The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Intense Androgen-Deprivation Therapy With Abiraterone Acetate Plus Leuprolide Acetate in Patients With Localized High-Risk Prostate Cancer: Results of a Randomized Phase II Neoadjuvant Study
Open accessAbstract
Purpose: Cure rates for localized high-risk prostate cancers (PCa) and some intermediate-risk PCa are frequently suboptimal with local therapy. Outcomes are improved by concomitant androgen-deprivation therapy (ADT) with radiation therapy, but not by concomitant ADT with surgery. Luteinizing hormone–releasing hormone agonist (LHRHa; leuprolide acetate) does not reduce serum androgens as effectively as abiraterone acetate (AA), a prodrug of abiraterone, a CYP17 inhibitor that lowers serum testosterone (< 1 ng/dL) and improves survival in metastatic PCa. The possibility that greater androgen suppression in patients with localized high-risk PCa will result in improved clinical outcomes makes paramount the reassessment of neoadjuvant ADT with more robust androgen suppression. Patients and Methods: A neoadjuvant randomized phase II trial of LHRHa with AA was conducted in patients with localized high-risk PCa (N = 58). For the first 12 weeks, patients were randomly assigned to LHRHa versus LHRHa plus AA. After a research prostate biopsy, all patients received 12 additional weeks of LHRHa plus AA followed by prostatectomy. Results: The levels of intraprostatic androgens from 12-week prostate biopsies, including the primary end point (dihydrotestosterone/testosterone), were significantly lower (dehydroepiandrosterone, Δ 4-androstene-3,17-dione, dihydrotestosterone, all P < .001; testosterone, P < .05) with LHRHa plus AA compared with LHRHa alone. Prostatectomy pathologic staging demonstrated a low incidence of complete responses and minimal residual disease, with residual T3- or lymph node–positive disease in the majority. Conclusion: LHRHa plus AA treatment suppresses tissue androgens more effectively than LHRHa alone. Intensive intratumoral androgen suppression with LHRHa plus AA before prostatectomy for localized high-risk PCa may reduce tumor burden.
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Cites
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Abiraterone and Increased Survival in Metastatic Prostate Cancer
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“Our data demonstrate that clinical manifestations of mineralocorticoid excess were not different than those reported in phase III AA trials.(19-21) More complete suppression of ACTH with alternative steroid dosing or inhibition of upstream steroid precursors with more intensive CYP17 inhibition may further lower tissu…”
MethodResultSelf-citationAbiraterone in Metastatic Prostate Cancer without Previous Chemotherapy
Ryan, C. J., Smith, M. R., de Bono, J. S., Molina, A., Logothetis, C. J., de Souza, P., Fizazi, K., Mainwaring, P., Piulats, J. M., Ng, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209096 · Cited by 2,796
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Self-citation20-Year Outcomes Following Conservative Management of Clinically Localized Prostate Cancer
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Cited by
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
Zhang, Z., Karthaus, W. R., Lee, Y. S., Gao, V. R., Wu, C., Russo, J. W., Liu, M., Mota, J. M., Abida, W., Linton, E., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.005 · Cited by 259
Self-citationZang, T., Tamae, D., Mesaros, C., Wang, Q., Huang, M., Blair, I. A., & Penning, T. M. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.08.001 · Cited by 29
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Metadata
- Authors
- Taplin, M.-E., Montgomery, B., Logothetis, C. J., Bubley, G. J., Richie, J. P., Dalkin, B. L., Sanda, M. G., Davis, J. W., Loda, M., True, L. D., Troncoso, P., Ye, H., Lis, R. T., Marck, B. T., Matsumoto, A. M., Balk, S. P., Mostaghel, E. A., Penning, T. M., Nelson, P. S., Xie, W., Jiang, Z., Haqq, C. M., Tamae, D., Tran, N., Peng, W., Kheoh, T., Molina, A., & Kantoff, P. W.
- Venue
- Journal of Clinical Oncology
- Published
- 2014-11-20
- Volume
- 32
- Issue
- 33
- Pages
- 3705-3715
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W2148143162
- Cited by
- 284
- References
- 25
- FWCI
- 19.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Intense Androgen-Deprivation Therapy With Abiraterone Acetate Plus Leuprolide Acetate in Patients With Localized High-Risk Prostate Cancer: Results of a Randomized Phase II Neoadjuvant Study. https://app.cochat.ai/papers/10.1200/jco.2013.53.4578
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- Taplin, M.-E., Montgomery, B., Logothetis, C. J., Bubley, G. J., Richie, J. P., Dalkin, B. L., Sanda, M. G., Davis, J. W., Loda, M., True, L. D., Troncoso, P., Ye, H., Lis, R. T., Marck, B. T., Matsumoto, A. M., Balk, S. P., Mostaghel, E. A., Penning, T. M., Nelson, P. S., . . . Kantoff, P. W. (2014). Intense Androgen-Deprivation Therapy With Abiraterone Acetate Plus Leuprolide Acetate in Patients With Localized High-Risk Prostate Cancer: Results of a Randomized Phase II Neoadjuvant Study. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2013.53.4578
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
