Cited by 660Estrogen and related hormone effectsProstate Cancer Treatment and ResearchGrowth Hormone and Insulin-like Growth Factors

The DOI matches its Crossref record.

Progestin regulation of cellular proliferation.

CLARKE, CHRISTINE L., SUTHERLAND, ROBERT L.·1990·Endocrine Reviews

DOI 10.1210/edrv-11-2-266

Open this paper in CoChat — free account

Abstract

THE control of cellular proliferation is known to involve a delicate balance between the effects of different regulatory molecules including hormones and growth factors which provide, in the immediate environment of the cell, signals to stimulate or inhibit cellular replication (1). The past decade has seen significant progress in the identification and characterization of novel regulatory molecules, generally referred to as growth factors, and definition of their molecular mechanisms of action (2, 3). With the recent emphasis on peptide growth factors it is perhaps less well appreciated that some of the largest physiological changes (both positive and negative) in rates of growth and cell proliferation are mediated by steroid hormones. Recent studies on breast cancer cells (4) and immature rat uterus (5, 6), illustrating estrogenic control of autocrine and paracrine growth factor production, support the view that some of these steroid-induced responses are intimately linked to growth factor-mediated pathways although debate continues as to whether the growth factor response is the cause, or the consequence, of the estrogenic effect on cellular proliferation (7, 8). Generally speaking, the molecular mechanisms by which steroid hormones control proliferation are not well defined, with the most developed knowledge being in the area of estrogen action where a number of recent reviews are available (4, 9–11).

Integrity signals

Registry

Crossref · 10.1210/edrv-11-2-266

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 501–600 of 660

Effect of steroid hormone receptor gene variants PROGINS (Alu insertion) and PGR C/T (rs1042839) as a risk factor for recurrent pregnancy loss in Kashmiri population (North India)
Khan, N., Zargar, M. H., Ahmed, R., Godha, M., Ahmad, A., Afroze, D., & Masoodi, S. R. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15054 · Cited by 8
Effects of supplemental flaxseed on the ovarian and uterine functions of adult cycling mice
Vlčková, R., Andrejčáková, Z., Sopková, D., et al. (2022) · General Physiology and Biophysics · doi:10.4149/gpb_2022003 · Cited by 8
“Progesterone attenuates the sensitivity of cells to oestrogen by decreasing its receptor levels (Clarke and Sutherland 1990) via direct interaction of progesterone receptors (PR) and ERα (Martin 1980).”
Background
Expression of progesterone receptor B is associated with G0/G1 arrest of the cell cycle and growth inhibition in NIH3T3 cells
Horiuchi, S., Kato, K., Suga, S., et al. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.01.003 · Cited by 8
Progesterone transfer among cohabitating female big brown bats ( Eptesicus fuscus )
Greville, L. J. S., Pollock, T., Salter, J. C., et al. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.02.003 · Cited by 8
Inhibition of proliferation of T47D human breast cancer cells: Alterations in progesterone receptor and p53 tumor suppressor protein
Dinda, S., Kodali-Gali, S., Sevilla, L. M., et al. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006841413053 · Cited by 8
“Physiological functions of the human breast are influenced by a number of hormones and growth factors [1, 2].”
Background
Stimulatory and inhibitory regulation of DNA synthesis during spermatogenesis: studies in Squalus acanthias
Piferrer, F., Redding, M. W., Dubois, W., et al. (1993) · Fish Physiology and Biochemistry · doi:10.1007/bf00004578 · Cited by 8
Hormonelle Substitutionstherapie und gynäkologische Malignome
Ortmann, O., Diedrich, K., & Schulz, K. ‐. (1997) · Der Gynäkologe · doi:10.1007/pl00003039 · Cited by 8
Regional Localization of Immunoreactive c-fos and Prolactin in Human Endometrium during the Normal Menstrual Cycle
dos Reis, F. M., Ribeiro, M. F. M., & Spritzer, P. M. (1999) · Gynecologic and Obstetric Investigation · doi:10.1159/000010074 · Cited by 8
No association between the progesterone receptor gene polymorphism (+331G/a) and the risk of breast cancer: an updated meta-analysis
Qi, X., Yao, J., & Zhang, Y. (2017) · BMC Medical Genetics · doi:10.1186/s12881-017-0487-3 · Cited by 7
“Progesterone (PR) is known to regulate cell proliferation and differentiation in the female reproduction system [3].”
Background
Paradigm shift in pathophysiology of vasomotor symptoms: Effects of estradiol withdrawal and progesterone therapy
Fan, Y., Tang, R., Prior, J. C., & Chen, R. (2020) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2020.11.004 · Cited by 7
A role of progesterone and its metabolites in regulation functions of the brain
Ivanova, G. P., Николаевна, Г. Л., Литвинов, А. В., Сергеевич, Б. В., & Василенко, Л. М. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201811851129 · Cited by 7
Estrogen and progesterone regulation of cell proliferation in the endometrium of muridae and humans
Tong, W., Niklaus, A. L., Zhu, L., Pan, H., Chen, B., Aubuchon, M., Santoro, N. F., & Pollard, J. W. (2008) · Reproductive medicine and assisted reproductive techniques series · doi:10.3109/9780203091500.008 · Cited by 7
The Role of Progesterone and Its Receptor on Cyclin G1 Expression in Endometrial Carcinoma Cells
Liu, F., Gao, X., Yu, H., et al. (2012) · Reproductive Sciences · doi:10.1177/1933719112446073 · Cited by 7
“Estrogen promotes proliferation and growth of the endometrial lining while progesterone antagonizes estrogen-driven growth and promotes differentiation.(1) Once the balance between the 2 hormones is destroyed, insufficient progesterone results in unoppposed estrogen, which can lead to the development of endometrial ca…”
Background
Epithelial proliferation in the normal human breast in relation to endogenous hormones and oral contraceptive use
Johansson, C. M., Anderson, T. J., Bergström, R., Lindgren, A., & Persson, I. (1998) · The Breast · doi:10.1016/s0960-9776(98)90029-7 · Cited by 7
Transit of Rat Uterine Stromal Cells through G1 Phase of the Cell Cycle Requires Temporal and Cell-Specific Hormone-Dependent Changes on Cell Cycle Regulators
Rider, V., Thomson, E., & Seifert, C. (2003) · Endocrinology · doi:10.1210/en.2003-0890 · Cited by 7
The Female Reproductive System
Jones, R. E. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-389770-1.50007-x · Cited by 7
Progestins, Progesterone Receptors, and Breast Cancer
Horwitz, K. B., Tung, L. W., & Takimoto, G. S. (1996) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4266-6_10 · Cited by 7
Progesterone Regulated Expression of Flavin-Containing Monooxygenase 5 by the B-Isoform of Progesterone Receptors: Implications for Tamoxifen Carcinogenicity
Miller, M. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.9.2956 · Cited by 7
Estrogen Replacement Therapy in Survivors of Breast Cancer
Eden, J. (1996) · Drugs & Aging · doi:10.2165/00002512-199608020-00006 · Cited by 7
HRT and cancer risk: separating fact from fiction
Schneider, H. P. G. (1999) · Maturitas · doi:10.1016/s0378-5122(99)00065-1 · Cited by 6
“It is thought that estrogens make breast tissue more sensitive to carcinogenic influences [27] and in vitro studies have shown that estrogen increases the rate of mitosis in breast cancer cells [28].”
Background
Menopausal status, adipose tissue, and breast cancer risk: impact of estrogen replacement therapy
Eden, J. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0007 · Cited by 6
Significance of p27 as a predicting marker for medroxyprogesterone acetate therapy against endometrial endometrioid adenocarcinoma
Watanabe, J., Watanabe, K., Jobo, T., et al. (2006) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-00009577-200602001-00086 · Cited by 6
Design and development of novel inhibitors of aldo-ketoreductase 1C1 as potential lead molecules in treatment of breast cancer
Verma, P., Hassan, M. I., Singh, A. K., & Singh, I. K. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04134-0 · Cited by 7
Endometrial Morphology and Progestogens
Critchley, H. (2006) · Springer eBooks · doi:10.1007/3-540-27147-3_4 · Cited by 5
CLINICAL REVIEW 139 Endometrial Cancer: Hormonal Factors, the Perimenopausal "Window of Risk," and Isoflavones
Hale, G. E., Hughes, C. L., & Cline, J. M. (2002) · Cited by 6
Correlation of TGF-(Si Expression with Medroxiprogesterone Acetate Responsiveness in Mouse Mammary Adenocarcinomas
Elizalde, P. V., Guerra, F. K., Gravano, M., et al. (1995) · Cancer Investigation · doi:10.3109/07357909509011687 · Cited by 6
Estrogen replacement therapy in women with previously treated breast cancer
(1994) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(94)90134-1 · Cited by 6
Divergent behavior of cyclin E and its low molecular weight isoforms to progesterone-induced growth inhibition in MCF-7 cells
Ghahremani, M., Montazeri, H., Bouzari, S., et al. (2014) · Advanced Biomedical Research · doi:10.4103/2277-9175.148299 · Cited by 5
“[3,4] Contrary to proliferative effects of estrogen, progesterone can be either proliferative or differentiative in a tissue‐specific manner.[5] As an example, progesterone collaborates with estrogen in proliferation of uterus stromal but inhibits estrogen‐induced cell mitosis in the epithelium.”
Role of Progestins and Progesterone Receptors in Breast Cancer Biology
Guiochon‐Mantel, A., & Milgröm, E. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-699-7_17 · Cited by 5
Positive growth of smooth muscle in uterine horns of myostatin homozygous mutant gilt
Liu, X., Choe, H. M., Li, Z.-Y., et al. (2022) · Research in Veterinary Science · doi:10.1016/j.rvsc.2022.07.030 · Cited by 5
Hormone replacement therapy and risk of breast cancer
Ortmann, G., Schulz, K. ‐., & Diedrich, K. (2000) · Der Gynäkologe · doi:10.1007/s001290050570 · Cited by 5
ESTROGEN AND PROGESTERONE IN BREAST AND GYNECOLOGIC CANCERS
Nason, F. G., & Nelson, B. E. (1994) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(21)00628-8 · Cited by 6
Cyclical Activity and ‘Ageing’ of the Human Breast: Clues to Assessment of Risk and Strategies for Prevention
Howell, A., Anderson, E., Laidlaw, I. J., Schor, A. M., Schor, S. L., & Potten, C. S. (1994) · Springer eBooks · doi:10.1007/978-3-642-78814-7_4 · Cited by 6
The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer
Richtmann, S., Marwitz, S., Muley, T., Koistinen, H. K., Christopoulos, P., Thomas, M., Kazdal, D. N., Allgäuer, M., Winter, H., Goldmann, T., et al. (2024) · Translational research · doi:10.1016/j.trsl.2024.02.007 · Cited by 4
Stochastic model of ERK-mediated progesterone receptor translocation, clustering and transcriptional activity
Marquez‐Lago, T. T., & Steinberg, S. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-13821-x · Cited by 4
Progesteron: Genitale und extragenitale Wirkungen
Römmler, A., & Römmler, J. (2009) · Zeitschrift für Orthomolekulare Medizin · doi:10.1055/s-0029-1185983 · Cited by 4
The Ecdysteroids' Effects in the Control of Cell Proliferation and Differentiation
Siaussat, D., Porcheron, P., & Debernard, S. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9112-4_7 · Cited by 4
Molecular Pathology of Breast Cancer
Gru, A. A., & Allred, D. C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4900-3_6 · Cited by 4
An efficient and convenient approach for synthesizing norethindrone prodrugs carrying anti-cancerous, anti-inflammatory and anti-asthmatic activity via Pd Catalized Sonogashira Coupling and their simulation studies
Srivastava, S., kumar, A., Pandey, S., et al. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138014 · Cited by 4
The Female Reproductive System
Jones, R. E., & Lopez, K. H. (2006) · Elsevier eBooks · doi:10.1016/b978-0-08-050836-8.50006-8 · Cited by 4
Progesterone Receptors in Normal and Neoplastic Breast
Balleine, R. L., Mote, P. A., Hunt, S. M. N., et al. (2000) · Endocrine Oncology · doi:10.1007/978-1-59259-223-4_3 · Cited by 4
Self-citation
Hormone replacement therapy in gynecological cancer survivors
Pecorelli, S. (1998) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(97)10032-4 · Cited by 4
Isolation of Hormone Responsive Uterine Stromal Cells: An In Vitro Model for Stromal Cell Proliferation and Differentiation
Rider, V. (2005) · Humana Press eBooks · doi:10.1385/1-59259-983-4:055 · Cited by 4
Should women who have had breast cancer take hormone replacement therapy?
Eden, J. (1995) · Maturitas · doi:10.1016/0378-5122(95)00919-c · Cited by 4
Towards improved endocrine therapy for advanced breast cancer
Rubens, R. D. (1993) · Annals of Oncology · doi:10.1093/oxfordjournals.annonc.a058650 · Cited by 4
Effects of standard and low doses of estradiol on markers of endometrial receptivity in frozen-thawed embryo transfer cycles: Double-blind, randomized clinical trial
Parkpinyo, N., Thanaboonyawat, I., Prechapanich, J., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328871 · Cited by 3
“This phenomenon may be attributed to progesterone’s role in downregulating estrogen receptor concentrations and promoting the metabolic conversion of estradiol to weaker metabolites, thereby influencing the hormonal milieu favorable for implantation [30].”
Hormonal regulation of pregnancy and related behavioral changes in rabbits
Chmurska-Gąsowska, M., & Sowińska, N. (2019) · Medycyna Weterynaryjna · doi:10.21521/mw.6332 · Cited by 3
“This hormone is responsible for ovulation, differentiation of ovarian structures, development of the uterus and mammary gland, maintenance of pregnancy, as well as the behavioral aspect of reproductive activity (19, 22, 69).”
Background
Autophagy in the corpus luteum correlates with tissue growth in pregnant rats
OISHI, Y., ASAKAWA, K., ISHIWATA, Y., Shota, O. K. A., TERASHIMA, R., Sugiyama, M., Kizaki, K., Kawaminami, M., & Kurusu, S. (2024) · Journal of Reproduction and Development · doi:10.1262/jrd.2024-019 · Cited by 3
“The former can be a possible cause of the latter, because altered metabolism and circulation of P4 in dams and fetuses are associated with intra-uterine growth restriction or perinatal death in rodents [47–49].”
Background
Aberrant Proliferation of Differentiating Alveolar Cells Induces Hyperplasia in Resting Mammary Glands of SV40-TAg Transgenic Mice
Quante, T., Wegwitz, F., Abe, J., Rossi, A., Deppert, W., & Bohn, W. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00168 · Cited by 3
SINGLE NUCLEOTIDE POLYMORPHISMS IN HUMAN PROGESTERONE RECEPTOR GENE AND ITS VALUE IN MISCARRIAGE OR PRETERM DELIVERY
Kryvopustov, О. S., & Dosenko, V. (2015) · Fìzìologìčnij žurnal · doi:10.15407/fz61.02.111 · Cited by 3
Microarray expression profiling of long noncoding RNAs in the progesterone‐treated lung cancer cells
Xie, M., Lu, X., & Chen, Q. (2020) · The Journal of Gene Medicine · doi:10.1002/jgm.3215 · Cited by 3
“By contrast, progesterone (P4) is reported to inhibit tumor cell proliferation and differentiation.(5) Progestin and its derivatives are currently used as a protective therapy to counteract the pro-proliferative effects of estrogen in breast cancer and endometrial carcinoma patients.”
Background
Pituitary and mammary growth hormone in dogs
Bhatti, S. F. M. (2006) · Ghent University Academic Bibliography (Ghent University) · Cited by 4
Cell Cycle Genes in a Mouse Mammary Hyperplasia Model
Said, T. K., & Medina, D. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000023590.63974.f8 · Cited by 3
“Initiation of cell proliferation in normal mammary epithelial cells, as well as in breast cancer cells, is primarily dependent on the ovarian steroids, estrogen [(64,70) and reviewed in (69–71)] and/or progesterone [(44), reviewed in (71) and (72)] or growth factors [reviewed in (73,74)].”
Background
Analysis of epidermal growth factor receptor mRNA expression by polymerase chain reaction assay in 94 human breast adenocarcinoma tumors
Falette, N., Artagaveytia, N., Rostan, M.-C., et al. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00665968 · Cited by 3
“The control of cell proliferation in human breast cancer cells involves the interactions of several hormones and growth factors [6-9].”
Background
Correction of hormonal imbalance in patients with diffuse forms of mastopathy – the basis of pathogenetic therapy and oncoprophylaxis
Косей, Н. В. (2018) · Reproductive Endocrinology · doi:10.18370/2309-4117.2018.39.8-14 · Cited by 3
Induction of p53 and melanoma cell death is reciprocal with down‐regulation of E2F, cyclin D1 and pRB
Rieber, M., & Strasberg–Rieber, M. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980529)76:5 · Cited by 16
Lack of evidence that progesterone in ovulatory cycles causes breast cancer
Gompel, A., Seifert‐Klauss, V., Simon, J. A., & Prior, J. C. (2023) · Climacteric · doi:10.1080/13697137.2023.2249813 · Cited by 2
“…to what is known about the effect of progesterone to decrease the proliferative breast actions of estrogen receptor alpha (erα) and prevent tumor growth in mice [8, 9], and the estradiol–progesterone-facilitated expansion of breast tissue during pregnancy which is crucial for lactation.”
Background
FKBP Co-Chaperones in Steroid Receptor Complexes
Cheung‐Flynn, J., Place, S. P., Cox, M. B., Prapapanich, V., & Smith, D. F. (2007) · Springer eBooks · doi:10.1007/978-0-387-39717-7_12 · Cited by 2
Clinical Effects of Sex Steroids on the Brain
Silva, I., & Naftolin, F. N. (2007) · Elsevier eBooks · doi:10.1016/b978-012369443-0/50019-3 · Cited by 2
Effects of drospirenone/estradiol on steroid receptors and Bcl-2 in the postmenopausal endometrium
Lima, S. M. R. R., Reis, B. F., Yamada, S. S., et al. (2011) · Climacteric · doi:10.3109/13697137.2011.559604 · Cited by 2
Flutamide Influences Placental Aldo–Keto Reductase Family 1 Member C 1 ( AKR 1 C 1) Expression in Pigs
Grzesiak, M., Knapczyk‐Stwora, K., Wieciech, I., et al. (2013) · Reproduction in Domestic Animals · doi:10.1111/rda.12263 · Cited by 2
The effects of hormone therapy, estrogen therapy and tibolone on apoptosis and cyclin D1 expression in postmenopausal vaginal epithelium
Sağsöz, N., Yücel, A., Noyan, V., et al. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.11.029 · Cited by 2
“Contrary to this finding, progesterone was reported to inhibit estrogeninduced DNA synthesis and cyclin D1 in uterine epithelial cells as a result of the inhibition of the cell cycle progression in the early G1 phase [33–35].”
Chapter 4 Progestin regulation of cellular proliferation
Musgrove, E. A., & Sutherland, R. L. (1996) · Advances in oncobiology/Advances in oncobiology (Print) · doi:10.1016/s1569-254x(96)80006-9 · Cited by 2
Self-citation
Progestin Regulation of Cell Proliferation in the Breast and Endometrium
Sutherland, R. L., Lee, C. S. L., Cornish, A. L., et al. (1995) · Springer eBooks · doi:10.1007/978-3-662-09153-1_5 · Cited by 2
Self-citation
Interactions Between Estradiol and Progesterone in Normal Breast
Plu‐Bureau, G., Touraine, P. A., & MAUVAIS-JARVIS, P. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-699-7_2 · Cited by 2
Growth Factors in Murine Mammary Adenocarcinomas Induced by Progestins
Charreau, E. H., Elizalde, P. V., Guerra, F. K., et al. (1992) · Springer eBooks · doi:10.1007/978-1-4613-9208-8_19 · Cited by 2
Characterization of Canine Mammary Carcinoma using Dog-Specific cDNA arrays
Appukudige, S. R. N. (2008) · Utrecht University Repository (Utrecht University) · Cited by 2
Response to Letter to the Editor: “Progesterone Is Important for Transgender Women’s Therapy—Applying Evidence for the Benefits of Progesterone in Ciswomen”
Prior, J. C. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00524 · Cited by 2
Rationale for Estrogen With Interrupted Progestin as a New Low-Dose Hormonal Replacement Therapy
Casper, R. F., MacLusky, N. J., Vanin, C., et al. (1996) · Journal of the Society for Gynecologic Investigation · doi:10.1177/107155769600300501 · Cited by 2
Effects of progesterone therapy on serum sclerostin levels in healthy menopausal women: a 3-month randomized, placebo-controlled clinical trial
Yang, Y., Goshtasebi, A., van Lierop, A. H., Kalidasan, D., Hitchcock, C. L., & Prior, J. C. (2020) · Osteoporosis International · doi:10.1007/s00198-020-05505-x · Cited by 1
“In all mammal species, estradiol and progesterone are partner hormones acting in multiple tissues in complementary or counter-balancing ways [20].”
Background
Progesterone and not estrogens or androgens causes breast cancer
Bennink, H. J. T. C., & Stanczyk, F. Z. (2024) · Climacteric · doi:10.1080/13697137.2023.2292073 · Cited by 1
“…contradictory based on studies that show a decrease by P4 in the proliferative breast actions of erα and prevention of tumor growth in mice [23,24]. however, tumor studies in mice and other animals are irrelevant to address the cause of breast cancer since the mutations leading to breast…”
Background
CHAPTER 1 – Molecular Pharmacology of Estrogen and Progesterone Receptors
McDonnell, D. (2000) · Elsevier eBooks · doi:10.1016/b978-012453790-3/50002-0 · Cited by 1
Hormonal Regulation of Circadian Pacemaker in Ovary and Uterus
Hattori, M. (2011) · InTech eBooks · doi:10.5772/18003 · Cited by 1
“In rodents, the endometrial stroma cells undergo proliferation and decidualization in response to ovarian steroids and embryo implantation at the early stage of pregnancy (Clarke & Sutherland, 1990; Dey et al., 2004).”
Background
Progesterone Resistance and Targeting the Progesterone Receptors: A Therapeutic Approach to Endometriosis
Pullen, N. (2012) · InTech eBooks · doi:10.5772/29021 · Cited by 1
“The steroid hormone, progesterone, is a key modulator of normal reproductive function, including ovulation, uterine and mammary gland development and the neurobehavioral expression associated with sexual responsiveness (Clarke & Sutherland, 1990; Lydon et al., 1995).”
Background
Wirkungen und Stoffwechsel der wichtigsten natürlichen Sexualsteroide der Frau
Gudermann, T. (2009) · Springer eBooks · doi:10.1007/978-3-540-89760-6_2 · Cited by 1
Entwicklung und Funktion der weiblichen Fortpflanzungsorgane
Strowitzki, T. (2009) · Springer eBooks · doi:10.1007/978-3-540-89760-6_3 · Cited by 1
Progestogens
Løbo, R. A. (2000) · Elsevier eBooks · doi:10.1016/b978-012453790-3/50031-7 · Cited by 1
Why does hormonal contraception and menopausal hormonal treatment have such a small effect on breast cancer risk?
Eden, J. (2024) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.13825 · Cited by 1
Long-Term Metformin Effect on Endometrial Cancer Development Depending on Glucose Environment In Vitro
Weber, A. M., Lange, C., Jauckus, J., Strowitzki, T., & Germeyer, A. (2021) · Open Journal of Obstetrics and Gynecology · doi:10.4236/ojog.2021.119111 · Cited by 1
The Progesterone Receptor Knockout Mouse Model
Lydon, J. P., Soyal, S. M., O’Malley, B. W., & Ismail, P. M. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-102-2_9 · Cited by 1
Endocrinology of physiological and progestin-induced canine anoestrus
Beijerink, N. (2007) · Utrecht University Repository (Utrecht University) · Cited by 1
The Use of Hormone Replacement Therapy in Women Previously Treated for Breast Cancer
Eden, J., & Wren, B. G. (1996) · Springer eBooks · doi:10.1007/978-1-4612-2332-0_34 · Cited by 1
Estrogene, Gestagene und Brust
Braendle, W. (2001) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 1
Hormones, Sex Hormones
Gunnet, J. W., & Dixon, L. A. (2000) · Kirk-Othmer Encyclopedia of Chemical Technology · doi:10.1002/0471238961.19052407211414.a01 · Cited by 2
"Pesquisa dos receptores de estrógeno (RE) e do receptor da progesterona (RP) in vivo e verificação da influência destes hormônios in vitro em duas linhagens de adenomas pelomórficos"
de Carvalhosa, A. A. (2001) · doi:10.11606/t.23.2001.tde-02042004-115521 · Cited by 1
Hormonal Regulation of Endometrial Gene Expression in the Rhesus Monkey
Okulicz, W. C., Ace, C. I., Tast, J., & Longcope, C. (1999) · Springer eBooks · doi:10.1007/978-1-4612-1548-6_16 · Cited by 1
Sein et hormones
Plu‐Bureau, G., Touraine, P. A., & Kuttenn, F. (2006) · EMC - Gynécologie · doi:10.1016/s0246-1064(02)00071-3 · Cited by 1
The Actions of Steroid Hormones on Animal Cells in Culture: Mechanisms and Applications
Darbre, P. D. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-092599-8.50012-2 · Cited by 1
Hormone Replacement Therapy, the Menopause and Breast Cancer
Marsden, J. (2002) · CRC Press eBooks · doi:10.1201/b14039-14 · Cited by 1
Molecular Mechanisms Regulating Uterine Decidualization and Implantation: Cell—Cell and Cell—Extracellular Matrix Interactions
Rider, V. (1999) · Springer eBooks · doi:10.1007/978-1-4612-1548-6_23 · Cited by 1
Kallikrein gene regulation in hormone-dependent cancer cell lines
Myers, S. (2003) · Cited by 1
Letters to the Editor
Eden, J., & Wren, B. G. (1996) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-199603020-00011 · Cited by 1
10.1016/s0246-1064(19)30103-3
(2000) · Time to knit · doi:10.1016/s0246-1064(19)30103-3 · Cited by 1
Functional and Pharmacological Analysis of the A and B Forms of the Human Progesterone Receptor
Giangrande, P. H., Pollio, G., & McDonnell, D. P. (1998) · Springer eBooks · doi:10.1007/978-3-662-03689-1_10 · Cited by 1
Progesterone Receptor Isoforms : functional Selectivity and Pharmacological Targeting
Khan, J. A. (2011) · theses.fr (ABES) · doi:10.70675/d565fcfezaed8z42f4za43az5b89ba52f3ae · Cited by 1
Breast Cancer Incidence in Women Exposed to Estrogen and Estrogen-Progestin Replacement Therapy
Persson, I. R. (1996) · Springer eBooks · doi:10.1007/978-1-4612-2332-0_10 · Cited by 1
Breast Cancer Risk: Role of Somatic Breast Stem Cells
Eden, J. (2011) · Springer eBooks · doi:10.1007/978-94-007-2016-9_24
“depends upon many factors (Eden, 2003; Clarke and Sutherland, 1990; Horwitz, 2008), which include altering of local breast aromatase activity, ER function, and number and effects on the paracrine peptide regulation of ductal cells.”
Background
Participación del factor de necrosis tumoral alfa en la proliferación de carcinomas mamarios
Rivas, M. A. (2010) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Steroids as Negative Regulators of Granulosa Cell Proliferation and Differentiation
Peluso, J. J. (1994) · Springer eBooks · doi:10.1007/978-3-662-03011-0_11
Funktionen von Tuben und Uterus und ihre endokrine Steuerung
Leidenberger, F. A. (1998) · Springer eBooks · doi:10.1007/978-3-662-08108-2_4

Authors: CLARKE, C. L., & SUTHERLAND, R. L.
Affiliations: Garvan Institute of Medical Research (AU)
Corresponding author: SUTHERLAND, ROBERT L.
ORCID: CLARKE, CHRISTINE L.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 1990-05
Volume: 11
Issue: 2
Pages: 266-301
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv-11-2-266
OpenAlex: W2056357500
Cited by: 650
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 12 · 2015: 18 · 2014: 12 · 2013: 15 · 2012: 21
FWCI: 10.36
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: progestins, cell proliferation, steroid hormones, growth factors, estrogen, breast cancer cells, immature uterus, autocrine and paracrine signaling, cell cycle regulation
MeSH terms: Animals, Haplorhini, Cell Division, Chickens, Humans, Progestins, Rabbits, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Progestin regulation of cellular proliferation.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks