The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Natural Variations in Maternal Care Are Associated with Estrogen Receptor α Expression and Estrogen Sensitivity in the Medial Preoptic Area
Abstract
Lactating rats exhibit stable individual differences in pup licking/grooming (LG) over the first week postpartum. Such naturally occurring variations in maternal behavior are associated with differences in estrogen-inducible oxytocin receptors in the medial preoptic area (MPOA) of the hypothalamus. We compared levels of ER alpha and ER beta mRNA in the MPOA of lactating High or Low LG mothers as well as in their nonlactating, female offspring, which inherit the maternal phenotype of their mothers. Among lactating females, High LG females exhibited significantly elevated levels of ER alpha mRNA compared with Low LG females. Likewise, the adult, virgin female offspring of High LG mothers showed higher levels of ER alpha mRNA in the MPOA compared with those of Low LG mothers. There were no group differences in levels of ER beta mRNA. Differences in ER alpha protein expression in the MPOA were confirmed using Western blot analysis. To further characterize the effects of estrogen in the MPOA, cFos immunoreactivity was compared in ovariectomized, adult offspring of High and Low LG dams treated with estradiol or oil. Increased cFos activity in the anterior ventral nucleus of the MPOA was observed in estradiol-treated High LG, but not Low LG females. These findings suggest that natural variations in maternal care are associated with differences in ER alpha expression in the MPOA and that such differences are transmitted from the mother to her female offspring.
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Self-citationComparative distribution of estrogen receptor-? and -? mRNA in the rat central nervous system
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Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
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Self-citationMaternal care, hippocampal synaptogenesis and cognitive development in rats
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“4722 Endocrinology, November 2003, 144(11):4720–4724 Champagne et al.”
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Cited by
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
Self-citationEpigenetic mechanisms and the transgenerational effects of maternal care
Champagne, F. A. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.03.003 · Cited by 812
Self-citationChampagne, F. A., Weaver, I. C. G., Diorio, J., Dymov, S., Szyf, M., & Meaney, M. J. (2006) · Endocrinology · doi:10.1210/en.2005-1119 · Cited by 675
Self-citationThe parent–infant dyad and the construction of the subjective self
Fonagy, P., Gergely, G., & Target, M. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01727.x · Cited by 555
Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513
Metadata
- Authors
- Champagne, F. A., Weaver, I. C. G., Diorio, J., Sharma, S., & Meaney, M. J.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2003-11-01
- Volume
- 144
- Issue
- 11
- Pages
- 4720-4724
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2154630934
- Cited by
- 295
- References
- 30
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Champagne, F. A., Weaver, I. C. G., Diorio, J., Sharma, S., & Meaney, M. J. (2003). Natural Variations in Maternal Care Are Associated with Estrogen Receptor α Expression and Estrogen Sensitivity in the Medial Preoptic Area. Endocrinology. https://doi.org/10.1210/en.2003-0564
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