Tissue thyroid hormone metabolism is differentially regulated during illness in mice
Open accessAbstract
Illness induces major modifications in central and peripheral thyroid hormone (TH) metabolism, so-called nonthyroidal illness syndrome (NTIS). As a result, organ-specific changes in local TH availability occur depending on the type and severity of illness. Local TH availability is of importance for the regulation of the tissue-specific TH target genes and determined by the interplay between deiodinating enzymes, TH transport and TH receptor (TR) expression. In the present study, we evaluated changes in TH transport, deiodination and TR expression, the resulting tissue TH concentrations and the expression of TH target genes in liver and muscle in three animal models of illness. We induced (1) acute systemic inflammation by intraperitoneal injection of bacterial endotoxin (LPS), (2) chronic local inflammation by a turpentine injection in the hind limb and (3) severe pneumonia and sepsis by intranasal inoculation with Streptococcus pneumoniae . We found that all aspects of peripheral TH metabolism are differentially regulated during illness, depending on the organ studied and severity of illness. In addition, tissue TH concentrations are not equally affected by the decrease in serum TH concentrations. For example, the decrease in muscle TH concentrations is less severe than the decrease observed in liver. In addition, despite lower TH concentrations in muscle in all three models, muscle T 3 action is differentially affected. These observations help to understand the complex nature of the nonthyroidal illness syndrome.
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The same observation of unaltered UCP3 and myogenin mRNA expression was made in mice with chronic inflammation and bacterial sepsis.
“The same observation was made in mice with chronic inflammation and bacterial sepsis [7].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [7]
The “Illness-induced alteration in muscle thyroid hormone metabolism” section reports unchanged muscle Myog (myogenin) mRNA in bacterial sepsis, but higher Myog expression in mice with chronic inflammation—not unchanged expression. The paper does not report UCP3 expression in the passages found (searched for UCP3 with myogenin and both illness models). No page number is available in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measuredLethal bacterial sepsis affects hepatic TH transport only marginally.
“Unexpectedly, lethal bacterial sepsis affects hepatic TH transport only marginally [7].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [7]
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- Authors
- Boelen, A., van der Spek, A. H., Bloise, F., de Vries, E. M., Surovtseva, O. V., van Beeren, M., Ackermans, M. T., Kwakkel, J., & Fliers, E.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- 1Department of Endocrinology & MetabolismLaboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- 2Department of Clinical ChemistryLaboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
- Corresponding author
- Boelen, Anita
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2017-04
- Volume
- 233
- Issue
- 1
- Pages
- 25-36
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2580359938
- Cited by
- 35
- References
- 42
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 1
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- low T3 syndrome, thyroid hormone metabolism, thyroid hormone transport, local inflammation, pneumococcal pneumonia, sepsis, liver, skeletal muscle
- MeSH terms
- Animals, Disease Models, Animal, Female, Inflammation, Iodide Peroxidase, Liver, Pneumonia, Receptors, Thyroid Hormone, Thyroid Hormones, Gene Expression, Muscle, Skeletal, Sepsis, Mice
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