Quetiapine Nanoemulsion for Intranasal Drug Delivery: Evaluation of Brain-Targeting Efficiency

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Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

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Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges

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Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier

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Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders

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Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations

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An update on the role of nanovehicles in nose-to-brain drug delivery

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Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion

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Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

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Optimization of Nanostructured Lipid Carriers of Lurasidone Hydrochloride Using Box-Behnken Design for Brain Targeting: In Vitro and In Vivo Studies

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Brain targeted rivastigmine mucoadhesive thermosensitive In situ gel: Optimization, in vitro evaluation, radiolabeling, in vivo pharmacokinetics and biodistribution

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Nanoemulsions in CNS drug delivery: recent developments, impacts and challenges

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Intranasal Nanoparticulate Systems as Alternative Route of Drug Delivery

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Drug targeting strategies into the brain for treating neurological diseases

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Nose-to-Brain (N2B) Delivery: An Alternative Route for the Delivery of Biologics in the Management and Treatment of Central Nervous System Disorders

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Nose-to-brain delivery of antipsychotics using nanotechnology: a review

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Thymoquinone-Enriched Naringenin-Loaded Nanostructured Lipid Carrier for Brain Delivery via Nasal Route: In Vitro Prospect and In Vivo Therapeutic Efficacy for the Treatment of Depression

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Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against Neurodegenerative Disorders

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Convolutions in the rendition of nose to brain therapeutics from bench to bedside: Feats & fallacies

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Direct nose to the brain nanomedicine delivery presents a formidable challenge

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Nanoparticlized System: Promising Approach for the Management of Alzheimer’s Disease through Intranasal Delivery

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An Overview on the Physiopathology of the Blood–Brain Barrier and the Lipid-Based Nanocarriers for Central Nervous System Delivery

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Chitosan coated clove oil-based nanoemulsion: An attractive option for oral delivery of leflunomide in rheumatoid arthritis

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Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most Promising Nanocarriers for Increased Bioavailability and Therapeutic Efficacy

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Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients

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Nose-to-brain drug delivery for the treatment of CNS disease: New development and strategies

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Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery

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Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate

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Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

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Advances in nasal drug delivery systems

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Nose-to-Brain Drug Delivery and Physico-Chemical Properties of Nanosystems: Analysis and Correlation Studies of Data from Scientific Literature

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In vitro appraisals and ex vivo permeation prospect of chitosan nanoparticles designed for schizophrenia to intensify nasal delivery

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Quercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies

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Nose-to-brain drug delivery

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Development of cannabidiol nanoemulsion for direct nose to brain delivery: statistical optimization, in vitro and in vivo evaluation

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Advancement in the Nose-to-Brain Drug delivery of FDA-approved drugs for the better management of Depression and Psychiatric disorders

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Non-Invasive Techniques of Nose to Brain Delivery Using Nanoparticulate Carriers: Hopes and Hurdles

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Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration

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Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems

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QbD Based Optimization of Curcumin Nanoemulsion: DoE and Cytotoxicity Studies

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Analyzing Nanotheraputics-Based Approaches for the Management of Psychotic Disorders

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Preparation, In Vitro and In Vivo Evaluation of Nanoemulsion In Situ Gel for Transnasal Delivery of Traditional Chinese Medicine Volatile Oil from Ligusticum sinense Oliv.cv. Chaxiong

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Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the new-generation antiepileptic drug perampanel

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Quantification of BSA-loaded chitosan/oligonucleotide nanoparticles using reverse-phase high-performance liquid chromatography

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Single and Multitarget Systems for Drug Delivery and Detection: Up-to-Date Strategies for Brain Disorders

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Excipients Used for Modified Nasal Drug Delivery: A Mini-Review of the Recent Advances

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NIOSOMES AS AN EMERGING FORMULATION TOOL FOR DRUG DELIVERY-A REVIEW

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Mathematical Modeling and Simulation to Investigate the CNS Transport Characteristics of Nanoemulsion-Based Drug Delivery Following Intranasal Administration

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Nanocarriers for effective drug delivery

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Antipsychotics-Loaded Nanometric Emulsions for Brain Delivery

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Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes

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Development and Comparative In Vitro and In Vivo Study of BNN27 Mucoadhesive Liposomes and Nanoemulsions for Nose-to-Brain Delivery

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Surface Modification of Nanoparticles to Oppose Uptake by the Mononuclear Phagocyte System

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Exploring the potential of site-specific co-delivery of Berberine alongside 5-fluorouracil in oral cancer: Formulation development, in-vitro apoptosis, ex-vivo permeability and in-vivo biocompatibility studies

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Nose to Brain Drug Delivery: A Recent Update

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Design and Fabrication of Brain-Targeted Drug Delivery

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Dissolving Microneedles Patch: A Promising Approach for Advancing Transdermal Delivery of Antischizophrenic Drug

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Intranasal delivery of transferrin conjugated chitosan nanoparticles to the brain: A comparative analysis of conjugated and un-conjugated nanoparticles in vivo

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W/O/W Microemulsions for Nasal Delivery of Hydrophilic Compounds: A Preliminary Study

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An Updated Review on Nanoemulsion: Factory for Food and Drug Delivery

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BBD assisted in-situ nanoliposomes of esculin hydrate via intranasal delivery for the amelioration of Parkinson's disease

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Nanotechnology-Based Drug Delivery System

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Investigating the potential of highly porous zopiclone-loaded 3D electrospun nanofibers for brain targeting via the intranasal route

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Revolutionizing nanomedicine: Expanding horizons of nanoemulsions in drug delivery and beyond

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Nose-to-brain delivery of biologics and stem cells

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Nanomaterials-mediated lysosomal regulation: a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Polymer–lipid hybrid nanostructures for drug delivery

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Applications of innovative technologies to the delivery of antipsychotics

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Phytomedicine nanoformulations for Parkinson's disease

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Applications of nanoemulsions as drug delivery vehicle for phytoconstituents

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Applications of Polymeric Nanoparticle in Nose to Brain Drug Delivery

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Microfluidic Preparation and Evaluation of Multivesicular Liposomes Containing Gastrodin for Oral Delivery across the Blood–Brain Barrier

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Application of Nano-based Drug Loading Systems in the Treatment of Neurological Infections: An Updated Review

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In vitro characterization of statistically optimized quetiapine-loaded self-nanoemulsified systems with quality by design

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Challenges in Targeting Nasal Passage and Nose-to-Brain Delivery via Nanoemulsions

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Formulation and characterization of dolutegravir sodium-loaded nanostructured lipid carrier in situ gel for targeted brain delivery via intranasal route

Taher, S. S., & Al-Kinani, K. K. (2025) · OpenNano · doi:10.1016/j.onano.2025.100270 · Cited by 5

Preparations, Applications, Patents, and Marketed Formulations of Nanoemulsions - A Comprehensive Review

Chauhan, M., Mazumder, R., Rani, A., Mishra, R., & Pal, R. S. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/0122117385325186240912110731 · Cited by 5

Pharmacokinetics of intranasal drugs, still a missed opportunity?

Sardu, M. L., & Poggesi, I. (2024) · Xenobiotica · doi:10.1080/00498254.2024.2349046 · Cited by 4

Surface-engineered Niosomes of Esculin Hydrate for the management of depression via intranasal route: Optimization, In vitro, Ex vivo and pharmacokinetic assessment

Alhowyan, A., Imran, M., Haque, A., & Kalam, M. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106417 · Cited by 4

A nanochitosan-D-galactose formulation increases the accumulation of primaquine in the liver

Gomes, F., Ribeiro, A. C. D. M., Sanches, G. S., Borges, H. S., Takahashi, L. A. U., Daniel‐Ribeiro, C. T., Tedesco, A. C., Nascimento, J. W. L., & Carvalho, L. J. M. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00915-23 · Cited by 4

Formulation, Optimization and In Vitro Studies of Flutamide-loaded Nanostructured Lipid Carrier Based Oral Drug Delivery for Enhanced Anticancer Activity

Sabale, V., Nikam, M., & Sabale, P. (2024) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-024-09859-1 · Cited by 4

Optimization and Evaluation of Functionally Engineered Paliperidone Nanoemulsions for Improved Brain Delivery via Nasal Route

Sawant, N. D., Tatke, P. A., & Desai, N. D. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00786 · Cited by 4

Application of nanoemulsion in pharmaceuticals industry

Jadhav, K., Singh, R., Ray, E., & Verma, R. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-90047-8.00011-x · Cited by 4

DESIGN, OPTIMIZATION AND EVALUATION OF INTRANASAL NANOTHERAPEUTIC OF ATYPICAL ANTIPSYCHOTIC DRUG

(2023) · European Chemical Bulletin · doi:10.48047/ecb/2023.12.si4.437 · Cited by 3

Systematic Approach in the Development of Chitosan Functionalized Iloperidone Nanoemulsions for Transnasal Delivery, In Vitro and In Vivo Studies

Sawant, N. D., Tatke, P. A., & Desai, N. D. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02964-x · Cited by 3

Effective Brain Targeting Using the Self-Emulsifying Drug Delivery Systems

Gawde, S., Bachhav, Y. G., & Kumar, M. S. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03398-3 · Cited by 2

Approaches for the delivery of anti-parkinsonian therapeutic agents via the intranasal route

Banyyounes, J., & Obeid, M. A. (2026) · Discover Neuroscience · doi:10.1186/s13064-026-00258-5 · Cited by 2

Intranasal Delivery of Piceatannol-Loaded Liposomes for Glioblastoma Management: Formulation Optimization, In Vitro, Ex Vivo, In Ovo and LC-MS/MS- Based In Vivo Pharmacokinetic and Brain Distribution Assessment

Sikder, A., Katarpawar, S. N., Phatale, V., Kumar, R., Vambhurkar, G. B., Wagh, S. S., Pandey, G., Kolipaka, T., Dikundwar, A. G., & Srivastava, S. (2026) · BioNanoScience · doi:10.1007/s12668-026-02757-5 · Cited by 2

Drug Delivery System and Technologies

Guo, W., Ding, P., Okoro, O. V., Sun, Y., Jiang, G., Shavandi, A., & Nie, L. (2025) · Smart nanomaterials technology · doi:10.1007/978-981-97-8086-0_3 · Cited by 2

An Emerging Prospective of Antipsychotics for Treating Neurodegenerative Disorders

Kumar, B., Sahoo, A., Singhal, M., Varshney, G., Halder, T., & Bali, V. (2025) · Current Pharmaceutical Design · doi:10.2174/0113816128344910241211112452 · Cited by 2

Approaches in Barriers, Modifications, Route of Administrations, and Formulations of Therapeutic Agents for Brain Delivery

Kotha, A. K., Ghosh, S., Komanduri, N., Wang, R., Bhowmick, S., & Chougule, M. B. (2019) · Springer eBooks · doi:10.1007/978-981-13-3642-3_11 · Cited by 2

Evaluation of wound healing potential and biochemical estimation of sage oil nanoemulsion on animal model.

Alam, M. S., Ali, M. D., Ahmad, S., Banu, N., Ali, M. S., Alam, N., Ali, M. S., Ansari, M. S., Shamim, M., & Mujtaba, M. A. (2021) · PubMed · Cited by 2

Controlled Drug Delivery via the Nasal Route

Conway, B. R., & Ghori, M. U. (2021) · doi:10.1002/9781119769644.ch16 · Cited by 2

Intranasal carvacrol nanoemulsion: Stroke imaging and neuroprotective study

Mahajan, H. S., & Girnar, G. (2025) · ADMET & DMPK · doi:10.5599/admet.2967 · Cited by 1

Intranasal nanoemulsion for targeted medication delivery to the brain: a novel approach to treat psychotic disorder

Das, S., Sarkar, M., Bagchi, A., & Bahadur, S. (2026) · Drug Delivery and Translational Research · doi:10.1007/s13346-026-02054-4 · Cited by 1

In Vitro and In Vivo Evaluation of Quetiapine Fumarate Nanoemulsion for Brain Targeting Through Intranasal Route

Priya, S., Sequira, S., Shetty, S. S., Jyothi, D., James, J. P., Koland, M., & Merugumolu, V. K. (2024) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.1352

DEVELOPMENT AND CHARACTERIZATION OF QUETIAPINE NANOEMULSION: A COMPREHENSIVE REVIEW OF FORMULATION STRATEGIES, CHARACTERIZATION TECHNIQUES, BRAIN TARGETING, AND THERAPEUTIC APPLICATIONS

B. Premkumar*, D. D. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.21702229

Brain Targeting of Quetiapine Fumarate via Intranasal Delivery of Loaded Lipospheres: Fabrication, In-Vitro Evaluation, Optimization, and In-Vivo Assessment

Zaki, R. M., Aldawsari, M. F., Alossaimi, M. A., Alzaid, S. F., Seshadri, V. D., Almurshedi, A. S., Aldosari, B. N., Yusif, R. M., & Sayed, O. M. (2022) · Pharmaceuticals · doi:10.3390/ph15091083 · Cited by 12

Quetiapine Fumarate Loaded Mucoadhesive Nanoemulsion: Formulation, Optimization & Brain Delivery via Intranasal Administration

Setia, A., & Ahlawat, S. (2017) · Drug Delivery Letters · doi:10.2174/2210303106666160808113114 · Cited by 4

Non-invasive intranasal delivery of quetiapine fumarate loaded microemulsion for brain targeting: Formulation, physicochemical and pharmacokinetic consideration

Shah, B. M., Khunt, D., Misra, M., & Padh, H. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.05.008 · Cited by 93