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Basic Clinical Radiobiology
Abstract
1.Introduction: the significance of radiobiology and radiotherapy for cancer treatment 2. Irradiation-induced damage and the DNA damage response 3. Cell death after irradiation: how, when and why cells die 4. Quantitating cell kill and cell survival 5. Models of radiation response 5. Dose-response relationships in radiotherapy 6. LET and RBE 7. Tumour growth and response to radiation 8. Fractionation: the L-Q approach 9. The L-Q approach in clinical practice 10. Modified fractionation 11. Time factors in normal-tissue response to radiation 12. The dose-rate effect 13. Pathogenesis of normal-tissue side-effects 14. The volume effect in radiotherapy 15. The oxygen effect and fractionated radiotherapy 16. The tumour microenvironment and cellular hypoxia responses 17. Therapeutic approaches to tumor hypoxia 18. Combined radiotherapy and chemotherapy 19. Retreatment tolerance of normal tissues 20.Molecular image-guided radiotherapy with positron emission tomography 21. Molecular-targeted agents for enhancing tumour response 22. Biological response modifiers in the clinic: tumor 22. Biological response modifiers: normal tissue 23. Molecular targeting and patient individualization 24.Protons and other ions in radiotherapy 25. Second cancers after radiotherapy
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Cited by
Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604
Bentzen, S. M., Constine, L. S., Deasy, J. O., Eisbruch, A., Jackson, A., Marks, L. B., Ten Haken, R. K., & Yorke, E. D. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.09.040 · Cited by 1,257
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements
Her, S., Jaffray, D. A., & Allen, C. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.12.012 · Cited by 865
Imaging hypoxia to improve radiotherapy outcome
Horsman, M. R., Mortensen, L. S., Petersen, J. B., Busk, M., & Overgaard, J. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.171 · Cited by 614
Gold nanoparticles for cancer radiotherapy: a review
Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., Solov’yov, A. V., Prise, K. M., Golding, J., & Mason, N. J. (2016) · Cancer Nanotechnology · doi:10.1186/s12645-016-0021-x · Cited by 445
Metadata
- Authors
- Joiner, M. C., & van der Kogel, A.
- Venue
- CRC Press eBooks
- Publisher
- CRC Press
- Published
- 2009-03-27
- OpenAlex
- W1529490909
- Cited by
- 1,068
- References
- 0
- FWCI
- 83.99
- Type
- book
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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