Cited by 943Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

The DOI matches its Crossref record; 351 of the 357 references it cites were found in a registry or an index.

Androgen Receptor (AR) Coregulators: An Overview

Heinlein, Cynthia A., Chang, Chawnshang·2002·Endocrine Reviews

Open this paper in CoChat — free account

Abstract

The biological action of androgens is mediated through the androgen receptor (AR). Androgen-bound AR functions as a transcription factor to regulate genes involved in an array of physiological processes, most notably male sexual differentiation and maturation, and the maintenance of spermatogenesis. The transcriptional activity of AR is affected by coregulators that influence a number of functional properties of AR, including ligand selectivity and DNA binding capacity. As the promoter of target genes, coregulators participate in DNA modification, either directly through modification of histones or indirectly by the recruitment of chromatin-modifying complexes, as well as functioning in the recruitment of the basal transcriptional machinery. Aberrant coregulator activity due to mutation or altered expression levels may be a contributing factor in the progression of diseases related to AR activity, such as prostate cancer. AR demonstrates distinct differences in its interaction with coregulators from other steroid receptors due to differences in the functional interaction between AR domains, possibly resulting in alterations in the dynamic interactions between coregulator complexes.

Integrity signals

Registry

Crossref · 10.1210/edrv.23.2.0460

Cites

351 of 351 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Molecular basis of agonism and antagonism in the oestrogen receptor
Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS
Tsai, M., & O’Malley, B. W. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002315 · Cited by 2,887
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
Spada, A. L., Wilson, E. M., Lubahn, D. B., Harding, A., & Fischbeck, K. (1991) · Nature · doi:10.1038/352077a0 · Cited by 2,801
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81717-1 · Cited by 2,759

Flagged first, then by citations

Show all 357 references

6 of the 357 references couldn’t be matched to a known paper.

Sorted by citations

Androgen Receptor in Prostate Cancer
Heinlein, C. A., & Chang, C. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0032 · Cited by 1,780
Self-citation
Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex
Heemers, H. V., & Tindall, D. J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0019 · Cited by 753
Androgens and Bone
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717
Androgens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 695
Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
Yeh, S., Tsai, M.-Y., Xu, Q., Mu, X., Lardy, H. A., Huang, K., Lin, H., Yeh, S.-D., Altuwaijri, S., Zhou, X., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212474399 · Cited by 683
Self-citation
Androgen Receptor Structure, Function and Biology: From Bench to Bedside.
(2016) · Europe PMC (PubMed Central) · Cited by 623
Pharmacology of anabolic steroids
Kicman, A. T. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.165 · Cited by 578
The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions
Heinlein, C. A., & Chang, C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0070 · Cited by 568
Self-citation
Chemistry and Structural Biology of Androgen Receptor
Gao, W., Bohl, C. E., & Dalton, J. T. (2005) · Chemical Reviews · doi:10.1021/cr020456u · Cited by 527
Sex differences in lipid and lipoprotein metabolism
Palmisano, B. T., Zhu, L., Eckel, R. H., & Stafford, J. M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.008 · Cited by 551
Direct effects of sex steroid hormones on adipose tissues and obesity
Mayes, J., & Watson, G. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00152.x · Cited by 509
Non-genomic actions of androgens
Foradori, C. D., Weiser, M. J., & Handa, R. J. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.005 · Cited by 493
Nuclear Receptor Coregulators: Judges, Juries, and Executioners of Cellular Regulation
Lonard, D. M., & O’Malley, B. W. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.08.012 · Cited by 507
SUMOylation and De-SUMOylation: Wrestling with Life's Processes
Yeh, E. T. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800050200 · Cited by 469
Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells
Chang, C., Chen, Y.-T., Yeh, S., Xu, Q., Wang, R.-S., Guillou, F., Lardy, H. A., & Yeh, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307306101 · Cited by 468
Self-citation
Androgen Receptor Roles in Spermatogenesis and Fertility: Lessons from Testicular Cell-Specific Androgen Receptor Knockout Mice
Wang, R.-S., Yeh, S., Tzeng, C., & Chang, C. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0025 · Cited by 487
Self-citation
Phosphorylation‐dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
Lin, H.-K., Wang, L., Hu, Y., Altuwaijri, S., & Chang, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf406 · Cited by 450
Self-citation
Spatial and Temporal Recruitment of Androgen Receptor and Its Coactivators Involves Chromosomal Looping and Polymerase Tracking
Wang, Q., Carroll, J. S., & Brown, M. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.018 · Cited by 455
Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects
Stanczyk, F. Z., Hapgood, J. P., Winer, S., & Mishell, D. R. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1008 · Cited by 429
Androgen receptors in hormone-dependent and castration-resistant prostate cancer
Shafi, A. A., Yen, A. E., & Weigel, N. L. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.003 · Cited by 435
Sex differences and sex steroids in lung health and disease
Townsend, E. A., Miller, V. M., & Prakash, Y. S. (2012) · Endocrine Reviews · doi:10.1210/er.2010-0031 · Cited by 395
Androgen receptor: A key molecule in the progression of prostate cancer to hormone independence
Taplin, M., & Balk, S. P. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10653 · Cited by 392
Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer
Sahu, B., Laakso, M., Ovaska, K., Mirtti, T. K., Lundin, J. E., Rannikko, A. S., Sankila, A., Turunen, J.-P., Lundin, M., Konsti, J., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.328 · Cited by 399
The functional role of long non-coding RNAs and epigenetics
Cao, J. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-11 · Cited by 368
Use of doping agents, particularly anabolic steroids, in sports and society
Sjöqvist, F., Garle, M., & Rane, A. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60801-6 · Cited by 349
AR, the cell cycle, and prostate cancer
Balk, S. P., & Knudsen, K. E. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06001 · Cited by 338
Androgen deprivation therapy for prostate cancer: Current status and future prospects
Miyamoto, H., Messing, E. M., & Chang, C. (2004) · The Prostate · doi:10.1002/pros.20115 · Cited by 318
Self-citation
Subfertility and defective folliculogenesis in female mice lacking androgen receptor
Hu, Y., Wang, P., Yeh, S., Wang, R.-S., Xie, C. L., Xu, Q., Zhou, X., Chao, H., Tsai, M., & Chang, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404372101 · Cited by 316
Self-citation
Drug Insight: testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging
Bhasin, S., Calof, O. M., Storer, T. W., Lee, M. L., Mazer, N. A., Jasuja, R., Montori, V. M., Gao, W., & Dalton, J. T. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0120 · Cited by 298
Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Robinson, J. L. L., MacArthur, S., Ross-Innes, C. S., Tilley, W. D., Neal, D. E., Mills, I. G., & Carroll, J. S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.216 · Cited by 300
Molecular cell biology of androgen receptor signalling
Bennett, N. C., Gardiner, R. A., Hooper, J. D., Johnson, D. W., & Gobe, G. C. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.11.013 · Cited by 292
The Role of Hepatocyte Nuclear Factor-3α (Forkhead Box A1) and Androgen Receptor in Transcriptional Regulation of Prostatic Genes
Gao, N., Zhang, J., Rao, M. A., Case, T. C., Mirosevich, J., Wang, Y., Jin, R., Gupta, A., Rennie, P. S., & Matusik, R. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0020 · Cited by 288
Molecular Mechanisms in Spermatogenesis
Cheng, C.-Y. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09597-4 · Cited by 280
DU‐145 and PC‐3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation
Alimirah, F., Chen, J., Basrawala, Z. K., Xin, H., & Choubey, D. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.041 · Cited by 264
Androgen Receptor Is a New Potential Therapeutic Target for the Treatment of Hepatocellular Carcinoma
Ma, W., Hsu, C., Wu, M., Wu, C., Wu, C., Lai, J., Jou, Y., Chen, C.-W. D., Yeh, S., & Chang, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.046 · Cited by 253
Self-citation
Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug development
Bruno, R. D., & Njar, V. C. O. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.05.046 · Cited by 255
Development of selective androgen receptor modulators (SARMs)
Narayanan, R., Coss, C. C., & Dalton, J. T. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.013 · Cited by 251
Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease
Boese, A. C., Kim, S. C., Yin, K., Lee, J., & Hamblin, M. H. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00217.2016 · Cited by 241
Androgen receptor and androgen-dependent gene expression in lung
Mikkonen, L., Pihlajamaa, P., Sahu, B., Zhang, F., & Jänne, O. A. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.022 · Cited by 243
Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases
Zhang, X., Morrissey, C. M., Sun, S., Ketchandji, M., Nelson, P. S., True, L. D., Vakar‐Lopez, F., Vessella, R. L., & Plymate, S. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027970 · Cited by 244
Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception
Africander, D., Verhoog, N. J. D., & Hapgood, J. P. (2011) · Steroids · doi:10.1016/j.steroids.2011.03.001 · Cited by 244
Androgen‐inducible TGF‐β1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understanding paradoxical effects of androgen on human hair growth
Inui, S., Fukuzato, Y., Nakajima, T., Yoshikawa, K., & Itami, S. (2002) · The FASEB Journal · doi:10.1096/fj.02-0043fje · Cited by 239
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling
Claessens, F., Denayer, S., Tilborgh, N. V., Kerkhofs, S., Helsen, C., & Haelens, A. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06008 · Cited by 232
Increased Expression of Androgen Receptor Sensitizes Prostate Cancer Cells to Low Levels of Androgens
Waltering, K. K., Helenius, M. A., Sahu, B., Manni, V., Linja, M. J., Jänne, O. A., & Visakorpi, T. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0919 · Cited by 228
Selective androgen receptor modulators as function promoting therapies
Bhasin, S., & Jasuja, R. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832a3d79 · Cited by 223
Molecular basis of androgenetic alopecia: from androgen to paracrine mediators through dermal papilla
Inui, S., & Itami, S. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.10.015 · Cited by 221
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)
Gao, W., & Dalton, J. T. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.01.003 · Cited by 217
Triclocarban Enhances Testosterone Action: A New Type of Endocrine Disruptor?
Chen, J., Ahn, K. C., Gee, N. A., Ahmed, M. I., Dulęba, A. J., Zhao, L., Gee, S. J., Hammock, B. D., & Lasley, B. L. (2007) · Endocrinology · doi:10.1210/en.2007-1057 · Cited by 214
Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver
Chang, C., Lee, S. O., Yeh, S., & Chang, T. M. (2013) · Oncogene · doi:10.1038/onc.2013.274 · Cited by 214
Self-citation
Increased hepatic steatosis and insulin resistance in mice lacking hepatic androgen receptor
Lin, H., Yu, I.-C. I., Wang, R.-S., Chen, Y., Liu, N.-C., Altuwaijri, S., Hsu, C., Ma, W., Jokinen, J. D., Sparks, J. D., et al. (2008) · Hepatology · doi:10.1002/hep.22252 · Cited by 212
Self-citation
Androgens and androgen receptor action in skin and hair follicles
Ceruti, J. M., Leirós, G. J., & Balañá, M. E. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.009 · Cited by 219
Epidermal Growth Factor Increases Coactivation of the Androgen Receptor in Recurrent Prostate Cancer
Gregory, C. W., Fei, X., Ponguta, L. A., He, B., Bill, H. M., French, F. S., & Wilson, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307649200 · Cited by 201
Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions
Loy, C. J., Sim, K. S., & Yong, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0736237100 · Cited by 202
Involvement of Proteasome in the Dynamic Assembly of the Androgen Receptor Transcription Complex*
Kang, Z., Pirskanen, A., Jänne, O., & Palvimo, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209074200 · Cited by 204
Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma
Shi, L., Yan, P., Liang, Y., Sun, Y., Shen, J., Zhou, S., Lin, H. M., Liang, X. H., & Cai, X. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.556 · Cited by 199
Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer
Feng, Q. F., & He, B. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00858 · Cited by 202
Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects
Ferraldeschi, R., Welti, J. C., Luo, J., Attard, G., & Bono, J. S. D. (2014) · Oncogene · doi:10.1038/onc.2014.115 · Cited by 199
Androgen Receptor in Sertoli Cell Is Essential for Germ Cell Nursery and Junctional Complex Formation in Mouse Testes
Wang, R.-S., Yeh, S., Chen, L.-M., Lin, H., Zhang, C., Ni, J., Wu, C., di Sant'Agnese, P. A., Bentley, K. L. D. M., Tzeng, C., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0138 · Cited by 191
Self-citation
Suppression Versus Induction of Androgen Receptor Functions by the Phosphatidylinositol 3-Kinase/Akt Pathway in Prostate Cancer LNCaP Cells with Different Passage Numbers
Lin, H., Hu, Y., Yang, L., Altuwaijri, S., Chen, Y.-T., Kang, H., & Chang, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300676200 · Cited by 187
Self-citation
Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT*
Liao, G., Chen, L.-Y., Zhang, A., Godavarthy, A., Xia, F., Ghosh, J. C., Li, H., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206374200 · Cited by 207
Expression and Degradation of Androgen Receptor: Mechanism and Clinical Implication
Lee, D., & Chang, C. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030261 · Cited by 184
Self-citation
Integration of Regulatory Networks by NKX3-1 Promotes Androgen-Dependent Prostate Cancer Survival
Tan, P. Y., Chang, C. W., Chng, K. R., Wansa, K. D. S. A., Sung, W.-K. K., & Cheung, E. C. W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05958-11 · Cited by 180
Self-citation
Androgen receptor modulates Foxp3 expression in CD4+CD25+Foxp3+ regulatory T-cells
Walecki, M., Eisel, F., Klug, J., Baal, N., Paradowska‐Dogan, A., Wahle, E., Hackstein, H., Meinhardt, A., & Fijak, M. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-08-1323 · Cited by 183
SENP1 Enhances Androgen Receptor-Dependent Transcription through Desumoylation of Histone Deacetylase 1
Cheng, J., Wang, D., Wang, Z., & Yeh, E. T. H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.6021-6028.2004 · Cited by 173
Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor
Lin, H., Xu, Q., Yeh, S., Wang, R.-S., Sparks, J. D., & Chang, C. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1717 · Cited by 176
Self-citation
Androgen receptor signaling and mutations in prostate cancer
Koochekpour, S. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2010.89 · Cited by 167
Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy
Nedelsky, N. B., Pennuto, M., Smith, R. B., Palazzolo, I., Moore, J., Nie, Z., Neale, G. A. M., & Taylor, J. P. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.034 · Cited by 167
Involvement of androgens in ovarian health and disease
Lebbe, M., & Woodruff, T. K. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat065 · Cited by 165
Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells1
Chang, C., Lee, S. O., Wang, R.-S., Yeh, S., & Chang, T. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.113.109132 · Cited by 170
Self-citation
ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor
Yang, Z., Chang, Y.-J., Yu, I.-C., Yeh, S., Wu, C.-C., Miyamoto, H., Merry, D., Sobue, G., Chen, L., Chang, S.-S., et al. (2007) · Nature Medicine · doi:10.1038/nm1547 · Cited by 164
Self-citation
Androgen resistance
Hughes, I. A., & Deeb, A. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.11.003 · Cited by 163
Recent advances in androgen receptor action
Lee, H.-J., & Chang, C. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2309-3 · Cited by 162
Self-citation
Androgen Action in the Epididymis
Robaire, B., & Hamzeh, M. (2011) · Journal of Andrology · doi:10.2164/jandrol.111.014266 · Cited by 160
Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells
Xu, Q., Lin, H., Yeh, S., Yu, I.-C. I., Wang, R.-S., Chen, Y.-T., Zhang, C., Altuwaijri, S., Chen, L., Chuang, K., et al. (2007) · Endocrine · doi:10.1007/s12020-007-9015-0 · Cited by 160
Self-citation
Phenotypic heterogeneity of mutations in androgen receptor gene
Rajender, S., Singh, L., & Kumarasamy Thangaraj, K. (2007) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2007.00250.x · Cited by 160
Selective androgen receptor modulators in preclinical and clinical development
Narayanan, R., Mohler, M. L., Bohl, C. E., Miller, D. D., & Dalton, J. T. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06010 · Cited by 159
The hinge region regulates DNA binding, nuclear translocation, and transactivation of the androgen receptor
Haelens, A., Tanner, T., Denayer, S., Callewaert, L., & Claessens, F. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1701 · Cited by 153
Region-specific gene expression in the epididymis
Belleannée, C., Thimon, V., & Sullivan, R. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1381-0 · Cited by 164
The Biology of Human Sex Differences
Federman, D. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052529 · Cited by 153
Nuclear actin and actin‐binding proteins in the regulation of transcription and gene expression
Zheng, B., Han, M., Bernier, M., & Wen, J. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06986.x · Cited by 167
Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells
Zhang, C., Yeh, S., Chen, Y.-T., Wu, C., Chuang, K., Lin, H., Wang, R.-S., Chang, Y., Mendis-Handagama, C., Hu, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608556103 · Cited by 152
Self-citation
Ras signaling in prostate cancer progression
Weber, M. J., & Gioeli, D. G. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10683 · Cited by 153
HOXB13 Induces Growth Suppression of Prostate Cancer Cells as a Repressor of Hormone-Activated Androgen Receptor Signaling
Jung, C., Kim, R.-S., Zhang, H., Lee, S.-J., & Jeng, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1330 · Cited by 147
Proteasome Activity Is Required for Androgen Receptor Transcriptional Activity via Regulation of Androgen Receptor Nuclear Translocation and Interaction with Coregulators in Prostate Cancer Cells*
Lin, H.-K., Altuwaijri, S., Lin, W.-J., Kan, P.-Y., Collins, L., & Chang, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204751200 · Cited by 160
Self-citation
Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer
Mishra, S., Deng, J., Gowda, P. S., Rao, M. K., Lin, C.-L., Chen, C., Huang, T. H. ‐., & Sun, L. (2013) · Oncogene · doi:10.1038/onc.2013.374 · Cited by 145
Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails
Niu, Y., Chang, T.-M., Yeh, S., Ma, W., Wang, Y. Z., & Chang, C. (2010) · Oncogene · doi:10.1038/onc.2010.121 · Cited by 146
Self-citation
Androgen receptor action in hormone‐dependent and recurrent prostate cancer
Agoulnik, I. U., & Weigel, N. L. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20811 · Cited by 141
Androgen receptor gene and male infertility
Yong, E. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg003 · Cited by 142
Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor and to their anabolic and androgenic activities
Fragkaki, A. G., Angelis, Y. S., Koupparis, M. Α., Tsantili‐Kakoulidou, A., Kokotos, G., & Georgakopoulos, C. G. (2008) · Steroids · doi:10.1016/j.steroids.2008.10.016 · Cited by 143
Expression of Androgen Receptor Coregulators in Prostate Cancer
Linja, M. J., Porkka, K. P., Kang, Z., Savinainen, K., Jänne, O. A., Tammela, T. L. J., Vessella, R. L., Palvimo, J. J., & Visakorpi, T. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0990-3 · Cited by 140
The androgen/androgen receptor axis in prostate cancer
Bluemn, E. G., & Nelson, P. S. (2012) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835105b3 · Cited by 145
Androgen receptor phosphorylation: biological context and functional consequences
Koryakina, Y. A., Ta, H. Q., & Gioeli, D. G. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0472 · Cited by 136
Role of Androgens in Female Genitourinary Tissue Structure and Function: Implications in the Genitourinary Syndrome of Menopause
Traish, A. M., Vignozzi, L., Simon, J. A., Goldstein, I., & Kim, N. N. (2018) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.03.005 · Cited by 142
The role of the androgen receptor in the development of prostatic hyperplasia and prostate cancer
Chatterjee, B. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026057402945 · Cited by 135
Expression and function of androgen receptor coactivators in prostate cancer
Čulig, Z., Comuzzi, B., Steiner, H., Bartsch, G. H., & Hobisch, A. (2004) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.10.003 · Cited by 133
Developmentally Essential Protein Flightless I Is a Nuclear Receptor Coactivator with Actin Binding Activity
Lee, Y., Campbell, H. D., & Stallcup, M. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.2103-2117.2004 · Cited by 131
BAF57 Governs Androgen Receptor Action and Androgen-Dependent Proliferation through SWI/SNF
Link, K. A., Burd, C. J., Williams, E., Marshall, T. W., Rosson, G. B., Henry, E. C., Weissman, B. E., & Knudsen, K. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2200-2215.2005 · Cited by 131
Triptolide Inhibits the Proliferation of Prostate Cancer Cells and Down-Regulates SUMO-Specific Protease 1 Expression
Huang, W., He, T., Chai, C., Yang, Y., Zheng, Y., Zhou, P., Qiao, X., Zhang, B., Liu, Z., Wang, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037693 · Cited by 130
Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats
Ostrowski, J., Kuhns, J. E., Lupisella, J. A., Manfredi, M. C., Beehler, B. C., Krystek, S. R., Bi, Y., Sun, C., Seethala, R., Golla, R., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0843 · Cited by 131
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer
Westaby, D., de la Maza, M. D. F., Paschalis, A., Jiménez‐Vacas, J. M., Welti, J. C., Bono, J. S. D., & Sharp, A. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-015912 · Cited by 133

Authors: Heinlein, C. A., & Chang, C.
Affiliations: University of Rochester Medicine (US)
Corresponding author: Chang, Chawnshang
ORCID: Chang, Chawnshang
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2002-04-01
Volume: 23
Issue: 2
Pages: 175-200
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv.23.2.0460
OpenAlex: W2161123101
Cited by: 943
References: 357
Citations by year: 2026: 13 · 2025: 18 · 2024: 28 · 2023: 22 · 2022: 30 · 2021: 19 · 2020: 26 · 2019: 25 · 2018: 23 · 2017: 30 · 2016: 32 · 2015: 48 · 2014: 34 · 2013: 48 · 2012: 44
FWCI: 12.87
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: University of Rochester
National Institutes of Health (14642)
Medical Center, University of Rochester
National Cancer Institute (CA55639, CA-715670)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen receptor, coregulators, transcriptional regulation, androgen signaling, histone modifications, chromatin remodeling, basal transcription machinery, ligand selectivity, DNA binding, prostate cancer, steroid hormone receptors, male sexual differentiation, spermatogenesis
MeSH terms: Animals, Gene Expression Regulation, Humans, Male, Mutation, Prostatic Neoplasms, Receptors, Androgen, Transcription Factors, Transcription, Genetic, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Androgen Receptor (AR) Coregulators: An Overview

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks