Cited by 660Estrogen and related hormone effectsProstate Cancer Treatment and ResearchGrowth Hormone and Insulin-like Growth Factors

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Progestin regulation of cellular proliferation.

CLARKE, CHRISTINE L., SUTHERLAND, ROBERT L.·1990·Endocrine Reviews

DOI 10.1210/edrv-11-2-266

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Abstract

THE control of cellular proliferation is known to involve a delicate balance between the effects of different regulatory molecules including hormones and growth factors which provide, in the immediate environment of the cell, signals to stimulate or inhibit cellular replication (1). The past decade has seen significant progress in the identification and characterization of novel regulatory molecules, generally referred to as growth factors, and definition of their molecular mechanisms of action (2, 3). With the recent emphasis on peptide growth factors it is perhaps less well appreciated that some of the largest physiological changes (both positive and negative) in rates of growth and cell proliferation are mediated by steroid hormones. Recent studies on breast cancer cells (4) and immature rat uterus (5, 6), illustrating estrogenic control of autocrine and paracrine growth factor production, support the view that some of these steroid-induced responses are intimately linked to growth factor-mediated pathways although debate continues as to whether the growth factor response is the cause, or the consequence, of the estrogenic effect on cellular proliferation (7, 8). Generally speaking, the molecular mechanisms by which steroid hormones control proliferation are not well defined, with the most developed knowledge being in the area of estrogen action where a number of recent reviews are available (4, 9–11).

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Background
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Background
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Background
Is Mechanically Induced Cystic Endometrial Hyperplasia (CEH) a Suitable Model for Study of Spontaneously Occurring CEH in the Uterus of the Bitch?
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Background
E1A-Mediated Repression of Progesterone Receptor-Dependent Transactivation Involves Inhibition of the Assembly of a Multisubunit Coactivation Complex
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Background
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Background
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“This results in the sequential phosphorylation of the central cell cycle regulatory molecule, pRb, and progression into S-phase (Clarke & Sutherland 1990, Tong & Pollard 2002, Doisneau-Sixou et al. 2003).”
BackgroundInfluential
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“The understanding that progestins are mediating their effects via classical regulating target genes after binding to nuclear receptors, progesterone receptors (PRs), has been commonly accepted (7).”
Background
Growth inhibition of MCF-7 human breast cancer cells by progesterone is associated with cell differentiation and phosphorylation of Akt protein
Alkhalaf, M., El‐Mowafy, A. M., & Karam, S. M. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200210000-00011 · Cited by 28
“Progestins are known to regulate the proliferation of hormone target tissues (e.g. uterus and breast) in both in vitro and in vivo systems (Clarke and Sutherland, 1990), and are used routinely as an endocrine therapy of human breast cancer (Santen et al., 1990).”
Influential
The 20-hydroxyecdysone-induced cellular arrest in G2 phase is preceded by an inhibition of cyclin expression
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“by downregulation of cytoplasmic and nuclear estrogen receptor concentrations [29].”
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Angiogenesis as a biologic and prognostic indicator in human breast carcinoma
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“Women’s health concepts today primarily focus on estradiol (E2) and its admittedly strong and important growthstimulating actions in every cell in the body (38).”
Background
Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice
Lontay, B., Bodoor, K., Sipos, A., Weitzel, D. H., Loiselle, D. R., Safi, R., Zheng, D., DeVente, J., Hickner, R. C., McDonnell, D. P., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.658120 · Cited by 27
“In accordance with this mechanism, it was reported that both ER and PR mutually regulate each others’ expression through transcriptionally controlled feedback mechanisms (19).”
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Profiling of circadian genes expressed in the uterus endometrial stromal cells of pregnant rats as revealed by DNA microarray coupled with RNA interference
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Progesterone receptor gene expression in preimplantation pig embryos
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Background
Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues
Walf, A. A., Paris, J. J., Rhodes, M. E., Simpkins, J. W., & Frye, C. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.11.081 · Cited by 26
“It is not surprising that important biological functions, such as reproduction and behaviors that may support successful reproduction (e.g. affect, cognition, stress responding), would have multiple targets and, even, interact (e.g. E2 induction of PRs).”
BackgroundInfluential
The nuclear receptor REV-ERBαrepresses the transcription ofgrowth/differentiation factor 10and15genes in rat endometrium stromal cells
Zhao, L., Isayama, K., Chen, H., Yamauchi, N., Shigeyoshi, Y., Hashimoto, S., & Hattori, M. (2016) · Physiological Reports · doi:10.14814/phy2.12663 · Cited by 23
“In rodents and humans, the uterus endometrial stromal cells (UESCs) undergo proliferation and differentiation into decidual cells in response to ovarian steroids and blastocyst implantation at the early stage of pregnancy (Clarke and Sutherland 1990; Zhang et al. 1994; Dey et al. 2004).”
Background
cAMP-Response Element-Binding 3-Like Protein 1 (CREB3L1) is Required for Decidualization and its Expression is Decreased in Women with Endometriosis
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Expression Pattern of Osteopontin in Endometrial Carcinoma: Correlation With Expression of the Adhesion Molecule CEACAM1
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“unopposed estrogenic stimulation on the basis of endometrial hyperplasias (1,34).”
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Ishida, M., Chang, K., Hirabayashi, K., Nishihara, M., & Takahashi, M. (1999) · Journal of Reproduction and Development · doi:10.1262/jrd.45.321 · Cited by 24
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Estrogen causes cell death of estrogen receptor stably transfected cells via apoptosis
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Progesterone-Growth Factor Interactions in Uterine Stromal Cells1
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Authors: CLARKE, C. L., & SUTHERLAND, R. L.
Affiliations: Garvan Institute of Medical Research (AU)
Corresponding author: SUTHERLAND, ROBERT L.
ORCID: CLARKE, CHRISTINE L.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 1990-05
Volume: 11
Issue: 2
Pages: 266-301
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv-11-2-266
OpenAlex: W2056357500
Cited by: 650
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 12 · 2015: 18 · 2014: 12 · 2013: 15 · 2012: 21
FWCI: 10.36
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: progestins, cell proliferation, steroid hormones, growth factors, estrogen, breast cancer cells, immature uterus, autocrine and paracrine signaling, cell cycle regulation
MeSH terms: Animals, Haplorhini, Cell Division, Chickens, Humans, Progestins, Rabbits, Mice

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Progestin regulation of cellular proliferation.

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