Cited by 943Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

The DOI matches its Crossref record; 351 of the 357 references it cites were found in a registry or an index.

Androgen Receptor (AR) Coregulators: An Overview

Heinlein, Cynthia A., Chang, Chawnshang·2002·Endocrine Reviews

Open this paper in CoChat — free account

Abstract

The biological action of androgens is mediated through the androgen receptor (AR). Androgen-bound AR functions as a transcription factor to regulate genes involved in an array of physiological processes, most notably male sexual differentiation and maturation, and the maintenance of spermatogenesis. The transcriptional activity of AR is affected by coregulators that influence a number of functional properties of AR, including ligand selectivity and DNA binding capacity. As the promoter of target genes, coregulators participate in DNA modification, either directly through modification of histones or indirectly by the recruitment of chromatin-modifying complexes, as well as functioning in the recruitment of the basal transcriptional machinery. Aberrant coregulator activity due to mutation or altered expression levels may be a contributing factor in the progression of diseases related to AR activity, such as prostate cancer. AR demonstrates distinct differences in its interaction with coregulators from other steroid receptors due to differences in the functional interaction between AR domains, possibly resulting in alterations in the dynamic interactions between coregulator complexes.

Integrity signals

Registry

Crossref · 10.1210/edrv.23.2.0460

Cites

351 of 351 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Molecular basis of agonism and antagonism in the oestrogen receptor
Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS
Tsai, M., & O’Malley, B. W. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002315 · Cited by 2,887
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
Spada, A. L., Wilson, E. M., Lubahn, D. B., Harding, A., & Fischbeck, K. (1991) · Nature · doi:10.1038/352077a0 · Cited by 2,801
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,759

Show all 357 references

Sorted by citations

Items 401–500 of 943

Differently regulated androgen receptor transcriptional complex in prostate cancer compared with normal prostate
Kinoshita, M., Nakagawa, T., Shimizu, A., & Katsuoka, Y. (2005) · International Journal of Urology · doi:10.1111/j.1442-2042.2005.01093.x · Cited by 30
Androgen receptor and caveolin‐1 in prostate cancer
Bennett, N. J., Hooper, J. D., Lee, C. S., & Gobe, G. C. (2009) · IUBMB Life · doi:10.1002/iub.244 · Cited by 30
Screening of genetic and expression alterations of SRC1 gene in prostate cancer
Mäki, H. E., Waltering, K. K., Wallén, M. J., MARTIKAINEN, P. M., Tammela, T. L. J., van Weerden, W. M., Vessella, R. L., & Visakorpi, T. (2006) · The Prostate · doi:10.1002/pros.20427 · Cited by 30
Testosterone exacerbates neuronal damage following cardiac arrest and cardiopulmonary resuscitation in mouse
Nakano, T., Hurn, P. D., Herson, P. S., & Traystman, R. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.013 · Cited by 30
Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity
Kollara, A., & Brown, T. J. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.09.017 · Cited by 30
A bioinformatics-based functional analysis shows that the specifically androgen-regulated gene SARG contains an active direct repeat androgen response element in the first intron
Steketee, K., der Made, A. C. J. Z.-V., van der Korput, H. A. G. M., Houtsmuller, A. B., & Trapman, J. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01478 · Cited by 30
Biology of Castration-Recurrent Prostate Cancer
Azzouni, F. S., & Mohler, J. L. (2012) · Urologic Clinics of North America · doi:10.1016/j.ucl.2012.07.002 · Cited by 30
Modulation of infection and cell viability by testosterone in bone marrow-derived macrophages: Signaling via surface binding sites
Liu, L., Benten, W. P. M., Wang, L., Xu, H., Li, Q., Zhang, H., Guo, D., WANG, Y., Wunderlich, F. T., & Qiao, Z. (2005) · Steroids · doi:10.1016/j.steroids.2005.02.020 · Cited by 30
Identification of a Highly Conserved Domain in the Androgen Receptor That Suppresses the DNA-binding Domain-DNA Interactions
Liu, G., Wang, H., & Wang, Z. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212229200 · Cited by 31
Sex hormones receptors play a crucial role in the control of femoral and mandibular growth in newborn mice
Hernandez, R. A. M., Ohtani, J., Fujita, T., Sunagawa, H., Kawata, T., Kaku, M., Motokawa, M., & Tanne, K. (2011) · European Journal of Orthodontics · doi:10.1093/ejo/cjq124 · Cited by 29
Single-Cell RNA Sequencing Defines the Regulation of Spermatogenesis by Sertoli-Cell Androgen Signaling
Cao, C., Ma, Q., Mo, S., Ge, S., Liu, Q., Ye, J., & Gui, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.763267 · Cited by 29
Targeting the relaxin hormonal pathway in prostate cancer
Neschadim, A., Summerlee, A. J. S., & Silvertown, J. D. (2014) · International Journal of Cancer · doi:10.1002/ijc.29079 · Cited by 29
Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs
Liu, P. Y., & Veldhuis, J. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00012-3 · Cited by 29
TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC‐3
Mu, X., & Chang, C. (2003) · The Prostate · doi:10.1002/pros.10282 · Cited by 29
Self-citation
Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats
Xu, T., Shen, Y., Pink, H. M., Triantafillou, J., Stimpson, S. A., Turnbull, P., & Han, B. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.07.008 · Cited by 29
Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity
Hong, J., Kim, S. T., Tranguch, S., Smith, D. F., & Dey, S. K. (2007) · Reproduction · doi:10.1530/rep-06-0180 · Cited by 28
TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2‐mediated degradation
Chen, M., Lingadahalli, S., Narwade, N. P., Lei, K. M. K., Liu, S., Zhao, Z., Zheng, Y., Lü, Q., Tang, A. H. N., Poon, T. C. W., et al. (2022) · EMBO Reports · doi:10.15252/embr.202153468 · Cited by 28
MicroRNA-185 downregulates androgen receptor expression in the LNCaP prostate carcinoma cell line
Liu, C., CHEN, Z., HU, X., Wang, L., Li, C., Xue, J., Zhang, P., Chen, W., & JIANG, A. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3332 · Cited by 28
CDC25A Functions as a Novel Ar Corepressor in Prostate Cancer Cells
Chiu, Y., Han, H., Leung, S. C. L., Yuen, H., Chau, C.-W., Guo, Z., Qiu, Y., Chan, K., Wang, X., Wong, Y.-C., et al. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.10.070 · Cited by 28
Sesquiterpenoids from myrrh inhibit androgen receptor expression and function in human prostate cancer cells
Wang, X., Kong, F., Shen, T., Young, C. Y., Lou, H., & Yuan, H. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.219 · Cited by 28
Sorbitol dehydrogenase expression is regulated by androgens in the human prostate
Vaarala, M. H. (2010) · Oncology Reports · doi:10.3892/or_00000755 · Cited by 28
Isolation of the Novel Human Guanine Nucleotide Exchange Factor Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor (SGEF) and of C-Terminal SGEF, an N-Terminally Truncated Form of SGEF, the Expression of Which Is Regulated by Androgen in Prostate Cancer Cells
Qi, H., Fournier, A., Grenier, J., Fillion, C., Labrie, Y., & Labrie, C. (2003) · Endocrinology · doi:10.1210/en.2002-220984 · Cited by 28
Disruption of Gene Expression and Induction of Apoptosis in Prostate Cancer Cells by a DNA-Damaging Agent Tethered to an Androgen Receptor Ligand
Marquis, J. C., Hillier, S., Dinaut, A. N., Rodrigues, D., Mitra, K., Essigmann, J. M., & Croy, R. G. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.05.009 · Cited by 28
Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement
Hamilton, B. R., Lima, G., Barrett, J., Seal, L., Kolliari-Turner, A., Wang, G., Karanikolou, A., Bigard, X., Löllgen, H., Zupet, P., et al. (2021) · Sports Medicine · doi:10.1007/s40279-021-01451-8 · Cited by 30
A Small RNA Derived from RNA Coactivator SRA Blocks Steroid Receptor Signaling via Inhibition of Pus1p-Mediated Pseudouridylation of SRA: Evidence of a Novel RNA Binding Domain in the N-Terminus of Steroid Receptors
Ghosh, S. K., Patton, J. R., & Spanjaard, R. A. (2012) · Biochemistry · doi:10.1021/bi300602r · Cited by 27
Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta‐analyses
Zhang, K., Yang, X., zhang, M., Wang, C., Fang, P., Xue, M., Zhao, J., Gao, X., Pan, R. L., & Gong, P. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24502 · Cited by 30
Identification of a Novel LXXLL Motif in α-Actinin 4-spliced Isoform That Is Critical for Its Interaction with Estrogen Receptor α and Co-activators
Khurana, S., Chakraborty, S., Zhao, X., Liu, Y., Guan, D., Lam, M. C., Huang, W., Yang, S., & Kao, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.401364 · Cited by 27
Suppression of Androgen Receptor Transactivation and Prostate Cancer Cell Growth by Heterogeneous Nuclear Ribonucleoprotein A1 via Interaction with Androgen Receptor Coregulator ARA54
Yang, Z., Chang, Y., Miyamoto, H., Yeh, S., Yao, J. L., di Sant'Agnese, P. A., Tsai, M.-Y., & Chang, C. (2006) · Endocrinology · doi:10.1210/en.2006-0716 · Cited by 27
Self-citation
Androgen-related sperm storage in oviduct of Chinese Soft-Shelled Turtle in vivo during annual cycle
Liu, T., Chu, X., Huang, Y., Yang, P., Li, Q., Hu, L., Chen, H., & Chen, Q. (2016) · Scientific Reports · doi:10.1038/srep20456 · Cited by 27
Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes
Carbajal-García, A., Reyes-García, J., & Montaño, L. M. (2020) · International Journal of Endocrinology · doi:10.1155/2020/8849641 · Cited by 29
Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53
Zhang, Z.-W., Yang, Z., Zheng, Y., & Chen, Z.-D. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2009.76 · Cited by 26
Reflections on the Diseases Linked to Mutations of the Androgen Receptor
Poletti, A., Negri‐Cesi, P., & Martini, L. (2005) · Endocrine · doi:10.1385/endo:28:3:243 · Cited by 28
Altered TNSALP Expression and Phosphate Regulation Contribute to Reduced Mineralization in Mice Lacking Androgen Receptor
Kang, H., Shyr, C., Huang, C., Tsai, M., Orimo, H., Lin, P., Chang, C., & Huang, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00582-08 · Cited by 29
Self-citation
Recent progress in the development of protein–protein interaction inhibitors targeting androgen receptor–coactivator binding in prostate cancer
Biron, É., & Bédard, F. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.006 · Cited by 27
SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer
Yang, S., Song, C.-H., Van, H. T. M., Park, E., Khadka, D. B., Gong, E., Lee, K., & Cho, W. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3014103 · Cited by 26
FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor
Obendorf, M., Meyer, R., Henning, K., Mitev, Y. A., Schröder, J., Patchev, V. K., & Wolf, S. S. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.012 · Cited by 26
Specific Properties of a C-terminal Truncated Androgen Receptor Detected in Hormone Refractory Prostate Cancer
Lapouge, G., Marcias, G., Erdmann, É., Kessler, P., Cruchant, M. D., Serra, S., Bergerat, J., & Céraline, J. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-69080-3_53 · Cited by 31
Androgens and androgen receptor in prostate and ovarian malignancies
Sadar, M. D. (2003) · Frontiers in bioscience · doi:10.2741/1063 · Cited by 26
Amplification and co-regulators of androgen receptor gene in prostate cancer.
Ch, G., Iliadis, I., Peschos, D., & Charalabopoulos, K. (2009) · PubMed · Cited by 26
Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol: Implication of DNA binding and acetylation of the receptor
Harada, N., Atarashi, K., Murata, Y., Yamaji, R., Nakano, Y., & Inui, H. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.11.002 · Cited by 25
Oestradiol-induced spermatogenesis requires a functional androgen receptor
Lim, P., Allan, C. M., Notini, A. J., Axell, A.-M., Spaliviero, J. A., Jimenez, M., Davey, R. A., McManus, J. F., MacLean, H. E., Zajac, J. D., et al. (2008) · Reproduction Fertility and Development · doi:10.1071/rd08144 · Cited by 25
Review: Understanding the role of androgens and placental AR variants: Insight into steroid-dependent fetal-placental growth and development
Meakin, A. S., & Clifton, V. L. (2019) · Placenta · doi:10.1016/j.placenta.2019.03.006 · Cited by 25
Nuclear receptors in oral cancer-Emerging players in tumorigenesis
Gangwar, S. K., Kumar, A., Jose, S., Alqahtani, M. S., Abbas, M. A. E., Sethi, G., & Kunnumakkara, A. B. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215666 · Cited by 25
Dominance of functional androgen receptor allele with longer CAG repeat in hepatitis B virus-related female hepatocarcinogenesis.
Yeh, S., Chang, C.-F., Shau, W., Chen, Y.-W., Hsu, H., Lee, P., Chen, D., & Chen, P. (2002) · PubMed · Cited by 25
Self-citation
Advances in male hormone substitution therapy
Qoubaitary, A., Swerdloff, R. S., & Wang, C. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.9.1493 · Cited by 25
Protein Arginine Methyltransferase 6 Involved in Germ Cell Viability during Spermatogenesis and Down-Regulated by the Androgen Receptor
Luo, M., Li, Y., Guo, H., Lin, S., Chen, J., Ma, Q., Gu, Y., Jiang, Z., & Gui, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226186 · Cited by 25
The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications
Cadwallader, A. B., Lim, C. S., Rollins, D. E., & Botrè, F. (2011) · Journal of Analytical Toxicology · doi:10.1093/anatox/35.9.594 · Cited by 25
Androgen Physiology, Pharmacology, and Abuse
Handelsman, D. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00137-4 · Cited by 26
Identification of a Novel Testicular Orphan Receptor-4 (TR4)-associated Protein as Repressor for the Selective Suppression of TR4-mediated Transactivation*
Yang, Y., Wang, X., Dong, T., Kim, E., Lin, W.-J., & Chang, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207116200 · Cited by 25
Self-citation
An Examination of How Different Mutations at Arginine 855 of the Androgen Receptor Result in Different Androgen Insensitivity Phenotypes
Elhaji, Y. A., Wu, J. H., Gottlieb, B., Beitel, L. K., Alvarado, C., Batist, G., & Trifiro, M. A. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0023 · Cited by 25
Androgen receptor antagonists: a patent review (2008 – 2011)
Mohler, M. L., Coss, C. C., Duke, C. B., Patil, S. A., Miller, D. D., & Dalton, J. T. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.682571 · Cited by 25
The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin‐remodeling complex
Lomelı́, H., & Castillo‐Robles, J. (2016) · FEBS Letters · doi:10.1002/1873-3468.12201 · Cited by 24
Effect of Paecilomyces tenuipes Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Sprague–Dawley Rats
Choi, Y., Kim, E., Fan, M., Tang, Y., Hwang, Y. J., & Sung, S.-H. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16193764 · Cited by 24
The disruption of protein-protein interactions as a therapeutic strategy for prostate cancer
Matos, B., Howl, J., Jerónimo, C., & Fardilha, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105145 · Cited by 26
Regenerating Skeletal Muscle in the Face of Aging and Disease
Jasuja, R., & LeBrasseur, N. K. (2014) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000118 · Cited by 24
Altered Differentiation and Proliferation of Prostate Epithelium in Mice Lacking the Androgen Receptor Cofactor p44/WDR77
Gao, S., Wu, H., Wang, F., & Wang, Z. (2010) · Endocrinology · doi:10.1210/en.2009-1080 · Cited by 24
Involvement of three glutamine tracts in human androgen receptor transactivation
Harada, N., Mitani, T., Higashimura, Y., Yamaji, R., Okamoto, K., Nakano, Y., & Inui, H. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.10.003 · Cited by 24
Hepatocyte nuclear factor-3 alpha (HNF-3α) negatively regulates androgen receptor transactivation in prostate cancer cells
Lee, H. J., Hwang, M., Chattopadhyay, S., Choi, H.-S., & Lee, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.162 · Cited by 24
Targeting AR Variant–Coactivator Interactions to Exploit Prostate Cancer Vulnerabilities
Magani, F., Peacock, S. O., Rice, M. A., Martinez, M. J., Greene, A. M., Magani, P. S., Lyles, R. D. Z., Weitz, J., & Burnstein, K. L. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0280 · Cited by 25
Psoralea corylifolia L. extract ameliorates benign prostatic hyperplasia by regulating prostate cell proliferation and apoptosis
Kim, H.-J., Jin, B., & An, H. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113844 · Cited by 24
Mutual transactivational repression of Runx2 and the androgen receptor by an impairment of their normal compartmentalization
Kawate, H., Wu, Y., Ohnaka, K., & Takayanagi, R. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.11.020 · Cited by 24
Second to fourth digit ratio and prostate cancer severity
Waters, M., Rebholz, C., Wood, B., Kuske, A., McIntyre, M., & Sartor, O. (2012) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2012.46 · Cited by 24
Non-classical localization of androgen receptor in the C2C12 skeletal muscle cell line
Pronsato, L., Boland, R., & Milanesi, L. M. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.12.011 · Cited by 24
Differential regulation of steroid nuclear receptor coregulator expression between normal and neoplastic prostate epithelial cells
Heemers, H. V., Schmidt, L. J., Kidd, E., Raclaw, K. A., Regan, K. M., & Tindall, D. J. (2010) · The Prostate · doi:10.1002/pros.21130 · Cited by 23
Recent advances in nuclear receptors-mediated health benefits of blueberry
Zou, H., Ye, H., Zhang, J., & Ren, L. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154063 · Cited by 23
Targeting Nuclear Receptors in Lung Cancer—Novel Therapeutic Prospects
Gangwar, S. K., Kumar, A., Yap, K. C.-H., Jose, S., Parama, D., Sethi, G., Kumar, A. P., & Kunnumakkara, A. B. (2022) · Pharmaceuticals · doi:10.3390/ph15050624 · Cited by 23
Mechanisms of solid lipid nanoparticles-triggered signaling pathways in eukaryotic cells
Moraes-Lacerda, T., & de Jesus, M. B. (2022) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2022.112863 · Cited by 23
Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy
Qin, W., Pan, J., Bauman, W. A., & Cardozo, C. P. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-596 · Cited by 23
Testosterone and phosphodiesterase type-5 inhibitors: new strategy for preventing endothelial damage in internal and sexual medicine?
Aversa, A., Bruzziches, R., Francomano, D., Natali, M., & Lenzi, A. (2009) · Therapeutic Advances in Urology · doi:10.1177/1756287209344992 · Cited by 23
Joint effects of inflammation and androgen metabolism on prostate cancer severity
Rebbeck, T. R., Rennert, H., Walker, A. H., Panossian, S., Tran, T. V., Walker, K., Spangler, E., Patacsil‐Coomes, M., Sachdeva, R., Wein, A. J., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23687 · Cited by 23
Identification of Ube2b as a Novel Target of Androgen Receptor in Mouse Sertoli Cells1
Mou, L., Zhang, Q., Wang, Y., Zhang, Q., Sun, L., Li, C., Huang, W., Yuan, Y., Duan, Y., Diao, R., et al. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.112.103648 · Cited by 23
Mechanisms of Testosterone's Anabolic Effects on Muscle and Function: Controversies and New Insights
Bhasin, S., Wang, C., Chandra, M. R. G., Gagliano‐Jucá, T., & Jasuja, R. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf041 · Cited by 27
Lxrα Regulates the Androgen Response in Prostate Epithelium
Viennois, É., Esposito, T., Dufour, J., Pommier, A., Fabre, S., Kémény, J., Guy, L., Morel, L., Lobaccaro, J. A., & Baron, S. (2012) · Endocrinology · doi:10.1210/en.2011-1996 · Cited by 22
Toward a global characterization of the phosphoproteome in prostate cancer cells: Identification of phosphoproteins in the LNCaP cell line
Giorgianni, F., Zhao, Y., Desiderio, D. M., & Beranová-Giorgianni, Š. (2007) · Electrophoresis · doi:10.1002/elps.200600782 · Cited by 22
Androgen receptor overexpression alters binding dynamics of the receptor to chromatin and chromatin structure
Urbanucci, A., Marttila, S., Jänne, O. A., & Visakorpi, T. (2011) · The Prostate · doi:10.1002/pros.22473 · Cited by 22
Current Status of Treatment of Spinal and Bulbar Muscular Atrophy
Tanaka, F., Katsuno, M., Banno, H., Suzuki, K., Adachi, H., & Sobue, G. (2012) · Neural Plasticity · doi:10.1155/2012/369284 · Cited by 22
Krüppel-like factor 8 is a novel androgen receptor co-activator in human prostate cancer
He, H., Gu, X., Xu, W., Yang, D., Wang, X., & Su, Y. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.130 · Cited by 22
Exogenous application of estradiol to eggs unexpectedly induces male development in two turtle species with temperature-dependent sex determination
Warner, D. A., Addis, E. A., Du, W., Wibbels, T., & Janzen, F. J. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.06.008 · Cited by 22
Androgen Receptor Could Be a Potential Therapeutic Target in Patients with Advanced Hepatocellular Carcinoma
Kanda, T., Takahashi, K., Nakamura, M., Nakamoto, S., Wu, S., Haga, Y., Sasaki, R., Jiang, X., & Yokosuka, O. (2017) · Cancers · doi:10.3390/cancers9050043 · Cited by 22
Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: A comparative study
Feldkoren, B., & Andersson, S. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.12.036 · Cited by 22
Dynamic communication between androgen and coactivator: Mutually induced conformational perturbations in androgen receptor ligand‐binding domain
Xu, X. J., Yang, W., Wang, X., Li, Y., Wang, Y., & Ai, C. (2010) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22951 · Cited by 22
Regulation of the transcriptional activation of the androgen receptor by the UXT-binding protein VHL
Chen, S., Chen, K., Zhang, Q., Cheng, H., & Zhou, R. (2013) · Biochemical Journal · doi:10.1042/bj20121711 · Cited by 22
Proteomic Analysis of Androgen-Regulated Protein Expression in a Mouse Fetal Vas Deferens Cell Line
Umar, A., Luider, T. M., Berrevoets, C., Grootegoed, J. A., & Brinkmann, A. O. (2003) · Endocrinology · doi:10.1210/en.2002-220974 · Cited by 22
The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments
Venkatesh, V. S., Grossmann, M., Zajac, J. D., & Davey, R. A. (2022) · Obesity Reviews · doi:10.1111/obr.13429 · Cited by 22
Decoding the epigenetics and chromatin loop dynamics of androgen receptor-mediated transcription
Altıntaş, U. B., Seo, J.-H., Giambartolomei, C., Özturan, D., Fortunato, B. J., Nelson, G. M., Goldman, S. R., Adelman, K., Hach, F., Freedman, M. L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53758-5 · Cited by 24
Analyzing the Androgen Receptor Interactome in Prostate Cancer: Implications for Therapeutic Intervention
Dahiya, U. R., & Heemers, H. V. (2022) · Cells · doi:10.3390/cells11060936 · Cited by 20
Cardiovascular and metabolic actions of the androgens: Is testosterone a Janus-faced molecule?
Stallone, J. N., & Oloyo, A. K. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115347 · Cited by 22
Novel Interaction between the Co-chaperone Cdc37 and Rho GTPase Exchange Factor Vav3 Promotes Androgen Receptor Activity and Prostate Cancer Growth*
Wu, F., Peacock, S. O., Rao, S., Lemmon, S. K., & Burnstein, K. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390963 · Cited by 21
Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells
Yang, Y.-C., Fu, H., Hsiao, B.-L., Sobue, G., Adachi, H., Huang, F.-J., Hsuuw, Y.-D., Wei, K.-T., Chang, C., Huang, K.-E., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.122 · Cited by 21
Self-citation
Detecting the presence of hippocampus membrane androgen receptors in male SAMP8 mice and their induced synaptic plasticity
Li, S., Kang, L., Zhang, Y., Feng, B., Du, J., & Cui, H. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.005 · Cited by 22
Hormones as doping in sports
Duntas, L. H., & POPOVIC, V. M. (2012) · Endocrine · doi:10.1007/s12020-012-9794-9 · Cited by 21
Tob proteins suppress steroid hormone receptor-mediated transcriptional activation
Kawate, H., Wu, Y., Ohnaka, K., Nawata, H., & Takayanagi, R. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.10.009 · Cited by 21
Variable Expression of Nuclear Receptor Coactivator 4 (NcoA4) During Mouse Embryonic Development
Kollara, A., & Brown, T. J. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955294 · Cited by 21
Sex steroid hormone receptors in fish ovaries
Thomas, P., Tubbs, C. W., Berg, H., & Dressing, G. E. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6235-3_8 · Cited by 21
Ubiquitin-like protein modifications in prostate and breast cancer
Wu, F. (2006) · Frontiers in bioscience · doi:10.2741/2094 · Cited by 21
Soccer players awarded one or more red cards exhibit lower 2D:4D ratios
Mailhos, Á., Buunk, A. P., del Arca, D., & Vallarino, V. T. (2015) · Aggressive Behavior · doi:10.1002/ab.21638 · Cited by 24
Kinetic and Thermodynamic Characterization of Dihydrotestosterone-Induced Conformational Perturbations in Androgen Receptor Ligand-Binding Domain
Jasuja, R., Ulloor, J., Yengo, C. M., Choong, K., Istomin, A. Y., Livesay, D. R., Jacobs, D. J., Swerdloff, R. S., Mikšovská, J., Larsen, R. W., et al. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0304 · Cited by 20
Regulatory Interactions between Androgens, Hoxb5, and TGFβSignaling in Murine Lung Development
Volpe, M. V., Ramadurai, S. M., Mujahid, S., Vong, T., Brandao, M., Wang, K. T., Pham, L. D., & Nielsen, H. C. (2013) · BioMed Research International · doi:10.1155/2013/320249 · Cited by 20
Blocking hyperactive androgen receptor signaling ameliorates cardiac and renal hypertrophy in Fabry mice
Shen, J.-S., Meng, X., Wight‐Carter, M., Day, T. S., Goetsch, S. C., Forni, S., Schneider, J. W., Liu, Z.-P., & Schiffmann, R. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv070 · Cited by 20
Apolipoprotein E Induction in Syrian Hamster Testis Following Tributyltin Exposure: A Potential Mechanism of Male Infertility
Kanimozhi, V., Kandasamy, P., Kadalmani, B., Krikun, G., & Taylor, H. S. (2014) · Reproductive Sciences · doi:10.1177/1933719114522519 · Cited by 20

Authors: Heinlein, C. A., & Chang, C.
Affiliations: University of Rochester Medicine (US)
Corresponding author: Chang, Chawnshang
ORCID: Chang, Chawnshang
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2002-04-01
Volume: 23
Issue: 2
Pages: 175-200
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv.23.2.0460
OpenAlex: W2161123101
Cited by: 943
References: 357
Citations by year: 2026: 13 · 2025: 18 · 2024: 28 · 2023: 22 · 2022: 30 · 2021: 19 · 2020: 26 · 2019: 25 · 2018: 23 · 2017: 30 · 2016: 32 · 2015: 48 · 2014: 34 · 2013: 48 · 2012: 44
FWCI: 12.87
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: University of Rochester
National Institutes of Health (14642)
Medical Center, University of Rochester
National Cancer Institute (CA55639, CA-715670)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen receptor, coregulators, transcriptional regulation, androgen signaling, histone modifications, chromatin remodeling, basal transcription machinery, ligand selectivity, DNA binding, prostate cancer, steroid hormone receptors, male sexual differentiation, spermatogenesis
MeSH terms: Animals, Gene Expression Regulation, Humans, Male, Mutation, Prostatic Neoplasms, Receptors, Androgen, Transcription Factors, Transcription, Genetic, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Androgen Receptor (AR) Coregulators: An Overview

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks