Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study
Abstract
Background It has been reported that women with polycystic ovary syndrome (PCOS) benefit from metformin therapy. Methods A randomized, placebo-controlled, double-blind study of obese (body mass index >30 kg/m2), oligo-/amenorrhoeic women with PCOS. Metformin (850 mg) twice daily was compared with placebo over 6 months. All received the same advice from a dietitian. The primary outcome measures were: (i) change in menstrual cycle; (ii) change in arthropometric measurements; and (iii) changes in the endocrine parameters, insulin sensitivity and lipid profile. Results A total of 143 subjects was randomized [metformin (MET) = 69; placebo (PL) = 74]. Both groups showed significant improvements in menstrual frequency [median increase (MET = 1, P Conclusions Metformin does not improve weight loss or menstrual frequency in obese patients with PCOS. Weight loss alone through lifestyle changes improves menstrual frequency.
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In Tang et al. (2006), pregnancy rates were 8.7% (6/69) on lifestyle plus metformin and 2.7% (2/74) on lifestyle plus placebo, with no significant difference.
“In another study with participants who all desired pregnancy, pregnancy rates were 8.7% (6/69) on lifestyle + metformin and 2.7% (2/74) on lifestyle + placebo, with no significant difference (Tang et al. , 2006).”
From Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis (2015) · cites this paper as Tang et al. , 2006
The remaining four studies did not report significant differences in menstruation between groups (Tang et al., 2006; Karimzadeh and Javedani, 2010; Ladson et al., 2011a, b).
“The remaining four studies did not report significant differences in menstruation betweengroups (Tang et al. , 2006; Karimzadeh and Javedani, 2010; Ladson et al. , 2011a, b).”
From Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis (2015) · cites this paper as Tang et al. , 2006
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- Authors
- Tang, T., Glanville, J., Hayden, C. J., White, D., Barth, J. H., & Balen, A. H.
- Affiliations
- Leeds General Infirmary (GB)
- Corresponding author
- Tang, Thomas
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-30
- Volume
- 21
- Issue
- 1
- Pages
- 80-89
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2137832653
- Cited by
- 335
- References
- 10
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 18 · 2019: 12 · 2018: 12 · 2017: 18 · 2016: 14 · 2015: 20 · 2014: 17 · 2013: 17 · 2012: 16
- FWCI
- 24.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, metformin, obesity, lifestyle modification, weight loss, menstrual frequency, insulin sensitivity, lipid profile, free androgen index, waist circumference
- MeSH terms
- Adult, Anthropometry, Double-Blind Method, Female, Humans, Hypoglycemic Agents, Insulin Resistance, Life Style, Lipids, Menstruation, Metformin, Obesity, Polycystic Ovary Syndrome, Pregnancy, Weight Loss, Treatment Outcome, Pregnancy Rate, Metabolic Syndrome
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