Cited by 176Escherichia coli research studiesGut microbiota and healthEnterobacteriaceae and Cronobacter Research

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Escherichia coli in Infants' Intestinal Microflora: Colonization Rate, Strain Turnover, and Virulence Gene Carriage

Nowrouzian, Forough, Hesselmar, Bill, Saalman, Robert, Strannegård, Inga-Lisa, Åberg, Nils, Wold, Agnes E, Adlerberth, Ingegerd·2003·Pediatric Research

DOI 10.1203/01.pdr.0000069843.20655.ee

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Abstract

Colonization by Escherichia. coli in infants might have decreased in the last decades, owing to changes in hospital routines and family lifestyle. In this study, the E. coli flora was characterized in 70 healthy Swedish infants followed for the first year of life. E. coli was isolated from rectal swabs obtained at 3 d of age and quantified in fecal samples collected at 1, 2, 4, and 8 wk of age and at 6 and 12 mo of age. Strains were typed using random amplified polymorphic DNA, and their virulence factor genes were identified by multiplex PCR. Colonization by E. coli occurred late; only 61% of the infants were positive by 2 mo of age. The turnover of individual strains in the microflora was slow (1.5 strains per infant during 6 mo, 2.1 during 1 y). Environmental factors, such as siblings, pets, or feeding mode, did not influence colonization kinetics or strain turnover rate. Genes encoding type 1 fimbriae, P fimbriae, and hemolysin were significantly more common in E. coli strains persisting for at least 3 wk in the microflora than in transient strains. The P-fimbrial class III adhesin gene was more common in E. coli from children who had a cat in their homes than in E. coli from children without pets (p = 0.01); this adhesin type is common in E. coli from cats. The late colonization and low E. coli strain turnover rate suggest limited exposure of Swedish infants to E. coli. Our results confirm that P fimbriae and other virulence factors facilitate persistence of E. coli in the human colonic microflora.

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Authors: Nowrouzian, F., Hesselmar, B., Saalman, R., Strannegård, I.-L., Åberg, N., Wold, A. E., & Adlerberth, I.
Affiliations: Sahlgrenska University Hospital (SE)
Corresponding author: Nowrouzian, Forough
ORCID: Nowrouzian, Forough
Hesselmar, Bill
Wold, Agnes E
Adlerberth, Ingegerd
Venue: Pediatric Research
Publisher: Springer Science and Business Media LLC
Published: 2003-07
Volume: 54
Issue: 1
Pages: 8-14
ISSN: 0031-3998 (ISSN-L)
1530-0447
DOI: 10.1203/01.pdr.0000069843.20655.ee
OpenAlex: W1977963936
Cited by: 176
References: 59
Citations by year: 2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 12 · 2013: 10 · 2012: 11
FWCI: 2.88
Type: journal article
Language: en
Open access: closed
Locations: Pediatric Research (publishedVersion)
PubMed (publishedVersion)
Funders: Vårdalstiftelsen
European Commission
Ellen, Walter and Lennart Hesselman Foundation for Scientific Research
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
Keywords: Escherichia coli, colonization rates, virulence genes, P fimbriae, type 1 fimbriae, hemolysin, fimbrial adhesins, cat exposure, feeding mode, fecal microbiota
MeSH terms: Animals, Animals, Domestic, Colon, DNA, Bacterial, Escherichia coli, Escherichia coli Infections, Family Characteristics, Female, Humans, Infant, Infant Food, Life Style, Male, Sweden, Virulence, Random Amplified Polymorphic DNA Technique

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Escherichia coli in Infants' Intestinal Microflora: Colonization Rate, Strain Turnover, and Virulence Gene Carriage

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