The DOI matches its Crossref record; 288 of the 288 references it cites were found in a registry or an index.
Genetics of Osteoporosis
Abstract
Osteoporosis is a common multifactorial disorder of reduced bone mass. The disorder in its most common form is generalized, affecting the elderly, both sexes, and all racial groups. Multiple environmental factors are involved in the pathogenesis. Genes also play a major role as reflected by heritability of many components of bone strength. Quantitative phenotypes in bone strength in the normal population do not conform to a monogenetic mode of inheritance. The common form of osteoporosis is generally considered to be a polygenic disorder arising from the interaction of common polymorphic alleles at quantitative trait loci, with multiple environmental factors. Finding the susceptibility genes underlying osteoporosis requires identifying specific alleles that coinherit with key heritable phenotypes in bone strength. Because of the close correspondence among mammalian genomes, identification of the genes underlying bone strength in mammals such as the mouse is likely to be of major assistance in human studies. Identification of susceptibility genes for osteoporosis is one of several important approaches toward the long-term goal of understanding the molecular biology of the normal variation in bone strength and how it may be modified to prevent osteoporosis. As with all genetic studies in humans, these scientific advances will need to be made in an environment of legal and ethical safeguards that are acceptable to the general public.
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Cites
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Cited by
Visscher, P. M., Brown, M. A., McCarthy, M. I., & Yang, J. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.029 · Cited by 2,425
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Multiple Genetic Loci for Bone Mineral Density and Fractures
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Metadata
- Authors
- Peacock, M., Turner, C. H., Econs, M. J., & Foroud, T.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2002-06-01
- Volume
- 23
- Issue
- 3
- Pages
- 303-326
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2081285803
- Cited by
- 468
- References
- 288
- FWCI
- 24.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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