The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A technical note
Open accessAbstract
Decreasing the dose frequency of cefpodoxime proxetil increases patient compliance; patients prefer to take the drug once daily. It also improves the rate of bacterial killing and hastens the cure from the indications, and therefore increases compliance. The hydrophilic matrix of HPMC controlled the cefpodoxime proxetil release effectively for 24 hours; hence, the formulation can be considered as a once-daily sustained-release tablet of cefpodoxime proxetil. The formulation showed acceptable pharmacotechnical properties and assay requirements. In vitro dissolution studies indicated a sustained-release pattern throughout 24 hours of the study that was comparable to the theoretical release profile. Drug release kinetics indicated that drug release was best explained by Higuchi's equation, as these plots showed the highest linearity (r 2=0.9734), but a close relationship was also noted with zero-order kinetics (r 2=0.9708). Korsmeyer's plots indicated ann value of 0.57, which was indicative of an anomalous diffusion mechanism or diffusion coupled with erosion; hence, the drug release was controlled by more than one process. Hixson-Crowell plots indicated a change in surface area and diameter of the tablets with the progressive dissolution of the matrix as a function of time.
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“Hardness values did not correlate with friability values [42].”
From In vitro quality evaluation of leading brands of ciprofloxacin tablets available in Bangladesh (2017) · cites this paper as [42]
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Cites
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Once-daily sustained-release matrix tablets of nicorandil: Formulation and in vitro evaluation
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Metadata
- Authors
- Merchant, H. A., Shoaib, H. M., Tazeen, J., & Yousuf, R. I.
- Affiliations
- University of Karachi (PK)
- Venue
- AAPS PharmSciTech
- Published
- 2006-09
- Volume
- 7
- Issue
- 3
- Pages
- E178-E183
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC2750520
- OpenAlex
- W2115770965
- Cited by
- 171
- References
- 16
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 13 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 12
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Huddersfield Repository (University of Huddersfield) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- cefpodoxime proxetil, hydroxypropyl methylcellulose, sustained-release tablets, once-daily dosing, in vitro drug release, Higuchi model, zero-order kinetics, anomalous diffusion, medication adherence, cephalosporins
- MeSH terms
- Cefpodoxime, Chemistry, Pharmaceutical, Delayed-Action Preparations, Methylcellulose, Tablets, Enteric-Coated, Ceftizoxime, Hypromellose Derivatives
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