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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

ACTH infusion impairs baroreflex sensitivity-implications for cardiovascular hypoglycemia-associated autonomic failure

Leung, Janet H, Bayomy, Omar F, Bonyhay, Istvan, Celli, Johanna, White, Jeffrey, Freeman, Roy, Adler, Gail K·2020·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/clinem/dgaa221
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Abstract

Context: Hypoglycemia attenuates cardiovascular homeostatic autonomic control. This attenuation, known as the cardiovascular component of hypoglycemia-associated autonomic failure (HAAF), is characterized most notably by decreased baroreflex sensitivity (BRS) that begins during hypoglycemia and persists until at least the next day, despite return to euglycemia. Understanding the mechanisms underlying this reduction in BRS is important because BRS attenuation is associated with increased morbidity and mortality. Objective: The objective of this work is to investigate the role of the adrenocorticotropin (ACTH)-adrenal axis in decreasing BRS. We tested the hypothesis that infusion of ACTH 1–24 (cosyntropin), as compared to placebo, would acutely suppress BRS, and that this decrease in BRS would be present the next day. Design: A double-blind, placebo-controlled, random-order, cross-over study was conducted. Setting: This study took place in a clinical research center. Participants: Participants included healthy men and women. Interventions: Interventions included an intravenous infusion of cosyntropin (70 μg/hour for 2.5 hours in the morning and again in the early afternoon) vs normal saline placebo. Main Outcome Measures: Outcome measures included BRS during and 16 hours after cosyntropin vs placebo infusions. Results: Cosyntropin infusion attenuated BRS (mm Hg/ms) as compared to placebo (baseline 17.8 ± 1.38 vs 17.0 ± 2.07; during 14.4 ± 1.43 vs 17.3 ± 1.65; and next day 14.8 ± 1.42 vs 18.9 ± 2.04; P < .05, time by treatment, analysis of variance). BRS was decreased during the final 30 minutes of the morning cosyntropin infusion as compared to baseline (P < .01) and remained suppressed the next day (16 hours after afternoon infusion) (P < .025). Placebo infusion did not significantly change BRS. Corrected QT interval was not affected. Conclusions: ACTH attenuates BRS, raising the possibility that hypoglycemia-induced increases in ACTH may contribute to the cardiovascular component of HAAF.

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Research works printed but not linked: 37

  1. Kinsley, 1996, Evidence for a hypothalamic-pituitary versus adrenal cortical effect of glycemic control on counterregulatory hormone responses to hypoglycemia in insulin-dependent diabetes mellitus, J Clin Endocrinol Metab., 81, 684
  2. Diedrich, 2002, Hypoglycemia associated autonomic failure, Clin Auton Res., 12, 358, 10.1007/s10286-002-0035-9 · DOI
  3. McGregor, 2002, Elevated endogenous cortisol reduces autonomic neuroendocrine and symptom responses to subsequent hypoglycemia, Am J Physiol Endocrinol Metab., 282, E770, 10.1152/ajpendo.00447.2001 · DOI · Paper page
  4. La Rovere, 2008, Baroreflex sensitivity: measurement and clinical implications, Ann Noninvasive Electrocardiol., 13, 191, 10.1111/j.1542-474X.2008.00219.x · DOI · Paper page
  5. Gustavson, 2008, Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man, Am J Physiol Endocrinol Metab., 294, E506, 10.1152/ajpendo.00589.2007 · DOI · Paper page
  6. McGuire, 1976, Effects of arterial versus venous sampling on analysis of glucose kinetics in man, J Appl Physiol., 41, 565, 10.1152/jappl.1976.41.4.565 · DOI · Paper page
  7. Adler, 1999, Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome, Am J Med., 106, 534, 10.1016/S0002-9343(99)00074-1 · DOI · Paper page
  8. Matthews, 1997, CRH and AVP-induced changes in synthesis and release of ACTH from the ovine fetal pituitary in vitro: negative influences of cortisol, Endocrine., 6, 293, 10.1007/BF02820506 · DOI
  9. Kubzansky, 2010, Aldosterone: a forgotten mediator of the relationship between psychological stress and heart disease, Neurosci Biobehav Rev., 34, 80, 10.1016/j.neubiorev.2009.07.005 · DOI
  10. Albiston, 1994, Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme, Mol Cell Endocrinol., 105, R11, 10.1016/0303-7207(94)90176-7 · DOI · Paper page
  11. Herman, 2016, Regulation of the hypothalamic-pituitary-adrenocortical stress response, Compr Physiol., 6, 603, 10.1002/cphy.c150015 · DOI · Paper page
  12. Korte, 2001, Corticosteroids in relation to fear, anxiety and psychopathology, Neurosci Biobehav Rev., 25, 117, 10.1016/S0149-7634(01)00002-1 · DOI · Paper page
  13. Boscaro, 1990, Inhibition of pituitary beta-endorphin by ACTH and glucocorticoids, Neuroendocrinology., 51, 561, 10.1159/000125391 · DOI
  14. Boscaro, 1988, Evidence for ultra-short loop autoregulation of adrenocorticotropin secretion in man, J Clin Endocrinol Metab., 66, 255, 10.1210/jcem-66-2-255 · DOI
  15. Nijsen, 2000, The role of the CRH type 1 receptor in autonomic responses to corticotropin-releasing hormone in the rat, Neuropsychopharmacology., 22, 388, 10.1016/S0893-133X(99)00126-8 · DOI
  16. Jiang, 2018, Local corticotropin-releasing factor signaling in the hypothalamic paraventricular nucleus, J Neurosci., 38, 1874, 10.1523/JNEUROSCI.1492-17.2017 · DOI
  17. Keller-Wood, 1988, Steroid inhibition of canine ACTH: in vivo evidence for feedback at the corticotrope, Am J Physiol., 255, E241
  18. Komesaroff, 1994, Differential glucocorticoid effects on catecholamine responses to stress, Am J Physiol., 266, E118
  19. Goldberg, 2006, Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure, Diabetes., 55, 1121, 10.2337/diabetes.55.04.06.db05-1169 · DOI
  20. Raju, 2003, Cortisol elevations comparable to those that occur during hypoglycemia do not cause hypoglycemia-associated autonomic failure, Diabetes., 52, 2083, 10.2337/diabetes.52.8.2083 · DOI
  21. Durocher, 2011, Attenuation of sympathetic baroreflex sensitivity during the onset of acute mental stress in humans, Am J Physiol Heart Circ Physiol., 300, H1788, 10.1152/ajpheart.00942.2010 · DOI
  22. Sleight, 1978, The effect of mental arithmetic on blood pressure variability and baroreflex sensitivity in man, Clin Sci Mol Med Suppl., 4, 381s
  23. Steptoe, 1989, Assessment of baroreceptor reflex function during mental stress and relaxation, Psychophysiology., 26, 140, 10.1111/j.1469-8986.1989.tb03145.x · DOI
  24. Virtanen, 2003, Anxiety and hostility are associated with reduced baroreflex sensitivity and increased beat-to-beat blood pressure variability, Psychosom Med., 65, 751, 10.1097/01.PSY.0000088760.65046.CF · DOI
  25. Adinoff, 1998, Disturbances of the stress response: the role of the HPA axis during alcohol withdrawal and abstinence, Alcohol Health Res World., 22, 67
  26. Kritikou, 2016, Sleep apnoea and the hypothalamic-pituitary-adrenal axis in men and women: effects of continuous positive airway pressure, Eur Respir J., 47, 531, 10.1183/13993003.00319-2015 · DOI
  27. Rohleder, 2006, The hypothalamic-pituitary-adrenal (HPA) axis in habitual smokers, Int J Psychophysiol., 59, 236, 10.1016/j.ijpsycho.2005.10.012 · DOI · Paper page
  28. Mancia, 1997, Smoking impairs baroreflex sensitivity in humans, Am J Physiol., 273, H1555
  29. Bär, 2006, Reduced baroreflex sensitivity in acute alcohol withdrawal syndrome and in abstained alcoholics, Drug Alcohol Depend., 85, 66, 10.1016/j.drugalcdep.2006.03.014 · DOI
  30. Mirizzi, 2013, A simple method for measuring baroreflex sensitivity holds prognostic value in heart failure, Int J Cardiol., 169, e9, 10.1016/j.ijcard.2013.08.120 · DOI
  31. De Ferrari, 2007, Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function, J Am Coll Cardiol., 50, 2285, 10.1016/j.jacc.2007.08.043 · DOI · Paper page
  32. La Rovere, 1998, Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators, Lancet., 351, 478, 10.1016/S0140-6736(97)11144-8 · DOI · Paper page
  33. Toner, 2016, Baroreflex impairment and morbidity after major surgery, Br J Anaesth., 117, 324, 10.1093/bja/aew257 · DOI
  34. Robinson, 2003, Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia, Diabetes., 52, 1469, 10.2337/diabetes.52.6.1469 · DOI · Paper page
  35. Reno, 2013, Severe hypoglycemia-induced lethal cardiac arrhythmias are mediated by sympathoadrenal activation, Diabetes., 62, 3570, 10.2337/db13-0216 · DOI
  36. Yee, 1998, Aldosterone blunts the baroreflex response in man, Clin Sci (Lond)., 95, 687, 10.1042/cs0950687 · DOI
  37. Adlan, 2018, Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men, J Physiol., 596, 4847, 10.1113/JP276644 · DOI

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Metadata

Authors
Leung, J. H., Bayomy, O. F., Bonyhay, I., Celli, J., White, J., Freeman, R., & Adler, G. K.
Affiliations
  • Division of Endocrinology and Diabetes, Virginia Mason Medical Center, Seattle, Washington
  • Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
  • Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts
ORCID
Adler, Gail K
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2020-04-30
Volume
105
Issue
7
Pages
2345-2353
ISSN
  • 0021-972X
  • 1945-7197
DOI
10.1210/clinem/dgaa221
Cited by
2
References
9
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Funders
National Center for Advancing Translational Sciences (UL1 TR001102)

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