The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies
Open accessAbstract
The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation and turnover, of many proteins vital to cellular regulation and function. The UPS comprises a sequential series of enzymatic processes using four key enzyme families: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-carrier proteins), E3 (ubiquitin-protein ligases), and E4 (ubiquitin chain assembly factors). Because the UPS is a crucial regulator of the cell cycle, and abnormal cell-cycle control can lead to oncogenesis, aberrancies within the UPS pathway can result in a malignant cellular phenotype and thus has become an attractive target for novel anticancer agents. This article will provide an overall review of the mechanics of the UPS, describe aberrancies leading to cancer, and give an overview of current drug therapies selectively targeting the UPS.
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Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy
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Metadata
- Authors
- Micel, L. N., Tentler, J. J., Smith, P. G., & Eckhardt, G. S.
- Venue
- Journal of Clinical Oncology
- Published
- 2013-03-20
- Volume
- 31
- Issue
- 9
- Pages
- 1231-1238
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2151224270
- Cited by
- 176
- References
- 22
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Micel, L. N., Tentler, J. J., Smith, P. G., & Eckhardt, G. S. (2013). Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2012.44.0958
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