The DOI matches its OpenAlex record.
Regulation of in Vivo Growth Hormone Secretion by Leptin
Open accessAbstract
Leptin, the product of the ob gene, is a recently discovered hormone secreted by adipocytes that regulates food intake and energy expenditure. Growth hormone (GH) secretion is markedly influence by body weight being markedly suppressed in obesity and underweight. The aim of the present study was to study whether leptin can act as a metabolic signal connecting the adipose tissue with the growth hormone axis. We administered leptin antiserum (10 ul, i.c.v.) or normal rabitt serum (NRS; 10 ul, i.c.v.) to freely moving fed rats. Furthermore we assessed the effect of leptin administration (10 ug, i.c.v.) on fed and fasted rats. Spontaneous GH secretion was assessed over 6 hours with blood samples taken every 15 min. Administration of leptin antiserum led to a decrease in spontaneous GH secretion as assessed by the area under the curve (AUC) (168+/-72 ng/ml/6h) in comparison to NRS-treated rats (813+/-179 ng/ml/6h, p<0.01). While leptin administration (10 ug/rat; i.c.v.) to normal fed rats did not modify spontaneous GH secretion, leptin administration to fasted rats led to a reversal of the inhibitory effect exerted by fasting on GH secretion (AUC, 1650+/-351 ng/ml/6h vs 77+/-32 ng/ml/6h, p<0.01). This data suggests that leptin is a metabolic signal that regulates GH secretion.
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Citations
Cited by
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253
Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
Unraveling the central nervous system pathways underlying responses to leptin
Elmquist, J. K., Maratos-Flier, E., Saper, C. B., & Flier, J. S. (1998) · Nature Neuroscience · doi:10.1038/2164 · Cited by 520
Leptin—Much More Than a Satiety Signal
Harris, R. B. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.45 · Cited by 222
Hamrick, M. W., Ding, K.-H., Ponnala, S., Ferrari, S. L., & Isales, C. M. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080213 · Cited by 143
Regulation of in vivo TSH secretion by leptin
Seoane, L. M., Carro, E., Tovar, S., Casanueva, F. F., & Dieguez, C. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00145-2 · Cited by 109
Self-citationLeptin reverses the inhibitory effect of caloric restriction on longitudinal growth
Gat-Yablonski, G., Ben-Ari, T., Shtaif, B., Potievsky, O., Moran, O., Eshet, R., Maor, G., Segev, Y., & Phillip, M. (2004) · Endocrinology · doi:10.1210/en.2003-0910 · Cited by 106
Mechanisms mediating renal sympathetic activation to leptin in obesity
Morgan, D. A., Thedens, D. R., Weiss, R., & Rahmouni, K. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90324.2008 · Cited by 89
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(2006) · Europe PMC (PubMed Central) · Cited by 74
LaPaglia, N., Steiner, J., Kirsteins, L., Emanuele, M., & Emanuele, N. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590079 · Cited by 70
von Schnurbein, J., Moss, A., Nagel, S. A., Muehleder, H., Debatin, K. M., Farooqi, I. S., & Wabitsch, M. (2012) · Hormone Research in Paediatrics · doi:10.1159/000336003 · Cited by 70
Miletta, M. C., Petkovic, V., Eblé, A., Ammann, R. A., Flück, C. E., & Mullis, P.-E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107388 · Cited by 51
Böni-Schnetzler, M., Hauri, C., & Zapf, J. (1999) · Diabetologia · doi:10.1007/s001250051134 · Cited by 45
Papathanasiou, A. E., Nolen-Doerr, E., Farr, O. M., & Mantzoros, C. S. (2019) · European Journal of Endocrinology · doi:10.1530/eje-18-0847 · Cited by 20
Metadata
- Authors
- Carro, E., Señaris, R., Considine, R. V., Casanueva, F. F., & Diéguez, C.
- Venue
- Endocrinology
- Publisher
- Oxford University Press
- Published
- 1997-05-01
- Volume
- 138
- Issue
- 5
- Pages
- 2203-2203
- ISSN
- 0013-7227 (ISSN-L)
- OpenAlex
- W1973102414
- Cited by
- 365
- References
- 0
- FWCI
- 28.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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