The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Minireview: The Glucagon-Like Peptides
Abstract
The glucagon-like peptides GLP-1 and GLP-2 are produced in enteroendocrine L cells of the small and large intestine and secreted in a nutrient-dependent manner. GLP-1 regulates nutrient assimilation via inhibition of gastric emptying and food intake. GLP-1 controls blood glucose following nutrient absorption via stimulation of glucose-dependent insulin secretion, insulin biosynthesis, islet proliferation, and neogenesis and inhibition of glucagon secretion. Experiments using GLP-1 antagonists and GLP-1 receptor-/- mice indicate that the glucoregulatory actions of GLP-1 are essential for glucose homeostasis. In the central nervous system, GLP-1 regulates hypothalamic-pituitary function and GLP-1-activated circuits mediate the CNS response to aversive stimulation. GLP-2 maintains the integrity of the intestinal mucosal epithelium via effects on gastric motility and nutrient absorption, crypt cell proliferation and apoptosis, and intestinal permeability. Both GLP-1 and GLP-2 are rapidly inactivated in the circulation as a consequence of amino-terminal cleavage by the enzyme dipeptidyl peptidase IV (DP IV). The actions of these peptides on nutrient absorption and energy homeostasis and the efficacy of GLP-1 and GLP-2 in animal models of diabetes and intestinal diseases, respectively, suggest that analogs of these peptides may be clinically useful for the treatment of human disease.
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A role for glucagon-like peptide-1 in the central regulation of feeding
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Self-citationExendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans
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Cited by
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
Perry, R. J., Peng, L., Barry, N. A., Cline, G. W., Zhang, D., Cardone, R. L., Petersen, K. F., Kibbey, R. G., Goodman, A. L., & Shulman, G. I. (2016) · Nature · doi:10.1038/nature18309 · Cited by 1,299
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
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Self-citationThe Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion
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Metadata
- Authors
- Drucker, D. J.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2001-02-01
- Volume
- 142
- Issue
- 2
- Pages
- 521-527
- ISSN
- 0013-7227 (ISSN-L)
- OpenAlex
- W2140137473
- Cited by
- 421
- References
- 12
- FWCI
- 21.57
- Type
- journal article
- Language
- en
- Open access
- closed
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