GEOFFREY HARRIS PRIZE LECTURE 2018: Novel pathways regulating neuroendocrine function, energy homeostasis and metabolism in humans
Open accessAbstract
The discovery of leptin, an adipocyte-secreted hormone, set the stage for unraveling the mechanisms dictating energy homeostasis, revealing adipose tissue as an endocrine system that regulates appetite and body weight. Fluctuating leptin levels provide molecular signals to the brain regarding available energy reserves modulating energy homeostasis and neuroendocrine response in states of leptin deficiency and to a lesser extent in hyperleptinemic states. While leptin replacement therapy fails to provide substantial benefit in common obesity, it is an effective treatment for congenital leptin deficiency and states of acquired leptin deficiency such as lipodystrophy. Current evidence suggests that regulation of eating behavior in humans is not limited to homeostatic mechanisms and that the reward, attention, memory and emotion systems are involved, participating in a complex central nervous system network. It is critical to study these systems for the treatment of typical obesity. Although progress has been made, further studies are required to unravel the physiology, pathophysiology and neurobehavioral mechanisms underlying potential treatments for weight-related problems in humans.
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Bodyweight is maintained through central nervous system circuitry integrating peripheral metabolic feedback signals of energy surplus or deficit.
“Bodyweight is usually maintained through central nervous system (CNS) circuitry integrating peripheral metabolic feedback signals of either energy surplus or deficit (21, 22).”
From GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin (2020) · cites this paper as [22]
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- Authors
- Papathanasiou, A. E., Nolen-Doerr, E., Farr, O. M., & Mantzoros, C. S.
- Affiliations
- Brigham and Women's Hospital (US)
- 2Division of Endocrinology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Mantzoros, Christos S
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-02
- Volume
- 180
- Issue
- 2
- Pages
- R59-R71
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- PMC
- PMC6378110
- OpenAlex
- W2901036660
- Cited by
- 20
- References
- 144
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 6
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- European Journal of Endocrinology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK081913)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, energy homeostasis, neuroendocrine regulation, obesity, appetite regulation, adipose tissue endocrine function, leptin deficiency, lipodystrophy, leptin replacement therapy, dietary habits
- MeSH terms
- Adipose Tissue, Body Weight, Brain, Energy Metabolism, Homeostasis, Humans, Neurosecretory Systems, Obesity, Leptin
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