Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

Bourganis, Vassilis; Kammona, Olga; Alexopoulos, Aleck; Kiparissides, Costas

doi:10.1016/j.ejpb.2018.05.009

Cited by 357Advanced Drug Delivery SystemsBarrier Structure and Function StudiesNanoparticle-Based Drug Delivery

Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

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Bourganis, Vassilis, Kammona, Olga, Alexopoulos, Aleck, Kiparissides, Costas·2018·European Journal of Pharmaceutics and Biopharmaceutics

DOI 10.1016/j.ejpb.2018.05.009

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Abstract

Central nervous system (CNS) disorders (e.g., multiple sclerosis, Alzheimer's disease, etc.) represent a growing public health issue, primarily due to the increased life expectancy and the aging population. The treatment of such disorders is notably elaborate and requires the delivery of therapeutics to the brain in appropriate amounts to elicit a pharmacological response. However, despite the major advances both in neuroscience and drug delivery research, the administration of drugs to the CNS still remains elusive. It is commonly accepted that effectiveness-related issues arise due to the inability of parenterally administered macromolecules to cross the Blood-Brain Barrier (BBB) in order to access the CNS, thus impeding their successful delivery to brain tissues. As a result, the direct Nose-to-Brain delivery has emerged as a powerful strategy to circumvent the BBB and deliver drugs to the brain. The present review article attempts to highlight the different experimental and computational approaches pursued so far to attain and enhance the direct delivery of therapeutic agents to the brain and shed some light on the underlying mechanisms involved in the pathogenesis and treatment of neurological disorders.

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Nose-to-brain drug administration pathways have advantages including increased patient compliance, high safety, ease of administration, rapid onset of action and minimized systemic exposure.
“These drug administration pathways are characterized by many advantages such as increased patient compliance, high safety, remarkable ease of administration and rapid onset of action, as well as minimized systemic exposure [7].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [7]
The human olfactory region, where olfactory and trigeminal nerve terminations are present, occupies 2-12.5 cm2, approximately 1.25-10% of the total nasal cavity surface area, and is about 60 μm thick.
“The human olfactory region, where olfactory and trigeminal nerve terminations are present, occupies 2–12.5 cm2, representing approximately 1.25–10% of the total surface area of the nasal cavity, and it is about 60 μm thick [7].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [7]

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Authors: Bourganis, V., Kammona, O., Alexopoulos, A., & Kiparissides, C.
Affiliations: Aristotle University of Thessaloniki (GR)
Centre for Research and Technology Hellas (GR)
Corresponding author: Kiparissides, Costas
ORCID: Bourganis, Vassilis
Kammona, Olga
Alexopoulos, Aleck
Kiparissides, Costas
Venue: European Journal of Pharmaceutics and Biopharmaceutics
Publisher: Elsevier BV
Published: 2018-07
Volume: 128
Pages: 337-362
ISSN: 0939-6411 (ISSN-L)
DOI: 10.1016/j.ejpb.2018.05.009
OpenAlex: W2801808920
Cited by: 357
References: 219
Citations by year: 2026: 31 · 2025: 39 · 2024: 52 · 2023: 61 · 2022: 53 · 2021: 54 · 2020: 38 · 2019: 23 · 2018: 6
FWCI: 2.63
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: European Framework Programme for Research and Innovation Horizon 2020 (721098)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: nose-to-brain delivery, blood-brain barrier, brain drug delivery, central nervous system disorders, multiple sclerosis, Alzheimer's disease, intranasal drug delivery
MeSH terms: Administration, Intranasal, Animals, Biological Transport, Blood-Brain Barrier, Brain, Central Nervous System Agents, Central Nervous System Diseases, Drug Carriers, Epithelium, Humans, Nasal Mucosa, Permeability

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