Cited by 660Estrogen and related hormone effectsProstate Cancer Treatment and ResearchGrowth Hormone and Insulin-like Growth Factors

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Progestin regulation of cellular proliferation.

CLARKE, CHRISTINE L., SUTHERLAND, ROBERT L.·1990·Endocrine Reviews

DOI 10.1210/edrv-11-2-266

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Abstract

THE control of cellular proliferation is known to involve a delicate balance between the effects of different regulatory molecules including hormones and growth factors which provide, in the immediate environment of the cell, signals to stimulate or inhibit cellular replication (1). The past decade has seen significant progress in the identification and characterization of novel regulatory molecules, generally referred to as growth factors, and definition of their molecular mechanisms of action (2, 3). With the recent emphasis on peptide growth factors it is perhaps less well appreciated that some of the largest physiological changes (both positive and negative) in rates of growth and cell proliferation are mediated by steroid hormones. Recent studies on breast cancer cells (4) and immature rat uterus (5, 6), illustrating estrogenic control of autocrine and paracrine growth factor production, support the view that some of these steroid-induced responses are intimately linked to growth factor-mediated pathways although debate continues as to whether the growth factor response is the cause, or the consequence, of the estrogenic effect on cellular proliferation (7, 8). Generally speaking, the molecular mechanisms by which steroid hormones control proliferation are not well defined, with the most developed knowledge being in the area of estrogen action where a number of recent reviews are available (4, 9–11).

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Prior, J. C. (2018) · Climacteric · doi:10.1080/13697137.2018.1472567 · Cited by 48
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Chetrite, G. S., Pâris, J., Botella, J., et al. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(96)00094-5 · Cited by 49
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Background
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BackgroundSelf-citation
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Amplification of c-myc by Fluorescence In Situ Hybridization in a Population-Based Breast Cancer Tissue Array
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Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells
Botella, J., Duranti, E., Duc, I., et al. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90170-8 · Cited by 47
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“enced by them and their receptors (1, 2).”
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Genome-wide association study of endometrial cancer in E2C2
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Background
Progestin-mediated activation of MAPK and AKT in nuclear progesterone receptor negative breast epithelial cells: The role of membrane progesterone receptors
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Result
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“In vitro and in vivo studies have shown different actions of progestins on human tissues mediated by specific receptors [4–6].”
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Genomic and non-genomic actions of progestogens in the breast
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Background
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“that progesterone antagonized estrogen’s effects in the uterus by downregulation of cytoplasmic and nuclear estrogen receptor concentrations [44].”
Background
A complex role for the progesterone receptor in the response to vascular injury
Karas, R. H., van Eickels, M., Lydon, J. P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11374 · Cited by 44
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“the placenta, pregnant uterus, and fetal tissue may be involved in protecting developing fetuses from progesterone, since high levels of progesterone exert cytotoxic effects [18].”
Background
Dominant Expression of Progesterone Receptor Form B mRNA in Ovarian Endometriosis
Misao, R., Iwagaki, S., Fujimoto, J., Sun, W.-S., & Tamaya, T. (1999) · Hormone Research in Paediatrics · doi:10.1159/000023429 · Cited by 43
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“In the endometrium, progesterone antagonizes estrogen-mediated cell proliferation and promotes differentiation [1].”
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“Both progesterone and its receptor are necessary for successful pregnancy and birth [22-24].”
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Cloning and cellular localization of the canine progesterone receptor: co-localization with growth hormone in the mammary gland
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“Progesterone is antagonistic to estrogenmediated cell proliferation and the principal hormone that promotes differentiation [2].”
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Progesterone and reproduction in marsupials: A review
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“It is well established that progesterone inhibits endometrial cell proliferation induced by estrogens through binding to the progesterone receptor [41].”
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Regulation of aromatase and 5α-reductase by 25-hydroxyvitamin D3, 1α,25-dihydroxyvitamin D3, dexamethasone and progesterone in prostate cancer cells
Lou, Y., Murtola, T. J., & Tuohimaa, P. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.01.024 · Cited by 41
Tissue- and hormone- dependent progesterone receptor distribution in the rat uterus
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Anti-progestins suppress the growth of established tumors induced by 7,12-dimethylbenz(a)anthracene: Comparison between RU486 and a new 21-substituted-19-nor-progestin
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“Unlike its role in the uterus as a differentiation agent that opposes the proliferative actions of ER, progesterone is mitogenic in the breast (1). highest mitotic activity in breast tissue is found in the luteal phase (2,3).”
p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas
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Hypothalamic progesterone receptor-A mediates gonadotropin surges, self priming and receptivity in estrogen-primed female mice
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“The ovarian steroid hormone progesterone (Prog) is important for female reproductive functions, including ovulation, uterine and mammary gland development, maintenance of pregnancy, and sexual behavior (Clarke & Sutherland 1990, Lydon et al. 1995).”
Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma
Dran, G., Lüthy, I. A., Molinolo, A., et al. (1995) · Breast Cancer Research and Treatment · doi:10.1007/bf00668207 · Cited by 40
“As already mentioned, progestin-stimulatory effects have also been repor ted for MCF-7 and T-47D cells [2].”
BackgroundInfluential
17β-Oestradiol stimulates capacitative Ca2+ entry in human endometrial cells
Perret, S., Dockery, P., & Harvey, B. J. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00464-6 · Cited by 40
Distribution of progesterone receptor in chicken: novel target organs for progesterone and estrogen action
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Expression of Progesterone Receptor Form A and B mRNAs in Uterine Leiomyoma
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Authors: CLARKE, C. L., & SUTHERLAND, R. L.
Affiliations: Garvan Institute of Medical Research (AU)
Corresponding author: SUTHERLAND, ROBERT L.
ORCID: CLARKE, CHRISTINE L.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 1990-05
Volume: 11
Issue: 2
Pages: 266-301
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv-11-2-266
OpenAlex: W2056357500
Cited by: 650
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 12 · 2015: 18 · 2014: 12 · 2013: 15 · 2012: 21
FWCI: 10.36
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: progestins, cell proliferation, steroid hormones, growth factors, estrogen, breast cancer cells, immature uterus, autocrine and paracrine signaling, cell cycle regulation
MeSH terms: Animals, Haplorhini, Cell Division, Chickens, Humans, Progestins, Rabbits, Mice

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Progestin regulation of cellular proliferation.

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