The DOI matches its Crossref record; 65 of the 66 references it cites were found in a registry or an index.
Comparative Study of Antidiabetic Activity and Oxidative Stress Induced by Zinc Oxide Nanoparticles and Zinc Sulfate in Diabetic Rats
Open accessAbstract
In the current study, antidiabetic activity and toxic effects of zinc oxide nanoparticles (ZnO) were investigated in diabetic rats compared to zinc sulfate (ZnSO4) with particular emphasis on oxidative stress parameters. One hundred and twenty male Wistar rats were divided into two healthy and diabetic groups, randomly. Each major group was further subdivided into five subgroups and then orally supplemented with various doses of ZnO (1, 3, and 10 mg/kg) and ZnSO4 (30 mg/kg) for 56 consecutive days. ZnO showed greater antidiabetic activity compared to ZnSO4 evidenced by improved glucose disposal, insulin levels, and zinc status. The altered activities of erythrocyte antioxidant enzymes as well as raised levels of lipid peroxidation and a marked reduction of total antioxidant capacity were observed in rats receiving ZnO. ZnO nanoparticles acted as a potent antidiabetic agent, however, severely elicited oxidative stress particularly at higher doses.
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“Specifically, SOD acts as an efficient catalyst and demonstrates high resistance to oxidative stress [32]”
From Innovative diagnostic strategies for equine habronemiasis: exploring molecular identification, gene expression, and oxidative stress markers (2025) · cites this paper as [32]
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“Antioxidants such as GSH and SOD are vital for mitigating these harmful effects, especially as the rate of parasitemia increases with their presence.”
From Innovative diagnostic strategies for equine habronemiasis: exploring molecular identification, gene expression, and oxidative stress markers (2025) · cites this paper as [32]
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The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications
Jiang, J., Pi, J., & Cai, J. (2018) · Bioinorganic Chemistry and Applications · doi:10.1155/2018/1062562 · Cited by 1,283
ZnO nanostructured materials and their potential applications: progress, challenges and perspectives
Raha, S., & Ahmaruzzaman, M. (2022) · Nanoscale Advances · doi:10.1039/d1na00880c · Cited by 1,159
Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications
Mishra, P. K., Mishra, H., Ekielski, A., Talegaonkar, S., & Vaidya, B. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.08.006 · Cited by 829
Singh, T. A., Sharma, A., Tejwan, N., Ghosh, N., Das, J., & Sil, P. C. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102495 · Cited by 291
ZnO Nanostructures for Drug Delivery and Theranostic Applications
Martínez‐Carmona, M., Gun’ko, Y. K., & Vallet‐Regí, M. (2018) · Nanomaterials · doi:10.3390/nano8040268 · Cited by 248
Metadata
- Authors
- Nazarizadeh, A., & Asri-Rezaie, S.
- Affiliations
- Urmia University (IR)
- Corresponding author
- Nazarizadeh, Ali
- ORCID
- Nazarizadeh, Ali
- Venue
- AAPS PharmSciTech
- Published
- 2015-09-08
- Volume
- 17
- Issue
- 4
- Pages
- 834-843
- ISSN
- 1530-9932 (ISSN-L)
- OpenAlex
- W1692084832
- Cited by
- 135
- References
- 66
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 14 · 2023: 17 · 2022: 22 · 2021: 22 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 6 · 2016: 3
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Keywords
- zinc oxide nanoparticles, zinc sulfate, antidiabetic activity, oxidative stress, diabetes mellitus, lipid peroxidation, antioxidant enzymes, erythrocytes, total antioxidant capacity, insulin, zinc status, oral supplementation, nanoparticle toxicity
- MeSH terms
- Animals, Antioxidants, Diabetes Mellitus, Experimental, Hypoglycemic Agents, Male, Streptozocin, Zinc Oxide, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Zinc Sulfate, Rats, Nanoparticles
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