The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Structural Variants of Prolactin: Occurrence and Physiological Significance
Abstract
PROLACTIN (PRL) is one of the most versatile hormones of the pituitary gland in terms of biological actions. More than 100 different and distinct effects of the hormone have been documented (1), ranging from mammary development and initiation of lactation in mammals to osmoregulation in fishes, nesting behavior in birds, and growth and metamorphosis in amphibians. These are far in excess of the reported actions of all other adenohypophyseal hormones combined. But how does a single molecule evoke so many different responses? Studies in the last few years have shown that the hormone exists in several molecular forms, some arising from posttranslational modifications and others from genetically determined factors. Such findings have led to the suggestion that PRL is perhaps a prohormone, which is synthesized as a precursor molecule and then converted to different bioactive forms as it traverses the secretory pathway. The purpose of this review is to provide an account of the recent advances in the characterization of the molecular heterogeneity of PRL and to consider the physiological implications of the structural polymorphism of this polyfunctional hormone. Previous reviews of the subject can be found in Refs. 2–9.
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The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
GOFFIN, V., SHIVERICK, K. T., KELLY, P. A., & MARTIAL, J. A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-4-385 · Cited by 293
Corbacho, A., Martinez De La Escalera, G., & Clapp, C. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1730219 · Cited by 256
Mazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181
Prolactin and Neuroimmunomodulation: In Vitro and in Vivo Observations
CHIKANZA, I. C. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07629.x · Cited by 132
Metadata
- Authors
- SINHA, Y. N.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1995-06
- Volume
- 16
- Issue
- 3
- Pages
- 354-369
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2032516148
- Cited by
- 433
- References
- 70
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- closed
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