Multiple molecular targets in cancer chemoprevention by curcumin

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 3,942

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1256 · Cited by 3,367

Anticancer potential of curcumin: preclinical and clinical studies.

Aggarwal, B. B., Kumar, A. J., & Bharti, A. C. (2003) · PubMed · Cited by 2,550

NF-κB in cancer: from innocent bystander to major culprit

Karin, M., Cao, Y., Greten, F. R., & Li, Z.-W. (2002) · Nature Reviews Cancer · doi:10.1038/nrc780 · Cited by 2,478

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433

Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action

Liu, R. H. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.12.3479s · Cited by 2,276

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

Balkwill, F., Charles, K. A., & Mantovani, A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.02.013 · Cited by 1,769

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation

Surh, Y.-J., Chun, K.-S., Cha, H.-H., Han, S. S., Keum, Y.-S., Park, K.-K., & Lee, S. S. (2001) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(01)00183-x · Cited by 1,620

Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation

Viatour, P., Merville, M.-P., Bours, V., & Chariot, A. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.11.009 · Cited by 1,496

Caught up in a Wnt storm: Wnt signaling in cancer

Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C., Munemitsu, S., & Polakis, P. (1996) · Science · doi:10.1126/science.272.5264.1023 · Cited by 1,422

Pharmacology of Curcuma longa

Ammon, H., & Wahl, M. (1991) · Planta Medica · doi:10.1055/s-2006-960004 · Cited by 1,347

Nitric Oxide Scavenging by Curcuminoids

Sreejayan, & Rao, M. N. A. (1997) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1997.tb06761.x · Cited by 1,135

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

BALOGUN, E., HOQUE, M., GONG, P., KILLEEN, E., GREEN, C. J., FORESTI, R., ALAM, J., & MOTTERLINI, R. (2003) · Biochemical Journal · doi:10.1042/bj20021619 · Cited by 1,036

Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).

Sporn, M. B., Dunlop, N. M., Newton, D. L., & Smith, J. M. (1976) · PubMed · Cited by 992

FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition

Cross, M. J., & Claesson-Welsh, L. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01676-x · Cited by 989

IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy

Luo, J.-L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26322 · Cited by 878

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress

Motterlini, R., Foresti, R., Bassi, R., & Green, C. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00294-x · Cited by 846

Inflammation as a Tumor Promoter in Cancer Induction

Philip, M., Rowley, D. A., & Schreiber, H. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.06.006 · Cited by 640

The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis

John, A., & Tuszynski, G. (2001) · Pathology & Oncology Research · doi:10.1007/bf03032599 · Cited by 609

Curcumin Suppresses the Paclitaxel-Induced Nuclear Factor-κB Pathway in Breast Cancer Cells and Inhibits Lung Metastasis of Human Breast Cancer in Nude Mice

Aggarwal, B. B., Shishodia, S., Takada, Y., Banerjee, S., Newman, R. A., Bueso-Ramos, C. E., & Price, J. E. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1192 · Cited by 584

Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.

Huang, M., Lou, Y.-R., Ma, W., Newmark, H. L., Reuhl, K. R., & Conney, A. H. (1994) · PubMed · Cited by 544

Nrf2 as a novel molecular target for chemoprevention

Lee, J.-S., & Surh, Y.-J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.09.042 · Cited by 516

Curcumin, an Anti-tumor Promoter and Anti-inflammatory Agent, Inhibits Induction of Nitric Oxide Synthase in Activated Macrophages

Brouet, I., & Ohshima, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1076 · Cited by 471

Curcumin (diferuloylmethane) inhibits constitutive NF-κB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

Shishodia, S., Amin, H. M., Lai, R., & Aggarwal, B. B. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.043 · Cited by 459

Inhibition of Activator Protein-1, NF-κB, and MAPKs and Induction of Phase 2 Detoxifying Enzyme Activity by Chlorogenic Acid

Feng, R., Lu, Y., Bowman, L. L., Qian, Y., Castranova, V., & Ding, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503347200 · Cited by 389

Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells

Goel, A., Boland, C. R., & Chauhan, D. P. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00655-3 · Cited by 381

β-Catenin-mediated transactivation and cell–cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells

Jaiswal, A. S., Marlow, B. P., Gupta, N., & Narayan, S. (2002) · Oncogene · doi:10.1038/sj.onc.1205947 · Cited by 363

Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals –

Surh, Y.-J., Kundu, J. K., Na, H.-K., & Lee, J.-S. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.12.2993s · Cited by 363

Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages

Pan, M.-H., Lin-Shiau, S.-Y., & Lin, J.-K. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00489-5 · Cited by 356

Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis.

Perkins, S., Verschoyle, R. D., Hill, K. A., Parveen, I., Threadgill, M. D., Sharma, R. A., Williams, M. L., Steward, W. P., & Gescher, A. J. (2002) · PubMed · Cited by 349

Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo

Dorai, T., Cao, Y., Dorai, B., Buttyan, R., & Katz, A. E. (2001) · The Prostate · doi:10.1002/pros.1074 · Cited by 338

Role of Hormones in Mammary Cancer Initiation and Progression

Russo, I. H., & Russo, J. (1998) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018770218022 · Cited by 337

Curcumin Selectively Induces Apoptosis in Deregulated Cyclin D1-expressed Cells at G2 Phase of Cell Cycle in a p53-dependent Manner

Choudhuri, T., Pal, S., Das, T., & Sa, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410670200 · Cited by 321

Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis

Mahmoud, N. N. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.921 · Cited by 317

Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression

Notarbartolo, M., Poma, P., Perri, D., Dusonchet, L., Cervello, M., & D'Alessandro, N. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.10.051 · Cited by 317

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

Takada, Y., Bhardwaj, A., Potdar, P., & Aggarwal, B. B. (2004) · Oncogene · doi:10.1038/sj.onc.1208169 · Cited by 310

Dietary Supplementation of Curcumin Enhances Antioxidant and Phase II Metabolizing Enzymes in ddY Male Mice: Possible Role in Protection against Chemical Carcinogenesis and Toxicity

Iqbal, M., Sharma, S. D., Okazaki, Y., Fujisawa, M., & Okada, S. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.920106.x · Cited by 304

Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1

Chen, A., Xu, J., & Johnson, A. C. (2006) · Oncogene · doi:10.1038/sj.onc.1209019 · Cited by 301

Nuclear factor‐κB and IκB kinase are constitutively active in human pancreatic cells, and their down‐regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

Li, L., Aggarwal, B. B., Shishodia, S., Abbruzzese, J., & Kurzrock, R. (2004) · Cancer · doi:10.1002/cncr.20605 · Cited by 289

Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor‐κB signaling

Aggarwal, S., Takada, Y., Singh, S., Myers, J. N., & Aggarwal, B. B. (2004) · International Journal of Cancer · doi:10.1002/ijc.20333 · Cited by 274

Immunomodulatory Effects of Curcumin

Yadav, V. S., Mishra, K. P., Singh, D. P., Mehrotra, S., & Singh, V. K. (2005) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923970500242244 · Cited by 215

Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols

Andreadi, C. K., Howells, L. M., Atherfold, P. A., & Manson, M. M. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018374 · Cited by 211

Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene.

Tanaka, T., Makita, H., Ohnishi, M., Hirose, Y., Wang, A., Mori, H., Satoh, K., Hara, A., & Ogawa, H. (1994) · PubMed · Cited by 178

Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells

Woo, M.-S., Jung, S.-H., Kim, S.-Y., Hyun, J.-W., Ko, K.-H., Kim, W.-K., & Kim, H.-S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.174 · Cited by 176

Epidemiology of digestive tract cancers in India. V. Large and small bowel.

Mohandas, K. M., & Desai, D. C. (1999) · PubMed · Cited by 166

Modulation of xenobiotic metabolising enzymes by anticarcinogens—focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis

Pool-Zobel, B., Veeriah, S., & Böhmer, F.-D. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2005.04.020 · Cited by 166

Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by curcumin.

Thaloor, D., Singh, A. K., Sidhu, G. S., Prasad, P. V., Kleinman, H. K., & Maheshwari, R. K. (1998) · PubMed · Cited by 165

Heme oxygenase‐1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3‐dioxygenase

Hill, M., Pereira, V., Chauveau, C., Zagani, R., Remy, S., Tesson, L., Mazal, D., Ubillos, L., Brion, R., Ashgar, K., et al. (2005) · The FASEB Journal · doi:10.1096/fj.05-3875com · Cited by 158

Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin

Singh, S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.8.1357 · Cited by 158

Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma

O'Hanlon, D. M., Fitzsimons, H., Lynch, J., Tormey, S. M., Malone, C., & Given, H. F. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00218-6 · Cited by 156

The loss of E-cadherin, α- and β-catenin expression is associated with metastasis and poor prognosis in invasive breast cancer

Yoshida, R., Kimura, N., Harada, Y., & Ohuchi, N. (2001) · International Journal of Oncology · doi:10.3892/ijo.18.3.513 · Cited by 146

Synergistic Inhibitory Effects of Curcumin and 5-Fluorouracil on the Growth of the Human Colon Cancer Cell Line HT-29

Du, B., Jiang, L., Xia, Q., & Zhong, L. (2005) · Chemotherapy · doi:10.1159/000090238 · Cited by 145

Altered expression and mutation of β‐catenin gene in gastric carcinomas and cell lines

Woo, D. K., Kim, H. S., Lee, H. S., Kang, Y. H., Yang, H. K., & Kim, W. H. (2001) · International Journal of Cancer · Cited by 143

The inhibitory mechanism of curcumin and its derivative against β‐catenin/Tcf signaling

Park, C. H., Hahm, E., Park, S., Kim, H.-K., & Yang, C. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.013 · Cited by 131

Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21WAF1/CIP1 and C/EBPβ expressions and suppressing NF‐κB activation

Hour, T., Chen, J., Huang, C., Guan, J., Lu, S., & Pu, Y. (2002) · The Prostate · doi:10.1002/pros.10089 · Cited by 130

Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface: Impact on human pancreatic carcinoma cell growth by autocrine regulation

Hidaka, H., Ishiko, T., Furuhashi, T., Kamohara, H., Suzuki, S., Miyazaki, M., Ikeda, O., Mita, S., Setoguchi, T., & Ogawa, M. (2002) · Cancer · doi:10.1002/cncr.10812 · Cited by 124

Osteopontin Expression and Prognostic Significance in Non–Small Cell Lung Cancer

Donati, V. L., Boldrini, L., Dell'Omodarme, M., Prati, M. C., Faviana, P., Camacci, T., Lucchi, M., Mussi, A., Santoro, M. M., Basolo, F., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0541 · Cited by 117

Pharmacological Intervention of Cyclooxygenase-2 and 5-Lipoxygenase Pathways. Impact on Inflammation and Cancer

Clària, J., & Romano, M. (2005) · Current Pharmaceutical Design · doi:10.2174/138161205774370753 · Cited by 108

RELATIVE CONTRIBUTION OF NF-κB AND AP-1 IN THE MODULATION BY CURCUMIN AND PYRROLIDINE DITHIOCARBAMATE OF THE UVB-INDUCED CYTOKINE EXPRESSION BY KERATINOCYTES

Grandjean-Laquerriere, A., Gangloff, S. C., Naour, R. L., Trentesaux, C., Hornebeck, W., & Guenounou, M. (2002) · Cytokine · doi:10.1006/cyto.2002.0888 · Cited by 100

Transcriptional regulation of VCAM‐1 expression by tumor necrosis factor‐α in human tracheal smooth muscle cells: Involvement of MAPKs, NF‐κB, p300, and histone acetylation

Lee, C., Lin, W., Lin, C., Luo, S., Wang, J., Pouysségur, J., & Yang, C. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20549 · Cited by 99

Is cyclooxygenase-2 the alpha and the omega in cancer?

Prescott, S. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10241 · Cited by 94

The interplay between innate and adaptive immunity regulates cancer development

de Visser, K. E., & Coussens, L. M. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0702-5 · Cited by 83

Cyclooxygenase-2 and Gastrointestinal Cancer

Mann, J. R., & DuBois, R. N. (2004) · The Cancer Journal · doi:10.1097/00130404-200405000-00001 · Cited by 80

Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol.

Atsumi, T., Murakami, Y., Shibuya, K., et al. (2006) · PubMed · Cited by 79

Curcumin Inhibits Phorbol Ester-Induced Up-Regulation of Cyclooxygenase-2 and Matrix Metalloproteinase-9 by Blocking ERK1/2 Phosphorylation and NF-κB Transcriptional Activity in MCF10A Human Breast Epithelial Cells

Lee, K. W., Kim, J. H., Lee, H. J., & Surh, Y. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1612 · Cited by 77

Matrix metalloproteinase-2: Mechanism and regulation of NF-?B-mediated activation and its role in cell motility and ECM-invasion

Philip, S., Bulbule, A., & Kundu, G. C. (2004) · Glycoconjugate Journal · doi:10.1007/s10719-004-5533-7 · Cited by 72

β-catenin expression, DNA ploidy and clinicopathological features in ovarian cancer: A study in 253 patients

Kildal, W., Risberg, B. Å., Abeler, V. M., Kristensen, G. B., Sudbø, J., Nesland, J. M., & Danielsen, H. E. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.01.022 · Cited by 64

Frequent β-catenin aberration in human hepatocellular carcinoma

Fujie, H. (2001) · Hepatology Research · doi:10.1016/s1386-6346(00)00116-9 · Cited by 59

Hirsutenone inhibits phorbol ester‐induced upregulation of COX‐2 and MMP‐9 in cultured human mammary epithelial cells: NF‐κB as a potential molecular target

Kim, J. H., Lee, K. W., Lee, M.-W., Lee, H. J., Kim, S., & Surh, Y. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.12.015 · Cited by 55

Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen, ferric nitrilotriacetate

Okazaki, Y., Iqbal, M., & Okada, S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.006 · Cited by 47

T Cell-Derived Matrix Metalloproteinase-9 in Breast Cancer: Friend or Foe?

Owen, J. L., Iragavarapu‐Charyulu, V., & Lopez, D. M. (2004) · Breast Disease · doi:10.3233/bd-2004-20115 · Cited by 28

Untitled work

(2001) · PubMed

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention

Alao, J. P. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-24 · Cited by 871

Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals

Surh, Y.-J., Kundu, J., & Na, H.-K. (2008) · Planta Medica · doi:10.1055/s-0028-1088302 · Cited by 758

Small Molecule Modulators of Keap1‐ Nrf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents

Magesh, S., Chen, Y., & Hu, L. (2012) · Medicinal Research Reviews · doi:10.1002/med.21257 · Cited by 760

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554

Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention

Bansal, S. S., Goel, M., Aqil, F., Vadhanam, M. V., & Gupta, R. C. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-10-0006 · Cited by 353