The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular Mechanisms of Ligand Interaction with the Gonadotropin-Releasing Hormone Receptor
Abstract
GONADOTROPIN-RELEASING hormone plays a central role in the biology of reproduction (1), and synthetic GnRH analogs have proven valuable in the treatment of a wide variety of endocrinological and nonendocrinological disorders (2–10). The decapeptide GnRH is generated in neurons of the medial basal hypothalamus through enzymatic processing of a larger precursor. Released in a pulsatile manner into the portal circulation, GnRH interacts with high-affinity receptors on the gonadotropes in the anterior pituitary, leading to the biosynthesis and release of the gonadotropins LH and FSH. The pulse-timing and concentration levels of GnRH are critical for the maintainence of gonadal steroidogenesis and for normal reproductive function. Chronic, high concentration agonist stimulation of the pituitary GnRH receptors induce regulatory changes that lead to gonadal hypoactivity. This paradoxical suppression of gonadal function in response to pharmacological levels of agonist is the basis for the utility of GnRH analogs in the treatment of gonadal-steroid sensitive tumors, such as prostate cancer.
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Cites
Equation of State Calculations by Fast Computing Machines
Metropolis, N., Rosenbluth, A. W., Rosenbluth, M. N., Teller, A. H., & Teller, E. (1953) · The Journal of Chemical Physics · doi:10.1063/1.1699114 · Cited by 37,192
A family of metabotropic glutamate receptors
Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992) · Neuron · doi:10.1016/0896-6273(92)90118-w · Cited by 940 · cited 1×
“The three classes are: the metabotropic glutamate receptors (42, 43), the secretin-calcitonin-PTH class (44–48), and the large rhodopsin-like GPCR superfamily (49, 50), of which the GnRH receptor proved to be a member.”
BackgroundCloning and functional expression of a mouse gonadotropin-releasing hormone receptor
Tsutsumi, M. (1992) · Molecular Endocrinology · doi:10.1210/me.6.7.1163 · Cited by 383
Cited by
A novel mammalian receptor for the evolutionarily conserved type II GnRH
Millar, R., Lowe, S., Conklin, D., Pawson, A., Maudsley, S., Troskie, B., Ott, T., Millar, M., Lincoln, G., Sellar, R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141048498 · Cited by 314
Self-citationActivins and Inhibins: Roles in Development, Physiology, and Disease
Namwanje, M., & Brown, C. W. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021881 · Cited by 294
GnRH signaling, the gonadotrope and endocrine control of fertility
Bliss, S. P., Navratil, A. M., Xie, J., & Roberson, M. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.04.002 · Cited by 259
GnRH pulse frequency-dependent differential regulation of LH and FSH gene expression
Thompson, I. R., & Kaiser, U. B. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.012 · Cited by 199
Jimenez-Liñan, M., Rubin, B. S., & King, J. C. (1997) · Endocrinology · doi:10.1210/endo.138.10.5454 · Cited by 140
Metadata
- Authors
- Sealfon, S. C., Weinstein, H., & Millar, R. P.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1997-04-01
- Volume
- 18
- Issue
- 2
- Pages
- 180-205
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2036423270
- Cited by
- 515
- References
- 3
- FWCI
- 20.55
- Type
- journal article
- Language
- en
- Open access
- closed
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