Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting
Open accessAbstract
Proper nutritional status is critical for maintaining growth and metabolic function, playing an intimate role in neuroendocrine regulation. Leptin, the recently identified product of the obese gene, may very well be an integral signal which regulates neuroendocrine responses in times of food deprivation. The present study examines leptin's ability to regulate hormonal synthesis and secretion within the GRF-GH-IGF axis in the adult male rat during almost 3 days of fasting. Serum levels of GH and IGF-I were drastically suppressed by fasting. Daily leptin administration was able to fully prevent the fasting-induced fall in serum GH. Leptin failed to restore IGF-I to control levels, however, suggesting possible GH resistance. Fasting caused an insignificant increase in GH mRNA, while leptin injections significantly increased steady-state levels of this message. The GRF receptor (GRFr) message was not altered with fasting or leptin treatment. Leptin also exhibited effects at the hypothalamic level. Fasting induced a sharp fall in GRF mRNA expression and leptin injections partially prevented this fall. However, there were no observed changes in the hypothalamic GRF content. These results provide evidence that leptin may function as a neuromodulator of the GRF-GH-IGF axis communicating to this hormonal system the nutritional status of the animal.
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Exogenous administration of leptin to fasted mice fully prevents the suppression of both GH and IGF-1 levels and corrects in part the fasting-induced suppression of growth hormone-releasing hormone mRNA expression.
“It has previously been shown that the exogenous administration of leptin to fasted mice fully prevents the suppression of both GH and IGF-1 levels and corrects in part the fasting-induced suppression of growth hormone-releasing hormone mRNA expression (46).”
From The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men (2003) · cites this paper as [46]
The Results report that leptin prevented the fasting-induced fall in GH and that GRF mRNA levels in leptin-treated fasted animals were intermediate between the other groups. But this study was in rats, not mice, and the Results state that IGF-I fell even further with leptin treatment—the opposite of the claimed prevention. (LLM, conf=0.90)
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Research works printed but not linked: 1
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- Authors
- LaPaglia, N., Steiner, J., Kirsteins, L., Emanuele, M., & Emanuele, N.
- Affiliations
- Loyola University Chicago (US)
- Pediatrics and Genetics (US)
- ORCID
- Emanuele, M
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 1998-10-01
- Volume
- 159
- Issue
- 1
- Pages
- 79-83
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2145755665
- Cited by
- 70
- References
- 45
- Citations by year
- 2025: 1 · 2024: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, growth hormone, insulin-like growth factor I, growth hormone-releasing hormone, fasting, food deprivation, GH resistance, hypothalamus, nutritional status, neuroendocrine regulation, growth hormone mRNA
- MeSH terms
- Animals, Fasting, Hypothalamus, Insulin-Like Growth Factor I, Male, Pituitary Gland, Proteins, Radioimmunoassay, RNA, Messenger, Growth Hormone, Growth Hormone-Releasing Hormone, Blotting, Northern, Rats, Sprague-Dawley, Receptors, Neuropeptide, Receptors, Pituitary Hormone-Regulating Hormone, Reverse Transcriptase Polymerase Chain Reaction, Leptin, Rats
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