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Cited by 416

The DOI matches its Crossref record; 288 of the 288 references it cites were found in a registry or an index.

Premature Adrenarche—Normal Variant or Forerunner of Adult Disease?*

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Ibáñez, Lourdes, DiMartino-Nardi, Joan, Potau, Neus, Saenger, Paul·2000·Endocrine Reviews
DOI 10.1210/edrv.21.6.0416
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Abstract

Adrenarche is the puberty of the adrenal gland. The descriptive term pubarche indicates the appearance of pubic hair, which may be accompanied by axillary hair. This process is considered premature if it occurs before age 8 yr in girls and 9 yr in boys. The chief hormonal product of adrenarche is dehydroepiandrosterone (DHEA) and its sulfated product DHEA-S. The well documented evolution of adrenarche in primates and man is incompatible with either a neutral or harmful role for DHEA and implies most likely a positive role for some aspect of young adult pubertal maturation and developmental maturation. Premature adrenarche has no adverse effects on the onset and progression of gonadarche in final height. Both extra- and intraadrenal factors regulate adrenal androgen secretion. Recent studies have shown that premature adrenarche in childhood may have consequences such as functional ovarian hyperandrogenism, polycystic ovarian syndrome, and insulin resistance in later life, sometimes already recognizable in childhood or adolescence. Premature adrenarche may thus be a forerunner of syndrome X in some children. The association of these endocrine-metabolic abnormalities with reduced fetal growth and their genetic basis remain to be elucidated.

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Citations

Cites

Show all 288 references

Research works printed but not linked: 32

  1. Migeon, 1956, Identification and isolation of androsterone from peripheral human plasma., J Biol Chem, 218, 941, 10.1016/S0021-9258(18)65856-9 · doi:10.1016/s0021-9258(18)65856-9
  2. Oberfield, 1994, Altered sensitivity to low dose dexamethasone in a subset of patients with premature adrenarche., J Clin Endocrinol Metab, 79, 1102
  3. Endoh, 1996, The zona reticularis is the site of biosynthesis of DHEA and DHEAS in the adult human adrenal cortex., J Clin Endocrinol Metab, 81, 3558
  4. Heinrichs, 1979, Differentiation and regulation of peripheral androgen metabolism in rats and rhesus monkeys., Am J Obstet Gynecol, 135, 974
  5. Meusy-Dessolle, 1985, Plasma concentrations of testosterone, dihydrotestosterone, 4-androstenedione, dehydroepiandrosterone and oestradiol-17 in the crab-eating monkey (Macaca fascicularis) from birth to adulthood., J Reprod Fertil, 74, 347, 10.1530/jrf.0.0740347 · doi:10.1530/jrf.0.0740347
  6. Cameron, 1969, Further studies on the relationship between C19 and C21 steroid synthesis in the human adrenal gland., J Endocrinol, 45, 215, 10.1677/joe.0.0450215 · doi:10.1677/joe.0.0450215
  7. Akamine, 1980, Studies on changes in the concentration of serum adrenal androgens in pubertal twins., Acta Endocrinol (Copenh), 93, 356, 10.1530/acta.0.0930356 · doi:10.1530/acta.0.0930356
  8. Kreiner, 1979, Altersveraenderungen der menschlichen Neben-niere., Zentralbl Allg Pathol Anat, 23, 351
  9. Wathen, 1985, The relationship between prolactin, DHEAS and testosterone in normally menstruating females., Acta Endocrinol (Copenh), 109, 173, 10.1530/acta.0.1090173 · doi:10.1530/acta.0.1090173
  10. Mattila, 1985, Epidermal growth factor in human urine from birth to puberty., J Clin Endocrinol Metab, 61, 997, 10.1210/jcem-61-5-997 · doi:10.1210/jcem-61-5-997
  11. Zogopoulos, 1996, Fetal- and tumor-specific regulation of growth hormone receptor messenger RNA expression in human liver., Cancer Res, 56, 2949
  12. Lin, 1997, Growth hormone receptor messenger ribonucleic acid in normal and pathologic human adrenocortical tissues: an analysis by quantitative polymerase chain reaction technique., J Clin Endocrinol Metab, 82, 2671
  13. Ghizzoni, 1989, Adrenal steroid, cortisol, adrenocorticotropin and β-endorphin responses to human corticotropin-releasing hormone stimulation test in normal children and children with premature pubarche., J Clin Endocrinol Metab, 69, 875
  14. Chan, 1983, Measurement of N-terminal (1–76) proopiomelanocortin in human plasma: correlation with adrenocorticotropin., J Clin Endocrinol Metab, 56, 791, 10.1210/jcem-56-4-791 · doi:10.1210/jcem-56-4-791
  15. Parker, 1993, Isolation, purification, synthesis and binding of human adrenal gland cortical androgen stimulating hormone., Endocr J, 1, 441
  16. Miller, 1982, Synthesis and glycosylation of pro- opiomelanocortin by a Cushing tumor., J Clin Endocrinol Metab, 55, 441, 10.1210/jcem-55-3-441 · doi:10.1210/jcem-55-3-441
  17. Anderson, 1978, The adrenal androgen-stimulated hormone does not exist., Lancet, 2, 454
  18. Sklar, 1980, Evidence for dissociation between adrenarche and gonadarche: studies in patients with idiopathic precocious puberty, gonadal dysgenesis, isolated gonadotropin deficiency, and constitutionally delayed growth and development., J Clin Endocrinol Metab, 51, 548, 10.1210/jcem-51-3-548 · DOI · Paper page
  19. Sigurjonsdottir, 1968, Premature pubarche., Clin Pediatr (Phila), 7, 29, 10.1177/000992286800700110 · doi:10.1177/000992286800700110
  20. Liu, 1965, Prevalence of electro-encephalographic abnormalities in idiopathic precocious puberty and premature pubarche: bearing on pathogenesis and neuroendocrine regulation of puberty., J Clin Endocrinol Metab, 25, 1296, 10.1210/jcem-25-10-1296 · doi:10.1210/jcem-25-10-1296
  21. Thamdrup, 1955, Premature pubarche: a hypothalamic disorder? Report of 17 cases., Acta Endocrinol (Copenh), 18, 564, 10.1530/acta.0.0180564 · doi:10.1530/acta.0.0180564
  22. Pang, 1984, Premature adrenarche., Pediatr Adolesc Endocrinol, 13, 173
  23. Dickerman, 1984, Intraadrenal steroid concentration in man: zonal differences and developmental changes., J Clin Endocrinol Metab, 59, 1031, 10.1210/jcem-59-6-1031 · DOI
  24. Virdis, 1993, Il pubarca prematuro., Riv Ital Pediatr (IJP), 19, 569
  25. De Peretti, 1980, Le sulfate de dehydroépiandrostérone plasmatique en endocrinologie pédiatrique., Arch Fr Pediatr, 37, 27
  26. De Fazio, 1985, Acute ovarian responses to a long-acting agonist of gonadotropin-releasing hormone in ovulatory women and women with polycystic ovarian disease., Fertil Steril, 44, 453, 10.1016/S0015-0282(16)48911-9 · doi:10.1016/s0015-0282(16)48911-9
  27. Heber, 1984, The stimulatory and down-regulatory effects of a gonadotropin-releasing hormone agonist in man., J Clin Endocrinol Metab, 58, 1084, 10.1210/jcem-58-6-1084 · doi:10.1210/jcem-58-6-1084
  28. Ehrmann, 1989, A new test of combined pituitary-testicular function using the gonadotropin-releasing hormone agonist nafarelin in the differentiation of gonadotropin deficiency from delayed puberty: pilot studies., J Clin Endocrinol Metab, 69, 963, 10.1210/jcem-69-5-963 · doi:10.1210/jcem-69-5-963
  29. Vuguin, The Society for Pediatric Research, May 1–4, 1999, San Francisco, CA, Pediatr Res, 45, 99
  30. DiMartino-Nardi, Acta Paediatr Suppl, 433, 1
  31. Fine, 1991, Acanthosis nigricans., Int J Dermatol, 30, 17, 10.1111/j.1365-4362.1991.tb05872.x · doi:10.1111/j.1365-4362.1991.tb05872.x
  32. de Zegher, Horm Res, 50, 243

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Metadata

Authors
Ibáñez, L., DiMartino-Nardi, J., Potau, N., & Saenger, P.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2000-12-01
Volume
21
Issue
6
Pages
671-696
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.21.6.0416
OpenAlex
W1983183763
Cited by
416
References
288
FWCI
11.31
Type
journal article
Language
en
Open access
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Ibáñez, L., DiMartino-Nardi, J., Potau, N., & Saenger, P. (2000). Premature Adrenarche—Normal Variant or Forerunner of Adult Disease?*. Endocrine Reviews. https://doi.org/10.1210/edrv.21.6.0416

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