Nanoemulsion components screening and selection: A technical note
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Common emulsifiers for nanoemulsions include lecithin, sodium deoxycholate, Tween 20/40/60/80, Span 20/40/60/80, poloxamers, sodium dodecyl sulfate, casein, polysaccharides and PEG-containing block copolymers.
“Lecithin (phosphatidylcholine) [36], sodium deoxycholate (bile salt) [37], polyoxyethlene sorbitan monolaurate (Tween 20, 40, 60, 80) [38] and sorbitan monolaurate (Span 20, 40, 60, 80) [39] are commonly employed in the preparation of NEs. Other surfactants proposed are poloxamers [40], sodium dodecyl sulfate [41], amphiphilic proteins like casein [42], polysaccharides (starch derivatives, gums) [”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [38]
The Screening of Surfactants and Components sections identify Tween 20, 60, and 80 as surfactants screened for nanoemulsion formulation. The citation is attached to the Tween list, but our copy does not identify Tween 40, so it does not support the full list attributed to this source. No page numbers are available in our copy. (LLM, conf=0.88)
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- Authors
- Azeem, A., Rizwan, M., Ahmad, F. J., Iqbal, Z., Khar, R. K., Aqil, M., & Talegaonkar, S.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Azeem, Adnan
- Venue
- AAPS PharmSciTech
- Published
- 2009-01-16
- Volume
- 10
- Issue
- 1
- Pages
- 69-76
- ISSN
- 1530-9932 (ISSN-L)
- PMC
- PMC2663668
- OpenAlex
- W2154862932
- Cited by
- 567
- References
- 41
- Citations by year
- 2026: 44 · 2025: 58 · 2024: 56 · 2023: 53 · 2022: 54 · 2021: 55 · 2020: 52 · 2019: 45 · 2018: 35 · 2017: 21 · 2016: 30 · 2015: 18 · 2014: 14 · 2013: 12 · 2012: 6
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- nanoemulsions, surfactant selection, cosurfactants, oil selection, formulation screening, ropinirole, lipophilic drugs, surfactant to cosurfactant ratio, spontaneous emulsification, drug delivery systems, surfactant toxicity
- MeSH terms
- Chemistry, Pharmaceutical, Drug Compounding, Drug Stability, Emulsions, Hydrogen-Ion Concentration, Indoles, Oils, Surface Properties, Surface-Active Agents, Technology, Pharmaceutical, Temperature, Viscosity, Water, Nanotechnology, Nanoparticles
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