The DOI matches its Crossref record; 40 of the 42 references it cites were found in a registry or an index.
Quetiapine Nanoemulsion for Intranasal Drug Delivery: Evaluation of Brain-Targeting Efficiency
Abstract
To evaluate the possibility of improved drug delivery of quetiapine fumarate (QTP), a nanoemulsion system was developed for intranasal delivery. Effects of different HLBs of Emalex LWIS 10, PEG 400 and Transcutol P, as co-surfactants, were studied on isotropic region of pseudoternary-phase diagrams of nanoemulsion system composed of capmul MCM (CPM) as oil phase, Tween 80 as surfactant and water. Phase behaviour, globule size, transmission electron microscope (TEM) photographs and brain-targeting efficiency of quetiapine nanoemulsion were investigated. In vitro dissolution study of optimised nanoemulsion formulation, with mean diameter 144 ± 0.5 nm, showed more than twofold increase in drug release as compared with pure drug. According to results of in vivo tissue distribution study in Wistar rats, intranasal administration of QTP-loaded nanoemulsion had shorter T max compared with that of intravenous administration. Higher drug transport efficiency (DTE%) and direct nose-to-brain drug transport (DTP%) was achieved by nanoemulsion. The nanoemulsion system may be a promising strategy for brain-targeted delivery of QTP.
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In the citing paper
“Brain distribution studies demonstrated that quetiapine is transported directly into the brain after the nasal administration of quetiapine NEs.”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [70]
In the citing paper
“In vivo studies carried out on male Wistar rats following the nasal administration of NEs containing Transcutol P and propylene glycol showed shorter Tmax compared with that of intravenous administrations, as well as higher drug transport efficiency into the brain.”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [70]
Citations
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Nanoemulsion: Concepts, development and applications in drug delivery
Singh, Y., Meher, J. G., Raval, K., Khan, F. A., Chaurasia, M., Jain, N. K., & Chourasia, M. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.008 · Cited by 1,358
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Nanoemulsions for “Nose-to-Brain” Drug Delivery
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Jeong, S., Jang, J.-H., & Lee, Y. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00589-5 · Cited by 289
Metadata
- Authors
- Boche, M., & Pokharkar, V.
- Affiliations
- Bharati Vidyapeeth (Deemed to be University) (IN)
- Corresponding author
- Pokharkar, Varsha
- ORCID
- Pokharkar, Varsha
- Venue
- AAPS PharmSciTech
- Published
- 2016-05-20
- Volume
- 18
- Issue
- 3
- Pages
- 686-696
- ISSN
- 1530-9932 (ISSN-L)
- OpenAlex
- W2405573244
- Cited by
- 109
- References
- 42
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 23 · 2023: 14 · 2022: 14 · 2021: 11 · 2020: 9 · 2019: 14 · 2018: 8 · 2017: 3
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AAPS PharmSciTech (publishedVersion)
- PubMed (publishedVersion)
- Funders
- All India Council for Technical Education
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- quetiapine, nanoemulsions, intranasal drug delivery, brain drug delivery, nose-to-brain transport, pseudo-ternary phase diagram, cosurfactants, globule size, drug release, tissue distribution, antipsychotic drug delivery
- MeSH terms
- Quetiapine Fumarate, Administration, Intranasal, Animals, Brain, Chemistry, Pharmaceutical, Emulsions, Male, Particle Size, Polysorbates, Solubility, Surface-Active Agents, Tissue Distribution, Drug Delivery Systems, Rats, Wistar, Rats, Nanoparticles, Drug Liberation
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