Cited by 266Stress Responses and CortisolHypothalamic control of reproductive hormonesNeuroendocrine regulation and behavior

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Gender and Puberty Interact on the Stress-Induced Activation of Parvocellular Neurosecretory Neurons and Corticotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Rat

Viau, Victor, Bingham, Brenda, Davis, Jennifer, Lee, Patricia, Wong, Margaret·2005·Endocrinology

DOI 10.1210/en.2004-0846

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Abstract

Individual variations in hypothalamic-pituitary-adrenal (HPA) function are most evident at or beyond the time of puberty, when marked changes in sex steroid release occur. To explore the nature by which gender differences in HPA function emerge we examined in prepubertal (∼30-d-old) and postpubertal (∼60-d-old) male and female rats HPA activity under basal conditions and in response to 30 min of restraint. Within the ACTH-regulating, medial parvocellular portion of the paraventricular nucleus, restraint-induced Fos protein and arginine vasopressin heteronuclear RNA were lower in 60- than in 30-d-old males. No such age-related shift in the response of these synaptic and transcriptional markers of cellular activation occurred in female rats. Basal CRH mRNA expression levels in the paraventricular nucleus increased with age in female but not male rats. Conversely, only male rats showed an age-related increase in basal CRH mRNA in the central amygdala, suggesting that neuronal and neurosecretory CRH-expressing cell types are subject to different pubertal and gender influences. We conclude that gonadal regulation of the HPA axis develops via distinct mechanisms in males and females. Puberty-related shifts in parvocellular neurosecretory function in males are emphasized by stress-induced shifts in neuronal activation, whereas biosynthetic alterations dominate in female rats.

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Viau, 2003, Proc 33rd Annual Meeting of the Society for Neuroscience
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Authors: Viau, V., Bingham, B., Davis, J., Lee, P., & Wong, M.
Affiliations: University of British Columbia (CA)
Corresponding author: Viau, Victor
ORCID: Viau, Victor
Davis, Jennifer
Lee, Patricia
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2005-01-01
Volume: 146
Issue: 1
Pages: 137-146
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.2004-0846
OpenAlex: W2159178030
Cited by: 266
References: 59
Citations by year: 2026: 10 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 22 · 2020: 13 · 2019: 15 · 2018: 10 · 2017: 11 · 2016: 17 · 2015: 13 · 2014: 13 · 2013: 16 · 2012: 14
FWCI: 3.66
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Michael Smith Health Research BC
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: puberty, sex differences, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, paraventricular nucleus, parvocellular neurons, vasopressin, Fos protein, restraint stress, central amygdala, age-related changes, neurosecretion, rats
MeSH terms: Amygdala, Animals, Arginine Vasopressin, Corticotropin-Releasing Hormone, Female, Gonads, Male, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Restraint, Physical, RNA, Heterogeneous Nuclear, RNA, Messenger, Sex Characteristics, Stress, Physiological, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Rats

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Gender and Puberty Interact on the Stress-Induced Activation of Parvocellular Neurosecretory Neurons and Corticotropin-Releasing Hormone Messenger Ribonucleic Acid Expression in the Rat

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