The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Schizophrenia and Autism: Both Shared and Disorder-Specific Pathogenesis Via Perinatal Inflammation?
Open accessAbstract
Prenatal exposure to infection and subsequent inflammatory responses have been implicated in the etiology of schizophrenia and autism. In this review, we summarize current evidence from human and animal studies supporting the hypothesis that the pathogenesis of these two disorders is linked via exposure to inflammation at early stages of development. Moreover, we propose a hypothetical model in which inflammatory mechanisms may account for multiple shared and disorder-specific pathological characteristics of both entities. In essence, our model suggests that acute neuroinflammation during early fetal development may be relevant for the induction of psychopathological and neuropathological features shared by schizophrenia and autism, whereas postacute latent and persistent inflammation may contribute to schizophrenia- and autism-specific phenotypes, respectively.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Multiple animal models of prenatal infection have found evidence of diverse neurobehavioral abnormalities, whether through direct exposure of pregnant mice or rodents to influenza virus, or through non-infectious activation of the maternal immune system (e.g., using RNA poly(I:C) to stimulate an antiviral inflammatory response or lipopolysaccharide to stimulate a bacterial inflammatory response) (”
From Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders (2015) · cites this paper as Meyer et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · cited 1×
“In support of this, several cytokines seem to modulate processes of learning and memory, anxiety-related behaviors, and social interaction (3,78,79).”
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · cited 7×
“This idea of multiple hits with either sensitizing or preconditioning effects is also central to several theories of prenatal immune priming, which have been put forward by others in the context of peripheral immunity, CNS inflammation, perinatal brain damage, retinopathy, and various forms of learning and memory (68–…”
InfluentialA review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346 · cited 1×
“One example is that autism has generally been associated with excessive brain growth (macrocephaly) involving thickening of cortex, increased gray and white matter, and lack of gray matter loss (41), whereas schizophrenia seems to be associated with microcephaly involving thinner cortical areas, reduced gray and white…”
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 1×
“For example, a nearly 50-fold increase in TNF- level was found in the cerebrospinal fluid (CSF) of autistic children (47), and severe inflammation is present in the brains of autistic patients from a broad range of ages (48), characterized by prominent activation of microglia and astroglia cells and enhanced proinflam…”
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · cited 1×
“Such genetic components seem highly essential because both autism and schizophrenia exhibit strong patterns of heritability (83,84).”
Epidemiology of Pervasive Developmental Disorders
Fombonne, E. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819e7203 · Cited by 1,971 · cited 1×
“In contrast to the delayed onset of schizophrenia, overt symptoms of autism often begin as early as by the age of 6 mo and become established by age 2 or 3 y (11,12).”
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · cited 3×
“In the CNS, microglia and astrocytes are the major immunocompetent cells, which regulate both the induction and limitation of inflammatory processes (45).”
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · cited 1×
“The concept is further supported by the findings that blocking the actions of the proinflammatory cytokine IL-6 in the pregnant maternal host by genetic or pharmacological interventions prevents the long-term brain and behavioral consequences of prenatal PolyI:C treatment (39) and that over-expression of the antiinfla…”
Microglia in neurodegenerative disease
Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543 · cited 2×
“On the other hand, chronic or exaggerated microglial activation has been linked to multiple neuroinflammatory and neurodegenerative diseases, including Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, and Huntington’s disease (46).”
Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies
Brown, A. S., & Derkits, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09030361 · Cited by 1,269 · cited 1×
“Epidemiologic studies suggest that the risk of schizophrenia is increased after prenatal maternal viral infections such as influenza, rubella, measles, and polio, as well as infections with bacterial pathogens and genital and/or reproductive infections (4).”
Cited by
Sorted by citations
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
Gandal, M. J., Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., et al. (2018) · Science · doi:10.1126/science.aat8127 · Cited by 1,247
Maternal immune activation: Implications for neuropsychiatric disorders
Estes, M. L., & McAllister, A. K. (2016) · Science · doi:10.1126/science.aag3194 · Cited by 1,206
The role of inflammation in perinatal brain injury
Hagberg, H., Mallard, C. E., Ferriero, D. M., Vannucci, S. J., Levison, S. W., Vexler, Z. S., & Gressèns, P. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.13 · Cited by 852
Rook, G. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313731110 · Cited by 760
Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems
Meyer, U. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.011 · Cited by 626
Self-citationEmerging Roles for the Gut Microbiome in Autism Spectrum Disorder
Vuong, H. E., & Hsiao, E. Y. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.024 · Cited by 595
Maternal infection and immune involvement in autism
Patterson, P. H. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.03.001 · Cited by 520
“These include some shared behavioral abnormalities as well as neuropathological features (29).”
BackgroundEpigenetic and transgenerational reprogramming of brain development
Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505
Giovanoli, S., Engler, H., Engler, A., Richetto, J., Voget, M., Willi, R., Winter, C., Riva, M. A., Mortensen, P. B., Feldon, J., et al. (2013) · Science · doi:10.1126/science.1228261 · Cited by 459
Self-citationTransforming the understanding of brain immunity
Castellani, G., Croese, T., Peralta Ramos, J. M., & Schwartz, M. (2023) · Science · doi:10.1126/science.abo7649 · Cited by 386
Garay, P. A., Hsiao, E. Y., Patterson, P. H., & McAllister, A. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.008 · Cited by 366
“…changes in common with both SZ and ASD reinforces the construct validity of the model, given that these disorders share the risk factor of maternal infection and that their psychiatric and anatomical pathologies significantly overlap (Lord et al., 2000; Meyer et al., 2011; Rapoport et al., 2009).”
Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?
Fleiss, B., & Gressèns, P. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70058-3 · Cited by 380
Maternal immune activation and autism spectrum disorder: From rodents to nonhuman and human primates
Careaga, M., Murai, T., & Bauman, M. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.020 · Cited by 348
“The emerging consensus among leaders in the field is that prenatal infection may be relevant to a number of CNS diseases and restricting interpretation to a specific human disorder may limit the utility and relevance of the MIA model (38, 39).”
BackgroundEffects of maternal obesity on placental function and fetal development
Howell, K. R., & Powell, T. L. (2016) · Reproduction · doi:10.1530/rep-16-0495 · Cited by 370
“2010, Brown & Derkits 2010, Meyer et al .”
BackgroundMaternal hospitalization with infection during pregnancy and risk of autism spectrum disorders
Lee, B. K., Magnusson, C., Gardner, R. M., Blomström, Å., Newschaffer, C. J., Burstyn, I., Karlsson, H., & Dalman, C. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.09.001 · Cited by 337
“, using RNA poly(I:C) to stimulate an antiviral inflammatory response or lipopolysaccharide to stimulate a bacterial inflammatory response) (Brown and Derkits, 2010; Deverman and Patterson, 2009; Meyer et al., 2011; Miller et al., 2013; Patterson, 2011).”
MethodZhou, Y., Kaiser, T., Monteiro, P., Zhang, X., Van der Goes, M. S., Wang, D., Barak, B., Zeng, M., Li, C., Lu, C., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.023 · Cited by 325
“This is particularly true between child onset schizophrenia and autism (Meyer et al., 2011; Rapoport et al., 2009).”
BackgroundCytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314
Developmental neuroinflammation and schizophrenia
Meyer, U. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.11.003 · Cited by 307
“Exposure to acute fetal inflammation may further induce latent neuroinflammatory abnormalities that can be unmasked by exposure to certain environmental stimuli throughout postnatal life (Meyer et al., 2011a).”
BackgroundMethodInfluentialSelf-citationBauman, M. D., Iosif, A.-M., Smith, S. E. P., Bregere, C., Amaral, D. G., & Patterson, P. H. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.025 · Cited by 294
Long-term Risk of Neuropsychiatric Disease After Exposure to Infection In Utero
al-Haddad, B. J. S., Jacobsson, B., Chabra, S., Modzelewska, D., Olson, E. M., Bernier, R., Enquobahrie, D. A., Hagberg, H., Östling, S., Rajagopal, L., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0029 · Cited by 289
The Consequences of Chorioamnionitis: Preterm Birth and Effects on Development
Galinsky, R., Polglase, G. R., Hooper, S. B., Black, M. J., & Moss, T. J. M. (2013) · Journal of Pregnancy · doi:10.1155/2013/412831 · Cited by 282
“Recent work suggests that persistent inflammation is responsible for phenotypic abnormalities observed in autism, whereas a latent inflammatory process in utero appears responsible for schizophrenia-specific brain and behavioural abnormalities [112].”
BackgroundGraham, A. M., Rasmussen, J. M., Rudolph, M. D., Heim, C. M., Gilmore, J. H., Styner, M., Potkin, S. G., Entringer, S., Wadhwa, P. D., Fair, D. A., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.027 · Cited by 282
“hit").(15, 53) An adaptive, evolutionary perspective further suggests potential survival advantages of the observed brain phenotypes.”
BackgroundResultInfluentialMeyer, U., Schwarz, M., & Müller, N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.003 · Cited by 262
“…and cellularmechanisms remain to be identified, it has been suggested that enhanced pro-inflammatory activity in general, andmicroglia over-activation in particular, may play a role in precipitating such progressive brain changes in schizophrenia (van Berckel et al., 2008; Meyer et al., 2011).”
BackgroundInfluentialSelf-citationKentner, A. C., Bilbo, S. D., Brown, A. S., Hsiao, E. Y., McAllister, A. K., Meyer, U., Pearce, B. D., Pletnikov, M. V., Yolken, R. H., & Bauman, M. D. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0185-7 · Cited by 259
“Although MIA models have been used most often to model ASD or SZ, the emerging consensus among leaders in the field is that prenatal infection may be relevant to a number of CNS diseases and restricting interpretation to any given human disorder may limit the utility and relevance of the MIA model [46, 47].”
Self-citationNeurologic Consequences of Preterm Birth
Ream, M. A., & Lehwald, L. M. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0862-2 · Cited by 251
Evolution, human-microbe interactions, and life history plasticity
Rook, G., Bäckhed, F., Levin, B. R., McFall-Ngai, M. J., & McLean, A. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30566-4 · Cited by 246
“(79) Similarly inflammation during pregnancy, from any cause, increases the risk of autism and schizophrenia in the child.((80)) It is hypothesized that diminished immunoregulation can increase this risk further.”
BackgroundMicrobial ‘Old Friends’, immunoregulation and stress resilience
Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2013) · Evolution Medicine and Public Health · doi:10.1093/emph/eot004 · Cited by 258
“Had space permitted there are other psychiatric conditions that could have been included in the discussion because of evidence for inflammatory components: attention deficit hyperactivity disorder, and PTSD [142, 143], schizophrenia and autism [144, 145].”
BackgroundAllen, J. L., Oberdorster, G., Morris-Schaffer, K., Wong, C., Klocke, C., Sobolewski, M., Conrad, K., Mayer-Proschel, M., & Cory-Slechta, D. A. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2015.12.014 · Cited by 241
“Both can involve auditory and visual hallucinations (Meyer et al., 2011; Barneveld et al., 2011), abnormalities of serotonergic, dopaminergic and glutamatergic systems (Brown et al., 2013; Shimmura et al., 2013; Sodhi and Sanders-Bush., 2004) and shared genetic causes (de Lacy and King, 2013;…”
Microbiome, inflammation, epigenetic alterations, and mental diseases
Alam, R., Abdolmaleky, H. M., & Zhou, J. (2017) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32567 · Cited by 240
“…risk factors in the pathogenesis of mental diseases, reduction in ancient and habitual human infections, disruption of the commensal microbes and diminished contact with environmental microbes may also increase the vulnerability to inflammatory as well as mental diseases (Meyer et al., 2011).”
BackgroundEnvironmental toxicology: Sensitive periods of development and neurodevelopmental disorders
Heyer, D. B., & Meredith, R. M. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.10.017 · Cited by 247
Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders
Gibney, S. M., & Drexhage, H. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9462-8 · Cited by 245
Neurodevelopmental Resilience and Susceptibility to Maternal Immune Activation
Meyer, U. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.08.001 · Cited by 230
Self-citationNeuroimmune crosstalk in the central nervous system and its significance for neurological diseases
Tian, L., Ma, L., Kaarela, T., & Li, Z. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-155 · Cited by 224
“Since immune functions of glia are much better known than those of neurons [4,5,9], we will emphasize more on the latter ones in this review.”
BackgroundInfluentialDuan, L., Zhang, X., Miao, W., Sun, Y., Xiong, G., Wu, Q.-Z., Li, G., Yang, P., Yu, H., Li, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.030 · Cited by 219
Rasmussen, J. M., Graham, A. M., Entringer, S., Gilmore, J. H., Styner, M. A., Fair, D. A., Wadhwa, P. D., & Buß, C. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.04.020 · Cited by 215
“Epidemiological findings have consistently associated maternal infection in pregnancy with suboptimal offspring cognitive and socioemotional development and increased risk for schizophrenia and autism (Khandaker et al., 2013; Brown et al., 2004; Brown and Patterson, 2011; Brown and Derkits, 2010; Buka et al., 2001; Fa…”
Microbial ‘old friends’, immunoregulation and socioeconomic status
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12269 · Cited by 218
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203
Influence of sex differences on microRNA gene regulation in disease
Sharma, S., & Eghbali, M. (2014) · Biology of Sex Differences · doi:10.1186/2042-6410-5-3 · Cited by 204
“linked to prenatal stress [122,123].”
The Epidemiologic Evidence Linking Autoimmune Diseases and Psychosis
Benros, M. E., Eaton, W. W., & Mortensen, P. B. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.023 · Cited by 196
Haddad, F. L., Patel, S. V., & Schmid, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.012 · Cited by 206
Abdallah, M. W., Larsen, N., Grove, J., Nørgaard-Pedersen, B., Thorsen, P., Mortensen, E. L., & Hougaard, D. M. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.639803 · Cited by 186
“IL-6, however, is a member of pro-infl ammatory cytokines involved in MIA and the development of neurodevelopmental disorders (Meyer et al. 2011).”
BackgroundChorioamnionitis and neonatal outcomes
Jain, V. G., Willis, K. A., Jobe, A. H., & Ambalavanan, N. (2021) · Pediatric Research · doi:10.1038/s41390-021-01633-0 · Cited by 181
Modeling Autistic Features in Animals
Patterson, P. H. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212b80f · Cited by 172
The microbiota, immunoregulation, and mental health: implications for public health
Lowry, C. A., Smith, D. G., Siebler, P. H., Schmidt, D., Stamper, C. E., Hassell, J. E., Yamashita, P. S., Fox, J. H., Reber, S. O., Brenner, L. A., et al. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0100-5 · Cited by 172
Preterm birth: Inflammation, fetal injury and treatment strategies
Boyle, A. K., Rinaldi, S. F., Norman, J. E., & Stock, S. J. (2016) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2016.11.008 · Cited by 172
Patient Similarity Networks for Precision Medicine
Pai, S., & Bader, G. D. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.05.037 · Cited by 159
“An early example is the use of improved phenotyping in 1971 to recognize that autism spectrum disorder was a different disease than schizophrenia 2 .”
BackgroundHarvey, L., & Boksa, P. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22043 · Cited by 151
“This approach has proved fruitful given there are significant similarities between the disorders, with a recent article even suggesting that it may be neuroinflammatory events during early fetal development which result in this shared pathogenesis (Meyer et al., 2011).”
BackgroundThe BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers
Meyza, K. Z., Defensor, E. B., Jensen, A. L., Corley, M. J., Pearson, B. L., Pobbe, R. L. H., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.021 · Cited by 147
Intermittent or sustained systemic inflammation and the preterm brain
Dammann, O., & Leviton, A. (2013) · Pediatric Research · doi:10.1038/pr.2013.238 · Cited by 142
Self-citationThe role of systemic inflammation linking maternal BMI to neurodevelopment in children
van der Burg, J. W., Sen, S., Chomitz, V. R., Seidell, J. C., Leviton, A., & Dammann, O. (2015) · Pediatric Research · doi:10.1038/pr.2015.179 · Cited by 142
“Cytokines such as TNF-α released during intrauterine inflammation are a possible cause of brain damage observed in animal studies linking preterm birth and periventricular white matter damage (61,85,94).”
Self-citationOsborne, A. L., Solowij, N., Babic, I., Huang, X., & Weston–Green, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.40 · Cited by 147
“Cognitive deficits often precede the onset of other symptoms and are associated with poor medication compliance and a higher tendency for relapse in first episode psychosis (Meyer et al, 2011b).”
Cytokines and the neurodevelopmental basis of mental illness
Ratnayake, U., Quinn, T., Walker, D. W., & Dickinson, H. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00180 · Cited by 141
“…in the brain that predisposes an individual, perhaps already at risk due to genetic and environmental influences, to develop the neuropathology and behavioral and cognitive impairments observed in major disorders such as schizophrenia and autism (Rehn and Rees, 2005; Meyer et al., 2011).”
BackgroundMaternal immune activation in nonhuman primates alters social attention in juvenile offspring
Machado, C. J., Whitaker, A. M., Smith, S. E. P., Patterson, P. H., & Bauman, M. D. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.035 · Cited by 136
Kim, K. C., Lee, D.-K., Go, H. S., Kim, P., Choi, C. S., Kim, J., Jeon, S. J., Song, M., & Shin, C. Y. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8535-2 · Cited by 138
Schaafsma, W., Bozal‐Basterra, L., Jacobs, S., Brouwer, N., Meerlo, P., Schaafsma, A., Boddeke, E., & Eggen, B. J. L. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.07.017 · Cited by 144
“, 2013; Patterson, 2011), schizophrenia (Meyer et al., 2011; Miller et al., 2013; Patterson, 2009), and cerebral palsy (Yoon et al.”
BackgroundAjram, L. A., Horder, J., Méndez, M. A., Galanopoulos, A., Brennan, L., Wichers, R., Robertson, D., Murphy, C. M., Zinkstok, J., Ivin, G., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.104 · Cited by 139
Wei, H., Alberts, I. L., & Li, X. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.025 · Cited by 139
“This is relevant as there are both clinical and biological links between autism and schizophrenia (Meyer et al., 2011).”
BackgroundTh17 Pathway-Mediated Immunopathogenesis of Schizophrenia: Mechanisms and Implications
Debnath, M., & Berk, M. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu049 · Cited by 131
O’Loughlin, E., Pakan, J. M. P., Yilmazer-Hanke, D., & McDermott, K. W. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0981-8 · Cited by 127
“ism spectrum disorders (ASD), and epilepsy [7, 22, 27].”
Lifetime stress experience: Transgenerational epigenetics and germ cell programming
Bale, T. L. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/tbale · Cited by 129
Molecular Mechanisms of Neonatal Brain Injury
Thornton, C., Rousset, C. I., Kichev, A., Miyakuni, Y., Vontell, R., Baburamani, A. A., Fleiss, B., Gressèns, P., & Hagberg, H. (2012) · Neurology Research International · doi:10.1155/2012/506320 · Cited by 132
“More speculatively, perinatal inflammation is suggested to play a critical role in the pathogenesis of autism and schizophrenia [157–159].”
Vuillermot, S., Joodmardi, E., Perlmann, T., Ove Ögren, S., Feldon, J., & Meyer, U. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4831-11.2012 · Cited by 127
“There has been increasing interested in and evidence for an important contribution of prenatal exposure to infection and/or inflammation in the etiology of developmental brain disorders (Brown and Derkits, 2010; Meyer et al., 2011; Patterson, 2011).”
BackgroundSelf-citation; for the ELGAN Study Investigators, O’Shea, T. M., Joseph, R. M., Kuban, K., Allred, E. N., Ware, J., Coster, T., Fichorova, R. N., Dammann, O., & Leviton, A. (2014) · Pediatric Research · doi:10.1038/pr.2014.41 · Cited by 127
Self-citationMajor Histocompatibility Complex I in Brain Development and Schizophrenia
McAllister, A. K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.003 · Cited by 130
“Although there is a wide range of environmental risk factors linked to SZ, the most compelling risk factor to date is maternal infection (4, 26, 95, 96), which has been estimated to account for up to one-third of cases (25).”
BackgroundPosttraumatic stress disorder: does the gut microbiome hold the key?
Leclercq, S., Forsythe, P., & Bienenstock, J. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716635535 · Cited by 121
Kirsten, T. B., Chaves‐Kirsten, G. P., Chaible, L. M., Silva, A. C., Martins, D. O., Britto, L. R. G., Dagli, M. L. Z., Torrão, A. S., Palermo‐Neto, J., & Bernardi, M. M. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23089 · Cited by 122
Microglia in development: linking brain wiring to brain environment
Paolicelli, R. C., & Gross, C. T. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x12000105 · Cited by 129
Abdallah, M. W., Larsen, N., Grove, J., Nørgaard‐Pedersen, B., Thorsen, P., Mortensen, E. L., & HOUGAARD, D. M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.003 · Cited by 126
“Also, increased levels of a neutrophil attractant chemokine (IL-8) were reported to be associated with other neurodevelopmental disorder, namely schizophrenia (Brown et al., 2004), which is hypothesized to share a common etiologic pathway with autism during pregnancy (Meyer et al., 2011).”
Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain
Basil, P., Li, Q., Dempster, E. L., Mill, J., Sham, P.-C., Wong, C. C. Y., & McAlonan, G. M. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.80 · Cited by 116
Microbiota, immunoregulatory old friends and psychiatric disorders
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_15 · Cited by 117
Cattane, N., Richetto, J., & Cattaneo, A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.001 · Cited by 129
Vuillermot, S., Luan, W., Meyer, U., & Eyles, D. W. (2017) · Molecular Autism · doi:10.1186/s13229-017-0125-0 · Cited by 116
“has accumulated to suggest that prenatal infection also is a risk factor for autism spectrum disorder (ASD) [3, 4].”
BackgroundSelf-citationPrata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115
Hygiene and other early childhood influences on the subsequent function of the immune system
Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2015) · Brain Research · doi:10.1016/j.brainres.2014.04.004 · Cited by 109
“In view of the significant epidemiological association with familial allergic disorder, where the birth order effect is clear, this is of great interest (discussed in Meyer et al., 2011; Onore et al., 2012).”
InfluentialGuma, E., Plitman, E., & Chakravarty, M. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.020 · Cited by 108
Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism
Theoharides, T. C., & Zhang, B. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-168 · Cited by 108
Immune system gene dysregulation in autism and schizophrenia
Michel, M., Schmidt, M. J., & Mirnics, K. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22044 · Cited by 107
“Autism spectrum disorder (ASD) is characterized by symptoms in the domains of social interaction, communication, and restricted and repetitive interests and behaviors (Meyer et al., 2011; Noterdaeme, 2011; Ratajczak, 2011).”
Samsam, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9942 · Cited by 113
Kirsten, T. B., Lippi, L. L., Bevilacqua, E. M. A. F., & Bernardi, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082244 · Cited by 111
“[4-7].”
Sullivan, S. A., Rai, D., Golding, J., Zammit, S., & Steer, C. D. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.010 · Cited by 104
Lim, C. K., Essa, M. M., Martins, R. D. P., Lovejoy, D. B., BILGIN, A. A. B., Waly, M. I., Al-Farsi, Y. M., Al‐Sharbati, M. M., Al‐Shaffae, M. A., & Guillemin, G. J. (2015) · Autism Research · doi:10.1002/aur.1565 · Cited by 100
Cataldo, I., Azhari, A., & Esposito, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00027 · Cited by 97
“…infection, either through direct exposure of preganant mice to viruses, or via activation of maternal immune response in the absence of an infectious agent, led to atypical behaviors in the resulting pups (Brown and Derkits, 2010; Meyer et al., 2011; Patterson, 2011; Miller V. M. et al., 2013).”
BackgroundMaternal Immune Activation Disrupts Dopamine System in the Offspring
Luchicchi, A., Lecca, S., Melis, M., Felice, M. D., Cadeddu, F., Frau, R., Muntoni, A. L., Fadda, P., Devoto, P., & Pistis, M. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw007 · Cited by 105
“This is not surprising when considering the similarities between schizophrenia and autismrelated disorders, which might also share a neuroinflammatory pathogenesis during early fetal development (Meyer et al., 2011).”
BackgroundInflammation impairs social cognitive processing: A randomized controlled trial of endotoxin
Moieni, M., Irwin, M. R., Jevtic, I., Breen, E. C., & Eisenberger, N. I. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.03.002 · Cited by 95
“It has been hypothesized that prenatal exposure to infection, including the subsequent maternal proinflammatory response, can alter the development of the fetal brain (Fineberg and Ellman, 2013; Meyer et al., 2009, 2011; Michel et al., 2012; Onore et al., 2012; Patterson, 2009).”
InfluentialToward an immune-mediated subtype of autism spectrum disorder
McDougle, C. J., Landino, S. M., Vahabzadeh, A., O’Rourke, J., Zurcher, N. R., Finger, B. C., Palumbo, M. L., Helt, J., Mullett, J. E., Hooker, J. M., et al. (2015) · Brain Research · doi:10.1016/j.brainres.2014.09.048 · Cited by 95
Abdallah, M. W., Larsen, N., Mortensen, E. L., Atladóttir, H. Ó., Nørgaard-Pedersen, B., Bonefeld-Jørgensen, E. C., Grove, J., & Hougaard, D. M. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.07.013 · Cited by 94
“An additional case group, OCPD, was introduced, comprising the subset of controls who had at least one childhood psychiatric disorder other than ASD.”
InfluentialEissa, N., Sadeq, A. S., Sasse, A., & Sadek, B. S. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00886 · Cited by 99
“Social cognitive impairments are hallmark behavioral deficits in both, ASD and SCH (Couture et al., 2006; Meyer et al., 2011).”
BackgroundInfluentialElmer, B. M., Estes, M. L., Barrow, S. L., & McAllister, A. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2366-13.2013 · Cited by 88
“Because MIA is a risk factor for both ASD and SZ (Atladóttir et al., 2010, 2012; Meyer et al., 2011; Brown, 2012), the MHCIMEF2 signaling pathway identified here may be critical for the pathogenesis of these disorders.”
BackgroundHarvey, L., & Boksa, P. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.022 · Cited by 94
Trevisan, D. A., Foss‐Feig, J. H., Naples, A. J., Srihari, V. H., Anticevic, A., & McPartland, J. C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00548 · Cited by 95
Anderson, G., & Maes, M. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9307-9 · Cited by 105
“Developmental neuroinflammation caused by maternal prenatal infections is pathophysiologically relevant and may contribute to progressive brain changes and thus progression of schizophrenia (Meyer et al. 2011).”
Klocke, C., Allen, J. L., Sobolewski, M., Mayer-Pröschel, M., Blum, J. L., Lauterstein, D., Zelikoff, J. T., & Cory-Slechta, D. A. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx010 · Cited by 87
Jyonouchi, H., Geng, L., & Davidow, A. L. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0187-2 · Cited by 87
“Mounting evidence indicates that in other neuropsychiatric conditions such as schizophrenia, inflammatory cytokines such as IL-1β and IL-6 have a role in onset and progress of neuropsychiatric symptoms [27-31].”
BackgroundEhrlich, K. B., Ross, K. M., Chen, E., & Miller, G. E. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000845 · Cited by 84
Fetal programming of schizophrenia: Select mechanisms
Debnath, M., Venkatasubramanian, G., & Berk, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.003 · Cited by 89
“This "second hit" due to stress, immune re-exposure or even peripubertal sex hormonal changes might potentially unmask and exacerbate the hitherto latent inflammatory processes with resultant onset of clinical symptoms (Meyer et al., 2011; Knickmeyer et al., 2010) .”
BackgroundEffects of inflammation on social processes and implications for health
Moieni, M., & Eisenberger, N. I. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13864 · Cited by 89
Innate Immune Regulation by Toll-Like Receptors in the Brain
Mallard, C. E. (2012) · ISRN Neurology · doi:10.5402/2012/701950 · Cited by 82
“Several studies have been performed to mimic viral infections during pregnancy by giving TLR3 ligands as models for developmentally induced psychiatric disorders [141, 142].”
BackgroundParker, W., Hornik, C. D., Bilbo, S. D., Holzknecht, Z. E., Gentry, L., Rao, R., Lin, S. S., Herbert, M. R., & Nevison, C. D. (2017) · Journal of International Medical Research · doi:10.1177/0300060517693423 · Cited by 87
Ardalan, M., Chumak, T., Vexler, Z. S., & Mallard, C. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092270 · Cited by 83
“Moreover, dysregulation of immune-related genes has been shown in the brains of patients with neuropsychiatric disorders such as schizophrenia [244], raising the possibility that immune-induced inflammation increases vulnerability of the brain that already is at risk due to genetic influences [245,246].”
BackgroundDoenni, V. M., Gray, J. M., Song, C. M., Patel, S., Hill, M. N., & Pittman, Q. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.152 · Cited by 80
“…changes occurring in the placenta Inflammation, particularly during the prenatal period, has been associated with increased incidence of disorders such as autism (Patterson, 2011) and schizophrenia (reviewed in Green and Nolan, 2014; Meyer et al., 2011; Miller et al., 2013) in the offspring.”
Metadata
- Authors
- MEYER, U., FELDON, J., & DAMMANN, O.
- Affiliations
- ETH Zurich (CH)
- Tufts Medical Center (US)
- Corresponding author
- MEYER, URS
- Venue
- Pediatric Research
- Published
- 2011-05
- Volume
- 69
- Issue
- 5 Part 2
- Pages
- 26R-33R
- ISSN
- 0031-3998 (ISSN-L)
- PMC
- PMC3086802
- OpenAlex
- W2011183628
- Cited by
- 357
- References
- 86
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 14 · 2023: 20 · 2022: 13 · 2021: 18 · 2020: 19 · 2019: 22 · 2018: 30 · 2017: 31 · 2016: 30 · 2015: 36 · 2014: 32 · 2013: 32 · 2012: 30
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- National Alliance for Research on Schizophrenia and Depression
- European Commission (LSHM‐CT‐2006‐036534, 241778)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (116719, 100309)
- Eidgenössische Technische Hochschule Zürich (11 07/03)
- National Institutes of Health
- National Eye Institute (R21EY019253)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- schizophrenia, autism spectrum disorder, perinatal inflammation, prenatal infection, neuroinflammation, fetal development, shared pathogenesis, chronic inflammation, psychopathology, neuropathology
- MeSH terms
- Autistic Disorder, Female, Humans, Inflammation, Models, Theoretical, Pregnancy, Pregnancy Complications, Schizophrenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
