Cited by 142Neuropeptides and Animal PhysiologyDiabetes Treatment and ManagementHeart Rate Variability and Autonomic Control

Neural contribution to the effect of glucagon-like peptide-1-(7—36) amide on arterial blood pressure in rats

Barragán, José Manuel, Eng, John, Rodríguez, Raquel, Blázquez, Enrique·1999·American Journal of Physiology-Endocrinology and Metabolism

Abstract

This study was designed to determine the contribution of the central nervous system (CNS) to the effects of glucagon-like peptide-1-(7—36) amide (tGLP-1) on arterial blood pressure and heart rate in rats. Accordingly, intracerebroventricular administration of the peptide produced an increase in cardiovascular parameters, which was blocked by previous administration of exendin-(9—39) through the same route, but not when it was intravenously injected. Intravenous administration of tGLP-1 produced a significant increase in arterial blood pressure and heart rate, which was blocked by the previous intracerebroventricular or intravenous administration of exendin-(9—39). Bilateral vagotomy blocked the stimulating effect of intracerebroventricular tGLP-1 administration on arterial blood pressure and heart rate. Also, bilateral vagotomy prevented the blocking effect of intracerebroventricular but not of intravenous exendin-(9—39) on cardiovascular parameters after intravenous administration of tGLP-1. These findings suggest that the action of tGLP-1 on cardiovascular parameters is under a dual control generated in the CNS and in peripheral structures and that the neural information emerging in the brain is transmitted to the periphery through the vagus nerve.

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Crossref · 10.1152/ajpendo.1999.277.5.e784

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Authors
Barragán, J. M., Eng, J., Rodríguez, R., & Blázquez, E.
Affiliations
  • Universidad de Salamanca (ES)
  • Veterans Health Administration (US)
  • Department of Biochemistry and Molecular Biology, University of Salamanca, 37007 Salamanca, Spain;
  • Universidad Complutense de Madrid (ES)
Venue
American Journal of Physiology-Endocrinology and Metabolism
Published
1999-11-01
Volume
277
Issue
5
Pages
E784-E791
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
OpenAlex
W2147973767
Cited by
142
References
39
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 6 · 2012: 9
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
glucagon-like peptide-1(7-36)amide, arterial blood pressure, heart rate, central nervous system, exendin-9-39, vagotomy, vagus nerve, intracerebroventricular administration, intravenous administration, incretins
MeSH terms
Animals, Blood Pressure, Glucagon-Like Peptides, Glucagon, Heart Rate, Humans, Injections, Intravenous, Injections, Intraventricular, Male, Peptide Fragments, Peptides, Vagotomy, Vagus Nerve, Rats, Sprague-Dawley, Neurotransmitter Agents, Rats, Glucagon-Like Peptide 1

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