The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Escherichia coli in Infants' Intestinal Microflora: Colonization Rate, Strain Turnover, and Virulence Gene Carriage
Abstract
Colonization by Escherichia. coli in infants might have decreased in the last decades, owing to changes in hospital routines and family lifestyle. In this study, the E. coli flora was characterized in 70 healthy Swedish infants followed for the first year of life. E. coli was isolated from rectal swabs obtained at 3 d of age and quantified in fecal samples collected at 1, 2, 4, and 8 wk of age and at 6 and 12 mo of age. Strains were typed using random amplified polymorphic DNA, and their virulence factor genes were identified by multiplex PCR. Colonization by E. coli occurred late; only 61% of the infants were positive by 2 mo of age. The turnover of individual strains in the microflora was slow (1.5 strains per infant during 6 mo, 2.1 during 1 y). Environmental factors, such as siblings, pets, or feeding mode, did not influence colonization kinetics or strain turnover rate. Genes encoding type 1 fimbriae, P fimbriae, and hemolysin were significantly more common in E. coli strains persisting for at least 3 wk in the microflora than in transient strains. The P-fimbrial class III adhesin gene was more common in E. coli from children who had a cat in their homes than in E. coli from children without pets (p = 0.01); this adhesin type is common in E. coli from cats. The late colonization and low E. coli strain turnover rate suggest limited exposure of Swedish infants to E. coli. Our results confirm that P fimbriae and other virulence factors facilitate persistence of E. coli in the human colonic microflora.
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“Scientific literature has shown that between 27 and 33% of E. coli detectable in the feces of European newborns are pks-positive [136–138].”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [136]
Citations
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The population genetics of commensal Escherichia coli
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The unexhausted potential of E. coli
Blount, Z. D. (2015) · eLife · doi:10.7554/elife.05826 · Cited by 476
E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity
Leimbach, A., Hacker, J. H., & Dobrindt, U. (2013) · Current topics in microbiology and immunology · doi:10.1007/82_2012_303 · Cited by 386
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Adlerberth, I., Lindberg, E., Åberg, N., Hesselmar, B., Saalman, R., Strannegård, I., & Wold, A. E. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000191137.12774.b2 · Cited by 317
Self-citation
Metadata
- Authors
- Nowrouzian, F., Hesselmar, B., Saalman, R., Strannegård, I.-L., Åberg, N., Wold, A. E., & Adlerberth, I.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Corresponding author
- Nowrouzian, Forough
- Venue
- Pediatric Research
- Published
- 2003-07
- Volume
- 54
- Issue
- 1
- Pages
- 8-14
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- OpenAlex
- W1977963936
- Cited by
- 176
- References
- 59
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 12 · 2013: 10 · 2012: 11
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vårdalstiftelsen
- European Commission
- Ellen, Walter and Lennart Hesselman Foundation for Scientific Research
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
- Keywords
- Escherichia coli, colonization rates, virulence genes, P fimbriae, type 1 fimbriae, hemolysin, fimbrial adhesins, cat exposure, feeding mode, fecal microbiota
- MeSH terms
- Animals, Animals, Domestic, Colon, DNA, Bacterial, Escherichia coli, Escherichia coli Infections, Family Characteristics, Female, Humans, Infant, Infant Food, Life Style, Male, Sweden, Virulence, Random Amplified Polymorphic DNA Technique
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