Cited by 357Tryptophan and brain disordersAutism Spectrum Disorder ResearchSchizophrenia research and treatment

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Schizophrenia and Autism: Both Shared and Disorder-Specific Pathogenesis Via Perinatal Inflammation?

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MEYER, URS, FELDON, JORAM, DAMMANN, OLAF·2011·Pediatric Research

DOI 10.1203/pdr.0b013e318212c196PMC PMC3086802

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Abstract

Prenatal exposure to infection and subsequent inflammatory responses have been implicated in the etiology of schizophrenia and autism. In this review, we summarize current evidence from human and animal studies supporting the hypothesis that the pathogenesis of these two disorders is linked via exposure to inflammation at early stages of development. Moreover, we propose a hypothetical model in which inflammatory mechanisms may account for multiple shared and disorder-specific pathological characteristics of both entities. In essence, our model suggests that acute neuroinflammation during early fetal development may be relevant for the induction of psychopathological and neuropathological features shared by schizophrenia and autism, whereas postacute latent and persistent inflammation may contribute to schizophrenia- and autism-specific phenotypes, respectively.

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“There is now clear evidence that environmental insults that alter the immune response can affect brain development as well as behavior (Patterson, 2009; Meyer et al., 2011).”
Background
Role of short-chain fatty acids in the gut-brain axis in schizophrenia: contribution to immune activation and pathophysiology in humans and micePreprint
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Exploratory Analysis of MicroRNA Alterations in a Neurodevelopmental Mouse Model for Autism Spectrum Disorder and Schizophrenia
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Background
The Role of Infections and Autoimmune Diseases for Schizophrenia and Depression: Findings from Large-Scale Epidemiological Studies
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Correlation of reduced social communicational and interactional skills with regional grey matter volumes in schizophrenia patients
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Galectins - Important players of the immune response to CNS parasitic infection
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“In any case, it is worth noting that a neuroimmune-based developmental hypothesis has been proposed for several psychiatric diseases in humans that are associated with deficiencies in the primary visual cortex (Meyer et al., 2011).”
BackgroundInfluential
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Group I mGluRs positive allosteric modulators improved schizophrenia-related behavioral and molecular deficits in the Poly I:C rat model
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Prenatal risk factors and postnatal cannabis exposure: Assessing dual models of schizophrenia-like rodents
Martín-Cuevas, C., Ramos‐Herrero, V. D., Crespo‐Facorro, B., & Sánchez-Hidalgo, A. C. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105409 · Cited by 6
Advanced Biomarkers of Hepatotoxicity in Psychiatry: A Narrative Review and Recommendations for New Psychoactive Substances
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Background
Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder
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Self-citation
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Authors: MEYER, U., FELDON, J., & DAMMANN, O.
Affiliations: ETH Zurich (CH)
Tufts Medical Center (US)
Corresponding author: MEYER, URS
ORCID: MEYER, URS
DAMMANN, OLAF
Venue: Pediatric Research
Publisher: Springer Science and Business Media LLC
Published: 2011-05
Volume: 69
Issue: 5 Part 2
Pages: 26R-33R
ISSN: 0031-3998 (ISSN-L)
DOI: 10.1203/pdr.0b013e318212c196
PMC: PMC3086802
OpenAlex: W2011183628
Cited by: 357
References: 86
Citations by year: 2026: 7 · 2025: 7 · 2024: 14 · 2023: 20 · 2022: 13 · 2021: 18 · 2020: 19 · 2019: 22 · 2018: 30 · 2017: 31 · 2016: 30 · 2015: 36 · 2014: 32 · 2013: 32 · 2012: 30
FWCI: 1.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Pediatric Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation
National Alliance for Research on Schizophrenia and Depression
European Commission (LSHM‐CT‐2006‐036534, 241778)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (116719, 100309)
Eidgenössische Technische Hochschule Zürich (11 07/03)
National Institutes of Health
National Eye Institute (R21EY019253)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: schizophrenia, autism spectrum disorder, perinatal inflammation, prenatal infection, neuroinflammation, fetal development, shared pathogenesis, chronic inflammation, psychopathology, neuropathology
MeSH terms: Autistic Disorder, Female, Humans, Inflammation, Models, Theoretical, Pregnancy, Pregnancy Complications, Schizophrenia

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Schizophrenia and Autism: Both Shared and Disorder-Specific Pathogenesis Via Perinatal Inflammation?

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