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Cited by 914

The DOI matches its Crossref record; 487 of the 487 references it cites were found in a registry or an index.

Changes in Proinflammatory Cytokine Activity after Menopause

Pfeilschifter, Johannes, Köditz, Roland, Pfohl, Martin, Schatz, Helmut·2002·Endocrine Reviews
DOI 10.1210/edrv.23.1.0456
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Abstract

There is now a large body of evidence suggesting that the decline in ovarian function with menopause is associated with spontaneous increases in proinflammatory cytokines. The cytokines that have obtained the most attention are IL-1, IL-6, and TNF-α. The exact mechanisms by which estrogen interferes with cytokine activity are still incompletely known but may potentially include interactions of the ER with other transcription factors, modulation of nitric oxide activity, antioxidative effects, plasma membrane actions, and changes in immune cell function. Experimental and clinical studies strongly support a link between the increased state of proinflammatory cytokine activity and postmenopausal bone loss. Preliminary evidence suggests that these changes also might be relevant to vascular homeostasis and the development of atherosclerosis. Better knowledge of the mechanisms and the time course of these interactions may open new avenues for the prevention and treatment of some of the most prevalent and important disorders in postmenopausal women.

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Research works printed but not linked: 31

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Metadata

Authors
Pfeilschifter, J., Köditz, R., Pfohl, M., & Schatz, H.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2002-02-01
Volume
23
Issue
1
Pages
90-119
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/edrv.23.1.0456
OpenAlex
W2060551064
Cited by
914
References
487
FWCI
16.49
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Changes in Proinflammatory Cytokine Activity after Menopause. https://app.cochat.ai/papers/10.1210/edrv.23.1.0456
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Pfeilschifter, J., Köditz, R., Pfohl, M., & Schatz, H. (2002). Changes in Proinflammatory Cytokine Activity after Menopause. Endocrine Reviews. https://doi.org/10.1210/edrv.23.1.0456

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