignant neoplasms and cardiovascular disease represent the most common potentially life-threatening late effects, typically occurring more than 10 years after treatment. Other long-term effects include pulmonary toxicity, nephrotoxicity, neurotoxicity, decreased fertility, hypogonadism, and psychosocial problems. The incidence and time to onset of these various adverse effects vary according to treatment type and intensity. There is still little knowledge about underlying mechanisms and genetic susceptibility of the various adverse effects. Apart from treatment burden, it is not yet possible to identify patients who are at high risk for certain late effects after TC treatment. In this clinical review, we present the current status regarding different somatic and psychosocial long-term late effects after treatment for TC, based on Medline searches and our own research. Moreover, we postulate recommendations for general medical evaluations that should begin after treatment is completed and continue during follow-up.
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Ormel, H. L., van der Schoot, G. G. F., Sluiter, W. J., Jalving, M., Gietema, J. A., & Walenkamp, A. M. E. (2018) · Psycho-Oncology · doi:10.1002/pon.4612 · Cited by 261
Self-citationSmith, A. “., Butow, P., Olver, I., Luckett, T., Grimison, P., Toner, G. C., Stockler, M. R., Hovey, E., Stubbs, J., Turner, S., et al. (2016) · Journal of Cancer Survivorship · doi:10.1007/s11764-015-0468-5 · Cited by 72
Raphael, M. J., Gupta, S., Wei, X., Peng, Y., Soares, C. N., Bedard, P. L., Siemens, D. R., Robinson, A. G., & Booth, C. M. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02298 · Cited by 34
Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act
Lubberts, S., Meijer, C., Demaria, M., & Gietema, J. A. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102963 · Cited by 19
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Metadata
- Authors
- Haugnes, H. S., Bosl, G. J., Boer, H., Gietema, J. A., Brydøy, M., Oldenburg, J., Dahl, A. A., Bremnes, R. M., & Fosså, S. D.
- Venue
- Journal of Clinical Oncology
- Published
- 2012-10-20
- Volume
- 30
- Issue
- 30
- Pages
- 3752-3763
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2098064059
- Cited by
- 294
- References
- 113
- FWCI
- 17.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haugnes, H. S., Bosl, G. J., Boer, H., Gietema, J. A., Brydøy, M., Oldenburg, J., Dahl, A. A., Bremnes, R. M., & Fosså, S. D. (2012). Long-Term and Late Effects of Germ Cell Testicular Cancer Treatment and Implications for Follow-Up. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2012.43.4431
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