Cited by 171Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsAntibiotics Pharmacokinetics and Efficacy

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Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A technical note

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Merchant, Hamid A., Shoaib, Harris M., Tazeen, Jaweria, Yousuf, Rabia I.·2006·AAPS PharmSciTech

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Abstract

Decreasing the dose frequency of cefpodoxime proxetil increases patient compliance; patients prefer to take the drug once daily. It also improves the rate of bacterial killing and hastens the cure from the indications, and therefore increases compliance. The hydrophilic matrix of HPMC controlled the cefpodoxime proxetil release effectively for 24 hours; hence, the formulation can be considered as a once-daily sustained-release tablet of cefpodoxime proxetil. The formulation showed acceptable pharmacotechnical properties and assay requirements. In vitro dissolution studies indicated a sustained-release pattern throughout 24 hours of the study that was comparable to the theoretical release profile. Drug release kinetics indicated that drug release was best explained by Higuchi's equation, as these plots showed the highest linearity (r 2=0.9734), but a close relationship was also noted with zero-order kinetics (r 2=0.9708). Korsmeyer's plots indicated ann value of 0.57, which was indicative of an anomalous diffusion mechanism or diffusion coupled with erosion; hence, the drug release was controlled by more than one process. Hixson-Crowell plots indicated a change in surface area and diameter of the tablets with the progressive dissolution of the matrix as a function of time.

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Authors: Merchant, H. A., Shoaib, H. M., Tazeen, J., & Yousuf, R. I.
Affiliations: University of Karachi (PK)
ORCID: Merchant, Hamid A.
Yousuf, Rabia I.
Venue: AAPS PharmSciTech
Publisher: Springer Science and Business Media LLC
Published: 2006-09
Volume: 7
Issue: 3
Pages: E178-E183
ISSN: 1530-9932 (ISSN-L)
DOI: 10.1208/pt070378
PMC: PMC2750520
OpenAlex: W2115770965
Cited by: 171
References: 16
Citations by year: 2026: 10 · 2025: 11 · 2024: 13 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 12
FWCI: 2.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: AAPS PharmSciTech (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Huddersfield Repository (University of Huddersfield) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
Keywords: cefpodoxime proxetil, hydroxypropyl methylcellulose, sustained-release tablets, once-daily dosing, in vitro drug release, Higuchi model, zero-order kinetics, anomalous diffusion, medication adherence, cephalosporins
MeSH terms: Cefpodoxime, Chemistry, Pharmaceutical, Delayed-Action Preparations, Methylcellulose, Tablets, Enteric-Coated, Ceftizoxime, Hypromellose Derivatives

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Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: A technical note

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