Escherichia coli in Infants' Intestinal Microflora: Colonization Rate, Strain Turnover, and Virulence Gene Carriage
Abstract
Colonization by Escherichia. coli in infants might have decreased in the last decades, owing to changes in hospital routines and family lifestyle. In this study, the E. coli flora was characterized in 70 healthy Swedish infants followed for the first year of life. E. coli was isolated from rectal swabs obtained at 3 d of age and quantified in fecal samples collected at 1, 2, 4, and 8 wk of age and at 6 and 12 mo of age. Strains were typed using random amplified polymorphic DNA, and their virulence factor genes were identified by multiplex PCR. Colonization by E. coli occurred late; only 61% of the infants were positive by 2 mo of age. The turnover of individual strains in the microflora was slow (1.5 strains per infant during 6 mo, 2.1 during 1 y). Environmental factors, such as siblings, pets, or feeding mode, did not influence colonization kinetics or strain turnover rate. Genes encoding type 1 fimbriae, P fimbriae, and hemolysin were significantly more common in E. coli strains persisting for at least 3 wk in the microflora than in transient strains. The P-fimbrial class III adhesin gene was more common in E. coli from children who had a cat in their homes than in E. coli from children without pets (p = 0.01); this adhesin type is common in E. coli from cats. The late colonization and low E. coli strain turnover rate suggest limited exposure of Swedish infants to E. coli. Our results confirm that P fimbriae and other virulence factors facilitate persistence of E. coli in the human colonic microflora.
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Between 27 and 33% of E. coli detectable in the feces of European newborns are pks-positive.
“Scientific literature has shown that between 27 and 33% of E. coli detectable in the feces of European newborns are pks-positive [136–138].”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [136]
Cites
Virulence factors in Escherichia coli urinary tract infection
Johnson, J. R. (1991) · Clinical Microbiology Reviews · doi:10.1128/cmr.4.1.80 · Cited by 1,274 · see citing works
Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution
Hacker, J. H., Blum–Oehler, G., Mühldorfer, I., & Tschäpe, H. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.3101672.x · Cited by 1,130 · see citing works
The Link between Phylogeny and Virulence in <i>Escherichia coli</i> Extraintestinal Infection
Picard, B., Garcia, J. S., Gouriou, S., Duriez, P., Brahimi, N., Bingen, E., Elion, J., & Denamur, E. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.546-553.1999 · Cited by 794 · see citing works
Stark, P. L., & Lee, A. (1982) · Journal of Medical Microbiology · doi:10.1099/00222615-15-2-189 · Cited by 616 · see citing works
Does early exposure to cat or dog protect against later allergy development?
HESSELMAR, Åberg, Åberg, Eriksson, �., & Björkstén (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00534.x · Cited by 540 · see citing works
Smith, H. W., & Linggood, M. A. (1971) · Journal of Medical Microbiology · doi:10.1099/00222615-4-4-467 · Cited by 495 · see citing works
Shroff, K. E., Meslin, K., & Cebra, J. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.3904-3913.1995 · Cited by 397 · see citing works
Detection of urovirulence factors in Escherichia coli by multiplex polymerase chain reaction
Yamamoto, S., Terai, A., Yuri, K., Kurazono, H., Takeda, Y., & Yoshida, O. (1995) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1995.tb00179.x · Cited by 353 · see citing works
Bouguénec, C. L., Archambaud, M., & Labigne-Roussel, A. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.5.1189-1193.1992 · Cited by 339 · see citing works
Duriez, P., Clermont, O., Bonacorsi, S., Bingen, É., Chaventré, A., Élion, J., Picard, B., & Denamur, É. (2001) · Microbiology · doi:10.1099/00221287-147-6-1671 · Cited by 326 · see citing works
Strömberg, N., Marklund, B. ‐., Lund, B., Ilver, D., Hamers, A. M., Gaastra, W., Karlsson, K.-A., & Normark, S. J. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08328.x · Cited by 286 · see citing works
Wold, A. E., Mestecky, J. F., Tomana, M., Kobata, A., Ohbayashi, H., Endo, T., & Edén, C. S. (1990) · Infection and Immunity · doi:10.1128/iai.58.9.3073-3077.1990 · Cited by 282 · see citing works
Self-citationSome current concepts in intestinal bacteriology
Moore, W., Cato, E., & Holdeman, L. V. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.10.s33 · Cited by 256 · see citing works
INTESTINAL COLONIZATION OF BREAST‐FED CHILDREN IN A RURAL AREA OF LOW SOCIOECONOMIC LEVEL*
Mata, L. J., & Urrutia, J. J. (1971) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1971.tb34996.x · Cited by 251 · see citing works
Intestinal Colonization with Enterobacteriaceae in Pakistani and Swedish Hospital‐Delivered Infants
Adlerberth, I., Carlsson, B., de Man, P., Jalil, F., Khan, S. R., Larsson, P., Mellander, L., Svanborg, C., Wold, A. E., & Hanson, L. Å. (1991) · Acta Paediatrica · doi:10.1111/j.1651-2227.1991.tb11917.x · Cited by 209 · see citing works
Self-citationLUNDEQUIST, B., Nord, C. E., & Winberg, J. (1985) · Acta Paediatrica · doi:10.1111/j.1651-2227.1985.tb10919.x · Cited by 187 · see citing works
Bingen, M., Clermont, O., Bonacorsi, S., Terki, M., Brahimi, N., Loukil, C., Barraud, D., & Bingen, É. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.3216-3226.2002 · Cited by 173 · see citing works
Karch, H., Schubert, S., Zhang, D., Zhang, W., Schmidt, H., Ölschläger, T., & Hacker, J. H. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.5994-6001.1999 · Cited by 173 · see citing works
Lauffer, R. B. (2018) · CRC Press eBooks · doi:10.1201/9781351073899 · Cited by 152 · see citing works
Resident Colonic Escherichia coli Strains Frequently Display Uropathogenic Characteristics
Wold, A. E., Caugant, D. A., Lidin-Janson, G., de Man, P., & Svanborg, C. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/165.1.46 · Cited by 143 · see citing works
Self-citationTHE SURVIVAL TIME FOR DIFFERENT BACTERIA IN VARIOUS TRANSPORT MEDIA
Gästrin, B., Kallings, L. O., & MARCETIC, A. (1968) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1968.tb03490.x · Cited by 122 · see citing works
Wold, A. E., Thorssén, M., Hull, S., & Edén, C. S. (1988) · Infection and Immunity · doi:10.1128/iai.56.10.2531-2537.1988 · Cited by 119 · see citing works
Self-citationFactors affecting the microecology of the gut
Freter, R. (1992) · Springer eBooks · doi:10.1007/978-94-011-2364-8_6 · Cited by 119 · see citing works
Sears, H. J., & Brownlee, I. (1952) · Journal of Bacteriology · doi:10.1128/jb.63.1.47-57.1952 · Cited by 115 · see citing works
Johnson, J. R., O’Bryan, T. T., Low, D. A., Ling, G. V., Delavari, P., Fasching, C. E., Russo, T. A., Carlino, U. B., & Stell, A. L. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3327-3336.2000 · Cited by 113 · see citing works
Dobrindt, U., Blum–Oehler, G., Hartsch, T., Gottschalk, G., Ron, E. Z., Fünfstück, R., & Hacker, J. H. (2001) · Infection and Immunity · doi:10.1128/iai.69.7.4248-4256.2001 · Cited by 113 · see citing works
The origin of O serotypes of Escherichia coli in babies after normal delivery
Bettelheim, K. A., Breadon, A., Faiers, M. C., O'Farrell, S. M., & Shooter, R. A. (1974) · Journal of Hygiene · doi:10.1017/s0022172400023226 · Cited by 110 · see citing works
Pap, papG and prsG DNA sequences in Escherichia coli from the fecal flora and the urinary tract
Johanson, I., Plos, K., Marklund, B. ‐., & Svanborg, C. (1993) · Microbial Pathogenesis · doi:10.1006/mpat.1993.1062 · Cited by 110 · see citing works
Johnson, J. R., & Brown, J. J. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/173.4.920 · Cited by 106 · see citing works
Bacterial Flora Associated With the Human Gastrointestinal Mucosa
Nelson, D. P., & Mata, L. J. (1970) · Gastroenterology · doi:10.1016/s0016-5085(70)80093-2 · Cited by 104 · see citing works
High turnover rate of Escherichia coli strains in the intestinal flora of infants in Pakistan
Adlerberth, I., Jalil, F., Carlsson, B., Mellander, L., Hanson, L. Å., Larsson, P., Khalil, K., & Wold, A. E. (1998) · Epidemiology and Infection · doi:10.1017/s0950268898001484 · Cited by 96 · see citing works
Self-citationLindberg, E., Nowrouzian, F. L., Adlerberth, I., & Wold, A. E. (2000) · Pediatric Research · doi:10.1203/00006450-200012000-00007 · Cited by 94 · see citing works
Self-citationSecretory IgA antibody response against Escherichia coli antigens in infants in relation to exposure
Mellander, L., Carlsson, B., Jalil, F., Söderström, T., & Hanson, L. Å. (1985) · The Journal of Pediatrics · doi:10.1016/s0022-3476(85)80528-x · Cited by 93 · see citing works
Johnson, J. R., Stapleton, A. E., Russo, T. A., Scheutz, F., Brown, J. J., & Maslow, J. N. (1997) · Infection and Immunity · doi:10.1128/iai.65.6.2153-2159.1997 · Cited by 81 · see citing works
P fimbriae, capsule and aerobactin characterize colonic resident Escherichia coli
Nowrouzian, F. L., Adlerberth, I., & Wold, A. E. (2001) · Epidemiology and Infection · doi:10.1017/s0950268801005118 · Cited by 80 · see citing works
Self-citationBråbäck, L., Kjellman, N. ‐. M., Sandin, A., & Björkstén, B. (2001) · Pediatric Allergy and Immunology · doi:10.1034/j.1399-3038.2001.012001004.x · Cited by 71 · see citing works
The development of bacterial flora of premature neonates
Rotimi, V. O., Olowe, S. A., & Ahmed, I. K. (1985) · Journal of Hygiene · doi:10.1017/s0022172400061532 · Cited by 68 · see citing works
Gothefors, L., Carlsson, B., Ahlstedt, S., Hanson, L. Å., & Winberg, J. (1976) · Acta Paediatrica · doi:10.1111/j.1651-2227.1976.tb16542.x · Cited by 66 · see citing works
Friman, V., Adlerberth, I., Connell, H., Svanborg, C., Hanson, L. Å., & Wold, A. E. (1996) · Infection and Immunity · doi:10.1128/iai.64.7.2794-2798.1996 · Cited by 64 · see citing works
Self-citationAdhesins ofassociated with extra–intestinal pathogenicity confer binding to colonic epithelial cells
Adlerberth, I., Hanson, Å. L., Svanborg, C., Svennerholm, A., Nordgren, S., & Wold, A. E. (1995) · Microbial Pathogenesis · doi:10.1006/mpat.1995.0034 · Cited by 60 · see citing works
Self-citationJohnson, J. R. (1998) · Infection and Immunity · doi:10.1128/iai.66.9.4568-4571.1998 · Cited by 59 · see citing works
Plasmids in Lactobacillus Strains Isolated from Meat and Meat Products
Ahrné, S., Molin, G., & Ståhl, S. R. (1989) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(89)80031-1 · Cited by 58 · see citing works
Kühn, I., Möllby, R., & Tullus, K. (1986) · Infection · doi:10.1007/bf01644802 · Cited by 56 · see citing works
Fryklund, B. A., Berglund, B., BURMAN, L. G., & Tullus, K. (1992) · Infection · doi:10.1007/bf01710789 · Cited by 55 · see citing works
van Delden, C. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9084-6_1 · Cited by 54 · see citing works
Escherichia coli serotype distribution in man and animals.
Bettelheim, K. A., Teoh-Chan, C. H., Chandler, M. E., O'Farrell, S. M., Rahamim, L., Shaw, E. J., & Shooter, R. A. (1974) · PubMed Central · Cited by 49 · see citing works
Nowrouzian, F. L., Wold, A. E., & Adlerberth, I. (2001) · Epidemiology and Infection · doi:10.1017/s095026880100512x · Cited by 40 · see citing works
Self-citationKrivan, H. C., Franklin, D. P., Wang, W., Laux, D. C., & Cohen, P. S. (1992) · Infection and Immunity · doi:10.1128/iai.60.9.3943-3946.1992 · Cited by 40 · see citing works
Hewitt, J. H., & Rigby, J. (1976) · Journal of Hygiene · doi:10.1017/s0022172400055601 · Cited by 36 · see citing works
The acquisition of fecal flora by infants from their mothers during birth
Gareau, F. E., Mackel, D. C., Boring, J. R., Payne, F. J., & Hammett, F. L. (1959) · The Journal of Pediatrics · doi:10.1016/s0022-3476(59)80005-6 · Cited by 33 · see citing works
Spread of Escherichia coli colonizing newborn babies and their mothers
Bettelheim, K. A., Teoh-Chan, C. H., Chandler, M. E., O'Farrell, S. M., Rahamim, L., Shaw, E. J., & Shooter, R. A. (1974) · Journal of Hygiene · doi:10.1017/s002217240004273x · Cited by 29 · see citing works
ESCHERICHIA COLI SEROGROUPS IN BREAST‐FED AND BOTTLE‐FED INFANTS
Ørskov, F., & SøRENSEN, K. B. (1975) · Acta Pathologica Microbiologica Scandinavica Section B Microbiology · doi:10.1111/j.1699-0463.1975.tb00065.x · Cited by 26 · see citing works
Distribution ofpapGalleles among uropathogenicEscherichia coliisolated from different species
Féria, C., Machado, J., Correia, J. D., Gonçalves, J., & Gaastra, W. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10804.x · Cited by 20 · see citing works
Distribution of papG alleles among uropathogenic Escherichia coli isolated from different species
Feria, C. P. (2001) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(01)00310-x · Cited by 20 · see citing works
Douglas, C. W. (1904) · PubMed Central · Cited by 17 · see citing works
Feeney, A. R., Cooke, E. M., & Shinebaum, R. (1980) · Journal of Hygiene · doi:10.1017/s0022172400026565 · Cited by 16 · see citing works
Faecal colonization with P-fimbriated Escherichia coli between 0 and 18 months of age
Tullus, K., Källenius, G., & Möllby, R. (1988) · Epidemiology and Infection · doi:10.1017/s0950268800067315 · Cited by 16 · see citing works
The ecology of Escherichia coli in a maternity ward in Christchurch, New Zealand.
Bettelheim, K. A., Peddie, B. A., & Chereshsky, A. (1983) · PubMed · Cited by 14 · see citing works
Effect of iron on serotypes and haemagglutination patterns ofEscherichia coli in bottle-fed infants
Mevissen-Verhage, E. A. E., Marcelis, J. H., Guinée, P. A. M., & Verhoef, J. (1985) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02013397 · Cited by 4 · see citing works
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The population genetics of commensal Escherichia coli
Tenaillon, O., Skurnik, D., Picard, B., & Denamur, É. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2298 · Cited by 1,536 · see citing works
The unexhausted potential of E. coli
Blount, Z. D. (2015) · eLife · doi:10.7554/elife.05826 · Cited by 420 · see citing works
E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity
Leimbach, A., Hacker, J. H., & Dobrindt, U. (2013) · Current topics in microbiology and immunology · doi:10.1007/82_2012_303 · Cited by 366 · see citing works
Savino, F., Cordisco, L., Tarasco, V., Palumeri, E., Calabrese, R., Oggero, R., Roos, S., & Matteuzzi, D. (2010) · PEDIATRICS · doi:10.1542/peds.2010-0433 · Cited by 342 · see citing works
Adlerberth, I., Lindberg, E., Åberg, N., Hesselmar, B., Saalman, R., Strannegård, I., & Wold, A. E. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000191137.12774.b2 · Cited by 317 · see citing works
Self-citationClinical use of E. coli Nissle 1917 in inflammatory bowel disease
Schultz, M. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20377 · Cited by 310 · see citing works
Azad, M. B., Konya, T., Maughan, H., Guttman, D. S., Field, C. J., Sears, M. R., Becker, A. B., Scott, J. A., Kozyrskyj, A. L., & CHILD Study Investigators (2013) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-9-15 · Cited by 305 · see citing works
Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli
Johnson, J. R., & Russo, T. A. (2005) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2005.07.005 · Cited by 286 · see citing works
Large-Scale Population Structure of Human Commensal Escherichia coli Isolates
Escobar‐Páramo, P., Grenet, K., Menach, A. L., Rode, L., Salgado, E., Amorin, C., Gouriou, S., Picard, B., Rahimy, M. C., Andremont, A., et al. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.9.5698-5700.2004 · Cited by 243 · see citing works
Extra-intestinal pathogenic Escherichia coli (ExPEC): Disease, carriage and clones
Dale, A. P., & Woodford, N. (2015) · Journal of Infection · doi:10.1016/j.jinf.2015.09.009 · Cited by 236 · see citing works
Genetic diversity and population structure of Escherichia coli isolated from freshwater beaches
Walk, S. T., Alm, E. W., Calhoun, L. M., Mladonicky, J. M., & Whittam, T. S. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01341.x · Cited by 235 · see citing works
The Early Settlers: Intestinal Microbiology in Early Life
Scholtens, P. A. M. J., Oozeer, R., Martı́n, R., Amor, K. B., & Knol, J. (2012) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022811-101120 · Cited by 220 · see citing works
<i>Escherichia coli</i> Residency in the Gut of Healthy Human Adults
Martinson, J. N. V., & Walk, S. T. (2020) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0003-2020 · Cited by 197 · see citing works
Nowrouzian, F. L., Wold, A. E., & Adlerberth, I. (2005) · The Journal of Infectious Diseases · doi:10.1086/427996 · Cited by 189 · see citing works
Self-citationNowrouzian, F. L., Adlerberth, I., & Wold, A. E. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.10.011 · Cited by 164 · see citing works
Self-citationDevelopment of gut microbiota in infants not exposed to medical interventions
Eggesbø, M. Å., Moen, B., Peddada, S. D., Baird, D. D., Rugtveit, J., Midtvedt, T., Bushel, P. R., Sekelja, M., & Rudi, K. (2010) · Apmis · doi:10.1111/j.1600-0463.2010.02688.x · Cited by 159 · see citing works
Molecular identification of coliform bacteria from colicky breastfed infants
Savino, F., Cordisco, L., Tarasco, V, Calabrese, R., Palumeri, E., & Matteuzzi, D. (2009) · Acta Paediatrica · doi:10.1111/j.1651-2227.2009.01419.x · Cited by 153 · see citing works
Clarke, E., & Desselberger, U. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.114 · Cited by 148 · see citing works
Reisner, A., Hoeller, B., Molin, S., & Zechner, E. L. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.10.3582-3588.2006 · Cited by 135 · see citing works
Karami, N., Martner, A., Enne, V. I., Swerkersson, S., Adlerberth, I., & Wold, A. E. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm327 · Cited by 129 · see citing works
Self-citationTetracycline Resistance in Escherichia coli and Persistence in the Infantile Colonic Microbiota
Karami, N., Nowrouzian, F. L., Adlerberth, I., & Wold, A. E. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.1.156-161.2006 · Cited by 125 · see citing works
Self-citationInfant B Cell Memory Differentiation and Early Gut Bacterial Colonization
Lundell, A., Björnsson, V., Ljung, A., Ceder, M., Johansen, S., Lindhagen, G., Törnhage, C., Adlerberth, I., Wold, A. E., & Rudin, A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103223 · Cited by 116 · see citing works
Self-citationKandasamy, S., Vlasova, A. N., Fischer, D. D., Kumar, A., Chattha, K. S., Rauf, A., Shao, L., Langel, S. N., Rajashekara, G., & Saif, L. J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501705 · Cited by 113 · see citing works
Nowrouzian, F. L., & Oswald, É. (2012) · Microbial Pathogenesis · doi:10.1016/j.micpath.2012.05.011 · Cited by 107 · see citing works
Self-citationFitness of Escherichia coli strains carrying expressed and partially silent IncN and IncP1 plasmids
Humphrey, B., Thomson, N. R., Thomas, C. M., Brooks, K. L., Sanders, M. J., Delsol, A. A., Roe, J. M., Bennett, P. M., & Enne, V. I. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-53 · Cited by 98 · see citing works
Velásquez, D. E., Parashar, U. D., & Jiang, B. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2018.1418665 · Cited by 93 · see citing works
Silverman, J. A., Schreiber, H. L., Hooton, T. M., & Hultgren, S. J. (2013) · Current Urology Reports · doi:10.1007/s11934-013-0354-5 · Cited by 91 · see citing works
Maternally acquired genotoxicEscherichia colialters offspring’s intestinal homeostasis
Payros, D., Sécher, T., Boury, M., Bréhin, C., Ménard, S., Salvador–Cartier, C., Ramos, G. C., Watrin, C., Marcq, I., Nougayrède, J., et al. (2014) · Gut Microbes · doi:10.4161/gmic.28932 · Cited by 89 · see citing works
Factors Influencing the Establishment of the Intestinal Microbiota in Infancy
Adlerberth, I. (2008) · Nestlé Nutrition Workshop series. Pediatric program/Nestlé Nutrition Workshop series. Paediatric program · doi:10.1159/000146245 · Cited by 88 · see citing works
Self-citationÖstblom, A., Adlerberth, I., Wold, A. E., & Nowrouzian, F. L. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.02405-10 · Cited by 84 · see citing works
Self-citationSánchez, E., Nadal, I., Donat, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-50 · Cited by 83 · see citing works
Molecular Epidemiology of Extraintestinal PathogenicEscherichia coli
Johnson, J. R., & Russo, T. A. (2018) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0004-2017 · Cited by 81 · see citing works
Gumpert, H., Kubicek-Sutherland, J. Z., Porse, A., Karami, N., Munck, C., Linkevičius, M., Adlerberth, I., Wold, A. E., Andersson, D. I., & Sommer, M. O. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01852 · Cited by 80 · see citing works
Self-citationSearle, L. J., Méric, G., Porcelli, I., Sheppard, S. K., & Lucchini, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117906 · Cited by 80 · see citing works
Petersen, A. M., Nielsen, E. M., Litrup, E., Brynskov, J., Mirsepasi‐Lauridsen, H. C., & Krogfelt, K. A. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-171 · Cited by 78 · see citing works
The Escherichia coli Acid Stress Response and Its Significance for Pathogenesis
Biase, D. D., & Lund, P. A. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.03.002 · Cited by 71 · see citing works
Effects of Intrapartum Penicillin Prophylaxis on Intestinal Bacterial Colonization in Infants
Jauréguy, F., Carton, M., Panel, P., Foucaud, P., Butel, M., & Doucet‐Populaire, F. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.11.5184-5188.2004 · Cited by 72 · see citing works
Interrelation of Diet, Gut Microbiome, and Autoantibody Production
Πέττα, Ι., Fraussen, J., Somers, V. A., & Kleinewietfeld, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00439 · Cited by 72 · see citing works
Bilirubin Induces Apoptosis and Necrosis in Human NT2-N Neurons
Hankø, E., Hansen, T. W. R., Almaas, R., Lindstad, J. K., & Rootwelt, T. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000148711.11519.a5 · Cited by 71 · see citing works
Porse, A., Gumpert, H., Kubicek-Sutherland, J. Z., Karami, N., Adlerberth, I., Wold, A. E., Andersson, D. I., & Sommer, M. O. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00126 · Cited by 69 · see citing works
Self-citationGio-Batta, M., Sjöberg, F., Jonsson, K., Barman, M., Lundell, A., Adlerberth, I., Hesselmar, B., Sandberg, A., & Wold, A. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-79737-6 · Cited by 63 · see citing works
Self-citationD(—)–Lactic Acid Producing Probiotics, D(—)–Lactic Acidosis and Infants
Mack, D. R. (2004) · Canadian Journal of Gastroenterology · doi:10.1155/2004/342583 · Cited by 63 · see citing works
Toxin-Producing Clostridium difficile Strains as Long-Term Gut Colonizers in Healthy Infants
Adlerberth, I., Huang, H., Lindberg, E., Åberg, N., Hesselmar, B., Saalman, R., Nord, C. E., Wold, A. E., & Weintraub, A. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.01701-13 · Cited by 62 · see citing works
Self-citationSchultz, M., Watzl, S., Oelschlaeger, T. A., Rath, H. C., Göttl, C., Lehn, N., Schölmerich, J., & Linde, H. (2005) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2005.01.007 · Cited by 60 · see citing works
Development of intestinal bifidobacteria and lactobacilli in breast-fed neonates
Chen, J., Cai, W., & Feng, Y. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.03.003 · Cited by 59 · see citing works
Espinar, M. J., Miranda, I. M., Costa‐de‐Oliveira, S., Rocha, R., Rodrigues, A. G., & Pina‐Vaz, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134737 · Cited by 59 · see citing works
Early settlers: which<i>E. coli</i>strains do you not want at birth?
Secher, T., Brehin, C., & Oswald, E. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00091.2016 · Cited by 58 · see citing works
Micenková, L., Štaudová, B., Bosák, J., Mikalová, L., Littnerová, S., Vrba, M., Ševčíková, A., Woznicová, V., & Šmajs, D. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-109 · Cited by 58 · see citing works
The human intestinal microbiota
Dore, J. M., & Corthier, G. (2010) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(10)70015-4 · Cited by 57 · see citing works
Damborg, P., Nielsen, S. S., & Guardabassi, L. (2009) · Epidemiology and Infection · doi:10.1017/s095026880900226x · Cited by 54 · see citing works
Wohlgemuth, S., Haller, D., Blaut, M., & Loh, G. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01883.x · Cited by 54 · see citing works
Community acquisition of β-lactamase producing Enterobacteriaceae in neonatal gut
Kothari, C., Gaind, R., Singh, L. C., Sinha, A., Kumari, V., Arya, S., Chellani, H. K., Saxena, S., & Deb, M. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-136 · Cited by 53 · see citing works
Tomas, J., Reygner, J., Mayeur, C., Ducroc, R. A., Bouet, S., Bridonneau, C., Cavin, J., Thomas, M., Langella, P., & Cherbuy, C. (2014) · The ISME Journal · doi:10.1038/ismej.2014.111 · Cited by 51 · see citing works
Molecular Epidemiology of Extraintestinal PathogenicEscherichia coli
Johnson, J. R., & Russo, T. A. (2004) · EcoSal Plus · doi:10.1128/ecosalplus.8.6.1.4 · Cited by 49 · see citing works
Fabich, A. J., Leatham, M. P., Grissom, J. E., Wiley, G. B., Lai, H., Najar, F. Z., Roe, B. A., Cohen, P. S., & Conway, T. (2011) · Infection and Immunity · doi:10.1128/iai.01199-10 · Cited by 48 · see citing works
Maternal-to-Infant Transmission of Probiotics: Concept Validation in Mice, Rats, and Pigs
Buddington, R. K., Williams, C. H., Kostek, B. M., Buddington, K. K., & Kullen, M. J. (2009) · Neonatology · doi:10.1159/000253756 · Cited by 46 · see citing works
Diarrheagenic Escherichia coli in acute gastroenteritis in infants in North-West Italy.
Amisano, G., Fornasero, S., Migliaretti, G., Caramello, S., Tarasco, V., & Savino, F. (2011) · PubMed · Cited by 46 · see citing works
Mise en place de la flore intestinale du nouveau-né
Campeotto, F., Waligora‐Dupriet, A., Doucet‐Populaire, F., Kalach, N., Dupont, C. M., & Butel, M. (2007) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(07)89424-3 · Cited by 45 · see citing works
Factors favouring the evolution of multidrug resistance in bacteria
Jacopin, E., Lehtinen, S., Débarre, F., & Blanquart, F. (2020) · Journal of The Royal Society Interface · doi:10.1098/rsif.2020.0105 · Cited by 50 · see citing works
Liu, J., Keelan, P., Bennett, P., & Enne, V. I. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn523 · Cited by 44 · see citing works
Erjavec, M. S., & Žgur‐Bertok, D. (2015) · FEMS Microbiology Letters · doi:10.1093/femsle/fnu061 · Cited by 43 · see citing works
Kõljalg, S., Truusalu, K., Vainumäe, I., Štšepetova, J., Sepp, E., & Mikelsaar, M. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.01419-08 · Cited by 43 · see citing works
Colonization dynamics of ampicillin-resistant Escherichia coli in the infantile colonic microbiota
Karami, N., Hannoun, C., Adlerberth, I., & Wold, A. E. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn263 · Cited by 43 · see citing works
Self-citationNowrouzian, F. L., Dauwalder, O., Meugnier, H., Bes, M., Étienne, J., Vandenesch, F., Lindberg, E., Hesselmar, B., Saalman, R., Strannegård, I., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir388 · Cited by 42 · see citing works
Self-citationNeonatal gut colonization by Bifidobacterium is associated with higher childhood cytokine responses
Rabe, H., Lundell, A., Sjöberg, F., Ljung, A., Strömbeck, A., Gio-Batta, M., Maglio, C., Nordström, I., Andersson, K. M., Nookaew, I., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1847628 · Cited by 42 · see citing works
Self-citationSécher, T., Payros, D., Bréhin, C., Boury, M., Watrin, C., Gillet, M., Bernard, I., Ménard, S., Théodorou, V., Saoudi, A., et al. (2015) · Infection and Immunity · doi:10.1128/iai.00064-15 · Cited by 41 · see citing works
Princisval, L., Rebelo, F. M., Williams, B. L., Coimbra, A. C., Crovesy, L., Ferreira, A. L. L., & Kac, G. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab008 · Cited by 44 · see citing works
The Effects of Maturation on the Colonic Microflora in Infancy and Childhood
Enck, P., Zimmermann, K., Rusch, K., Schwiertz, A., Klosterhalfen, S., & Frick, J.-S. (2009) · Gastroenterology Research and Practice · doi:10.1155/2009/752401 · Cited by 41 · see citing works
Millar, M. R., Philpott, A., Wilks, M., Whiley, A., Warwick, S., Hennessy, E., Coen, P. G., Kempley, S. T., Stacey, F., & Costeloe, K. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00832-07 · Cited by 40 · see citing works
Nowrouzian, F. L., Lina, G., Hodille, E., Lindberg, E., Hesselmar, B., Saalman, R., Adlerberth, I., & Wold, A. E. (2016) · British Journal of Dermatology · doi:10.1111/bjd.15138 · Cited by 36 · see citing works
Self-citationKarami, N., Wold, A. E., & Adlerberth, I. (2016) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2854-y · Cited by 35 · see citing works
Self-citationQuin, C., & Gibson, D. L. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1736973 · Cited by 35 · see citing works
Mills, M. C., Lee, S., Piperata, B. A., Garabed, R. B., Choi, B., & Lee, J. (2023) · Microbiome · doi:10.1186/s40168-023-01636-5 · Cited by 34 · see citing works
Kumagai, H., Maisawa, S., Tanaka, M., Takahashi, M., Takasago, Y., Nishijima, A., & Watanabe, S. (2012) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2012.00487.x · Cited by 34 · see citing works
LASTOURS, V. D., Cambau, E., Guillard, T., Marcadé, G., Chau, F., & Fantin, B. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis511 · Cited by 33 · see citing works
Kleter, G. A., Peijnenburg, A., & Aarts, H. J. M. (2005) · BioMed Research International · doi:10.1155/jbb.2005.326 · Cited by 33 · see citing works
High Abundance of Escherichia During the Establishment of Fecal Microbiota in Brazilian Children
Taddei, C. R., de Oliveira, F. F., Duarte, R. T. D., Talarico, S. T., Takagi, E. H., Carvalho, I. I. R., Gomes, F. M. D. S., Brandt, K. G., & Martinez, M. B. (2014) · Microbial Ecology · doi:10.1007/s00248-014-0381-x · Cited by 31 · see citing works
Establishment of the bacterial fecal community during the first month of life in Brazilian newborns
Brandt, K. G., Taddei, C. R., Takagi, E. H., de Oliveira, F. F., Duarte, R. T. D., Irino, I., Martinez, M. B., & Carneiro-Sampaio, M. M. S. (2012) · Clinics · doi:10.6061/clinics/2012(02)05 · Cited by 30 · see citing works
Burgaya, J., Marin, J., Royer, G., Condamine, B., Gachet, B., Clermont, O., Jauréguy, F., Burdet, C., Lefort, A., LASTOURS, V. D., et al. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010842 · Cited by 29 · see citing works
Diversity, transmission and persistence of Escherichia coli in a cohort of mothers and their infants
de Muinck, E. J., Øien, T., Storrø, O., Johnsen, R., Stenseth, N. C., Rønningen, K. S., & Rudi, K. (2011) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2010.00231.x · Cited by 28 · see citing works
Candida species as commensal gut colonizers: A study of 133 longitudinally followed Swedish infants
Kondori, N., Nowrouzian, F. L., Ajdari, M., Hesselmar, B., Saalman, R., Wold, A. E., & Adlerberth, I. (2019) · Medical Mycology · doi:10.1093/mmy/myz091 · Cited by 28 · see citing works
Self-citationHashemizadeh, Z., Kalantar-Neyestanaki, D., & Mansouri, S. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.07.046 · Cited by 27 · see citing works
Nowrouzian, F. L., Clermont, O., Edin, M., Östblom, A., Denamur, É., Wold, A. E., & Adlerberth, I. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.01681-19 · Cited by 27 · see citing works
Self-citationChanges in Intestinal Flora and Metabolites in Neonates With Breast Milk Jaundice
Li, Y., Shen, N., Li, J., Hu, R., Mo, X., & Xu, L. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00177 · Cited by 25 · see citing works
Le microbiote intestinal humain
Dore, J. M., & Corthier, G. (2010) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(10)70002-6 · Cited by 25 · see citing works
Bok, E., Mazurek, J., Myc, A., Stosik, M., Wojciech, M., & Baldy-Chudzik, K. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15040617 · Cited by 21 · see citing works
Walk, S. T., & Young, V. B. (2008) · Interdisciplinary Perspectives on Infectious Diseases · doi:10.1155/2008/125081 · Cited by 23 · see citing works
Nowrouzian, F. L., Östblom, A., Wold, A. E., & Adlerberth, I. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.02706.x · Cited by 23 · see citing works
Self-citationLASTOURS, V. D., Bleibtreu, A., Chau, F., Burdet, C., Duval, X., Denamur, É., & Fantin, B. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt422 · Cited by 21 · see citing works
Escherichia coli: An arduous voyage from commensal to Antibiotic-resistance
Chetri, S. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.107173 · Cited by 21 · see citing works
Armand-Lefèvre, L., Rondinaud, E., Desvillechabrol, D., Mullaert, J., Clermont, O., Petitjean, M., Ruppé, É., Cokelaer, T., Bouchier, C., Tenaillon, O., et al. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000576 · Cited by 20 · see citing works
Lim, J., Cha, J., Jung, S. A., Kim, N., Song, M., Lim, Y., & Kim, D. (2023) · Animals · doi:10.3390/ani13213378 · Cited by 20 · see citing works
Communication between B-Cells and Microbiota for the Maintenance of Intestinal Homeostasis
Liu, Y., & Rhoads, J. M. (2013) · Antibodies · doi:10.3390/antib2040535 · Cited by 20 · see citing works
Hetzer, B., Orth‐Höller, D., Würzner, R., Kreidl, P., Lackner, M., Müller, T., Knabl, L., Geisler-Moroder, D. R., Mellmann, A., Sesli, Ö., et al. (2019) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-019-0522-6 · Cited by 20 · see citing works
Host Species Adaptation of Obligate Gut Anaerobes Is Dependent on Their Environmental Survival
Karasová, D., Faldynová, M., Matiasovicova, J., Šebková, A., Crhánová, M., Kubasová, T., Seidlerová, Z., Prikrylova, H., Volf, J., Zeman, M., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10061085 · Cited by 20 · see citing works
Rotavirus Infections: Pathophysiology, Symptoms, and Vaccination
Pawłuszkiewicz, K., Ryglowski, P. J., Idzik, N., Błaszczyszyn, K., Kucharczyk, E., Gaweł-Dąbrowska, D., Siczek, M., Widelski, J., & Paluch, E. (2025) · Pathogens · doi:10.3390/pathogens14050480 · Cited by 21 · see citing works
Kurakawa, T., Kubota, H., Tsuji, H., Matsuda, K., Takahashi, T., Ramamurthy, T., Nair, G. B., Takeda, Y., & Nomoto, K. (2012) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2012.12.008 · Cited by 18 · see citing works
Jang, J., Di, D. Y. W., Lee, A., Unno, T., Sadowsky, M. J., & Hur, H.-G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100585 · Cited by 18 · see citing works
Salah, M. A. A., Badran, E., & Shehabi, A. A. (2014) · The International Arabic Journal of Antimicrobial Agents · Cited by 17 · see citing works
Fecal carriage and phylo-diversity of community-acquired blaTEM Enteric bacilli in Southwest Nigeria
Akinduti, P. A., Olasehinde, G. I., Ejilude, O., Olugbenga, T. S., & Obafemi, Y. D. (2018) · Infection and Drug Resistance · doi:10.2147/idr.s178243 · Cited by 17 · see citing works
- Authors
- Nowrouzian, F., Hesselmar, B., Saalman, R., Strannegård, I.-L., Åberg, N., Wold, A. E., & Adlerberth, I.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Nowrouzian, Forough
- Venue
- Pediatric Research
- Published
- 2003-07
- Volume
- 54
- Issue
- 1
- Pages
- 8-14
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W1977963936
- Cited by
- 176
- References
- 59
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 12 · 2013: 10 · 2012: 11
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vårdalstiftelsen
- European Commission
- Ellen, Walter and Lennart Hesselman Foundation for Scientific Research
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Enterobacteriaceae and Cronobacter Research
- Keywords
- Escherichia coli, colonization rates, virulence genes, P fimbriae, type 1 fimbriae, hemolysin, fimbrial adhesins, cat exposure, feeding mode, fecal microbiota
- MeSH terms
- Animals, Animals, Domestic, Colon, DNA, Bacterial, Escherichia coli, Escherichia coli Infections, Family Characteristics, Female, Humans, Infant, Infant Food, Life Style, Male, Sweden, Virulence, Random Amplified Polymorphic DNA Technique
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