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Cited by 57Gestational Diabetes Research and ManagementBirth, Development, and HealthPancreatic function and diabetes

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Regulation of Placental Glucose Transfer and Consumption by Fetal Glucose Production

Digiacomo, Jane E, Hay, William W·1989·Pediatric Research
DOI 10.1203/00006450-198905000-00001
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Abstract

We studied ten normoglycemic [maternal glucose (GA) = 70 mg/dL] and six insulin-induced hypoglycemic (GA = 22 mg/dL) pregnant sheep to test the hypothesis that development of fetal glucose production (GPR) could help maintain fetal glucose concentration, limit uteroplacental-fetal glucose transfer (UPGT), and sustain uteroplacental glucose consumption (UPGC). Compared with the normoglycemic group, the hypoglycemic group demonstrated the following values: fetal glucose concentration (Ga) was 9.8 +/- 0.8 mg/dL (51% lower, p less than 0.01), uterine glucose uptake (UtGU) was 16.7 +/- 1.4 mg/min (54% lower, p less than 0.01), UPGT was 3.1 +/- 0.6 mg/min (81% lower, p less than 0.001), and UPGC was 13.6 +/- 1.4 mg/min (30% lower, p less than 0.05). The reduction in UPGC was significantly less (p less than 0.05) than the reductions in UPGT and UtGU. Fetal glucose utilization rate (GUR) was decreased 20% (p less than 0.05) to 3.99 +/- 0.35 mg/min/kg. A further decrease in GUR was prevented by the appearance of fetal GPR of 2.82 +/- 0.32 mg/min/kg (p less than 0.05) compared with negligible GPR in the normoglycemic group. UPGT and UPGC in both groups were not influenced by maternal or fetal insulin infusions as long as Ga did not change; however, fetal glucose infusion that increased Ga increased UPGC in both groups. We conclude that, during chronic maternal hypoglycemia, increased fetal GPR limits the simultaneous decrease in fetal GUR and glucose concentration. By sustaining Ga fetal GPR limits UPGT to a significantly greater extent than UtGU, diverting UtGU to UPGC. Thus, fetal GPR promotes placental as well as fetal metabolic autonomy when the maternal supply of glucose is reduced.

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Crossref · 10.1203/00006450-198905000-00001

Cites

14 of 14 references verified0 citation errors · 0 not checkable

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  • Variations in maternal nutritional state have little effect on oxygen consumption by the ovine utero-placental tissues.

    “Variations in maternal nutritional state have little effect on oxygen consumption by the ovine utero-placental tissues (99,148,190,554).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [148]

  • This may reflect the ability of the sheep fetus to supplement its own glucose supply by activating gluconeogenesis, thereby reducing its demand for maternal glucose and sparing glucose for placental functions essential to maintaining pregnancy.

    “This too, may reflect the ability of the sheep fetus to supplement its own glucose supply by activating gluconeogenesis, thereby reducing its demand for maternal glucose and sparing glucose for placental functions essential to maintaining pregnancy (148,194).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [148]

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Metadata

Authors
Digiacomo, J. E., & Hay, W. W.
Affiliations
University of Colorado Anschutz (US)
ORCID
Hay, William W
Venue
Pediatric Research
Publisher
Springer Science and Business Media LLC
Published
1989-05
Volume
25
Issue
5
Pages
429-434
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
DOI
10.1203/00006450-198905000-00001
OpenAlex
W1979417846
Cited by
57
References
14
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 3
FWCI
6.12
Type
journal article
Language
en
Open access
closed
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (HD-00781)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK35836)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD20761, HD-00781)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
placental glucose transfer, maternal hypoglycemia, sheep pregnancy, insulin
MeSH terms
Animals, Blood Glucose, Female, Fetus, Hypoglycemia, Maternal-Fetal Exchange, Oxygen, Placenta, Pregnancy, Sheep, Uterus

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