Cited by 396Thyroid Disorders and TreatmentsDrug Transport and Resistance MechanismsIon Transport and Channel Regulation

The DOI matches its Crossref record; 254 of the 255 references it cites were found in a registry or an index.

Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability

Open access

Hennemann, Georg, Docter, Roelof, Friesema, Edith C. H., de Jong, Marion, Krenning, Eric P., Visser, Theo J.·2001·Endocrine Reviews

DOI 10.1210/edrv.22.4.0435

Open this paper in CoChat — free account

Abstract

Although it was originally believed that thyroid hormones enter target cells by passive diffusion, it is now clear that cellular uptake is effected by carrier-mediated processes. Two stereospecific binding sites for each T4 and T3 have been detected in cell membranes and on intact cells from humans and other species. The apparent Michaelis-Menten values of the high-affinity, low-capacity binding sites for T4 and T3 are in the nanomolar range, whereas the apparent Michaelis- Menten values of the low-affinity, high-capacity binding sites are usually in the lower micromolar range. Cellular uptake of T4 and T3 by the high-affinity sites is energy, temperature, and often Na+ dependent and represents the translocation of thyroid hormone over the plasma membrane. Uptake by the low-affinity sites is not dependent on energy, temperature, and Na+ and represents binding of thyroid hormone to proteins associated with the plasma membrane. In rat erythrocytes and hepatocytes, T3 plasma membrane carriers have been tentatively identified as proteins with apparent molecular masses of 52 and 55 kDa. In different cells, such as rat erythrocytes, pituitary cells, astrocytes, and mouse neuroblastoma cells, uptake of T4 and T3 appears to be mediated largely by system L or T amino acid transporters. Efflux of T3 from different cell types is saturable, but saturable efflux of T4 has not yet been demonstrated. Saturable uptake of T4 and T3 in the brain occurs both via the blood-brain barrier and the choroid plexus-cerebrospinal fluid barrier. Thyroid hormone uptake in the intact rat and human liver is ATP dependent and rate limiting for subsequent iodothyronine metabolism. In starvation and nonthyroidal illness in man, T4 uptake in the liver is decreased, resulting in lowered plasma T3 production. Inhibition of liver T4 uptake in these conditions is explained by liver ATP depletion and increased concentrations of circulating inhibitors, such as 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, indoxyl sulfate, nonesterified fatty acids, and bilirubin. Recently, several organic anion transporters and L type amino acid transporters have been shown to facilitate plasma membrane transport of thyroid hormone. Future research should be directed to elucidate which of these and possible other transporters are of physiological significance, and how they are regulated at the molecular level.

Integrity signals

Registry

Crossref · 10.1210/edrv.22.4.0435

Cites

254 of 254 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Thyroid Gland.
Ingbar, S. H. (1965) · Archives of Internal Medicine · doi:10.1001/archinte.1965.03870060154035 · Cited by 1,745
Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins
Sato, H., Tamba, M., Ishii, T., & Bannai, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11455 · Cited by 1,111
Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)
Kanai, Y., Segawa, H., Miyamoto, K., Uchino, H., Takeda, E., & Endou, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23629 · Cited by 1,109
Protein disulphide isomerase: building bridges in protein folding
Freedman, R. B., Hirst, T. R., & Tuite, M. F. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90072-8 · Cited by 755
Molecular Identification and Characterization of Novel Members of the Human Organic Anion Transporter (OATP) Family
Tamai, I., Nezu, J., Uchino, H., Sai, Y., Oku, A., Shimane, M., & Tsuji, A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2922 · Cited by 643
A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)
Hsiang, B. C., Zhu, Y., Wang, Z., Wu, Y., Sasseville, V. G., Yang, W.-P., & Kirchgessner, T. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37161 · Cited by 638
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
König, J., Cui, Y., Nies, A. T., & KEPPLER, D. O. R. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.1.g156 · Cited by 619
Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family
Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P. J., Loffing, J., Shoemaker, C. B., & Verrey, F. (1998) · Nature · doi:10.1038/26246 · Cited by 557
Relationships between Circulating and Intracellular Thyroid Hormones: Physiological and Clinical Implications*
Larsen, P. R., Silva, J. E., & Kaplan, M. M. (1981) · Endocrine Reviews · doi:10.1210/edrv-2-1-87 · Cited by 546
Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1
Abe, T., Kakyo, M., Tokui, T., Nakagomi, R., Nishio, T., Nakai, D., Nomura, H., Unno, M., Suzuki, M., Naitoh, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17159 · Cited by 543

Flagged first, then by citations

Show all 255 references

1 of the 255 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

Beraud Th, Cruchaud, 1958, Influence du support specifique de la thyroxine sur sa penetration dans la cellule., Schweiz Med Wochenschr, 88, 105
Kaptein, 1997, Hormone specific alterations of T4, T3 and reverse T3 metabolism in ethanol abstinence in humans, Am J Physiol, 272, E191
Larsen, 1997, An update on thyroxine activation in humans., Thyroid Int, 4, 8
Krenning, 1986, Serum factors in severe non-thyroidal illness (NTI) inhibit metabolism of thyroid hormone., Ann Endocrinol (Paris), 47, 58
Cattori, 2000, Cloning of a new member of the oatp family from rat kidney, GenBank, GI, 6691171
Pizzagalli, 2000, Identification of a new human organic anion transporting polypeptide OATP-F, GenBank, GI, 8394290

Sorted by citations

Items 101–200 of 396

Clinical implications of altered thyroid status in male testicular function
Wajner, S. M., Wagner, M. S., & Maia, A. L. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000800011 · Cited by 67
The Significance of Thyroid Hormone Transporters in the Brain
Bernal, J. (2005) · Endocrinology · doi:10.1210/en.2005-0134 · Cited by 64
Mitochondrial Actions of Thyroid Hormone
Lanni, A., Moreno, M., & Goglia, F. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150019 · Cited by 71
Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes
Groeneweg, S., Peeters, R. P., Visser, T. J., & Visser, W. E. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.029 · Cited by 65
Self-citation
Salamander Paedomorphosis
Johnson, C., & Voss, S. R. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385979-2.00008-3 · Cited by 62
Iodine and thyroid hormones during pregnancy and postpartum
Pérez-López, F. R. (2007) · Gynecological Endocrinology · doi:10.1080/09513590701464092 · Cited by 63
The importance of thyroid hormone transporters for brain development and function
Heuer, H. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.003 · Cited by 61
The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N‐Tera‐2 neurodifferentiation
Chan, S., Martín-Santos, A., Loubiere, L., Gonzalez, A. M., Stieger, B., Logan, A., McCabe, C. J., Franklyn, J. A., & Kilby, M. D. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.207290 · Cited by 61
Nongenomic effect of thyroid hormone on free-radical production in human polymorphonuclear leukocytes
Mezősi, E., Szabó, J., Nagy, E. V., Borbely, A., Varga, E., Paragh, G., & Varga, Z. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05968 · Cited by 59
Levothyroxine Absorption in Morbidly Obese Patients Before and After Roux-En-Y Gastric Bypass (RYGB) Surgery
Rubio, I. G. S., Galrão, A. L., Santo, M. A., Zanini, A. C., & Medeiros-Neto, G. (2012) · Obesity Surgery · doi:10.1007/s11695-011-0452-8 · Cited by 58
Increased Thyroxine Sulfate Levels in Critically Ill Patients as a Result of a Decreased Hepatic Type I Deiodinase Activity
Peeters, R. P., Kester, M. H. A., Wouters, P. J., Kaptein, E., van Toor, H., Visser, T. J., & Van den Berghe, G. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0866 · Cited by 57
Self-citation
Thyroid Function and Mood Disorders: A Mendelian Randomization Study
Kuś, A., Kjaergaard, A. D., Marouli, E., Fabiola Del Greco, M., Sterenborg, R. B. T. M., Chaker, L., Peeters, R. P., Bednarczuk, T., Åsvold, B. O., Burgess, S., et al. (2021) · Thyroid · doi:10.1089/thy.2020.0884 · Cited by 63
Level of Thyroid-Stimulating Hormone (TSH) in Patients with Acute Schizophrenia, Unipolar Depression or Bipolar Disorder
Wysokiński, A., & Kłoszewska, I. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1305-3 · Cited by 58
Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice
Darcy, J., McFadden, S., Fang, Y., Huber, J. A., Zhang, C., Sun, L. Y., & Bartke, A. (2016) · Endocrinology · doi:10.1210/en.2016-1593 · Cited by 58
Thyroid hormone action and liver disease, a complex interplay
Marino, L., Kim, A., Ni, B., & Celi, F. S. (2023) · Hepatology · doi:10.1097/hep.0000000000000551 · Cited by 59
Transport of Iodothyronines by Human L-Type Amino Acid Transporters
Zevenbergen, C., Meima, M. E., Lima de Souza, E. C., Peeters, R. P., Kinne, A., Krause, G., Visser, W. E., & Visser, T. J. (2015) · Endocrinology · doi:10.1210/en.2015-1140 · Cited by 55
Self-citation
The Remarkable Effect of Halogen Substitution on the Membrane Transport of Fluorescent Molecules in Living Cells
Ungati, H., Govindaraj, V., & Mugesh, G. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201804128 · Cited by 55
Elevated serum triiodothyronine and intellectual and motor disability with paroxysmal dyskinesia caused by a monocarboxylate transporter 8 gene mutation
Fuchs, O., Pfarr, N., Pohlenz, J., & Schmidt, H. (2009) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2008.03125.x · Cited by 55
Hypothalamic Thyroid Hormone in Energy Balance Regulation
Herwig, A., Ross, A., Nilaweera, K. N., Morgan, P. J., & Barrett, P. (2008) · Obesity Facts · doi:10.1159/000123428 · Cited by 54
The difficult patient: drug interaction and the influence of concomitant diseases on the treatment of hypothyroidism
Ward, L. S. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000500002 · Cited by 53
Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs
Westholm, D. E., Stenehjem, D. D., Rumbley, J. N., Drewes, L. R., & Anderson, G. W. (2009) · Endocrinology · doi:10.1210/en.2008-0188 · Cited by 53
Helicobacter pyloriinfection and drugs malabsorption
Lahner, E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i30.10331 · Cited by 53
A Role for Thyroid Hormone Transporters in Transcriptional Regulation by Thyroid Hormone Receptors
Ritchie, J., Shi, Y., Hayashi, Y., Baird, F. E., Muchekehu, R. W., Christie, G. R., & Taylor, P. M. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0179 · Cited by 53
Disposition of BDE 47 in Developing Mice
Staskal, D. F., Diliberto, J. J., & Birnbaum, L. S. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj098 · Cited by 53
Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells
Ohtsuki, S., Takizawa, T., Takanaga, H., Hori, S., Hosoya, K., & Terasaki, T. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02549.x · Cited by 52
Characteristics of 3,5,3′-triiodothyronine (T3)-uptake system of tadpole red blood cells: effect of endocrine-disrupting chemicals on cellular T3 response
Shimada, N., & Yamauchi, K. (2004) · Journal of Endocrinology · doi:10.1677/joe.1.05893 · Cited by 52
Tissue uptake of thyroid hormone by amino acid transporters
Taylor, P. M., & Ritchie, J. W. A. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.002 · Cited by 51
MCT8 Deficiency: The Road to Therapies for a Rare Disease
Grijota-Martínez, C., Bárez‐López, S., Gómez‐Andrés, D., & Guadaño‐Ferraz, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00380 · Cited by 50
The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development
Mastorakos, G. P., Karoutsou, E., Mizamtsidi, M., & Creatsas, G. C. (2007) · Endocrine · doi:10.1007/s12020-007-0030-y · Cited by 50
Structure and Function of Thyroid Hormone Plasma Membrane Transporters
Schweizer, U., Johannes, J., Bayer, D., & Braun, D. (2014) · European Thyroid Journal · doi:10.1159/000367858 · Cited by 52
Steroid Hormone Entry into the Brain Requires a Membrane Transporter in Drosophila
Okamoto, N., & Yamanaka, N. (2020) · Current Biology · doi:10.1016/j.cub.2019.11.085 · Cited by 49
Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist
Li, Q., Yao, B., Zhao, S., Lu, Z., Zhang, Y., Xiang, Q., Wu, X., Yu, H., Zhang, C., Li, J., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00144 · Cited by 46
Association between ambient air pollution and thyroid hormones levels: A systematic review and meta-analysis
Liu, J., Zhao, K., Qian, T., Li, X., Yi, W., Pan, R., Huang, Y., Ji, Y., & Su, H. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166780 · Cited by 46
Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy
Wirth, E. K., Sheu, S., Chiu-Ugalde, J., Sapin, R., Klein, M., Moßbrugger, I., Quintanilla‐Martinez, L., de Angelis, M. H., Krude, H., Riebel, T., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0369 · Cited by 46
Hypothyroidism and mood disorders: integrating novel insights from brain imaging techniques
Pilhatsch, M., Marxen, M., Winter, C., Smolka, M. N., & Bauer, M. (2011) · Thyroid Research · doi:10.1186/1756-6614-4-s1-s3 · Cited by 46
Transport and Metabolism at Blood–Brain Interfaces and in Neural Cells: Relevance to Bilirubin-Induced Encephalopathy
Gazzin, S., Strazielle, N., Tiribelli, C., & Ghersi‐Egea, J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00089 · Cited by 45
Maternal-Fetal Thyroid Interactions
Ahmed, R. G. (2012) · InTech eBooks · doi:10.5772/48076 · Cited by 43
New Scoping Document on in vitro and ex vivo Assays for the Identification of Modulators of Thyroid Hormone Signalling
OECD (2014) · OECD series on testing and assessment · doi:10.1787/9789264274716-en · Cited by 45
Prognostic significance of nonthyroidal illness syndrome in critically ill adult patients with sepsis
Padhi, R. K., Kabi, S., Panda, B. N., & Jagati, S. (2018) · International Journal of Critical Illness and Injury Science · doi:10.4103/ijciis.ijciis_29_17 · Cited by 45
Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention
Shi, Y., Ritchie, J. W. A., & Taylor, P. M. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00219-x · Cited by 41
Impact of Endocrine Disruptors on the Thyroid Hormone System
Gutleb, A. C., Cambier, S., & Serchi, T. (2016) · Hormone Research in Paediatrics · doi:10.1159/000443501 · Cited by 40
Effects of tyrosine kinase inhibitors on thyroid function and thyroid hormone metabolism
Basolo, A., Matrone, A., Elisei, R., & Santini, F. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.12.008 · Cited by 43
Molecular and genetic studies suggest that thyroid hormone receptor is both necessary and sufficient to mediate the developmental effects of thyroid hormone
Das, B., Matsuda, H., Fujimoto, K., Sun, G., Matsuura, K., & Shi, Y. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.01.019 · Cited by 40
The Role of Arg445 and Asp498 in the Human Thyroid Hormone Transporter MCT8
Groeneweg, S., Friesema, E. C. H., Kersseboom, S., Klootwijk, W., Visser, W. E., Peeters, R. P., & Visser, T. J. (2013) · Endocrinology · doi:10.1210/en.2013-1521 · Cited by 39
Self-citation
Defects of Thyroid Hormone Synthesis and Action
Hannoush, Z. C., & Weiss, R. E. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.01.005 · Cited by 39
Thyroid Hormone Receptor Isoform Expression in Livers of Critically Ill Patients
Thijssen‐Timmer, D. C., Peeters, R. P., Wouters, P. J., Weekers, F., Visser, T. J., Fliers, E., Wiersinga, W. M., Bakker, O., & den Berghe, G. V. (2007) · Thyroid · doi:10.1089/thy.2006.0164 · Cited by 39
Self-citation
Expression and Function of Thyroid Hormone Transporters in the Microvillous Plasma Membrane of Human Term Placental Syncytiotrophoblast
Loubiere, L., Vasilopoulou, E., Glazier, J. D., Taylor, P. M., Franklyn, J. A., Kilby, M. D., & Chan, S. (2012) · Endocrinology · doi:10.1210/en.2012-1753 · Cited by 44
Thyroid hormone transporters in the brain
Suzuki, T., & Abe, T. (2008) · The Cerebellum · doi:10.1007/s12311-008-0029-9 · Cited by 38
Clinical and Molecular Characteristics of SLC16A2 (MCT8) Mutations in Three Families with the Allan-Herndon-Dudley Syndrome
Novara, F., Groeneweg, S., Freri, E., Estienne, M., Reho, P., Matricardi, S., Castellotti, B., Visser, W. E., Zuffardi, O., & Visser, T. J. (2016) · Human Mutation · doi:10.1002/humu.23140 · Cited by 38
Self-citation
Role for inner ring deiodination preventing transcutaneous passage of thyroxine
Santini, F., Vitti, P., Chiovato, L., Ceccarini, G., Macchia, M., Montanelli, L., Gatti, G., Rosellini, V., Mammoli, C., Martino, E., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021439 · Cited by 37
Evolution of thyroid hormone distributor proteins
McLean, T. R., Rank, M. M., Smooker, P. M., & Richardson, S. J. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.038 · Cited by 39
Tissue thyroid hormone metabolism is differentially regulated during illness in mice
Boelen, A., van der Spek, A. H., Bloise, F., de Vries, E. M., Surovtseva, O. V., van Beeren, M., Ackermans, M. T., Kwakkel, J., & Fliers, E. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0483 · Cited by 35
Thyroid Hormone Transporters and Resistance
Visser, T. J. (2013) · Endocrine development · doi:10.1159/000343695 · Cited by 35
Self-citation
Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology
Fairweather, S. J., Shah, N., & Bröer, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_584 · Cited by 37
Patterns and processes of human life history evolution
Muehlenbein, M. P., & Flinn, M. V. (2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199568765.003.0012 · Cited by 37
Thyroid Hormone Transporters in Pregnancy and Fetal Development
Chen, Z., Meima, M. E., Peeters, R. P., & Visser, W. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315113 · Cited by 35
Higher thyroid hormone receptor expression correlates with short larval periods in spadefoot toads and increases metamorphic rate
Hollar, A. R., Choi, J., Grimm, A. T., & Buchholz, D. R. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.05.013 · Cited by 34
Interleukin-12 plasmid DNA delivery using l-thyroxine-conjugated polyethylenimine nanocarriers
Dehshahri, A., Sadeghpour, H., Oskuee, R. K., Fadaei, M., Sabahi, Z., Alhashemi, S. H., & Mohazabieh, E. (2014) · Journal of Nanoparticle Research · doi:10.1007/s11051-014-2423-1 · Cited by 34
Targeting amino acids metabolic profile to identify novel metabolic characteristics in atrial fibrillation
She, J., Guo, M., Li, H., Liu, J., Liang, X., Liu, P., Zhou, B., Liu, S., Deng, Y., Lou, B., et al. (2018) · Clinical Science · doi:10.1042/cs20180247 · Cited by 34
The relationship between ingested thyroid hormones, thyroid homeostasis and iodine metabolism in humans and teleost fish
Eales, J. G. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.04.012 · Cited by 32
Perinatal exposure to diesel exhaust affects gene expression in mouse cerebrum
Tsukue, N., Watanabe, M., Kumamoto, T., Takano, H., & Takeda, K. (2009) · Archives of Toxicology · doi:10.1007/s00204-009-0459-2 · Cited by 33
Role of UDP-Glucuronosyltransferase (UGT) 2B2 in Metabolism of Triiodothyronine: Effect of Microsomal Enzyme Inducers in Sprague Dawley and UGT2B2-Deficient Fischer 344 Rats
Richardson, T. A., & Klaassen, C. D. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq125 · Cited by 32
Monocarboxylate Transporter 10 Functions as a Thyroid Hormone Transporter in Chondrocytes
Abe, S., Namba, N., Abe, M., Fujiwara, M., Aikawa, T., Kogo, M., & Ozono, K. (2012) · Endocrinology · doi:10.1210/en.2011-1713 · Cited by 33
Update of hypothyroidism and its management in Unani medicine
Alam, M. A., Quamri, M. A., Sofi, G., & Ansari, S. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2020-0121 · Cited by 31
The importance of thyroid hormone signaling during early development: Lessons from the zebrafish model
Lazcano, I., Pech-Pool, S. M., Olvera, A., García-Martínez, I., Palacios-Pérez, S., & Orozco, A. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114225 · Cited by 34
Characterization of thyroid hormone transporter expression during tissue-specific metamorphic events in Xenopus tropicalis
Connors, K. A., Korte, J. J., Anderson, G. W., & Degitz, S. J. (2010) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2010.04.015 · Cited by 31
Effect of Hypothyroidism and Hyperthyroidism on Tissue Thyroid Hormone Concentrations in Rat
Donzelli, R., Colligiani, D., Kusmic, C., Sabatini, M., Lorenzini, L., Accorroni, A., Nannipieri, M., Saba, A., Iervasi, G., & Zucchi, R. (2016) · European Thyroid Journal · doi:10.1159/000443523 · Cited by 31
Genetic variation in thyroid hormone transporters
van der Deure, W. M., Peeters, R. P., & Visser, T. J. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.006 · Cited by 31
Self-citation
Post‐translational modifications of transthyretin affect the triiodonine‐binding potential
Henze, A., Homann, T., Serteser, M., Can, Ö., Sezgin, O., Coşkun, A., Ünsal, İ., Schweigert�, F. J., & Özpınar, A. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12446 · Cited by 30
Thyroid hormone receptors are down-regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock
Lado-Abeal, J., Romero, A., Castro-Piedras, I., Rodriguez-Perez, A., & Alvarez-Escudero, J. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0376 · Cited by 29
Tissue thyroid hormones and thyronamines
Accorroni, A., Saponaro, F., & Zucchi, R. (2016) · Heart Failure Reviews · doi:10.1007/s10741-016-9553-8 · Cited by 29
Directing Traffic: Halogen‐Bond‐Mediated Membrane Transport
Govindaraj, V., Ungati, H., Jakka, S. R., Bose, S., & Mugesh, G. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201902243 · Cited by 29
Evidence for a Homodimeric Structure of Human Monocarboxylate Transporter 8
Visser, W. E., Philp, N. J., van Dijk, T. B., Klootwijk, W., Friesema, E. C. H., Jansen, J., Beesley, P. W., Ianculescu, A. G., & Visser, T. J. (2009) · Endocrinology · doi:10.1210/en.2009-0699 · Cited by 29
Self-citation
Restoration of Cardiac Tissue Thyroid Hormone Status in Experimental Hypothyroidism: A Dose-Response Study in Female Rats
Weltman, N. Y., Ojamaa, K., Savinova, O. V., Chen, Y., Schlenker, E. H., Zucchi, R., Saba, A., Colligiani, D., Pol, C. J., & Gerdes, A. M. (2013) · Endocrinology · doi:10.1210/en.2012-2087 · Cited by 29
Thyroid hormone metabolism in the brain of domestic animals
Rudas, P., Rónai, Z., & Bartha, T. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.02.032 · Cited by 29
Editorial: Local Control of the Timing of Thyroid Hormone Action in the Developing Human Brain
Zoeller, R. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0950 · Cited by 29
Interplay between thyroxin, BDNF and GABA in injured neurons
Shulga, A., & Rivera, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.007 · Cited by 28
Effects of Ethinylestradiol and the Fungicide Prochloraz on Metamorphosis and Thyroid Gland Morphology in Rana temporaria~!2009-09-28~!2010-02-25~!2010-05-17~!
Brande‐Lavridsen, N., Christensen‐Dalsgaard, J., & Korsgaard, B. (2010) · The Open Zoology Journal · doi:10.2174/1874336601003020007 · Cited by 28
Thyroid hormone transport across L-type amino acid transporters: what can molecular modelling tell us?
Krause, G., & Hinz, K. M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.03.018 · Cited by 27
Endocrine interventions in the ICU.
Ellger, B., Debaveye, Y., & den Berghe, G. V. (2005) · European journal of internal medicine · doi:10.1016/j.ejim.2004.10.014 · Cited by 26
Importance of His192 in the Human Thyroid Hormone Transporter MCT8 for Substrate Recognition
Groeneweg, S., de Souza, E. C. L., Visser, W. E., Peeters, R. P., & Visser, T. J. (2013) · Endocrinology · doi:10.1210/en.2012-2225 · Cited by 26
Self-citation
Outward-Open Model of Thyroid Hormone Transporter Monocarboxylate Transporter 8 Provides Novel Structural and Functional Insights
Groeneweg, S., de Souza, E. C. L., Meima, M. E., Peeters, R. P., Visser, W. E., & Visser, T. J. (2017) · Endocrinology · doi:10.1210/en.2017-00082 · Cited by 26
Self-citation
Cellular Uptake of Thyroid Hormones
Visser, T. J. (2016) · MDText.com, Inc. eBooks · Cited by 26
Self-citation
Expression of Organic Anion Transporting Polypeptide 1c1 and Monocarboxylate Transporter 8 in the Rat Placental Barrier and the Compensatory Response to Thyroid Dysfunction
Sun, Y., Liu, Y., Zhang, L., Yan, Y., Lin, L., Li, Y., Yan, Y.-Q., & Zu-pei, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096047 · Cited by 25
Thyroid hormone and the developing hypothalamus
Alkemade, A. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00015 · Cited by 25
Thyroid Hormone Transport by the Rat Fatty Acid Translocase
van der Putten, H. H. A. G. M., Friesema, E. C. H., Abumrad, N. A., Everts, M. E., & Visser, T. J. (2003) · Endocrinology · doi:10.1210/en.2002-220520 · Cited by 25
Self-citation
Impaired Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism and Action
Dumitrescu, A. M., & Refetoff, S. (2015) · Cited by 24
Thyroid Hormone Transporters in the Brain
Braun, D., Wirth, E. K., & Schweizer, U. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.3.173 · Cited by 24
Novel mutations in SLC16A2 associated with a less severe phenotype of MCT8 deficiency
Masnada, S., Groeneweg, S., Saletti, V., Chiapparini, L., Castellotti, B., Salsano, E., Visser, W. E., & Tonduti, D. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00464-7 · Cited by 24
Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10*
Johannes, J., Braun, D., Kinne, A., Rathmann, D., Köhrle, J., & Schweizer, U. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1037 · Cited by 23
The role and potential sites of action of thyroid hormone in timing the onset of puberty in male primates
Mann, D. R., & Plant, T. M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.082 · Cited by 23
Species-specific lipophilicity of thyroid hormones and their precursors in view of their membrane transport properties
Tóth, G., Mazák, K., Hosztafi, S., Kökösi, J., & Noszál, B. (2012) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2012.12.010 · Cited by 23
Transthyretin Is a Key Regulator of Myoblast Differentiation
Lee, E. J., Bhat, A. R., Kamli, M. R., Pokharel, S., Chun, T., Lee, Y., Nahm, S., Nam, J., Hong, S., Yang, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063627 · Cited by 24
The Targeted Inactivation of TRβ Gene in Thyroid Follicular Cells Suggests a New Mechanism of Regulation of Thyroid Hormone Production
Selmi‐Ruby, S., Bouazza, L., Obregón, M.-J., Conscience, A., Flamant, F., Samarut, J., Borson‐Chazot, F., & Rousset, B. (2013) · Endocrinology · doi:10.1210/en.2013-1435 · Cited by 23
Polychlorinated Biphenyl Congeners that Increase the Glucuronidation and Biliary Excretion of Thyroxine Are Distinct from the Congeners that Enhance the Serum Disappearance of Thyroxine
Martin, L. A., Wilson, D. T., Reuhl, K. R., Gallo, M. A., & Klaassen, C. D. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.042796 · Cited by 23
Levothyroxine treatment and gastric juice pH in humans: the proof of concept
Virili, C., Bruno, G., Santaguida, M. G., Gargano, L., Stramazzo, I., De Vito, C., Cicenia, A., Scalese, G., Porowska, B., Severi, C., et al. (2022) · Endocrine · doi:10.1007/s12020-022-03056-1 · Cited by 22
Regulation of thyroid hormone-induced development in vivo by thyroid hormone transporters and cytosolic binding proteins
Choi, J., Moskalik, C. L., Ng, A., Matter, S. F., & Buchholz, D. R. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.07.006 · Cited by 25
Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion
Kaipainen, A., Zhang, A., da Costa, R. M. G., Lucas, J. M., Marck, B. T., Matsumoto, A. M., Morrissey, C. M., True, L. D., Mostaghel, E. A., & Nelson, P. S. (2019) · The Prostate · doi:10.1002/pros.23874 · Cited by 22
Thyroid Hormone Transporters
Visser, T. J. (2007) · Hormone Research in Paediatrics · doi:10.1159/000110469 · Cited by 22
Self-citation
Is Thyroid Hormone Signaling Relevant for Vertebrate Embryogenesis?
Morvan-Dubois, G., Fini, J., & DEMENEIX, B. A. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385979-2.00013-7 · Cited by 22

Authors: Hennemann, G., Docter, R., Friesema, E. C. H., de Jong, M., Krenning, E. P., & Visser, T. J.
Affiliations: Erasmus MC (NL)
Department of Internal Medicine (R.D., E.C.H.F., T.J.V.), Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
Department of Nuclear Medicine (G.H., M.d.J., E.P.K.), Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
ORCID: Friesema, Edith C. H.
Krenning, Eric P.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2001-08-01
Volume: 22
Issue: 4
Pages: 451-476
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv.22.4.0435
OpenAlex: W2108671981
Cited by: 394
References: 255
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 14 · 2022: 12 · 2021: 8 · 2020: 14 · 2019: 19 · 2018: 13 · 2017: 16 · 2016: 21 · 2015: 17 · 2014: 18 · 2013: 23 · 2012: 15
FWCI: 2.00
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: thyroid hormone transport, plasma membrane transport, thyroid hormone uptake, triiodothyronine, thyroxine, carrier-mediated transport, system L amino acid transporter, organic anion transporters, blood-brain barrier, low T3 syndrome, starvation
MeSH terms: Animals, Binding Sites, Biological Availability, Biological Transport, Active, Brain, Carrier Proteins, Cell Membrane, Humans, Species Specificity, Starvation, Thyroid Hormones, Hepatocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks