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Cited by 798Hormonal and reproductive studiesNutrition and Health in AgingMenopause: Health Impacts and Treatments

Low Serum Testosterone and Mortality in Older Men

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Laughlin, Gail A., Barrett-Connor, Elizabeth, Bergstrom, Jaclyn·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-1792PMC PMC2190742
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Abstract

CONTEXT: Declining testosterone levels in elderly men are thought to underlie many of the symptoms and diseases of aging; however, studies demonstrating associations of low testosterone with clinical outcomes are few. OBJECTIVE: The objective of the study was to examine the association of endogenous testosterone levels with mortality in older community-dwelling men. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, population-based study of 794 men, aged 50-91 (median 73.6) yr who had serum testosterone measurements at baseline (1984-1987) and were followed for mortality through July 2004. MAIN OUTCOME MEASURE: All-cause mortality by serum testosterone level was measured. RESULTS: During an average 11.8-yr follow-up, 538 deaths occurred. Men whose total testosterone levels were in the lowest quartile (<241 ng/dl) were 40% [hazards ratio (HR) 1.40; 95% confidence interval (CI) 1.14-1.71] more likely to die than those with higher levels, independent of age, adiposity, and lifestyle. Additional adjustment for health status markers, lipids, lipoproteins, blood pressure, glycemia, adipocytokines, and estradiol levels had minimal effect on results. The low testosterone-mortality association was also independent of the metabolic syndrome, diabetes, and prevalent cardiovascular disease but was attenuated by adjustment for IL-6 and C-reactive protein. In cause-specific analyses, low testosterone predicted increased risk of cardiovascular (HR 1.38; 95% CI 1.02-1.85) and respiratory disease (HR 2.29; 95% CI 1.25-4.20) mortality but was not significantly related to cancer death (HR 1.34; 95% CI 0.89-2.00). Results were similar for bioavailable testosterone. CONCLUSIONS: Testosterone insufficiency in older men is associated with increased risk of death over the following 20 yr, independent of multiple risk factors and several preexisting health conditions.

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Authors
Laughlin, G. A., Barrett-Connor, E., & Bergstrom, J.
Affiliations
University of California San Diego (US)
Corresponding author
Bergstrom, Jaclyn
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-01-01
Volume
93
Issue
1
Pages
68-75
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-1792
PMC
PMC2190742
OpenAlex
W2143959240
Cited by
798
References
2
Citations by year
2026: 11 · 2025: 21 · 2024: 18 · 2023: 26 · 2022: 22 · 2021: 30 · 2020: 31 · 2019: 31 · 2018: 38 · 2017: 39 · 2016: 24 · 2015: 53 · 2014: 62 · 2013: 61 · 2012: 70
FWCI
45.79
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Aging (R37AG007181, AG07181, R01AG007181)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031801)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
androgen deficiency, hypogonadism, all-cause mortality, older men, endogenous testosterone, cardiovascular mortality, respiratory mortality, cancer mortality, bioavailable testosterone, aging, community-dwelling men
MeSH terms
Aged, Aged, 80 and over, Blood Glucose, C-Reactive Protein, California, Cardiovascular Diseases, Humans, Cholesterol, HDL, Male, Middle Aged, Neoplasms, Prospective Studies, Respiratory Tract Diseases, Testosterone, Triglycerides, Cohort Studies, Interleukin-6, Body Mass Index, Statistics, Nonparametric

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